Mesoporous Silica Nanoparticles Research Articles

Turn Hood into Good: Recycling Silicon from Mesoporous Silica Nanoparticles through Magnesium Modification to Lower Toxicity and Promote Tissue Regeneration.

Mesoporous silica nanoparticles (MSNs) have gained wide application as excellent carrier materials; however, their limited degradation in the biological system and potential chronic toxicity pose challenges to their clinical applications. Previous studies have focused on optimizing the elimination performance of MSNs; interestingly, silicon has been well-documented as an essential body component. Therefore, converting MSNs into a form readily utilizable by the organism is a way to turn waste into a valuable resource. However, the recycling and utilization of MSNs are associated with significant hurdles. This study proposes an approach to impede the formation of siloxane, the crucial core in MSNs, by introducing a gradient concentration of Mg2+. The invasion of Mg2+ significantly reduces the stability of Si-O-Si bonds by substituting silicon ions while preserving the functional three-dimensional structure. Recycling the increased release of Mg and Si ions enhances cellular antioxidant capacity, reduces oxidative stress reactions, improves mitochondrial function, and regulates macrophage inflammatory states. The proposed approach to converting MSN materials shows significant advantages for tissue regeneration in the periodontal defect model. This study opens an insight for applying MSNs in clinical applications in regenerative medicine.

Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment.

Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (Zn-MSN) and microneedle (MN), designed to enhance drug utilization for prolonged anti-inflammatory and anti-itch effects. The MN system facilitated the transdermal delivery of betamethasone dipropionate (BD), allowing its slow release. The BD@Zn-MSN-MN system promoted the polarization of macrophages towards the anti-inflammatory M2 phenotype, achieving superior anti-inflammatory effects compared to the clinically used BD cream. Additionally, this study demonstrated that BD@Zn-MSN-MN could further alleviate itching in psoriasis-afflicted mice by decreasing the excitability of the transient receptor potential vanilloid V1 (TRPV1) ion channel positive neurons and reducing the release of calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG). These findings offer new insights and effective therapeutic options for the future design of transdermal drug delivery for psoriasis.

Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia

Androgenetic alopecia (AGA) is caused by the impact of dihydrotestosterone (DHT) on hair follicles, leading to progressive hair loss in men and women. In this study, we developed caffeine-loaded hollow mesoporous silica nanoparticles coated with ultradeformable liposomes (ULp-Caf@HMSNs) to enhance caffeine delivery to hair follicles. Caffeine, known to inhibit DHT formation, faces challenges in skin penetration due to its hydrophilic nature. We investigated caffeine encapsulated in liposomes, hollow mesoporous silica nanoparticles (HMSNs), and ultradeformable liposome-coated HMSNs to optimize drug delivery and release. For ultradeformable liposomes (ULs), the amount of polysorbate 20 and polysorbate 80 was varied. TEM images confirmed the mesoporous shell and hollow core structure of HMSNs, with a shell thickness of 25–35 nm and a hollow space of 80–100 nm. SEM and TEM analysis showed particle sizes ranging from 140–160 nm. Thermal stability tests showed that HMSNs coated with ULs exhibited a Td10 value of 325 °C and 70% residue ash, indicating good thermal stability. Caffeine release experiments indicated that the highest release occurred in caffeine-loaded HMSNs without a liposome coating. In contrast, systems incorporating ULp-Caf@HMSNs exhibited slower release rates, attributable to the dual encapsulation mechanism. Confocal laser scanning microscopy revealed that ULs-coated particles penetrated deeper into the skin than non-liposome particles. MTT assays confirmed the non-cytotoxicity of all HMSN concentrations to human follicle dermal papilla cells (HFDPCs). ULp-Caf@HMSNs promoted better cell viability than pure caffeine or caffeine-loaded HMSNs, highlighting enhanced biocompatibility without increased toxicity. Additionally, ULp-Caf@HMSNs effectively reduced ROS levels in DHT-damaged HFDPCs, suggesting they are promising alternatives to minoxidil for promoting hair follicle growth and reducing hair loss without increasing oxidative stress. This system shows promise for treating AGA.

Antibacterial Effects of Silica Nanoparticles Loading Nano-silver and Chlorhexidine in Root Canals Infected by Enterococcus faecalis.

The persistence of microbial infection can lead to endodontic failure. Enterococcus faecalis (E. faecalis) is acknowledged to be a closely associated bacterium. This study investigated the antimicrobial effects of mesoporous silica nanoparticles (nMS) carrying nano-silver and chlorhexidine (nMS-nAg-Chx) on E. faecalis. Analyses were conducted to assess the antimicrobial efficacy of nMS-nAg-Chx towards planktonic E. faecalis, including the zone of inhibition, minimal inhibitory concentration (MIC), and growth curves. The measurement of lactic acid, scanning electron microscopy (SEM), live-dead bacteria staining, and quantitative real-time PCR (qRT-PCR) were done to further investigate its anti-biofilm effect. Colony forming unit (CFU) and SEM were used to assess its efficacy in infected root canals. The growth of planktonic E. faecalis was suppressed with a MIC value of 25 μg/mL (P＜0.05). nMS-nAg-Chx concentration-dependently inhibited biofilm formation of E. faecalis with the reduction of lactic acid (P < 0.05), sparse biofilm structure, reduced percentage of viable bacteria (P < 0.05), and suppressed expression of ebpR, gelE, ace, and efa genes (P < 0.05). The seven-day sealing of nMS-nAg-Chx resulted in a notable reduction in bacterial counts compared to the saline control group in the E. faecalis infected root canals (P < 0.05). NMS-nAg-Chx effectively inhibits E. faecalis and removes its biofilm from infected human root canals. It may be used for endodontic treatments in the control of E. faecalis bacteria as an intracanal medication.

Preparation of Glutathione-Regulated Sorafenib Targeted Nanodrug Delivery System and Its Antihepatocellular Carcinoma Activity.

To enhance the therapeutic effect of sorafenib (SOR) on liver cancer, we have developed a targeted nanodrug delivery system with glutathione (GSH) downregulation functionality. The preparation process comprises the synthesis of amino-functionalized mesoporous silica nanoparticles (MSN-NH2), surface modification with ethacrynic acid (EA), loading of SOR into the pores, and final surface coating with hyaluronic acid (HA) to obtain SOR@MSN-EA@HA (SMEH) nanoparticles. SMEH nanoparticles specifically enter tumor cells via CD44 receptor-mediated endocytosis. EA binds to GSH to consume it, while SOR is slowly released from the pores to exert antitumor effects while inhibiting GSH production. This results in sustained oxidative stress in the cells, thus enhancing the antitumor efficacy. Both in vitro and in vivo antitumor experiments as well as hemolysis tests have demonstrated that SMEH nanoparticles can accurately target liver cancer cells, effectively downregulate GSH concentration, exhibit good antitumor effects, and possess excellent safety, showing great potential in tumor treatment.

Extracellular matrix mimetic supramolecular hydrogels reinforced with covalent crosslinked mesoporous silica nanoparticles.

The extracellular matrix (ECM) is a dynamic environment that is primarily built up from fibrous proteins (e.g., elastins, fibronectins, collagens, and laminins) and plays a vital role in tissue regeneration processes. Therefore, the development of supramolecular hydrogels that can mimic the ECM's dynamicity and fibrous structure is of great interest in regenerative medicine. However, such hydrogels generally have weak mechanical properties and poor structural stability, which significantly limits their potential applications. To overcome this drawback, we developed a new type of hybrid network composed of supramolecular assemblies with covalent nanoparticle-based crosslinkers. The ECM mimetic hydrogels were created through UV-initiated thiol-ene crosslinking between norbornene functionalized benzene-1,3,5-tri carboxamide (NBTA) macromonomers and thiol functionalized mesoporous silica nanoparticles (MSN). We hypothesized that the MSN would improve the mechanical properties by crosslinking the NBTA supramolecular fibrous hydrogels. Notably, the covalent incorporation of MSNs did not disrupt the fibrous morphology of the resulting NBTA-MSN nanocomposites. Furthermore, these supramolecular nanocomposites demonstrated higher structural stability and elasticity compared to pristine NBTA hydrogels. Rheology studies showed that the mechanical properties of NBTA-MSN hydrogels could be tuned by adjusting MSN wt%. Interestingly, NBTA-MSN nanocomposites exhibited self-healing and injectability despite the covalent crosslinking of MSNs. In vitro studies confirmed that NBTA-MSN nanocomposites showed good cytocompatibility and maintained the viability of encapsulated MG63 cells. As a proof of concept, we also demonstrated that MSNs could act as ion reservoirs for calcium and phosphate within the hydrogel networks in addition to being covalent crosslinkers. Taken together, our work offers a promising strategy to create hybrid, biomimetic supramolecular nanocomposite materials for various applications such as injectable materials for bone tissue engineering, and reinforced bioinks for 3D printing applications.

Smart Mesoporous Silica Nanoparticles Loading Curcumin Inhibit Liver Cancer.

Curcumin (CUR) as one of the natural edible pigments is approved by the World Health Organization due to its nontoxic and anticancer effect. However, the utility of CUR is restricted due to its low oral bioavailability. Nanoparticle drug delivery systems like mesoporous silica nanoparticles (MSNs) have been extensively used due to their high specific surface area, high loading rate, and ease of modification. This study developed lactobionic acid (LA)-modified carboxymethyl chitosan (CMCS)-coated MSNs to deliver CUR specifically targeting hepatocellular carcinoma. Among these nanoparticles, LA targets liver cancer cells. CMCS utilizes pH-responsive release of CUR. The LA-CMCS-MSN@CUR (MSN@CUR) were evaluated using several methods, including Fourier transform infrared spectroscopy, transmission electron microscopy, and zeta potential measurements. Liver cellular uptake of MSN@CUR depends on a specific LA receptor-mediated endocytosis mechanism. Additionally, MSN@CUR performed with a better antitumor effect than Cur in H22 orthotopic transplantation of liver cancer and H22 solid tumor mouse models. Treatment with MSN@CUR significantly reduced the protein of VEGF, p-PI3K, and AKT, increased the protein of caspases 3 and 8, ultimately inhibited tumor migration, and promoted apoptosis. This study provides a new path for delivery of natural active ingredients with excellent bioavailability in the antitumor field.

Dendritic mesoporous silica loaded with gold nanoclusters and their application in immunochromatographic assay.

Novel green-emitting fluorescent microspheres (GreFMPs) were assembled by loading highly luminescent gold nanoclusters (Arg/ATT/AuNCs) ondendritic mesoporous silica nanoparticles (DMSNs) via PEI-mediated electrostatic adsorption. The fluorescence microspheres exhibit excellent monodispersion with average diameters about (254.5 ± 34.6nm). Compared with free Arg/ATT/AuNCs, the GreFMPs have similar fluorescent properties and biocompatibility but superior environmental tolerance. Subsequently, an immunochromatographic assay based on GreFMPs (GreFMP-ICA) has been successfully developed, which is highly selective toward alphafetoprotein (AFP) in human serum. Under the optimal parameters, there is a good linear range between 0.5 and 160.0ng/mL, the limit of detection was found to be about 0.5ng/mL, and the recovery and relative standard deviation are 81.0 ~ 100.6% and 3.5 ~ 16.6%, respectively. These results manifested that the GreFMPs are beneficial for the rational design of the ICA platform, and the proposed GreFMP-ICA has the potential to screen AFP in clinical applications.

Inhibition of Polyphenol Oxidase Activity by Mesoporous Silica Nanoparticles and Multiwalled Carbon Nanotubes Modified with Surfactants.

Polyphenol oxidase (PPO) is the culprit behind the browning of fruits and vegetables. Therefore, how to reduce the thermal deactivation temperature of PPO or use as few safe reagents as possible to inhibit enzymatic browning has practical significance. Mesoporous silica nanoparticles (MSNs) and multiwalled carbon nanotubes (MWCNTs) are stable and have high biosafety. In the present study, efficient PPO inhibitors were developed based on MSNs and MWCNTs. It is found that after modification with a very small amount of dodecyl trimethylammonium bromide (DTAB, ≥60 μg/mL), MSNs can significantly inhibit the activity of PPO although single MSNs and single DTAB show very limited effect on PPO activity. After modification with a very small amount of sodium dodecyl sulfate (SDS, 5.7-9.5 μg/mL), MWCNTs almost completely inactivate PPO. However, SDS@MSN and DTAB@MWCNT cannot decrease PPO activity significantly.

Migrated silicon dioxide nanoparticles activates the rice immunity for systemic resistance against two pathogens

Rice, the world's primary staple food, is under severe threat from several devastating diseases. To sustainably management rice diseases, developing safe, environmentally friendly alternatives urgently need to be developed. In this study, we synthesized two silicon dioxide nanoparticles, spherical mesoporous silica nanoparticles (MSNs) and virus-like mesoporous silica nanoparticles (VMSNs), and we performed a resistance assay on rice for two major diseases, bacterial blight caused by Xanthomonas oryzae pv. oryzae and sheath blight caused by Rhizoctonia solani. Compared to the control, the two nanoparticle treatments increased rice resistance, with VMSNs exhibiting the highest efficacy in controlling these two diseases, causing a shorter lesion length than those plants treated by MSNs. Coincidentally, the foliar application of VMSNs activates a higher expression level of several pathogenesis-related (PR) genes compared to those of MSNs and SiO2 treatment. By using fluorescein isothiocyanate (FITC)-labeled VMSNs (VMSNs-FITC) to soak the top expanded leaf tips or roots, we observed that the fluorescence of the nanoparticles firstly accumulated at the local site of the top leaves or roots, rapidly migrated to the hypocotyl of rice, and then redistributed sequentially from the bottom leaves to the upper leaves. Furthermore, the foliar or root application of VMSNs-FITC could trigger the local and systemic resistance to PXO99. Notably, no significant toxicity was observed on plants and mice after excessive foliar treatment or feeding tests, respectively. Overall, our research revealed that VMSNs are an effective, systemic, and safe nano-pesticides for controlling rice diseases. Boosting the immune responses may be associated with the transporting of nanoparticles.

Nanometer-Scale Tunable mesopores in silica fillers for Facile enhancement of epoxy adhesion

Epoxy resins are essential polymeric materials for various industrial applications owing to their excellent adhesion, thermal properties, and processability. Reported improvement methods for overcoming the limitations of epoxy-resin adhesives involve incorporating fillers such as silica, clay, carbon nanotubes, and graphene. While silica nanoparticles are commonly used in industrial applications, their properties often require enhancement. In this study, mesoporous silica nanoparticles (MSNs) were synthesized using cetyltrimethylammonium bromide and novel swelling agents, 2,6-dihydroxybenzoic acid and decane, to control pore sizes within the 2–4 nm range. Transmission electron microscope and nitrogen adsorption analyses confirmed pore sizes of 2.0, 3.1, and 3.9 nm. Applying MSNs as nanofillers to epoxy resin adhesive resulted in enhanced adhesive properties with increasing pore size, particularly with 0.5 wt% MSN-4 nm, achieving a 51.4 % improvement in shear strength compared to that of bare epoxy resin. This enhancement is attributed to the increased specific surface area of the MSNs, providing more interaction sites with the epoxy resin and improving resin penetration and interaction. These findings highlight the critical role of nanopore size in optimizing adhesion in nanofiller applications and emphasize the potential of MSNs as superior nanofillers for future industrial applications.

An innovative biosensor utilizing aptamer-gated mesoporous silica nanoparticles for determination of aminoglycoside antibiotics through indirect-lateral flow

BackgroundAminoglycoside antibiotics (AGs) are commonly utilized in both human and veterinary medicine to treat and manage a range of infections. These antibiotics are recognized for their narrow therapeutic window, with an overdose potentially resulting in severe side effects like kidney and ear damage. Hence, the implementation of a quick, precise, and on-the-spot testing method is crucial in clinical settings. In the present investigation, we designed an innovative indirect lateral flow assay (LFA) utilizing aptamers to detect kanamycin, a type of aminoglycoside antibiotics. We prepared mesoporous silica nanoparticles (MSNs) functionalized with amino groups, loaded them with morphine (MOP), and then sealed them with aminoglycoside aptamers (Apt). The complex of gated-MSNs@Apt was tested using the MOP LFA in the presence or absence of kanamycin antibiotics. ResultsThe indirect LFA system displayed a single colored line in the test line for positive samples, whereas it exhibited double colored lines in both the control line and test line for negative samples. Our custom-designed LFA biosensors demonstrated two linear ranges, from 10 nM to 350 nM and 500 nM to 1500 nM, with a limit of detection (LOD) of 5 nM in serum media under optimized conditions. The introduced indirect LFA biosensor was effectively utilized to detect kanamycin, achieving a satisfactory recovery rate of 92.9-109.9% with RSD of 1.68-7.73% in serum samples. SignificanceIn general, the created LFA system offers a portable, straightforward, and affordable approach for point-of-care (POC) identification of kanamycin and other AGs.

Engineered Biomimetic Nanoparticles-Mediated Targeting Delivery of Allicin Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis.

Cardiac microvascular damage is substantially related with the onset of myocardial ischaemia-reperfusion (IR) injury. Reportedly, allicin (AL) effectively protects the cardiac microvascular system from IR injury. However, the unsatisfactory therapeutic efficacy of current drugs and insufficient drug delivery to the damaged heart are major concerns. Here, inspired by the natural interaction between neutrophils and inflamed cardiac microvascular endothelial cells (CMECs), a neutrophil membrane-camouflaged nanoparticle for non-invasive active-targeting therapy for IR injury by improving drug delivery to the injured heart is constructed. In this study, we engineered mesoporous silica nanoparticles (MSNs) coated with a neutrophil membrane to act as a drug delivery system, encapsulating AL. The potential of the nanoparticles (named AL@MSNs@NM) for specific targeting of infarcted myocardium was assessed using small animal vivo imaging system. The cardiac function of AL@MSNs@NM after treatment was evaluated by Animal Ultrasound Imaging system, HE staining, and Laser Speckle Imaging System. The therapeutic mechanism was analyzed by ELISA kits, immunofluorescence, and PCR. We discovered that AL@MSNs@NM significantly improves cardiac function index, reduced infarct size and fibrosis, increased vascular perfusion in ischemic areas, and also promoted the function of CMECs, including migration, tube formation, shear stress adaptation, and nitric oxide production. Further research revealed that AL@MSNs@NM have cardio-protective functions in IR rats by inhibiting CMEC ferroptosis and increasing platelet endothelial cell adhesion molecule-1 (PECAM-1) expression. Our results indicated that AL@MSNs@NM significantly reversed CMEC ferroptosis and increased PECAM-1 expression, enhanced cardiac function, and reduced myocardial infarction size. Therefore, this strategy demonstrates that engineered biomimetic nanotechnology effectively delivers AL for targeted therapy of myocardial infarction.

Bioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury

Traumatic brain injury (TBI) can lead to severe neurotrauma, leading to long-term cognitive decline and even death. Massive neuronal loss and excessive neuroinflammation are critical issues in the treatment of secondary TBI. To tackle these challenges, we developed a GelMA and CSMA hydrogel loaded with Erythropoietin (EPO) and Interleukin-4 (IL-4), named GC/I/E. By directly loading the hydrogel with EPO, rapid neuroprotection and angiogenesis were achieved. Meanwhile, by loading Mesoporous silica nanoparticles (MSNs) with IL-4 (MSN@IL-4), sustained inflammation modulation during inflammation was attained. In vitro experiments demonstrated that GC/I/E hydrogel were biocompatible and could provide neuroprotection for HT22 cells in H2O2 environment, regulate RAW264.7 polarization from M1 to M2 phenotype and promote HUVEC angiogenesis. In vivo experiments demonstrated that GC/I/E hydrogel reduced brain oedema and Nissl body damage, inhibited inflammatory expression of G3-FFAP and neural scarring, improved microvascular and vascular function reconstruction, and facilitated neuronal and synaptogenesis, ultimately improving neurofunctional recovery in TBI. RNA sequencing results demonstrated that GC/I/E hydrogel treatment significantly correlated with the regulation of genes such as apoptosis, inflammation regulation, and neural regeneration. This bioactive hydrogel with neuroprotection, inflammation modulation and promotion of angiogenesis has great potential for TBI treatment.

Thrombin Immobilized on Magnetic Core-Shell Mesoporous Silica Nanoparticles for Screening of the Enzyme Inhibitors From Notopterygium Incisum.

Thrombin was immobilized on magnetic core-shell mesoporous silica nanoparticles (Fe3O4@nSiO2@mSiO2) for the first time and used to screen enzyme inhibitors from extracts of Notopterygium incisum. The immobilized thrombin was characterized by Fourier-transform infrared spectroscopy, transmission electronic microscopy, thermal gravimetric analysis, and vibrating sample magnetometry. The results demonstrated that the immobilized thrombin possessed good thermal stability and high-temperature resistance for feasible storage and reuse. Two ligands, notopterol (1) and isoimperatorin (2) were fished out from the extract of N. incisum using the immobilized thrombin. They inhibited thrombin with IC50 values of 59.35±1.420 and 107.8±1.660µM, respectively. This is the first report of thrombin-inhibitory activity associated with notopterol and isoimperatorin. Meanwhile, the inhibition mechanism of both compounds was investigated by enzyme kinetic analysis and molecular docking. The method used enables rapid screening for thrombin inhibitors from medicinal plants, providing an efficient tool for the discovery of anti-thrombotic active compounds.

Microfluidic-assisted synthesis of mesoporous silica nanoparticles as drug carriers: characterization and biocompatibility studies

Microfluidic-assisted synthesis of mesoporous silica nanoparticles as drug carriers: characterization and biocompatibility studies

Microstructure evolution of alite in-situ carbonated by aminated mesoporous silica nanoparticles

Microstructure evolution of alite in-situ carbonated by aminated mesoporous silica nanoparticles

Fabrication of composite RGD-tagged poly(lactic acid)-graphene oxide nanofiber containing bone-forming peptide-3 loaded-dendritic silica nanoparticles for bone regeneration in rabbit

In the current study, polylactic acid (PLA)/graphene oxide (GO) based composite scaffolds were fabricated by electrospinning method and then covalently modified with bone-forming peptide-3 (BFP-3)-loaded thiol-functionalized dendritic mesoporous silica nanoparticles (BFP-3@HS-DMSNs) and RGD. In this regard, PLA electrospinning nanofibers and composite of PLA/GO electrospinning nanofibers containing 0.02, 0.01, 0.04, 0.1, 0.2 % of GO were prepared and characterized in terms of mechanical strength, nanofibers diameter, thermal stability, crystallinity, specific surface area, total pore volume and cell adhesion properties. Among the prepared composites, PLA nanofibers containing 0.02 % GO demonstrated superior mechanical and morphological characteristics along with better cell adhesion for mesenchymal stem cell. Then, the PLA/0.02 %GO nanofiber was treated with plasma and consequently modified with N-(2-aminoethyl)maleimide linker which was applied for Cys-RGD and BFP-3@HS-DMSNs conjugation. The obtained results showed desirable adhesion of PLA/0.02 %GO nanofiber after incorporation of RGD (5 % of maleimide groups of the linker) and DMSNs which significantly increase cell adhesion potency (1.53 folds). By incorporation of BFP-3@HS-DMSNs (equivalent to 0.1 µg of BFP-3) to the RGD-tagged PLA/0.02 %GO nanofiber, the scaffold demonstrated better cytocompatibility and MSC differentiation to osteoblast based on biomineralization assay via alizarin red (4.2 folds) and alkaline phosphatase activity (1.7 folds) tests. In preclinical stage, after skull defect creation in rabbits, 5 treatments groups comprising PLA/0.02 %GO nanofiber, PLA/0.02 %GO/DMSNs, PLA/0.02 %GO/DMSNs/Cys-RGD, PLA/0.02 %GO/BFP-3@DMSNs and PLA/0.02%GO/BFP-3@DMSNs/Cys-RGD were used for bone regeneration in skull defects. After 3 months, the implantation of PLA/0.02GO/BFP-3@DMSNs/Cys-RGD showed higher bone regeneration based on CBCT imaging (18.875 mm2 bone formed area) in comparison with other treatment groups. This hybrid multimodal platform is purposely organized interactive processes which lead to potential bone regeneration.

Multifunctional and novelty green composite film containing sodium alginate, chitosan, rice husk and curcumin

Foodborne diseases are a global public health issue, with their causes often originating from lapses in food production or transportation leading to food contamination. Therefore, food packaging plays a crucial role in preserving the safety and quality of food. In pursuit of sustainable development, this study aims to utilize agricultural waste-derived functional mesoporous silica nanoparticles in combination with biodegradable molecules to create food packaging films. Through recycling and the use of environmentally friendly green films, the goal is to achieve sustainability and the objectives of green chemistry. The study anticipates the production of biodegradable films and the testing of their antibacterial capabilities, antioxidant properties, biocompatibility, and film stress coefficients. This research will provide robust support for advancing green packaging technology to address the challenges of global food safety and environmental sustainability.The experiment is divided into two parts. The first part involves the synthesis of multifunctional mesoporous silica nanoparticles with antibacterial properties derived from rice husk (Rice husk mesoporous silica nanoparticles, rMSN) as nano-fillers. These nanoparticles are surface modified with a biodegradable polymer, chitosan (Chi), that interacts with the material. Natural extract curcumin (Cur), known for its antioxidant capabilities, is loaded into the pores, and the material's inherent antibacterial properties are utilized. The second part involves blending the material with the natural polymer sodium alginate (SA) to form a film (rMSN-Chi@Cur/Alg film). The film's thickness, stress strength, antibacterial, and antioxidant capabilities are tested to ensure the material possesses antibacterial and antioxidant properties.

Doxorubicin- and Selenium-Incorporated Mesoporous Silica Nanoparticles as a Combination Therapy for Osteosarcoma

Doxorubicin- and Selenium-Incorporated Mesoporous Silica Nanoparticles as a Combination Therapy for Osteosarcoma