Meso-tetra 4-carboxyphenyl Porphine Research Articles

Investigation of Photodynamic Therapy on Breast Cancer Cell Lines Using LaF3:Tb Nanoparticles Conjugated with Meso-tetra(4-carboxyphenyl) Porphine

Photodynamic therapy (PDT) is a clinically appropriate therapeutic procedure with a minimum invasion that can apply a selective cytotoxic effect toward intended cells. Generally, PDT involves the administration of light and a photosensitive drug (photosensitizer). In the presence of oxygen molecules, the excited photosensitizer can produce reactive oxygen species (ROS) to kill the cancerous cells. In PDT, drug or light can administrate in high doses at short time (acute PDT) or in low doses in a period of time (metronomic PDT). In addition, to solve the problem of light access to the tissues, new modality that named Self Light PDT (SLPDT), was introduced recently. According to the studies, LaF3:Tb conjugated with meso-tetra(4-carboxyphenyl) porphine (MTCP) nanosystem can function as an efficient nanosystem in SLPDT due to the ability of energy transfer between the light-exited NPs and MTCP to emissions which can generate ROS. In this research besides synthesizing and characterizing LaF3:Tb-MTCP nanosystems, we also studied energy transfer feasibility under UV radiation between NP and PS. Afterward, we tried to design several in vitro test using breast cancer cell lines, T47D and mcf-7, to understanding LaF3:Tb conjugated MTCP potentials for SLPDT or mPDT.

Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activation

In this letter, we report the synthesis of LaF3:Tb3+–meso-tetra(4-carboxyphenyl) porphine (MTCP) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following x-ray irradiation. Our observations indicate that LaF3:Tb3+-MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by x-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen production in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can potentially be used to activate photodynamic therapy as a promising deep cancer treatment modality.

Rapid Prescreening for Antiviral Agents against HIV-1 Based on Their Inhibitory Activity in Site-Directed Immunoassays. Approaches Applicable to Epidemic HIV-1 Strains

Several compounds, including the triphenylmethane derivative aurintricarboxylic acid (ATA) and porphyrins, were reported to inhibit the binding of anti-V3 loop-specific antibodies to the V3 loop of gp120 from HIV-1 III-B and to have antiviral activity, probably due to interference with the biological function of the V3 loop. However, these compounds can be applied to antiviral chemotherapy only if they interact with envelope glycoproteins from a multitude of epidemic HIV-1 strains and inhibit their replication. Since recombinant envelope glycoproteins, synthetic peptides and anti-V3 monoclonal antibodies may not be available for these HIV-1 strains, alternative assays are needed to prescreen different compounds for potential antiviral activity against these viruses. Results presented here indicate that: (1) virions of HIV-1 MN, most closely related to primary HIV-1 isolates from European and North American countries, and human anti-HIV-1 antibodies, can also be used for rapid prescreening of antiviral agents, (2) compounds with antiviral activity against HIV-1 MN, discerned by site-directed immunoassays, inhibited the reaction of human anti-HIV-1 with a V3 loop consensus peptide corresponding to European/North American HIV-1 isolates, and (3) meso-tetra (4-carboxyphenyl) porphine (MTCPP), one of the most potent inhibitors of HIV-1 replication selected on the basis of site-directed immunoassays, preferentially attached to the V3 loop of gp120.