The aim is to evaluate the fracture resistance of endodontically treated teeth restored with posterior direct composite (PRC) resin, bulk-fill composite resin, dual-cure composite (DCC) resin, and short fiber-reinforced composite (SFC) resin material.Materials and methodsNinety sound maxillary premolar teeth were divided into 6 groups which comprised 15 teeth each. Group I was a negative control group where neither cavity preparation nor root canal treatment was done on the specimen. Group II was named positive control group as it was left unrestored after mesio-occluso-distal (MOD) preparation and root canal treatment. Groups III to VI were filled with PRC, bulk-fill composite, DCC, and SFC, respectively, and subjected to fracture testing in a universal testing machine.ResultsAfter statistical analysis, it was seen that group VI had increased mean fracture resistance as compared to other groups.ConclusionIt was concluded that short fiber-reinforced composite proved to have superior properties that other experimental groups and hence can be used as a core build-up material.Clinical significanceThe core build-up is requisite as the residual tooth structure after endodontic procedure decreases and core build-up supplements the resistance and retention of the tooth structure.How to cite this articleKaur B, Gupta S, Grover R, et al. Comparative Evaluation of Fracture Resistance of Endodontically Treated Teeth Restored with Different Core Build-up Materials: An In Vitro Study. Int J Clin Pediatr Dent 2021;14(1):51–58.