Abstract In order to realize the rapid design of warp-knitted jacquard spacer shoe-upper materials and to explore the influence of different fabric surface organization structures on their air permeability, it is proposed to numerically simulate the air permeability performance of jacquard shoe-upper materials using ANSYS fluid analysis. First, four kinds of shoe material specimens with different upper and lower layer mesh alignment relationships are designed and tested, then the corresponding geometric structure models of the fabric are established based on the samples and appropriately processed, and finally the air permeability of the shoe material is numerically simulated and calculated based on computational fluid dynamics. The results show that, under the same conditions, the air permeability of double-sided mesh structure is significantly better than that of single-sided mesh structure, and its air permeability can be optimized by adjusting the relationship between the upper and lower layers of the fabric mesh; the airflow mainly passes through the fabric pores and gaps between the yarns, and the closer the fabric structure is, the more the air flow is hindered, and the worse the air permeability is. The simulation results of the established numerical model are consistent with the measured results, and the error is less than 10%, so it can be used to simulate and predict the air permeability of the warp-knitted jacquard spacer footwear materials, and provide theoretical support for the design and performance research of footwear materials.