Merging Palladium Catalysis Research Articles

Synergistic Approach for Decarboxylative Ortho C−H Aroylation of 2‐Aryl‐pyrido[1,2‐a]pyrimidin‐4‐ones and Thiazolopyrimidinones by Merging Palladium Catalysis with Photocatalysis

AbstractA mild and efficient synergistic approach for decarboxylative aroylation of 2‐aryl‐pyrido[1,2‐a]pyrimidin‐4‐ones having intrinsic directing group has been developed by merging of palladium catalysis and photoredox catalysis at room temperature. Therapeutically interesting aryl ketones of pyrido[1,2‐a]pyrimidin‐4‐one have been synthesized in good to excellent yield with good functional group tolerance.

Direct C–H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis

Herein, we report that merging palladium catalysis with hydrogen atom transfer (HAT) photocatalysis enabled direct arylations and alkenylations of aldehyde C–H bonds, facilitating visible light-cat...

Merging Transition-Metal Catalysis with Photoredox Catalysis: An Environmentally Friendly Strategy for C–H Functionalization

Transition-metal-catalyzed C–H functionalization is already a useful tool in organic synthesis, whilst the rapid development of photoredox catalysis provides new pathways for C–H functionalization with high selectivity and efficiency under mild reaction conditions. In this review, recent advances in C–H functionalization through merging transition­-metal catalysis with photoredox catalysis are discussed. 1 Introduction 2 Merging Nickel Catalysis with Photoredox Catalysis 3 Merging Palladium Catalysis with Photoredox Catalysis 4 Merging Cobalt Catalysis with Photoredox Catalysis 5 Merging Photoredox Catalysis with Other Transition-Metal Catalysis­ 6 Conclusions

Merging Transition-Metal Catalysis with Photoredox Catalysis: An Environmentally Friendly Strategy for C–H Functionalization

Transition-metal-catalyzed C–H functionalization is already a useful tool in organic synthesis, whilst the rapid development of photoredox catalysis provides new pathways for C–H functionalization with high selectivity and efficiency under mild reaction conditions. In this review, recent advances in C–H functionalization through merging transition­-metal catalysis with photoredox catalysis are discussed.1 Introduction2 Merging Nickel Catalysis with Photoredox Catalysis3 Merging Palladium Catalysis with Photoredox Catalysis4 Merging Cobalt Catalysis with Photoredox Catalysis5 Merging Photoredox Catalysis with Other Transition-Metal Catalysis­6 Conclusions

Palladium-Catalyzed Direct C-H Functionalization of Indoles with the Insertion of Sulfur Dioxide: Synthesis of 2-Sulfonated Indoles.

A palladium-catalyzed direct C-H bond sulfonylation of indoles with the insertion of sulfur dioxide is achieved through a three-component reaction of 1-(pyridin-2-yl)indoles, DABCO·(SO2)2, and aryldiazonium tetrafluoroborates under mild conditions. Diverse 2-sulfonated indoles are generated by using 10 mol % of palladium(II) bromide as the catalyst at room temperature. This synthetic approach is efficient by merging palladium catalysis and insertion of sulfur dioxide via a radical process. 2-Pyrimidinyl can be used as the directing group well as for the C-H bond sulfonylation. Additionally, the directing group can be easily removed.

Visible-Light-Promoted C-H Arylation by Merging Palladium Catalysis with Organic Photoredox Catalysis.

The use of a dual palladium/organic photoredox catalytic system enables the directed arylation of arenes with aryldiazonium salts with a broad substrate scope at room temperature under mild reaction conditions. This study thus serves as not only an alternative route for the biaryl motifs but also a new example for the application of an organic photoredox catalyst.

Catalytic Asymmetric Allylation of 3‐Aryloxindoles by Merging Palladium Catalysis and Asymmetric H‐Bonding Catalysis

AbstractA catalytic asymmetric allylic alkylation reaction of 3‐aryloxindoles was accomplished via a dual catalysis merging palladium catalysis and asymmetric H‐bonding catalysis for the first time. Using this approach, allylated oxindoles bearing chiral all‐carbon quaternary centers were produced in high yields with good enantioselectivities (up to 92 % yield and 96:4 er).magnified image

ChemInform Abstract: Construction of Enantioenriched Polysubstituted Hexahydropyridazines via a Sequential Multicatalytic Process Merging Palladium Catalysis and Aminocatalysis.

An efficient multicatalytic strategy for the construction of nitrogen-containing heterocycles has been reported. The powerful combination of organic and metal catalysis in a single vessel allowed the formation of enantioenriched polysubstituted cyclic 6-membered hydrazines bearing a quaternary stereocenter in good yields and selectivities.

Construction of enantioenriched polysubstituted hexahydropyridazines via a sequential multicatalytic process merging palladium catalysis and aminocatalysis.

An efficient multicatalytic strategy for the construction of nitrogen-containing heterocycles has been reported. The powerful combination of organic and metal catalysis in a single vessel allowed the formation of enantioenriched polysubstituted cyclic 6-membered hydrazines bearing a quaternary stereocenter in good yields and selectivities.