Thioglycolic Acid Research Articles

Microwave-assisted synthesis and functionalization of nanocrystalline molybdenum trioxide for enhanced antimicrobial and photocatalytic activity

Molybdenum Trioxide nanoparticles (MoO3) were synthesized using ammonium heptamolybdate tetrahydrate [(NH4)6Mo7O24·4H2O] as the primary precursor via the microwave-assisted method and subsequently functionalized with surfactants such as Cetyltrimethylammonium bromide (CTAB), Sodium n-dodecyl sulfate (SDS), and Thioglycolic acid (TGA). The characterization involved X-ray diffraction, field emission scanning electron microscopy with energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, and UV–Visible spectroscopy, revealing hexagonal plate-like morphology, UV absorbance at 202–216 nm with a band gap of 4.2 eV, and a crystalline structure with a 44 nm size calculated by the Scherrer's equation. The synthesized pure (MoO3) and functionalized molybdenum trioxide nanoparticles (FMoO3) were tested for antibacterial activity against gram-positive Staphylococcus aureus and gram-negative Salmonella typhi. Furthermore, MoO3 and FMoO3 also demonstrated enhanced antifungal activity against the fungi Aspergillus niger (Accession No. MZ435922) and Aspergillus fumigatus (Accession No. MZ435863). Photocatalytic experiments demonstrated significant degradation of malachite green dye under UV light irradiation, notably with SDS functionalized MoO3 achieving 98.17 % degradation rate within 20 min, with a linear rate constant of 0.20343 min−1. These findings highlight the potential of MoO3 and FMoO3 nanoparticles as effective antimicrobial agents and their suitability for water purification due to their low toxicity.

Synthesis, Antimicrobial Evaluation, and In Silico Studies of 2-Substituted-Phenyl-3-(5-Aryl/Heteroaryl Substituted Thiazol-2-yl) Thiazolidin-4-One Derivatives.

In a one-pot reaction involving 3-(2-aminothiazol-5-yl)-2H-chromen-2-one/5-(naphthalen-1-yl)thiazol-2-amines 5-6 with various substituted aldehydes and mercaptoacetic acid, we obtained the corresponding 2-(4-substituted-phenyl)-3-[5-(2-oxo-2H-chromen-3-yl)thiazol-2-yl] thiazolidin-4-ones 8(a-h) and 2-(4-substituted-phenyl)-3-[5-(naphthalen-1-yl)thiazol-2-yl] thiazolidin-4-ones 9(a-h). The antimicrobial activity of all compounds was evaluated against Pseudomonas aeruginosa (MTCC-424), Salmonella typhi (MTCC-531), Staphylococcus aureus (MTCC-737), and Candida albican (MTCC-227). Molecular docking further supported the findings, which showed that the compounds 8d and 9d had excellent antibacterial action against all tested pathogens.

“Green” Aqueous Synthesis, Structural, and Optical Properties of Quaternary Cu2ZnSnS4 and Cu2NiSnS4 Nanocrystals

Element substitution in Cu2ZnSnS4‐like chalcogenides offers the potential to create alternative low‐cost photovoltaic and thermoelectric materials with tunable properties. In this work, the “green” synthesis of colloidal cation‐substituted Cu–Ni–Sn–S nanocrystals (CNTS NCs) in aqueous solutions using thioglycolic acid as a stabilizer is reported for the first time. The structural and optical properties of CNTS NCs are studied in colloidal solutions and thin films, and are compared with those of Cu–Zn–Sn–S (CZTS) NCs obtained under similar conditions. The NC sizes of both compounds are estimated to be in the range of 1.5–2.5 nm. Both NCs exhibit strongly non‐stoichiometric composition and a structure corresponding to cationically disordered kesterite Cu2ZnSnS4, which are common features of such quaternary metal‐based chalcogenides. The phonon Raman spectra of CNTS and CZTS NCs exhibit very similar lineshapes, but the CNTS phonon band has a larger width and lower frequency, presumably due to stronger cation disorder. The absorption of both types of NCs extends continuously through the visible range with an estimated bandgap of ≈2.2 eV and sub‐bandgap absorption due to an Urbach tail. The absorption coefficient of CNTS is determined to be α > 102 cm−1 at 700 nm and α > 104 cm−1 at 400 nm.

Ultrasound-assisted synthesis of 4-thiazolidinone Schiff bases and their antioxidant, α-glucosidase, α-amylase inhibition, mode of inhibition and computational studies

AbstractDiabetes mellitus (DM) has become a growing concern to global public health, being at the forefront of acute disorders and causes of mortality across the globe. Clinically approved drugs that are currently being used are faced with severe side effects, consequently necessitating the development of new drugs with no/fewer side effects and improved pharmacological potency. Herein, we report a rapid and efficient synthesis of thiazolidinone Schiff bases (2a-2t) from benzylidenehydrazines and thioglycolic acid under neat conditions through ultra-sonication. All the synthesized compounds were obtained in exceptional yields (89–95%) and confirmed by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, as well as High-resolution mass spectrometry (HRMS). The synthesized compounds were then evaluated for their antidiabetic activity through α-glucosidase and α-amylase inhibitory potentials and their antioxidant activity through Nitric Oxide (NO), 2,2′-diphenyl-1-picrylhydrazyl (DPPH), and Ferric reducing antioxidant power (FRAP) assays. Among them, 2q (IC50 = 96.63 μM) and 2h (IC50 = 125.27 μM) emerged as the most potent derivatives against α-amylase relative to reference drug acarbose (IC50 = 131.63 µM), respectively. Antioxidant evaluation further revealed that the synthesized derivatives were excellent NO scavengers disclosing 2n (IC50 = 44.95 µM) as the most potent derivative. Moreover, in silico ADME calculations predicted these compounds to have excellent drug-like properties. Kinetic studies disclosed the mode of α-amylase inhibition as competitive while molecular docking studies of the most active derivatives performed into the binding active site of human pancreatic α-amylase enzyme deciphered their ligand-protein interactions that explicated their observed experimental potencies.

Synthesis, Characterization and Biological Activity Evaluation of Some 1,N-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) Alkanes

In this paper, we present the synthesis, characterization and evaluation of antiproliferative activity for four compounds carrying the 4-amino-5-mercapto-1,2,4-triazol-3-yl scaffold. The synthesis of 1,n-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) alkanes was carried out using as starting reagents the dihydrazides of oxalic, malonic, succinic and adipic acids, using mercaptoacetic acid dianion as a leaving group, by a one-pot synthesis method implemented in our research group for the synthesis of 3-substituted-5-mercapto-1,2,4-triazoles. The compounds were obtained with modest yields (12–60%) but with good purity and were characterized by elemental analysis, FTIR, 1H-NMR and 13C-NMR spectroscopy. Also, the stability of the synthesized bis-triazoles was investigated under controlled thermal stress in a dynamic oxidative atmosphere. The last part of the study consisted of biological activity evaluation, by evaluating the antiproliferative activity against the A375 line (human malignant melanoma), as well as on viability of the BJ fibroblast cell line, using MTT and LDH assays.

Preparation of Mxene-AuNPs/TGA nanocomposites explored as an electrochemical aptasensor for Digoxin analysis

Despite the existence of numerous methods for measuring digoxin, advancements in science have led to improvements in methods, making it possible to measure very low levels of this drug. However, considering the high cost of previous methods, new methods are being developed, allowing for the measurement of very low amounts of this drug. An aptasensor was prepared by attaching digoxin aptamer to a Mxene and gold nanoparticles-modified screen-printed carbon electrode via thioglycolic acid molecules (SPCE/Mxene-AuNPs/TGA/Apt). The physicochemical features of the nanocomposite synthesized were characterized Microscopic and voltammetry techniques. The presence of Mxene, AuNPs, and TGA species all together contributed to the expansion of the active surface area, facilitating electron transfer phenomena, and improving the electrical conductivity, stability, and longevity of the prepared aptasensor. The detection limit of 0.03 pM was calculated based on a criterion of S/N = 3.Furthermore, the biosensor exhibited excellent stability and a prolonged shelf life, with a low detection cost of under 100 USD per sample. Given these benefits, the authors are confident that the electrochemical biosensor developed using Mxene-AuNPs/TGA for enhanced signal amplification offers a promising strategy for detecting digoxin in environmental samples.

تحضير، تشخيص و دراسة الفعالية البيولوجية لمركبات حلقية غير متجانسة جديدة حاوية على الكرياتينين

This work included the synthesis of new heterocyclic compounds containing creatinine moiety (A4-A9). These compounds were synthesized from reaction of Schiff bases (A2, A3) with glycine, thioglycolic acid, and glycolic acid to produce imidazolidine-4-one (A4, A5), thiazolidine-4-one A6, A7, and oxazolidine-4-one (A8, A9) respectively. FTIR and 1HNMR were used to identify these compounds. In vitro experiments, the antimicrobial properties of compounds (A1, A2, and A4) were evaluated and showed good results.

تحضير وتشخيص بعض المركبات الحلقية غير المتجانسة المشتقة من عقار الميتوكلوبراميد وقياس فعاليتها البايلوجية

This study included the synthesis of some new Schiff bases and heterocyclic compounds [1‐6] from the reaction of metoclopramide with some aromatic aldehydes by the classical Schiff method, then the Schiff bases were treated with chloroacetyl chloride and thioglycolic acid to obtain cyclic derivatives of beta-lactams [5,6] and 4-thiazolidinone [3,4], respectively. These derivatives were characterized by their melting points by FT IR, 1H NMR. Some compounds prepared were evaluated for their antioxidant activity by oxidation with 2,2-diphenyl-1-picrylhydryl (DPPH). Comparison of the antioxidant activity of the bioactive molecules of the compounds [3–6] with that of the conventional drug metoclopramide showed encouraging results.

Phytochemical Compounds and the Antifungal Activity of Centaurium pulchellum Ethanol Extracts in Iraq

The current study included a variety of phytochemical substances that were extracted from Centaurium pulchellum and showed a wide range of medicinal properties from the plant's reproductive and vegetative parts against the pathogenic fungus Aspergillus flavus. The vegetative and reproductive components of Centaurium pulchellum were subjected to (GC-MS) analysis for phytochemical study. The data indicated that fungal activity was the highest. Four extract concentrations of 5, 10, 15, and 20 mg/ml were utilized in the investigation, and the diameter of the colonies measured at each concentration was 90.00, 36.00, 28.00, 18.00, and 0.00 mm, respectively. Nine bioactive phytochemical compounds were found in Centaurium pulchellum's vegetative and reproductive portions, according to GC-MS analysis of the chemicals. Another study reported phytochemical substances that: 1-H-Imidazole-2-carboxaldehyde, 1-methyl-;Acetaminophen; n-Hexadecanoic acid; Mercaptoacetic acid, 2TMS derivative; 1.2,3-Dimethyl-5-(trifluoromethyl)-1,4-benzenediol #; Mercaptoethanol, 2TMS derivative-; Bis-(3,5,5-trimethylhexyl) phthalate Tetrakis(trimethylsilyl) orthosilicate #;- 1.1-Isopropoxy-3,3,3-trimethyl-1-[(trimethylsilyl)oxy]disiloxanyl tris(trimethylsilyl) orthosilicate #.

Synthesis, Characterization and Antimicrobial Evaluation of New Substituted Thiazolidinones Bearing Triazole Moiety

Series of thiazolidinone derivatives containing triazole moiety have been synthesized by condensing various substituted aldehydes to form Schiff bases which further reacts with thioglycolic acid undergoes ring condensation to form 3-(3-mercapto-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)-2-substituted phenylthiazolidin-4-one followed by reaction with ethyl chloroacetate to form ethyl 2-((4-(2-subtituted phenyl-4-oxothiazolidin-3-yl)-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate. The synthesized compounds were characterized by elemental analysis, fourier-tranform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and mass spectrometry. All synthesized compounds were evaluated for invitro antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and for antifungal activity against Candida albicans, Aspergillus niger. The results of synthesized compounds showed that T-III, T-IX, T-X, and T-XVIII have antimicrobial activity when compared to standard drugs. The compounds having p-bromo, p-chloro, p-methoxy and p-nitro groups showed potent antimicrobial agent

Preparation and Evaluation of Ficus racemosa Extract Transdermal Gel for Antimicrobial and Anti-inflammatory Activity

Background: Ficus racemosa (FR) belongs to the Moraceae family having different pharmacological activities. The primary aim of the researchers was to examine how varying polymer concentrations affect the outcome, additionally nature of penetration enhancers on microbial growth inhibition, and the protein denaturation inhibition capability of F. racemosa extract (FRE). Method: FRE has been prepared by a simple maceration process. By performing an antimicrobial assay procedure and in-vitro protein denaturation inhibition method, the antimicrobial and protein denaturation capability of the extract has been confirmed. Furthermore, 12 formulations of transdermal gel were developed with polymer (carbopol 934), which was used at non-identical concentrations (1, 1.5, 2, 2.5%) along with three dissimilar kinds of penetration enhancers, i.e., Tween 80, oleic acid, thioglycolic acid at the same concentration (1%). Transdermal gels have been prepared by a dispersion method & evaluated by physical parameters, viscosity, spreadability, pH, skin irritation, drug content, and in-vitro study with Franz diffusion cell. Result: Formulation B3 showed the best results, having a polymer concentration of 1.5% and Tween 80 as a penetration enhancer.

Adsorption and separation of lead ions in phosphoric acid by co-doped carbon nanotubes with sulfur, oxygen, and manganese

The purpose of this study was to prepare a novel and efficient adsorbent for the removal of trace Pb(II) from phosphoric acid. Manganese oxide/sulfur-oxygen doped carbon nanotube composites (CNTs-S-O-Mn) were prepared from multi-walled carbon nanotubes modified with nitric acid, mercaptoacetic acid, acetic anhydride, concentrated sulfuric acid and potassium permanganate. Characterisation revealed that CNTs-S-O-Mn contained hydroxyl, sulphonate groups, MnO and Mn3O4. At 298 K, 15.362 mg·L-1 initial concentration of lead ions, and 18.4 % phosphoric acid concentration, the adsorption capacity of the composites for lead ions was 38.65 mg·g−1, which was higher than that of the unmodified CNTs, 8.04 mg·g−1. The adsorption kinetic data at 298 K conformed to the quasi-second-order kinetic equation, R2 = 0.997; 298, adsorption isotherms at 308 and 318 K conformed to the Langmuir equation, R2 = 0.990–––0.991. The adsorption capacity increased with decreasing phosphoric acid concentration. In this system, the adsorption is affected by a certain concentration of lead ions. Adsorption occurs via chemisorption and is exothermic. Sulfonic acid groups and hydroxyl groups on manganese oxides play an important role in the adsorption of Pb (II) through surface complexation with Pb (II). These results indicate that the removal of trace Pb (II) from phosphoric acid by modified carbon nanotubes is feasible, revealing a new use of carbon nanotubes for phosphoric acid purification.

MAA Encapsulated MoS2 Quantum Dots as a Fluorescent Probe for the Sensing of Flavonoid

Transition metal dichalcogenide (TMDs) quantum dots (QDs) have attracted widespread attention among scientific community as fluorescent nanomaterial. Among TMDs, MoS2 has received particular interest due to its novel and intriguing optical properties. In this work hydrothermal method is used to prepare aqueous soluble MoS2 QDs using Molybdenyl acetylacetonate and thiourea as Mo and S precursors, respectively. The solubility of unfunctionalized MoS2 is poor in water and organic solvent, therefore thioglycolic acid is used as surfactant for surface functionalization and to enhance the aqueous solubility & stability. These functionalized QDs have been synthesized at pH 11 using hydrothermal method and explored their structural and optical properties. The as synthesized QDs are characterized using TEM, XRD, FTIR, UV-Vis and PL spectroscopy. The morphological shape of as prepared QDs is spherical with size 4-6.5 nm. The MAA encapsulated MoS2 QDs are further explored as fluorescent probe for the sensitive sensing of flavonoid Quercetin.

CdS/Bi2S3/NiS ternary heterostructure-based photoelectrochemical immunosensor for the sensitive detection of carbohydrate antigen 125

The sensitive, accurate and rapid detection of carbohydrate antigen 125 (CA125) is essential for the early diagnosis and clinical management of ovarian cancer, but there is still challenge. Herein, a photoelectrochemical (PEC) immunosensor based on CdS/Bi2S3/NiS ternary sulfide heterostructured photocatalyst was presented for the detection of CA125. The CdS/Bi2S3/NiS was synthesized by a one-step hydrothermal approach. The heterojunction comprising of CdS and Bi2S3 could separate photogenerated carriers, the introduced narrow bandgap NiS could act as electron-conducting bridge to facilitate the transfer of interfacial photogenerated electrons, thereby improving the photoelectric conversion efficiency. Due to their synergistic effect, the photocurrent response produced by the composite was up to 14.6 times of pure CdS. On the basis, a PEC immunosensor was constructed by introducing the CA125 antibody through thioglycolic acid linkage. It was found that the resulting immunosensor showed good performance. Under the optimized conditions, its linear detection range was as wide as 1 pg mL−1−50 ng mL−1, and the detection limit was low to 0.85 pg mL−1. Furthermore, we experimentally tested its anti-interference, stability and reproducibility, and satisfactory results were achieved. The practicable feasibility of the sensor was confirmed by testing serum sample. Thus this work provided a simple, fast and enough sensitive approach for CA125 monitoring.

Enhancement of the alloyed CdZnSeS/ZnS quantum dots photoluminescence by thiol ligands capping

Most of the existing hydrophilization techniques for the semiconductor quantum dots (QDs) lead to degradation of photoluminescence (PL). Therefore, for the applying of QDs in the areas requiring their stability in water media (e.g. bio- and chemical analysis, labeling and sensing), it is often necessary to find a balance between high stability, good optical properties, and difficulty of acquiring. This article describes simple, fast, and easy scalable methods for alloyed CdZnSeS/ZnS QDs ligand exchange using 2-mercaptoethanol, thioglycolic, 3-mercaptorpopionic and dihydrolipoic acids. The proposed ligand exchange techniques provide the enhancement of the QDs photoluminescence intensity in contrast to most of other ligand exchange procedures on the QDs surface. In optimized conditions the twofold photoluminescence quantum yield increase compared to the initial hydrophobic CdZnSeS/ZnS QDs was achieved. Hydrophilized nanoparticles maintained colloidal stability for a period more than 13 months. The suggested mechanism of the PL increase is the passivation of the QDs surface with molecules containing a thiol group. The combination of the proposed effective CdZnSeS/ZnS QDs synthesis and modification methods shows the prospect of their implementation as basic luminescent material for a wide range of applications.

Highly sensitive and novel dual-emission fluorescence nanosensor utilizing hybrid carbon dots-quantum dots for ratiometric determination of chlorpromazine.

Herein, a ratiometric fluorimetric nanosensor is introduced for the sensitive and selective analysis of chlorpromazine (CPZ) via employing blue-emitting B-doped carbon dots (B-CDs) as the reference fluorophore and green-emitting CdTe capped thioglycolic acid (TGA) quantum dots (TGA-CdTe-QDs) as the specific recognition probe. The sensor exhibits dual emission centered at 440 and 560nm, under a single excitation wavelength of 340nm. Upon the addition of ultra-trace amount of CPZ, the fluorescence signal of TGA-CdTe-QDs declines due to electron transfer process from excited TGA-CdTe-QDs to CPZ molecules, whereas the fluorescence peak of B-CDs is unaffected. Therefore, a new fluorimetric platform was prepared for the assay of CPZ in the range of 2.2 × 10-10 to 5.0 × 10-9M with a detection limit of 1.3 × 10-10M. Moreover, the practicability of the designed strategy was investigated for the detection of CPZ in biological samples and the results demonstrate that it possesses considerable potential to be utilized in practical applications.

ZIF-67 loaded thio-groups modified chitosan hydrogel for high efficient Hg(II) removal from water

In the past few years, there has been an increasing worry about the pollution of water caused by the presence of heavy metals. To address this environmental issue, a highly effective adsorbent called ZIF-67/CS-SH was developed. This adsorbent was prepared by grafting thioglycolic acid and loading a metal-organic framework called ZIF-67 onto chitosan, to remove Hg(II) from water. Confirmation of the ZIF-67/CS-SH was achieved by employing a range of techniques including FTIR, XRD, TGA, SEM, EDS, BET, and XPS. Due to the presence of abundant active sites (-SH, O/N-containing functional groups) and ZIF-67, ZIF-67/CS-SH exhibited a high adsorption capacity (949 mg/g at 298 K) and rapid adsorption kinetics (20 min for 91 % removal). The optimal pH for the adsorption process was found to be 5. The adsorption process followed a pseudo-second-order kinetics and Langmuir isotherm, with chemisorption being the main adsorption mechanism. The adsorption process was determined to be spontaneous and endothermic. Additionally, ZIF-67/CS-SH demonstrated selective adsorption in the presence of other metal cations at concentrations of 100 mg/L. Furthermore, ZIF-67/CS-SH exhibited excellent regenerative properties, with only a 10 % decrease in adsorption capacity after ten cycles. The key adsorption sites were identified as the –SH groups, O/N-containing functional groups, and ZIF-67 in ZIF-67/CS-SH through FTIR, EDS, and XPS analyses. Considering its outstanding performance in removing Hg(II), ZIF-67/CS-SH shows promise for application in industrial wastewater treatment.

Organocatalyst 1,4-diazabicyclo [2.2.2]octane (DABCO)-catalyzed Sustainable Synthesis of Bis-thiazolidinones Derivatives and their Spectral and DFT Analysis

Abstract: Organocatalyst 1,4-diazabicyclo [2.2.2]octane (DABCO) has proven to be an efficient and environmentally friendly catalyst in the multicomponent reaction involving aldehydes, ethylenediamine, and thioglycolic acid under microwave conditions. DABCO stands out among other organic catalysts due to its cost-effectiveness, non-toxic nature, and environmentally conscious profile. The method employed in this study exhibited exceptional attributes, such as high yields, swift reaction times, atom economy, catalyst reusability, and minimal catalyst loading. Additionally, there were excellent yields of products (90-94%). The melting points, UV-Vis, IR, 1HNMR, 13CNMR, were used to analyze the produced compounds. The invitro antibacterial activity of the synthesized compounds was investigated against pathogenic strains E. coli and Bacillus supstalis, and the results obtained were further explained with the help of DFT and molecular orbital calculations. Moreover, the compound 4b was found to be the most potent antibacterial agent amongst all tested compounds.

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

In this research investigation, a total of eighteen diverse tetra- and penta-lateral cyclic compounds were synthesized. These included 1,3,4-thiadiazole, thiazolidin-4-one (via an alternative method), 1,2,4-triazole, carbothioamide, thiazole-4-one, azetidin-2-one, and oxazole. The synthesis procedure entailed a sequence of reactions. The thiazolidine-4-one 1 was obtained by reaction p-aminobenzoic acid with thiosemicarbazide, followed by treatment with p-tolualdehyde to produce Schiff base 2. Reaction Schiff base 2 with mercaptoacetic acid in dry benzene was carried out to produce thiazolidine-4-one 3. In another synthesis pathway, the esterification of p-nitro benzoic acid with ethanol in the presence of sulfuric acid was obtained to formation of compound 4. Compound 4 was subsequently reacted with thiosemicarbazide, yielding compound 5. Cyclization of compound 5 was then achieved using 4% sodium hydroxide solution. This formed the 1,2,4-triazole heterocycle, designated compound 6. Thiosemicarbazone 7-9 were prepared by reaction of thiosemicarbazide with different aldehydes. Additionally, 2-substituted-1,3-thiazolidine-4-one derivatives 10-12 were synthesized through the reaction of thiosemicarbazone with chloroacetic acid in the presence of anhydrous sodium acetate. The Oxazole derivative 15 was obtained through a series of reactions starting with the reaction of p-amino benzoic acid with ethyl chloroacetate, resulting in compound 13. Compound 13 was then treated with urea to obtain compound 14, followed by a reaction with 4-phenyl phenacyl bromide to yield the final product, the Oxazole derivative 15. The 2-aminooxadiazole derivative 16 was synthesized by reaction urea with 4-bromoacetophenone which was reacted with 4-bromobenzaldehyde to produce Schiff base derivative 17. Finally, β-lactam 18 is obtained through reaction Schiff base with chloroacetyl chloride in the presence of triethyl amine. FT-IR, 1H-NMR, and 13C-NMR spectroscopy were used to confirm their proposed structures. Moreover, the antibacterial and antifungal activities of certain synthesized compounds, specifically 2,3,6,11,13,15,17, and 18, were assessed against Staphylococcus aureus, Escherichia coli, and Candida albicans, demonstrating encouraging outcomes.Keywords: Antibacterial, antifungal activity, oxadaizole, heterocyclic derivatives, Oxazole.

Antioxidant Activity of New Tetrazole, Thiazolidin-4-one, and Aza-beta Lactam Linking to Secondary Imines of Imidazopyridine

In this contribution, new derivatives of bicyclic fused rings with a bridgehead nitrogen atom were synthesized from the imidazo[1,2-a]pyridine derivatives C1 by reacting two moles of 2-aminopyridine and 4-aminoacetophenone with iodine in a one-pot reaction. This compound (C1) was then condensed with 2-nitrobenzaldehyde and 2,4-dichlorobenzaldehyde to form new derivatives of Schiff bases (C2 and C3). These Schiff bases were then cyclized to synthesize thiazolidin-4-one derivatives (C4 and C5), tetrazole derivatives (C6 and C7), and aza-β-lactam derivatives (C8 and C9) through the reactions with thioglycolic acid, sodium azide, and 1-naphthylisocyanate, respectively. FT-IR, 1H NMR, and 13C NMR spectroscopy were used to characterize these new compounds. In the second part of this work, the antioxidants of these compounds were measured, and results ranged from good to medium.