This study is based on phytochemical properties of L. gerardiana, as well as the pharmacological and biological activities of crude methanolic extract (Crd. MeOH Ext.) and other fractions. A range of pharmacological and biological activities, such as antibacterial, antifungal, phytotoxic, were examined in Crd. MeOH Extract and different plant fractions. The results of the pharmacological and biological examinations showed that the chloroform (CHCl3) fraction had good antibacterial activity against Salmonella typhi (48.0%), Bacillus cereus, Proteus merabilus (50.0%), and Klebsiella pneumoniae (57.1%). Also demonstrating strong (55.5%) antibacterial activity against S. typhi was the nâhexane fraction. Low phytotoxicity was demonstrated by the plant materials at 1000 and 100μg/ml concentrations.