Substance misuse is a global and substantial health concern that includes the inappropriate use of illicit substances or prescription and over-the-counter medications, which subsequently leads to poor outcomes such as a mental health disorder, financial distress, work malfunction, and academic failure. This study aimed to assess the prevalence of substance use, identify associated risk factors, explore potential complications within this specific demographic, and investigate the relationship between sociodemographic/lifestyle variables such as age, gender, marital status, family income, smoking, physical activity, and academic variables including grade point averages (GPAs), study hours, and the parental educational level with substance use history among students in health colleges in Saudi Arabia. This quantitative, descriptive cross-sectional study employed a questionnaire-based approach to collect data from students in health colleges across the regions of Saudi Arabia in the year 2022. The study found the prevalence of the use of various substances among students in health colleges to be 20.2%. Multiple factors were found to be associated with substance abuse. Smoking habits were the strongest predictor of substance misuse, with 49.1% of smokers reporting a history of substance use, compared to only 15.5% of non-smokers. This makes smoking the most impactful lifestyle factor related to substance use. Sleep patterns also played a significant role. A notable 43.6% of those who took up to two hours to fall asleep reported substance use, followed by 32.4% of those with sleep disorders and 25.5% with poor sleep quality. Unpredictable sleep patterns and a history of sleep disorders further strengthened the link between disrupted sleep and substance misuse. Academic performance, specifically GPA, showed that individuals with lower academic achievement were more likely to report substance use. Among those with a GPA below 3.0, 43.5% had a history of substance use, while only 16.7% of those with a GPA above 4.5 did so. The findings underscored the high prevalence of substance use, even among students in health colleges, and shed light on its connection to specific determinants. This poses a serious public health concern, as substance use is associated with poorer GPA, diminished knowledge acquisition, and overall academic performance. This, in turn, may negatively impact their future roles as healthcare providers, compromising both the quality of patient care and their personal well-being. These results emphasize the need for further investigations to unravel the underlying mechanisms of substance misuse and formulate innovative strategies to address this pressing issue effectively.
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