Mental Vitality Research Articles

Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial

PurposeWe aimed to investigate the link of vitamin C status with vitality and psychological functions in a cross-sectional study, and examine their causal relationship through a randomized controlled trial (RCT).MethodsWe first conducted a population-based cross-sectional investigation of healthy young adults (n = 214, 20–39 years), and analyzed the associations of serum vitamin C concentrations with vitality (fatigue and attention) and mood status (stress, depression, and positive and negative affect) using Pearson’s correlation and multiple linear regression analyses. Next, we performed a double-blind RCT in healthy subjects whose serum vitamin C concentrations were inadequate (< 50 μmol/L). Subjects were randomly allocated to receive 500 mg of vitamin C twice a day for 4 weeks (n = 24) or a placebo (n = 22). We assessed vitality, which included fatigue, attention, work engagement, and self-control resources, and measured mood status, including stress, depression, positive and negative affect, and anxiety. ELISA determined serum brain-derived neurotrophic factor (BDNF), and a Stroop color–word test evaluated attention capacity and processing speed.ResultsIn the cross-sectional data, the serum vitamin C concentration was positively associated with the level of attention (r = 0.16, p = 0.02; standardized β = 0.21, p = 0.003), while no significant associations with the levels of fatigue and mood variables being found. In the RCT, compared to the placebo, the vitamin C supplementation significantly increased attention (p = 0.03) and work absorption (p = 0.03) with distinct tendency of improvement on fatigue (p = 0.06) and comprehensive work engagement (p = 0.07). The vitamin C supplementation did not affect mood and serum concentrations of BDNF. However, in the Stroop color–word test, the subjects supplemented with vitamin C showed better performance than those in the placebo group (p = 0.04).ConclusionInadequate vitamin C status is related to a low level of mental vitality. Vitamin C supplementation effectively increased work motivation and attentional focus and contributed to better performance on cognitive tasks requiring sustained attention.Trial registration number and date of registrationCross-sectional study: KCT0005074 (cris.nih.go.kr)/1 June, 2020 (retrospectively registered). Intervention study: KCT0004276 (cris.nih.go.kr)/4 September, 2019.

Successful Aging Focused on the Dimensions of Perceived Social Support and Mental Vitality in the Elderly Referred to the Health Centers of Iran University of Medical Sciences (2020)

Successful Aging Focused on the Dimensions of Perceived Social Support and Mental Vitality in the Elderly Referred to the Health Centers of Iran University of Medical Sciences (2020)

Judgments of happiness during trail running: Pleasure, engagement, and meaning

ObjectivesIt has been theorized that happiness is derived from three major, unique sets of life experience: pleasure, engagement, and meaning. The present study examined the mental processes by which individuals combined five information cues (relatedness, autonomy, competence, mental vitality and physical vitality) when judging the degree of happiness felt by a trail runner during a run. Design/methodThe participants (104 adult male athletes; Mage = 32.70; SD = 10.86) rated pleasure, engagement, and meaning in 32 scenarios built from combinations of these cues. ResultsThe results of multivariate and univariate analyses of variance indicated that all five cues had a positive effect on judgments of pleasure, engagement, and meaning. The participants used three different information integration rules, depending on the pathway to happiness being probed. ConclusionsThe information integration and the integration rules highlighted the different contributions of pleasure, engagement, and meaning in cognitive building of happiness.

Comparison of the Effectiveness of Mindfulness-Based Cognitive Therapy and Metacognitive Therapy on Psychological Well-Being, Mental Vitality and Resilience among Mothers of Children with Cerebral Palsy

Comparison of the Effectiveness of Mindfulness-Based Cognitive Therapy and Metacognitive Therapy on Psychological Well-Being, Mental Vitality and Resilience among Mothers of Children with Cerebral Palsy

Mapping judgment of well-being in sport

ABSTRACT This study aims to map different positions regarding the way in which 71 adolescents (Mage = 15.46, SD = 1.55), 104 young adults (Mage = 21.10, SD = 1.33), and 57 middle-aged adults (Mage = 48.30, SD = 6.59) integrated mentally five elements of eudaimonia (relatedness, autonomy, competence, mental vitality, and physical vitality) for judging the degree of well-being in sport. The participants indicated their judgment of well-being in 32 scenarios constructed from the combination of these information cues. A cluster analysis, ANOVAs, and chi-square test were conducted. Two positions on judgment were observed and called “Additive rule and Moderate Well-Being” and “Disjunctive rule and High Well-Being”. The five elements of eudaimonia had a positive effect on the judgment of well-being. They were combined differently according to the age of the participants. This type of study may be useful for health educators and exercise or health promotion specialists.

Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on mental health-related quality of life

Quality of life (QoL) disturbances are common after aneurysmal subarachnoid hemorrhage (aSAH) both in physical and mental health domains and their causes are not clearly understood. Corticotropin-releasing hormone receptor 1 (CRHR1) is involved in stress reactivity and development of mental health disturbances after negative life-events. We performed a retrospective cohort study of long-term QoL outcomes among 125 surgically treated aSAH patients (2001–2013). QoL was assessed with Short Form Health Survey (SF-36) and compared to an age and gender matched general population. Genotyping of CRHR1 single nucleotide polymorphisms was performed (Rs7209436, Rs110402, Rs242924) and their effect on QoL scores was explored. aSAH patients experienced a reduced quality of life in all domains. CRHR1 minor genotype was associated with higher SF-36 mental health (OR = 1.31–1.6, p < 0.05), role-emotional (OR = 1.57, p = 0.04) and vitality scores (OR = 1.31–1.38, p < 0.05). Association of all studied SNP’s with vitality and Rs242924 with mental health scores remained statistically significant after Bonferroni correction. Mental quality of life scores were associated with physical state of patients, antidepressant history and CRHR1 genotype. Predisposition to mental health disturbances after stressful life-events might be associated with reduced mental QoL after aSAH and selected patients could be provided advanced counselling in the recovery phase.

Domestic work stress and self-rated psychological health among women: a cross-sectional study in Japan

BackgroundDespite the huge burden of domestic work on women in Japan, its effects on their health have been poorly investigated. We aimed to assess the association between domestic work stress and self-rated psychological health among women.MethodsWe conducted a cross-sectional survey using an online social research panel in February 2018. Participants were 2,000 women with paid work (the “workers” group) and 1,000 women without paid work (the “homemakers” group), aged between 25 and 59 years old and living with a partner. Self-rated psychological health (Mental Health and Vitality scales of the Japanese SF-36), occupational and domestic work stress (the Brief Job Stress Questionnaire), the 10-item Work–Family Conflict Scale, and sociodemographic factors were assessed.ResultsThe workers had lower domestic job control and higher support from a partner and their parents than the homemakers (p < 0.001), whereas domestic job demand and psychological health were similar between the groups. After adjustment for the covariates using multiple linear regression models, better psychological health was significantly associated with lower domestic job demand, higher domestic job control, and having a young child in both groups. In addition, work–family conflicts and occupational job stress among the workers and caregiving among the homemakers showed negative associations with psychological health.ConclusionSelf-rated psychological health in women was associated with domestic work stress regardless of employment status. To promote women’s health, we need to take into account the effects of domestic work, work–family conflicts, and social support from families, as well as occupational factors.

LIFESTYLE PHYSICAL ACTIVITY IN OLDER WOMEN: ASSOCIATIONS OF CHANGE, SELF-EFFICACY, AND WELL-BEING

Reduction of cardiovascular disease risk in undeserved populations, such as older women, is a top priority of the U.S. Our innovative trial tested a new approach to PA promotion for older women—motivational interviewing (MI), shifting the paradigm from structured exercise to self-selected activities. We present data comparing stage of change (SOC), self-efficacy for exercise (SEE), and well-being: 8 dimensions (physical, social, role limitations, emotional, general mental health, vitality, health perceptions and pain) and associations with physical activity outcomes in the Lifestyle Physical Activity for Women (LPAW) clinical trial. Methods: 106 women, > 60 years old, who did not engage in regular PA, and were not frail, participated in a clinical trial of a tailored MI intervention to increase PA. We report baseline, 3 and 6 month repeated measures and PA associations with SOC, SEE, and well-being (SF36). Results: Of 106 women, 36% were Black and 63% White, with a mean age of 69. Significant improvement in SOC in both arms noted but the proportion in action/maintenance was significantly higher in the PA arm at 3 mos (78% vs. 55%, P=0.045) and 6 mos (79% vs. 50%, P= 0.019). A decrease in SEE for control (p=.001), but not for PA arm (p=.45); at 6 months, The PA arm had greater SEE compared to control. There were significant arm difference for physical component scores of SF36 (p=.02), but not for mental scores. Associations with PA will be tabulated. Conclusions: Preliminary results support the PA intervention, more data to be presented.

Defining Vitality Using Physical and Mental Well-Being Measures in Nursing Homes: A Prospective Study

ObjectivesTo propose an objective definition of vitality and to evaluate its predictive value regarding the evolution of functional ability, as well as the risk of hospitalization and mortality in very old NH residents.DesignObservational study.SettingsNursing homes.Participants541 participants.MeasurementsWe operationalized tree definitions of vitality (binary variables discriminating vital from non-vital individuals): Mental vitality, assessed using three items of the geriatric depression scale; Physical vitality measured through hand grip strength test; and combined vitality, which combined mental and physical vitality definitions. Outcome measures were the 1-year evolution of functional ability as measured by a scale of activities of daily living (ADL) (score from 0 to 6) and the incidence of hospitalizations and mortality (time-to-event).ResultsFirst, 204 (37.7%) residents were defined as mentally vital. Second, 139 (27.5%) residents were defined as physically vital. And 52 (9.6%) were defined as vital when combining physical and. Combined vitality was associated with a reduced risk of hospitalization compared to combined non-vitality. Physically vital residents were associated with a reduced risk of mortality. No prospective associations were found between vital and non-vital individuals on the evolution of ADL scores across the three vitality definitions. But mentally vital individuals were associated with a worsening of ADL score.ConclusionsBetter combined vitality seems to be associated with a reduced risk for hospitalizations, but more studies are needed to confirm a valid measurement of vitality in people living in NH in regards to ADL and mortality.

Quality of Life but not Cognition is Impacted by Radiotherapy in Patients with Non-Functioning Pituitary Adenoma.

Non-functioning pituitary adenomas (NFPA) are benign neoplasms that are first treated by surgery and secondary radiation therapy in case of residual tumor or regrowth. The consequences of surgery and radiotherapy are still debated. The objective of the work was to assess the impact of surgery, radiotherapy (RT) and pituitary deficiencies on long term health-related quality of life (QoL) and cognitive function among NFPA patients. Forty-six NFPA patients were studied after 9.6±7.5 years follow-up using: i) the MoCA questionnaire to detect mild cognitive disabilities, ii) the McNair and Kahn scale to assess perceived cognitive impairment, iii) the HADS questionnaire to score anxiety and depression, and iv) the SF-36 and QLS-H questionnaires to assess QoL. All NFPA patients had surgery and 54% patients had radiation therapy (RT+). The MoCA score was abnormal in 41% NFPA patients. Neither the type of surgery nor radiotherapy influenced the prevalence of cognitive disabilities. The depression score was higher in RT+than RT- patients. Overall, no alteration in SF-36 and QLS-H QoL scales were observed in NFPA patients when compared with the French reference population. Among NFPA patients, mental composite score, general health and vitality scores were altered in RT+compared to RT- patients. The presence of multiple pituitary axis deficiencies worsened general health and vitality scale scoring. Consistent follow-up had a beneficial impact on psycho-emotional dimensions of health. Surgery and radiotherapy had no adverse effects on cognitive functions, however, QoL was altered in RT+patients. These latter alterations may be partly related to pituitary hormone deficiencies.

Mental health and traffic behavior among drivers in Republic of Srpska

&amp;lt;p&amp;gt;Introduction. Mental health is related to risky driving behavior and traffic accidents. The aim of this study is to investigate both social and demographic characteristics of drivers, as well as the connection between mental health and risky driving behavior among drivers in the Republic of Srpska, Bosnia and Herzegovina. Methods. The study was part of the population health survey conducted in the Republic of Srpska in 2010. The survey included 1866 households and a total of 4178 adults were interviewed (1688 drivers and 2490 non-drivers). The Chi-square test and independent samples t-test were used for data analysis. Results. Among 4178 respondents, 59.6% were non-drivers and 40.4% were drivers. There were significantly higher percentage of male drivers (73.3%), adults aged 25-54 years (66.1%), who lived in rural areas (55.3%) and were in employment (50.1%). Significantly higher percentage of drivers (58.2%) were present in the category with score values 58 to 78 on the mental distress scale, while most non-drivers were found in the category with mental distress score values 58 and lower (43.2%), p &amp;amp;lt; 0.001. Also, a significantly higher percentage of non-drivers (91.5%) were found in the category with the lowest level of mental vitality (&amp;amp;ge; 62.5), while the percentage of drivers increased in categories with higher scores on the mental vitality scale (p &amp;amp;lt; 0.001). Persons driving under the influence of alcohol had lower values on the mental distress scale (p &amp;amp;lt; 0.05, eta square = 0.005), while those who tended to use mobile phones while driving achieved higher scores on the mental vitality scale (p &amp;amp;lt; 0.001, eta square = 0.15). Conclusion. Study results have revealed significant differences in the level of mental health between drivers and non-drivers. People who drive under the influence of alcohol have a lower level of mental health, taking into account the results on the mental distress scale, while those who use mobile phones while driving have a higher level of mental vitality. In subsequent research, it is necessary to thoroughly examine the influence of mental health on tendency towards risky driving behavior.&amp;lt;/p&amp;gt;

Occupational Loss and Perceived Burden: Addressing Care Partner Needs After Stroke

Abstract Date Presented 4/20/2018 Stroke can lead to occupational loss and increase perceived burden in care partners. Implications of this study suggest that care partner needs must be addressed to enhance occupational participation, improve mental health and vitality, and potentially improve rehabilitation for people with stroke. Primary Author and Speaker: Jackie Einerson Additional Authors and Speakers: Alexandra Terrill Contributing Authors: Beth Cardell, Lorie Richards

Investigating the Effect of Religious Intervention on Mental Vitality and Sense of Loneliness Among the Elderly Referring to Community Healthcare Centers.

The growth of elderly population is among the most important issues in the world, and religious interventions can help them to keep their health. For this reason, this study was conducted with the aim of determining the effect of religious intervention on subjective vitality and sense of loneliness of the elderly referring to healthcare centers. This semi-experimental study was conducted on 88 elderlies referring to community healthcare centers of Ilam City. The elderlies were randomly assigned into test and control groups, and subjective vitality and sense of loneliness questionnaire was distributed to them. For the elderly in the test group, twelve 30-45-min sessions of religious intervention were held. Then, at intervals of immediately, 1month, and 2months after the study, the studied questionnaires were redistributed again among the elderly, and the data were analyzed using SPSS 16 and through descriptive statistics as well as repeated measures of analysis of variance. Before intervention, there was no difference between mental vitality and fear of loneliness in the elderly, but after intervention, the amount of mental vitality increased and fear of loneliness decreased. Since in this study, implementation of religious intervention resulted in improved subjective vitality and diminished sense of loneliness among the elderly, it is suggested that this effective intervention be also used in other studies.

Quality of life assessment among individuals with sickle cell disease attending hematology clinic of a Tertiary Hospital in Northwest Nigeria

Background: Globally, sickle cell disease (SCD) is the most common inherited disorder, with Nigeria having the greatest burden of the disease. SCD was thought to be a disease of childhood because many died early in life from related complications. However, advances in SCD treatment have altered its course such that the majority of children are living into adulthood. Individuals with SCD suffer increased school absenteeism, poor school performance, increased hospital visits, and increased hospitalization, thus affecting their quality of life (QOL) compared to normal individuals. Subjects and Methods: We conducted a hospital-based, descriptive, cross-sectional study among 120 individuals with SCD attending hematology clinic in a tertiary hospital, selected using systematic sampling technique. Pretested, structured, interviewer-administered questionnaire adapted from RAND's Short Form-36 was used for the data collection. Completed questionnaires were coded, and data were entered into SPSS software version 23.0 for analysis. Univariate and bivariate analyses were conducted among variables. Associations between categorical variables were tested for significance using Chi-square test and Student's t-test. Statistical significance was said to be achieved where P < 0.05. Results: A total of 120 participants were studied with an age range of 10–45 years and a median age of 20 years. Majority (54.2%) of the participants were in the age group of 10–20 years. In addition, 13 (10.8%) perceived their general health status as poor, whereas 71 (59.2%) had the perception of falling sick easily, than the normal individuals. The Health-Related Quality of Life (HRQOL) scores for the eight domains are as follows: bodily pain (62.3 ± 24.3), physical functioning (56.7 ± 25.5), physical role limitation (32.1 ± 37.7), social activities (59.5 ± 27.4), general mental health (42.0 ± 39.7), emotional status (59.1 ± 14.1), vitality (52.9 ± 13.1), and general health perceptions (50.8 ± 21.1). Conclusion: We found that the QOL of individuals with SCD is generally poor in all the domains of HRQOL, especially in the areas of role limitations due to physical and emotional health. Therefore, in addition to measures taken to reduce SCD complications, other interventions should target improving their physical and emotional health. We also recommend improving HRQOL among all the other domains as a clinical end point.

French translation and validation of the “Anterior Knee Pain Scale” (AKPS)

Purpose: To linguistically and cross-culturally translate the Anterior Knee Pain Scale into French and to evaluate the reliability and validity of this translated version of the questionnaire.Methods: The translation part was performed in six stages, according to international guidelines: (i) two initial translations from English to French; (ii) synthesis of the two translations; (iii) backward translations into the original language; (iv) expert committee to compare the backward translations with the original questionnaire; (v) pre-final version testing and (VI) expert committee appraisal. To validate the French version of the Anterior Knee Pain Scale, we assessed its validity, reliability and floor/ceiling effects. To do this, volunteer patients from the French part of Belgium and from France, with patellofemoral pain were asked to answer the French version of the Anterior Knee Pain Scale at baseline and after 7 days, as well as the generic SF-36 questionnaire.Results: The Anterior Knee Pain Scale was translated without any major difficulties. A total of 101 subjects aged 34.5 ± 11.4 years (58.4% of women) were included in this study. Results indicated an excellent test-retest reliability (Intra-class correlation coefficient (ICC) = 0.97, 95%CI: 0.96–0.98), a high internal consistency (Cronbach’s alpha = 0.87), a consistent construct validity (high correlations with the SF-36 questionnaire were found with domains related to physical function (r = 0.80), physical role (r = 0.70) and pain (r = 0.64)) and low or moderate correlations with domains related to mental health (r = 0.26), vitality (r = 0.32) and social function (r = 0.41). Moreover, no floor/ceiling effects have been found.Conclusions: A valid French version of the Anterior Knee Pain Scale is now available and can be used with confidence to better assess the disease burden associated with patellofemoral pain. It was successfully cross-culturally adapted into French.Implications for rehabilitationThe results on psychometric properties of the French Anterior Knee Pain Scale are comparable with six validated versions obtained for the Finnish, the Turkish, the Chinese, the Dutch, the Thai and the Persian populations.The French translated version of the Anterior Knee Pain Scale is a reliable and valid instrument for assessing the functional limitations associated with patellofemoral pain.The test–retest reliability of the French Anterior Knee Pain Scale was excellent, the internal consistency was high and the construct validity was consistent. There were no floor/ceiling effects.

Relationship Between Basic Psychological Needs and Mental Vitality in the Elderly

Relationship Between Basic Psychological Needs and Mental Vitality in the Elderly

Active Mobility and Subjective General Health: Roles of Mental Health, Social Support and Physical Activity

Background Active mobility (i.e. walking and cycling) has been associated with multiple health benefits from reduction to cardiovascular risk, lowering of body weight, improvement of fitness, reduced risk of diabetes, to higher levels of physical and mental well-being. The association between active mobility and subjective general health remains unexplored, as are the mechanisms which mediate this association. The current study evaluates the association between active mobility and subjective general health in an adult population in seven European cities, and explores whether mental health, vitality, stress, social support, and physical activity are mediators of this association. Methods A cross-sectional study has been performed in seven European cities (Antwerp, Barcelona, London, Orebro, Rome, Vienna, and Zurich). Participants responded to a comprehensive survey concerning their mobility behaviour and self-perceived health. Participants were categorized as either those who have active mobility patterns or non-active mobility patterns, and as with “good or more” or “less than good” subjective general health. Multilevel Logistic regression models will be used to evaluate the association between subjective general health status and active mobility, adjusting for potential confounders. We will follow Baron and Kenny's framework to establish the mediation roles and we will further quantify the relative contribution of each mediator. Results Analyses are on-going. The sample had more than 3,000 adults, fairly distributed in the seven cities (16% Antwerp, 16% Barcelona, 14% London, 10% Orebro, 14% Rome, 16% Vienna, 14% Zurich). We expect to find association between active mobility use and better subjective general health. We also expect to find indications for mediation of this association by mental health status, perceived social support, perceived stress, and physical activity. Conclusions A better mental health status, perceived social support, perceived stress and higher levels of physical activity may be important consequences of active mobility which could lead to a better subjective general health. these should be considered by decision makers as other potential benefits of active mobility promotion.

Relationship between the cumulative burden (CB) of chronic health conditions (CHC) and health-related quality of life (HRQoL) among childhood cancer survivors (CCS): The St. Jude Lifetime (SJLIFE) cohort.

10560 Background: Adult CCS experience an excess burden of CHC. The association between disease burden (estimated using CB) and HRQoL has not been extensively assessed. Methods: 2878 CCS (mean [range] age 32.1 [18.3-66.2] years; time from diagnosis 25.0 [10.2-51.0] years) were enrolled in SJLIFE (eligibility: survived &gt;10 years and &gt;18 years of age) and clinically evaluated for 168 graded CHC using the St. Jude modified Common Terminology Criteria for Adverse Events. HRQoL was assessed using the Short Form 36 survey and categorized into Low (&lt; -0.5 SDs), Average (-0.5 to 0.5 SDs), and High (&gt; 0.5 SDs) subgroups from the Physical and Mental Component Summary (PCS, MCS) and Vitality Scale using cohort age- and sex-specific values. CB (average number of grade 3-4 [severe/life-threatening] CHC/survivor) for each CHC was calculated and summed for each HRQoL subgroup. Results: Survivors with low PCS had, on average, more CHC CB compared to those with High and Average PCS. Higher CHC CB was also associated with poorer Vitality and MCS, but the differences in effect size were smaller than PCS. When CB for each of the 3 HRQoL scores were compared by subgroups across 12 organ systems and subsequent neoplasms, CB at age 50 differed significantly (p&lt;0.05) across PCS, MCS, and Vitality in 9, 3 and 7 of the 13 systems, respectively. Conclusions: Survivors with lower HRQoL scores have more CHC, but the patterns of this association vary in PCS, MCS and Vitality by CHC organ systems, suggesting adult CCS adjust better to certain types of CHC than others. Future research will focus on CHC with greatest impact on functioning. [Table: see text]

Adult CHD patients under clinical follow-up have a similar quality of life to the general population in Malta.

The improved survival of patients born with CHD has led to increasing interest in research on quality of life of adult survivors. We report the findings of the first study in Malta carried out to investigate quality of life in adults with CHD under follow-up. A self-reporting questionnaire modelled on the basis of the European Health Interview Survey 2008, including questions on mental health and vitality, was administered to consecutive adult CHD outpatients, aged 16 years and over, between May, 2013 and May, 2014. Foreigners and patients with learning difficulties or cognitive impairment were excluded. Quality-of-life data were compared with that from 371 age- and sex-matched 2008 survey responders - general population cohort. The impact of congenital lesion complexity, hospitalisation in the preceding 12 months, arrhythmias, co-morbidities, and cardiac medication use on quality of life of the CHD cohort was also investigated. There were a total of 120 patient responders (63 males; mean age 30.53, SD 12.77 years). Overall, there were no significant differences in mental health and vitality between patient and general population cohorts, although older patients had better mental health scores compared with age-matched controls. Within the adult CHD cohort, hospitalisation in the preceding 12 months was the only factor associated with a poorer quality of life. Overall, CHD has no negative impact on mental health and vitality in Maltese adult patients under follow-up. Patients needing frequent hospitalisations might warrant closer attention by clinical psychologists.

Abstract 3466: Mental health-related quality of life assessment at diagnosis as a predictor for prognosis of colorectal cancer patients

Abstract Purpose: Health-related quality of life (HR-QoL) is emerging as an important metric for assessing and predicting outcomes in colorectal cancer (CRC) patients. While most studies focus on QoL in treatment response, few studies have investigated the impact of baseline mental health QoL variables on prognosis of CRC patients. The objective of our study was to explore mental health and vitality QoL measurements and association with prognosis in CRC patients. Patients and Methods: QoL was assessed in a hospital-based cohort of 2,900 non-Hispanic white CRC patients that completed the SF-12 questionnaire within 1-year of diagnosis. Mental Component Summary (MCS) scores were dichotomized by the normalized scoring-based mean of 50. Hazard ratios were generated using univariate cox regression analysis and survival estimates generated using the Kaplan-Meier method. Sub-domain variables under mental health (“downhearted and blue” and “calm and peaceful”) and vitality (“energy”), were scored and dichotomized before stratifying by patient demographics and statistically evaluated. Results: We observed that CRC patients with poor mental QoL (MCS&amp;lt;50) had a 1.48-fold increased risk (95%CI:1.31-1.66; P = 5.17×10−14) of a poorer prognosis compared to those with a high MCS score (≥50). This corresponded to a 61.9 month reduction in median survival time in this group (log-rank P = 5.88×10−11). Patients that reported feeling downhearted and blue compared to those that did not, had a 65.7 month reduction in median survival time (log-rank P = 1.13×10−5). Similarly, there was an increased survival time for patients that felt peaceful and calm (MST:113.1 months) compared to those that reported not feeling peaceful and calm (MST:59.4 months; log-rank P = 1.36×10−5). The most striking finding was for the energy variable. Patients that reported having energy compared to those that did not, were found to have significantly better survival with MSTs of &amp;gt;175 months and 42.3 months, respectively (log-rank P = 2.91×10−27). Several patient characteristics (alcohol use, tobacco use, gender and marital status) were significantly associated with these sub-domain measurements. We found those that reported combined poor mental health and vitality had a dramatic reduction in survival by 102.7 months (log-rank P = 8.39×10−18). Conclusion: We conclude that baseline mental QoL assessment may identify CRC patients at increased risk of a poor prognosis and merits further investigation of these variables as independent CRC prognostic factors. Interestingly, a potential coping mechanism may underlie the protective effect observed among current users of alcohol, while smoking may serve as a risk factor for poor prognosis in those that reported poor mental QoL. Further studies are warranted to explore the relationship between these MCS sub-domain variables and survival in CRC patients. Citation Format: Monica E. Reyes, Yeling Zhou, Yuanqing Ye, Xifeng Wu, Michelle Hildebrandt. Mental health-related quality of life assessment at diagnosis as a predictor for prognosis of colorectal cancer patients. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3466.