This article aims at providing a more comprehensive picture of how meanings of “run” are transferred from spatial to non-spatial meanings by using the combined framework of Multimodal Image Theory and Extended Conceptual Metaphor. To be specific, 368 concordances of “run” extracted from the corpus of Contemporary American English in 2017, Genre Spoken were systematically analyzed to first identify the word’s meanings in its contexts of use and then account for its meaning transference. In other words, the prototypical meaning of “run” and its image complexes in three spaces namely Visual space, Maneuver space, and Kinetic space were analyzed in the light of Multimodal Image Theory, which provides concrete image-schemas mapped onto the word’s non-spatial meanings found in its Mental space in association with a range of conceptual metaphors. It has been shown that mapping together with image-schema transformations are the mechanisms of the word meaning transference.