Mental Scores Research Articles

Leveraging Mobile Health to Improve Capecitabine Adherence Among Women With Breast Cancer: A Pilot Randomized Controlled Trial.

Oral capecitabine improves convenience compared to intravenous therapies but presents monitoring challenges. We conducted a randomized pilot trial to evaluate a mobile health intervention to remotely monitor capecitabine adherence and patient-reported outcomes (PROs) among women with breast cancer. Patients with breast cancer prescribed capecitabine, an oral chemotherapy with a complex, cyclical regimen, were randomly assigned to enhanced usual care (EUC) or PRO arm. Participants were asked to use a smart pill bottle to measure adherence (timing and dose) and complete baseline and 90-day follow-up surveys. PRO participants received text messages for missed or incorrect doses and weekly text-based symptom assessments, and their oncologists received alerts for severe symptoms or missed doses. We compared nonadherence (<80%) and changes from enrollment to follow-up on reported physical and mental health quality-of-life scores and number of severe symptoms by study arm. Overall, 32 women were randomly assigned (17 EUC and 15 PRO): 28 (87.5%) received the intervention and 24 (78.1%) completed the follow-up survey. Among participants who received the intervention, PRO participants responded to 83.3% of symptom questions; 7.7% of PRO participants were nonadherent compared with 40.0% of EUC participants (P = .049). Among those who completed the follow-up survey, 12.5% of PRO participants had reductions in their mental health composite scores compared with 69.2% of EUC participants (P = .011); 10% of PRO participants had more severe symptoms at follow-up compared with 57.1% of EUC participants (P = .019). A mobile health intervention using text message reminders and symptom assessments improved medication adherence and mental health quality-of-life scores and lowered symptom burden of patients with breast cancer prescribed capecitabine. Future work should evaluate the longer-term impacts of this intervention.

Psychometric characteristics of the Spanish version of the HIV Symptom Index

BackgroundThe aim of this study was to determine the psychometric properties of the Spanish-language version of the HIV-Symptom Index (HIV-SI) questionnaire in Spanish patients undergoing antiretroviral therapy.MethodsBetween 2014 and 2016, an observational, multicenter, prospective cohort study was conducted in seventeen Spanish hospitals to validate HIV-SI questionnaire in terms of: construct validity (confirmatory factor analysis), internal consistency (Cronbach’s alpha), convergent validity (Pearson’s correlation coefficient) and Known-group validity. In addition, a sensitivity to change analysis was also performed.ResultsA total of 232 patients were included in the study. They had a mean age of 46.17 (SD9.82) and were 75% male. The median overall score for the HIV-SI was 10 (IQR 4– 19.5) and the most common symptoms reported were feelings of nervousness or anxiety, fatigue or energy loss, feeling sad or depressed, stomach pain or bloating, and difficulty sleeping. In the current study, the Spanish HIV-SI questionnaire showed a high internal consistency (α = 0.89) and adequate construct validity (CFI and TLI > 0.90). When contrasted with the MOS-HIV questionnaire, an inverse correlation was found. It showed a good association with the mental (r=-0.61; P < 0.0001) and physical score (r=-0.60; P < 0.0001). In a multivariate analysis, the age of the patient, female condition, hepatitis C coinfection, concomitant treatment and non-adherence resulted in a higher HIV-SI score.ConclusionsOur study has shown that the Spanish HIV-SI is a valid and reliable self-administered PROM for routine measurement of patient- reported symptoms among Spanish patients on antiretroviral treatment.

Inter-rate Reliability Of Mental Toughness Scores By Head And Assistant Coaches: A Repeated-measure Design

Inter-rate Reliability Of Mental Toughness Scores By Head And Assistant Coaches: A Repeated-measure Design

A Dual-Modality Home-Based Cardiac Rehabilitation Program for Adults With Cardiovascular Disease: Single-Arm Remote Clinical Trial.

Cardiac rehabilitation (CR) is a safe, effective intervention for individuals with cardiovascular disease (CVD). However, a majority of eligible patients do not complete CR. Growing evidence suggests that home-based cardiac rehabilitation (HBCR) programs are comparable in effectiveness and safety with traditional center-based programs. More research is needed to explore different ways to deliver HBCR programs to patients with CVD. We aimed to assess the feasibility and impact of a digital HBCR program (RecoveryPlus.Health) that integrates both telehealth and mHealth modalities on functional exercise capacity, resting heart rate, and quality of life among adults with CVD. This 12-week prospective, single-arm remote clinical trial used a within-subject design. We recruited adults with CVD (aged ≥40 years) from the community with a CR-eligible diagnosis (stable angina pectoris, myocardial infarction, and heart failure) between May and August 2023. All enrolled patients referred to the RPH clinic in Roanoke, Texas, were included. The care team provided guideline-concordant CR services to study participants via two modalities: (1) a synchronous telehealth exercise training through videoconferencing; and (2) an asynchronous mobile health (mHealth) coaching app (RPH app). Baseline intake survey, electronic health record, and app log data were used to extract individual characteristics, care processes, and platform engagement data. Feasibility was measured by program completion rate and CR service use. Efficacy was measured by changes in the 6-minute walk test, resting heart rate, and quality of life (12-Item Short-Form Health Survey) before and after the 12-week program. Paired t tests were used to examine pre- and postintervention changes in the outcome variables. In total, 162 met the inclusion criteria and 75 (46.3%) consented and were enrolled (mean age 64, SD 10.30 years; male: n=37, 49%; White: n=46, 61%). Heart failure was the most common diagnosis (37/75, 49%). In total, 62/75 (83%) participants completed the 12-week study and used the telehealth modality with 9.63 (SD 3.33) sessions completed, and 59/75 (79%) used the mHealth modality with 10.97 (SD 11.70) sessions completed. Post intervention, 50/62 (81%) participants' performance in the 6-minute walk test had improved, with an average improvement of 40 (SD 63.39) m (95% CI 25.6-57.1). The average 12-Item Short-Form Health Survey's physical and mental summary scores improved by 2.7 (SD 6.47) points (95% CI 1.1-4.3) and 2.2 (SD 9.09) points (95% CI 0.1-4.5), respectively. There were no changes in resting heart rate and no exercise-related adverse events were reported. The RecoveryPlus.Health digital HBCR program showed feasibility and efficacy in a group of nationally recruited patients with CVD. The findings add to the evidence that a telehealth and mHealth dual-modality HBCR program may be a promising approach to overcome some of the main barriers to improving CR access in the United States. ClinicalTrials.gov NCT05804500; https://clinicaltrials.gov/search?cond=NCT05804500.

Medical student’s attitude toward severe mental illness and its associated factors at the University of Gondar, Northwest Ethiopia

IntroductionMental illness is mental and emotional disturbances that affect individual thinking, feeling, decision-making, mood, and daily functioning. A poor attitude toward severe mental illness means an individual has a distorted perception or attitude toward severely mentally ill patients. Despite the presence of a high burden of negative attitudes toward severe mental illness, there is a limited study conducted on Ethiopian University students. Therefore, this study aimed to reveal the prevalence of poor attitudes toward severe mental illness and its associated factors among University Gondar medical students in Northwest Ethiopia. MethodAn institutional-based cross-sectional study design was employed from Jun 25 to August 15, 2022. A structured self-administered questionnaire was used to screen the attitudes of students toward severe mental illness. Mental Illness Clinician’s Attitude fourth version and Mental Health Knowledge Schedule score tools were used to screen the attitude of students. Bi-variable logistic regression analysis was employed and variables with a p-value of less than 0.25 were entered into the multivariable logistic regression for further analysis. Factors with a p-value less than 0.05 at a 95% Confidence Interval (CI) in the multivariable logistic regression analysis were considered statistically significantly associated. ResultsFrom the total of 423 study participants with a 100% response rate the overall prevalence of poor attitude towards severe mental illness among university students was 68.1% with a 95% CI (63.6-72.6). Age (18-24) [AOR=2.47; 95% CI: (1.37,4.45)], being male [AOR= 3.22; 95% CI: (2.01-5.17)], from a rural area [AOR= 1.82; 95% CI: (1.13-2.93)], and with no family history of mental illness [AOR=2.07; 95% CI: (1.12-3.82)] were statistically significantly associated factors with poor attitude towards severe mental illness. Conclusionsand recommendations: Approximately three-fourths of university Gondar medical students (68.1%) had poor attitudes towards severe mental illness. Age (18-24), being male, originating from a rural area, and with no family history of mental illness were significantly associated with a poor attitude toward severe mental illness. Awareness creation about mental illness can change the attitude of students which can be done by the mental health department to give as a common course can help the student to have a positive attitude.

The Association Between Lifestyle Factors and Mental Well-being among Dental Students

Dentistry can be considered a challenging field, with dental students often experiencing high levels of stress and poor mental health. Hence, maintaining mental well-being is important so that dental students can cope with their stressors effectively. Lifestyle factors like physical activity, sleep problems, and addictions impact the levels of mental well-being. This paper aimed to identify the association between dental students’ lifestyle factors and mental well-being. This cross-sectional descriptive study was conducted among all the undergraduate dental students at a university in Malaysia. Data were collected by using a self-administered questionnaire [which included questions on demographic background, lifestyle factors, and the Warwick-Edinburgh Mental Well-being Scale (WEMWBS)] and analysed using SPSS (version 26.0). Out of the surveyed students, 83.2% responded. The mean WEMWBS score for this study population was 46.09 ± 7.93. The results showed that engagement in physical activity positively affected mental well-being scores, while the presence of sleep-related problems was associated with lower mental well-being scores. Encouraging the adoption of healthier lifestyle factors, such as regular physical activity and practising good sleep hygiene along with the intervention of sleep-related problems, could improve mental well-being levels among dental students significantly.

Current Status and Factors Influencing Mental Health Literacy in Patients With Coronary Heart Disease: A Cross-Sectional Study.

This study aimed to investigate the current status of mental health literacy and related influencing factors in patients with coronary heart disease. Four hundred and thirty-five patients with coronary heart disease were recruited in this survey. Data collection was conducted using the General Information Questionnaire, the Chinese version of the Mental Health Literacy Scale, Coronary Artery Disease Self-Management Scale, Social Support Rating Scale, and Coronary Heart Disease Self-Efficacy Scale. Descriptive methods, independent samples t-test or one-way ANOVA, Pearson's correlation analysis, and multiple linear regression were used for data analysis. The results showed that the mean total mental health literacy score of patients with coronary heart disease was 96.42 ± 8.40; gender, age, education level, monthly per capita family income, first diagnosed with coronary heart disease, cardiac function classification, self-management ability, social support, and self-efficacy were the factors influencing the level of mental health literacy in patients with coronary heart disease (all p < 0.05). The study suggests that mental health literacy can improve patients' self-management ability and self-efficacy, and healthcare professionals should emphasize the strengthening of this aspect of health education in order to better improve patient's prognosis.

The Relationship Between Leisure-Time Physical Activity and Mental Health Conditions in Undergraduate Students

Purpose: This study aimed to investigate the relationship between self-reported leisure-time physical activity (LTPA) and self-reported symptoms of mental health conditions on mental health condition questionnaires among undergraduate students. Methods: Forty undergraduates (females: n=17, males: n=23; age=20.25±1.05) from Western University participated in this study. They completed a series of questionnaires which included the ASRS-V1.1, GAD-7, PTSD-ST, and PHQ-9, and were allocated into an attention deficit hyperactivity disorder (ADHD) (n=9, 3 females, age: 20.55±1.01), anxiety (n=11, 6 females, age: 20.55±1.22), multiple condition (n=3, 1 females, age: 19.33±0.58), or control group (n=17, 7 females, age: 20±0.87). LTPA was quantified using the Godin-Shephard Leisure-time Physical Activity Questionnaire for a 7-day period and a 6-month period. Spearman’s rank correlation coefficients were used to examine the relationship between LTPA and mental health condition scores. Results: There was no statistically significant relationship between the total mental health score and self-reported LTPA scores in the 7-day period (r = -0.178, p = 0.272) or the 6-month period (r = -0.081, p = 0.621). There was no apparent relationship between self-reported LTPA scores and the questionnaire scores of each condition. Conclusion: Our results indicate that self-reported LTPA has no significant relationship with mental health among undergraduate students. Interestingly, LTPA in kinesiology students may be higher than in other undergraduate faculties. More research is required to determine if kinesiology students experience altered motivations for engaging in LTPA.

The Effects of Laughter Therapy on Perceived Stress and Quality of Life in Women With Breast Cancer Receiving Chemotherapy: A Parallel-Group Randomized Controlled Pilot Trial.

Women with breast cancer experience various symptoms secondary to chemotherapy that reduce their quality of life and increase their stress levels. To evaluate the effects of laughter therapy on perceived stress levels and quality of life in women with breast cancer receiving chemotherapy using a parallel-group randomized controlled pilot trial. Forty-two women were randomly assigned to intervention and control groups. The intervention group received 40 minutes of laughter therapy twice a week for 8 weeks. The control group received routine treatment. The women in both groups completed the Perceived Stress Scale and SF-12 Health Survey at baseline, week 5, and week 9 after randomization. There was a significant decrease in the mean Perceived Stress Scale scores in the intervention group compared with those in the control group at weeks 5 and 9 compared with baseline, and the difference between groups by measurement week was significant (P < .001). Women in the intervention group had higher Physical Component Summary-12 and Mental Component Summary-12 scores in weeks 5 and 9 compared with those in the control group, and there was a significant difference between groups in terms of change in the Physical Component Summary-12 and Mental Component Summary-12 mean scores over time (P < .001). Laughter therapy is possible to use as a nursing intervention to reduce the perceived stress levels and increase the quality of life of women receiving chemotherapy for breast cancer. Nurses can apply laughter therapy in the symptom management of women receiving chemotherapy.

Effect of Flaxseed on Pain Relief and Quality of Life in Patients With Mastalgia: A Single Arm Interventional Study.

Mastalgia, a common complaint among women, denotes breast discomfort that can manifest as cyclical or non-cyclical. Reassurance, mechanical support and various non-pharmacological treatments, like flaxseeds, have been seen to have a good effect in treating mastalgia. Thus, the aim of this study was to investigates the efficacy of flaxseed in alleviating pain associated with mastalgia and its impact on the overall health-related quality of life among female patients. Conducted at a tertiary care center in Northern India over 18 months, it employed a single-arm interventional design. The participants included females aged 18 years and older presenting with breast pain at the Department of General Surgery. The intervention involved daily consumption of 30 g of milled flaxseed for each participant, administered over a period of six months. Pain severity was assessed using the visual analogue scale (VAS) before supplementation and at follow-up intervals up to six months. Concurrently, the Short Form-12 (SF-12) items Health Survey measured health-related quality of life, encompassing both physical and mental health domains. Statistical analysis employed parametric (paired t-test) and non-parametric tests (chi-square, McNemar) where appropriate, with statistical significance set at p<0.05. Two hundred women with mastalgia were included with a significant reduction in mean VAS scores from 6.03±0.83 at baseline to 2.19±0.66 at six months post-intervention (p = 0.0001). This reduction in pain intensity demonstrated a positive correlation with duration of flaxseed supplementation, notably declining after the initial three months. The mean difference in physical and mental SF-12 score at first visit and at 6 months after intervention was significant (p = 0.0001). This study underscores the potential of flaxseed as a therapeutic option for managing mastalgia and enhancing health-related quality of life among affected individuals.

Exploring Factors Influencing the Physical and Mental Quality of Life of Caregivers of Cancer Patients: A Cross-Sectional Study at Hassan II University Hospital Center.

Background Cancer is a serious public health problem worldwide, causing an impact not only on the patient's quality of life (QoL) but also on their caregiver. This study aims to assess the socio-demographic characteristics, physical and mental QoL, and associated factors among caregivers of cancer patients at the Hassan II University Hospital Center in Fez, Morocco. Methods This is a cross-sectional study of 247 caregivers of cancer patients. Their QoL including physical and mental health aspects was assessed using a 12-item Short Form health survey (SF-12). Statistical analysis was conducted utilizing IBM SPSS Statistics for Windows v26.0 (IBM Corp., Armonk, USA). This included calculating frequency distributions and percentages. The general and socio-demographic data associated with QoL were analyzed using the student's t-test and one-way analysis of variance (ANOVA). Only variables with p-value <0.05 were considered statistically significant. Results The majority of the participants were 40 years old and over, and 54.3% of the total participants were women. The average physical QoL score was 47.32 (±7.08), while the average mental QoL score was 31.64 (±14.44).For caregivers, certain personal attributes and circumstances were found to influence their mental and physical QoL. Age, gender, and being unemployed were common factors impacting both the mental and physical well-being of caregivers. Moreover, being married (P=0.019) was an additional factor affecting their physical QoL. In contrast, specific aspects related to the caregiving role itself also played a significant role. Caregivers who were close family members of patients (P=0.0001) and those providing care for patients with genitourinary cancer (P=0.048) experienced a notable detrimental effect on their mental QoL. Conclusion This study highlights several factors associated with the poor QoL of caregivers, such as gender, age, professional activity, and the relationship with the patient. It is imperative to establish a specific support system for caregivers of cancer patients, including social and economic assistance, to enhance their physical and mental QoL.

Abstract C071: Comprehensive genomics-informed prospective older adult (OA) cancer registry: Initial findings from gastrointestinal (GI) malignancy

Abstract The REACH study (Resilience and Equity in Aging, Cancer, and Health) assesses the impact of geriatric consultation on reducing emergency department and/or unplanned hospitalization visits (EDH) for OA age 70+ diagnosed with GI cancer. We sought to develop an OA GI cancer registry (REACH Registry) within the REACH intervention integrating 1) disease and treatment factors from the PRISSMM cancer taxonomy model with 2) patient reported outcomes and 3) geriatric assessment (GA) measures predictive of function, toxicity, and survival. We reviewed GA measures using the modified Rockwood frailty scale, PROMIS-10 global mental and physical scores, Karnofsky performance status, health-related social needs, and disease/treatment factors using PRISSMM cancer taxonomy for OA consented to REACH in the GI Cancer Center at Dana-Farber Cancer Institute (DFCI) from January 2022–April 2024. OA were eligible if age 70+ at initial DFCI consult visit and diagnosed with any GI cancer. The GA stratifies OA by frailty level on a 0-1 scale: Fit/Robust (score range 0–0.19), Pre-Frail (0.2–0.34), and Frail (0.35–1.0). PRISSMM is a cancer data modeling system developed for the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (GENIE) Biopharma Collaborative; it includes pathology, radiology/imaging, symptoms, and molecular markers curated by trained research staff from unstructured EHR data. From Jan. 2022–Apr. 2024, 50 OA consented to REACH registry (94 eligible). Of those, 44% (n=22) have PRISSMM data available for analysis. Most OA reported white race (90%, n=45) and female gender (52%, n=26). Pancreatic cancer was the most common diagnosis (n=21), followed by colon (9), biliary (5), and esophageal (4). Most OA completed GA (90%, n=45) with 51% screened Fit/Robust (n=23), 47% Pre-Frail (n=21), and 2% Frail (n=1). Type 2 diabetes mellitus was the most commonly reported comorbid condition (26%, n=13), followed by chronic kidney disease (n=6) and congestive heart failure (n=3). Of the 22 OA with available PRISSMM data, 59% (n=13) were diagnosed with stage IV disease and 100% received cancer-directed therapy; 72% (n=16) received standard care, 27% clinical trial (n=6). Most OA consented for tumor somatic genomic testing (77%, n=17). At the time of data curation 24 months from assessment, 20 patients had died, 30 were alive. Evaluation of the REACH intervention geriatric consultation on EDH outcome is forthcoming. REACH registry is the first GI cancer database inclusive of geriatric specific measures alongside curated disease, treatment and genomic data. We observed a higher rate of genomic testing and treatment initiation than reported in the literature. We anticipate that by September 2024, a larger cohort of REACH Registry participants will have completed PRISSMM data available for analysis. Future study will compare EDH for REACH vs. non-REACH OA as well as treatment patterns of this OA cohort evaluated at a large comprehensive cancer center and associated community sites. Citation Format: Tammy T. Hshieh, Rachel L. Weitzner, Siri Rosenberg, Leila Rostamnjad, Lauren K. Brais, Nora Horick, Tamryn Gray, Jiping Wang, Jeffrey Meyerhardt, Nadine J. McCleary. Comprehensive genomics-informed prospective older adult (OA) cancer registry: Initial findings from gastrointestinal (GI) malignancy [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C071.

The Relationship of Active Aging Perspectives and Social Participation of Elderly Individuals with Their Mental States and Functional Independence

Objective: The aim of this study is to examine the active aging perspectives and social participation of older adults and to determine their relationship with their mental states and functional independence. Method: A total of 298 participants over the age of 60, with a mean age of 70.94±8.1 were included in the study. The degree of cognitive function of the individuals included in the study was evaluated with the Mini Mental State Examination (MMSE), the level of functional independence was evaluated with the Barthel Index. The social participation statuses of the older adult participants included in the study were analyzed with the social participation evaluation form created by the researchers. Results: Individuals with high social participation evaluation form mean scores had higher Mini Mental State Examination mean scores and Barthel Index mean scores (r1: 0.329, p

An Analysis of Welfare Standards Within Tiger (Panthera tigris) Facilities in Thailand.

In Thailand, tigers are more numerous in captivity than they are in the wild, with 51 facilities housing approximately 1962 tigers. As charismatic fauna, tigers are popular with tourists, and the majority of facilities offer a variety of entertainment activities with controversial reports towards the animals' welfare. The aim of this research was to investigate tiger welfare in Thai zoos to identify specific welfare issues. We assessed 34 tourism facilities holding tigers in Thailand in 2019 using a 25-point welfare assessment that utilizes the Five Domain model (incorporating all five domains: nutrition, physical environment, health, behavioural interactions and mental state). The mental domain score was derived from the scores of the other four domains. Additional data were collected from each facility, including the number of tigers, any colour variants, types of human interaction and admission cost. Welfare scores for each domain were calculated by totalling the scores per domain and dividing by the number of points allocated to that domain. A multiple regression was used to identify any significant predictors of mental domain score. The results revealed that the provision of a suitable physical environment scored the lowest, while nutrition scored the highest though this was still a low score overall. The multiple regression showed that 45.4% of the variance for the mental domain score was significantly affected by the number of colour variants housed and the types of human interaction available with facilities, with more of both these factors contributing to a more negative score. Our results demonstrate the need for urgent, comprehensive infrastructural, species-appropriate environment and design and animal management improvements to increase animal welfare. Informed institutional change toward the breeding and use of tigers for public interactions is also required. This is the first assessment completed of captive tiger welfare of tiger facilities in Thailand and shows that the welfare concerns encountered are within a high proportion (67%) of Thailand's facilities. This supports the need for the creation and enforcement of effective and clear captive wildlife operational standards to provide a sustained solution for captive tiger welfare and can provide a considered approach to ex-situ tiger management that, in conjunction with in-situ efforts, can improve much needed conservation efforts of this species.

Mental wellness and health-related quality of life of young adult survivors of childhood cancer in Singapore.

Childhood cancer survivors (CCS) are at risk of experiencing psychological distress years after completing cancer treatments. We aimed to assess the prevalence and associated risk factors affecting psychological distress and health-related quality of life (HRQOL) among CCS in Singapore, and compare with their siblings without a history of or existing cancer as control. We recruited 143 young adult CCS aged ≥18 years attending survivorship clinics at KK Women's and Children's Hospital in Singapore who were in remission for ≥5 years and treatment-free for ≥2 years, and 57 siblings. CCS and siblings were matched at a 1:1 ratio based on sociodemographic factors yielding 46 pairs for comparison. Among CCS participants, 79 (55.2%) were male, 86 (60.1%) had leukaemia, 29 (20.3%) had solid tumours, 15 (10.5%) had lymphoma and 13 (9.1%) had brain tumours. All participants completed the Brief Symptom Inventory-18 (BSI-18) and Medical Outcomes Short Form-36 (MOS SF-36) questionnaires from August 2021 to July 2022. There were 35 (24.5%) CCS who reported psychological distress in the BSI-18 Global Severity Index. Five (3.5%) and 31 (21.7%) CCS reported low HRQOL in the physical and mental composite scores, respectively. Mean scores between CCS and their siblings were not statistically significant across all domains of the BSI-18 and MOS SF-36. Associated risk factors for psychological distress and low HRQOL among CCS were history of psychiatric illness after cancer diagnosis and mood affected by the COVID-19 pandemic. CCS reported significant psychological distress and low HRQOL although they were not statistically different from their siblings. A holistic and risk factor-centric follow-up programme can aid early detection and mitigation of psychological late effects for CCS and their families.

Pengukuran Beban Kerja Mental Mahasiswa Pekerja Fakultas Ekonomi Dan Bisnis Universitas Muhammadiyah Gresik Menggunakan Metode Nasa-TLX

Background – Mental workload is the difference between the workload demands of a task and capacity. Mental workload is a human evaluation or assessment of the limits of attentional load while carrying out tasks optimally, which is influenced by the workload demands of a task and the worker's capacity to handle the task, especially for students who carry out work activities while studying. Therefore, it is necessary to examine how much mental workload is actually borne by student workers so that the negative impacts it causes can be minimized. Aim – To measure the mental workload of student workers at the Faculty of Economics and Business, Muhammadiyah University of Gresik using the NASA-TLX method Design / methodology / approach – The research approach used is Quantitative Descriptive. Quantitative data was obtained from the results of questionnaire responses from student workers at the Faculty of Economics and Business, Muhammadiyah University of Gresik regarding the level of mental workload using the NASA-TLX method. Findings – High mental workload can have a negative impact on a person's mental health, especially for students who work while studying. Mental workload is defined as the difference between task demands and an individual's capacity to handle the task, focusing more on the mental aspect than the physical. Students who work while studying often experience fatigue, lack of time to rest and socialize, and experience sleep disorders and stress which can reduce their academic and work performance. Therefore, it is important to measure and analyze the level of mental workload experienced by student workers in order to reduce its negative impact. The method used to measure mental workload is NASA-TLX (Task Load Index). Conclusion – Student workers at the Faculty of Economics and Business, Muhammadiyah University of Gresik experience a high mental workload, with the time demand indicator (Temporal Demand/TD) having the highest weight and the level of effort (Effort/EF) getting the highest score. The time requirement (TD) indicator most dominantly influences their mental workload, while the level of frustration (FR) has the lowest influence. Overall, their average mental workload score was in the high category, namely 77.64. Research implication – This research is aimed at students who are studying while working, with the aim of measuring the level of mental load that objects experience. The load in question is a high mental workload, with indicators of time requirements (Temporal Demand/TD), level of effort (Effort/EF) and indicators of time requirements (TD), as well as levels of frustration (Frustration/FR). Limitations – The limitations of this research only include the mental workload variable on the research object (student workers)

Analysis of disease burden in patients with hereditary angioedema from Japan by patient-reported outcomes.

Hereditary angioedema (HAE) symptoms can vary greatly. Disease burden evaluation is essential for providing adequate treatments for patients. Patient-reported outcome measures (PROMs), including the 12-Item Short Form Health Survey (SF-12), the Angioedema Quality of Life (AE-QoL), the Hospital Anxiety and Depression Scale (HADS), and the Work Productivity and Activity Impairment: Specific Health Problem (WPAI:SHP) questionnaires, were collected in 2021, before modern medications for long-term prophylaxis (LTP) of HAE were licensed in Japan. Patients also reported their HAE attack frequency as "annual" (several attacks annually), "monthly" (several attacks monthly) or "weekly" (several attacks weekly). Multiple linear regression analyses were conducted on the relationship between independent parameters (sex, age, attack frequency, HAE type, and HADS scores) and dependent parameters (AE-QoL and SF-12 scores). Fifty-four patients reported PROMs. All PROMs showed substantial health-related quality of life (HRQoL) impairment. Overall, the higher the attack frequencies, the greater the reported impairment in the PROMs tended to be. In multiple linear regression analyses, higher AE-QoL Fatigue/Mood and Fears/Shame domain scores (greater impairment) were associated with higher HADS anxiety subscale scores; higher AE-QoL total scores (greater HRQoL impairment) and lower SF-12 Physical and Mental Health Composite scores (greater general health impairment) were associated with higher HADS depression subscale scores. Patients with monthly or weekly HAE attacks reported numerically low absenteeism and numerically high presenteeism and work productivity loss as measured by the WPAI:SHP questionnaire. In this study, conducted before modern LTP options were available in Japan, patients with HAE reported notable impairment in HRQoL and work productivity. Weekly or monthly HAE attack frequencies were associated with a high disease burden. Furthermore, a substantial number of patients reported notable fatigue/mood impairment as measured by the AE-QoL and depression as measured by the HADS regardless of attack frequency. These results provide a basis for future studies evaluating the effect of LTP on the clinical manifestations and HRQoL in patients with HAE.

The Quality of Life in Elderly Patients in Comprehensive Conservative Management or Hemodialysis: A Case-Control Study in Analogous Basal Conditions.

Comprehensive conservative management (CCM) is a viable treatment option for elderly patients with end-stage kidney disease (ESKD). However, it involves a significant change in dietary habits, such as adopting a low-protein diet. Therefore, it is crucial to understand its impact on the patient's quality of life (QoL), particularly when compared to hemodialysis (HD). The study aims to evaluate the differences in the QoL between patients undergoing CCM and HD. The study included 50 patients over 75 with ESKD, with 25 patients in the CCM group and 25 in the HD group. The CCM group followed a personalized low-protein diet, while the HD group did not have protein restrictions. Various parameters were assessed, including demographic data, urine output, blood tests, comorbidity index, Visual Analog Scale (VAS), and hospitalization. The SF-12 questionnaire assessed the QoL, and the Physical Composite Score (PCS) and Mental Composite Score (MCS) were calculated. The study revealed no age and comorbidity index differences between CCM and HD patients. In contrast, CCM patients reported significantly better physical and mental well-being than HD patients. In univariate analysis, CCM (B 0.24, p = 0.001), protein intake (B -0.004, p = 0.008), hospitalization (B -0.18, p = 0.024), urine output (B 0.25, p = 0.001), and VAS (B -0.26, p < 0.001) influenced the PCS. At the same time, only the type of treatment (B = 0.15, p = 0.048), urine output (B 0.18, p = 0.02), and VAS (B -0.14, p = 0.048) influence the MCS. In contrast, in multivariate analysis, only CCM contributed to an improved PCS (B 0.19, p = 0.003) and MCS (B 0.16, p = 0.03), while a higher VAS worsened the PCS (B -0.24, p < 0.001) and MCS (B -0.157, p = 0.0024). In elderly patients with similar basal conditions, health-related QoL perception is better in CCM than in HD patients.

Long- and short-term effectiveness of traditional Chinese exercises in improving the overall physical capacity of patients with knee osteoarthritis: A systematic review and meta-analysis.

The increasing global popularity of traditional Chinese exercise (TCE) provides substantial evidence of its significant efficacy in treating knee osteoarthritis (KOA). To assess the impact of different types of TCE and varying exercise durations on KOA patients, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) on this topic. Two investigators extensively searched four electronic databases (PubMed, Embase, Cochrane, and Web of Science) from their inception until December 16, 2023, to identify all relevant RCTs on the use of TCE for KOA treatment. The included studies were assessed for risk of bias using the Cochrane Collaboration Risk of Bias Tool (CCRBT), and data analysis was performed using Stata 15.0. A total of 20 RCTs, involving 1367 patients with KOA, met the inclusion criteria. Compared to the control group, TCE demonstrated significant improvement in three subscale scores of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) [Pain (SMD = -0.44; P = .0001); Stiffness (SMD = -0.35; P = .001); Physical function (SMD = -0.52; P = .0001)] and two subscale scores of the 36-item Short-Form (SF-36) [Physical score (WMD = 2.76; P = .001); Mental score (WMD = 2.49; P = .0001)] in KOA patients. Subgroup analysis showed that both long-term habitual exercise (over 12 weeks) and short-term exercise (within 12 weeks) were more effective than the control group in improving pain, joint stiffness, and physical function in KOA patients. Tai Chi, among the four TCE modalities analyzed, demonstrated improvements in all indicators. Based on the results of our meta-analysis, it can be concluded that both long-term and short-term TCE interventions are effective in alleviating the main symptoms of KOA and improving patients' physical function. However, due to limited methodological quality and inconsistent outcome measures in the included RCTs, further high-quality RCTs with larger sample sizes and longer-term interventions are necessary to validate our findings before TCE can be recommended as a treatment for KOA.

The Role of Outdoor Mindfulness Intervention in Optimizing Mental Well-Being in Adolescents with Specific Learning Disabilities

Adolescents with specific learning disabilities may experience mental well-being challenges as a result of struggling academically, facing social stigma, being subjected to negative stereotypes, and experiencing heightened levels of anxiety, poor mental health, lower self-esteem, and increased stress. This study explores the potential benefits of outdoor-based mindfulness interventions as a complementary approach to remedial education, in improving mental well-being in adolescents with specific learning disabilities. This study was conducted at an institution that gives remedial education for children with specific learning disability in Thrissur, Kerala. Convenient sampling was used to select 30 students aged 13-18 years. Later, participants were randomly divided into two groups the experimental group (n=15) received outdoor mindfulness training in addition to their regular remedial education program. In contrast, the control group (n=15) received only remedial training. The study duration spanned four weeks, during which the mindfulness group participated in weekly outdoor mindfulness sessions conducted individually. They were instructed to practice mindfulness exercises daily between sessions. Both groups were assessed using the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) at the beginning (pre-intervention) and at the end (post-intervention) of the four weeks to measure changes in mental well-being. The outdoor mindfulness interventions included a range of activities, designed to optimize the level of well-being experienced by the participants in their day-to-day lives. These activities focused on enhancing the skills of mindfully listening, walking, breathing, and observing without any judgments of self and surroundings and being in the present at the moment. Results indicated significant improvements in mental well-being scores among participants in the mindfulness group compared to the control group. This underscores the potential of integrating mindfulness practices into educational settings to enhance emotional regulation and overall well-being in adolescents with specific learning disabilities, highlighting interdisciplinary opportunities across psychology, education, environmental psychology, public health, and social work to support comprehensive student development.