Down syndrome also known as Trisomy 21 is a genetic disorder. It occurs in about one per 700 babies and it is one of the main reasons about mental retardation in children. They grow up like other children, but with slower pace. The disorder occurs with very typical expression of the face, difficulties in learning new skills and knowledge, defects of the cardiovascular system, eyes, orthopedic abnormalities, gastrointestinal and respiratory difficulties. Thanks to health care and change in social policy, the duration and quality of life of children with Down syndrome has significantly increased. Aim of this study was to determine nursing skills, knowledge and awareness of students about children with Down syndrome. Material and Methods : sociological method - survey, conducted in the March 2016 among students of third year of specialty `Nurse` MU-Varna. Documentary method - analysis of literature, academic documentation. Results: More than half of surveyed students said that the skills and knowledge they got from the education so far is enough for giving health care to children with Down syndrome. Bigger part of the problems of the students comes from lack of experience with such patients. They evaluate the specifics of the disease and think that they need more practical exercises. Conclusions : Future nurses value their skills and knowledge high. They need more information and more practical exercises.