Substance use disorders are highly widespread in the United States, exerting significant adverse effects on individuals’ wellbeing, overall contentment, and societal functionality. Our review of the literature shows a close connection between Substance Use Disorder (SUD) and oral health problems, revealing a mutual association between drug addiction and oral health. Moreover, our review further indicates that individuals seeking treatment for addiction display a notably elevated occurrence of coexisting mental health disorders. Recent studies suggest a potential bidirectional relationship between mental health and dental well-being, emphasizing the broader implications for mental health and oral health outcomes even in individuals not involved in substance use. Based on the above review, we perceive a considerable gap to examine any relationship between oral health and mental health in individuals with SUD. Having co-occurring oral health and mental health problems can significantly reduce quality of life in individuals with SUD. There appears to be a critical need to investigate any relationship between oral health and mental well-being in individuals grappling with SUD. It is crucial to inform both mental health and dental health professionals, as well as substance addiction counselors about any potential existence of such a relationship. Recognizing this link could contribute to the development of more effective strategies to encourage individuals with SUD to seek treatment and address both their oral and mental health needs.