Health Of People Research Articles

Advancements in Alzheimer's disease classification using deep learning frameworks for multimodal neuroimaging: A comprehensive review

Over the past years, Alzheimer's disease has emerged as a serious concern for people's health. Researchers are facing challenges in effectively categorizing and diagnosing the different stages of Alzheimer's disease (AD). Current promising studies have shown that multimodal Neuroimaging has the potential to offer vital information about the structural and functional alterations associated with Alzheimer's. Using advanced computational techniques, Machine Learning calculations have been demonstrated to be highly precise in deciphering patterns and connections within the multimodal Neuroimaging data, eventually aiding in the arrangement of Alzheimer's illness stages. This research aimed to survey the adequacy of Machine Learning techniques in correctly categorizing stages of Alzheimer's disease by working on multiple neuroimaging modalities. In this review, a detailed analysis was carried out on the classification algorithms included. The study specifically examines publications published between 2016 and 2024. From the review, it was found that deep learning frameworks are more robust in Alzheimer's disease classification.

Assessing metals and metalloids impact of roadside dust on human health in Osogbo, Osun state, Nigeria

BackgroundMetals and metalloids in roadside dust pose considerable threats to both human health and the environment. ObjectivesThis study assesses human health risks of metal exposure to roadside dust by conducting a health risk assessment (HRA) for metals and metalloids uptake rates for children and adults via exposure pathways. MethodsSettled dust samples were collected from the major roads in Osogbo, Osun state. These samples were subjected to standard laboratory procedures for metals and metalloids analysis using Atomic Absorption Spectroscopy (AAS). ResultsAll the metals and metalloids except Cd had their concentration below the WHO limit. The average concentration of Cd was 1.54 mg kg-1, significantly above the WHO guideline of 0.80 mg kg-1, indicating a possible health concern. A strong positive correlation exits between Ni and Cd (0.774⁎⁎) (p < 0.01), Pb (0.662⁎⁎) (p < 0.01), Zn (0.606⁎⁎) (p < 0.01), and as (0.549*) (p < 0.05), showing that greater Ni concentrations are associated with higher concentrations of Cd, Pb, Zn, and As. Two principal components were identified, accounting for 80 % of the overall variation. PC1 has an eigenvalue of 60.834; however, PC2 has a higher eigenvalue of 74.952, implying that PC2 explains more of the variation in the data than PC1. Non-carcinogenic risk evaluations identify possible health risks linked with Cu, Cd, Cr, and As exposure, primarily through inhalation routes. Carcinogenic risk showed that Cd demonstrated high CR values ranging from 3740 to 1.30×1012 for adults and children throughout the study's various exposure paths. ConclusionThis study offered significant insight into the metals and metalloids pollution status in Osogbo, Nigeria, employing data and statistics, highlighting the need for evidence-based actions for environmental preservation to safeguarding people's health.

Loneliness, Psychological Well-being, Depression, and Social Participation in the Older Persons: Rural and Urban Differences.

The purpose of this study is to compare the loneliness, psychological well- being, depression, and social participation of elderly people living in Turkish society between rural and urban areas. The sample group of the study, in which a correlational survey model was used, consisted of 610 elderly adults. The study population consists of two groups: the first group consists of individuals over 65 years of age living in the city (Istanbul) (n= 291), and the second group consists of individuals over 65 years of age living in rural areas (rural areas of Ordu) (n= 319). Socio-demographic Information Form, Loneliness in the Elderly Scale, Geriatric Depression Scale, Psychological Well-Being in the Elderly Scale, and Social Inclusion Scale were applied online. Statistical analyses of the study were conducted using SPSS 27.00, and the Independent Samples t-test and ANOVA test were used. According to the findings of this study, statistically significant results were found in psychological well-being, social inclusion, social relations, loneliness and depression, and place of residence. It was observed that the social isolation and social acceptance levels of those living in urban areas were higher than those living in rural areas. Social, loneliness, and depression scores of those living in the village/town were found to be higher than those living in the city centre. Furthermore, the social relationship scores of those living in the village/town were found to be higher than those living in the city centre. The increasing elderly population worldwide has become an issue that requires global measures. Place of residence is one of the factors thought to affect older people's health and well- being. It is thought that the study data will contribute to new policies that will ensure the protection and promotion of elderly health and those working in this field. In addition, the study, which provides information about Turkish culture, will also enable intercultural comparisons.

Computational analysis on 3D airway model of obstructive sleep apnea patient for optimal maxillomandibular advancement.

Obstructive sleep apnea (OSA) can have many adverse effects on people's health, including cognitive decline and high blood pressure. Typical surgical treatment methods include the commonly performed uvulopalatopharyngoplasty and the highly successful maxillomandibular advancement (MMA). These surgical methods are more effective than non-surgical methods because they widen the airway where a collapse has occurred through direct treatment. However, few studies has shown that moving the upper and lower jaws in a specific manner is the most efficient way to treat OSA during an MMA surgery. In this study, the airway of an OSA patient was reproduced digitally, and computational fluid dynamics analysis was performed on various models with changed airway shapes, including the original model based on an actual CT image and three resizing models of the retropalatal (RP) and retroglossal (RG) regions of the airway. Consequently, it was possible to provide more quantitative predicted flow data, which could be helpful in performing sophisticated OSA surgery. Among the four airway models of the OSA patient, a reduction in the epiglottis regional pressure difference of up to 40.2% was evident in the model with an expanded RG region, and a reduction in the wall shear stress of up to 25.8% was confirmed. The proposed process could be an important aid for surgeons in determining the optimal surgical method suitable for an individual patient's uniquely-shaped airway.

High-performance volatile organic compounds free silica-filled butadiene rubber green nanocomposites using ionic liquid peroxide vulcanization

Manufacturing green rubber nanocomposites with higher performance and without volatile organic compounds (VOCs) is a big bottleneck for academics and the industry. Bis(3-triethoxysilylpropyl) tetra sulfide or Si69 silane is the most commonly used for green tires while during tire production it releases VOCs which are dangerous for people's health. Herein we elucidate that ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate can mediate physical and chemical reactions among silica and butadiene rubber (BR) and replace Si69 to fabricating rubber nanocomposites with free VOCs cured by Di cumyl peroxide (DCP). The findings reveal that IL chemically reacts with BR and that combining IL and Si69 shows similar tensile properties (φ = 0.079- 0.147) and higher strain at break in comparison with that containing Si69. Moreover, IL synergistically impacts silica-filled BR nanocomposites viscoelastic, thermal, and dielectric properties. It influences the Payne effect by reducing loss modulus improving weak strain overshoot markedly (the ΔG''/G''0 and tanδ0 values of the vulcanizate containing IL/Si69 are 465% higher and 42.8% lower than that containing Si69) and thermal stability and dielectric properties. Compared with BR nanocomposites containing Si69 at the same amount, IL significantly reduces the tangent value and dissipation energy, providing a simple method to fabricate green rubber nanocomposites with tunable reinforcement behaviors.

Prevalence of inhaled allergen sensitization among patients with suspected allergic diseases in Sichuan province: 3-year data from a single center.

Allergic diseases are becoming increasingly common, and they are a threat to people's health. Exploring the distribution characteristics of allergen-specific immunoglobulin E (sIgE) in people from Sichuan province, southwest China, can provide clinical epidemiological data. This study enrolled 12,204 consecutive patients with suspected allergies from May 2018 to May 2021. Among the patients, 4206 were diagnosed with allergic rhinitis or asthma. The Rayto Lumiray 1600 detection system and sIgE and total IgE (tIgE) detection kits were used to measure the levels of nine common sIgE and tIgE. sIgE ≥ 0.35 IU/mL was considered positive. The sensitization rate of D1 (Dermatophagoides pteronyssinus) is the highest (22.97%), followed by D2 (Dermatophagoides farinae) (23.33%); M3 (Aspergillus fumigatus) has the lowest positive rate (1.5%). E5 (Canis familiaris) and I6 (Blatella germanica) exhibited relatively high sensitization rates (8.64% and 12.35%, respectively). Allergen sensitization was significantly higher in men than in women. Moreover, 90.3% of sensitization samples from D1 were combined with at least one of the other eight allergens. Similarly, a positive correlation was demonstrated between D1, D2, and E1 (Felis domesticus). In addition, patients with allergic rhinitis (91.88% and 91.54%, respectively), allergic asthma (72.44% and 74.01%, respectively), and allergic rhinitis with asthma (92.12% and 93.22%, respectively) were mainly sensitized to D1 and D2. D1, D2, I6, and E5 are the main allergens. Moreover, D1 and D2 are the main allergens in patients with respiratory allergic diseases. Research focusing on the distribution of allergens and the characteristics of hypersensitivity in different people helps prevent, diagnose, and treat allergic diseases.

Virus contamination, removal characteristics and quantitative risk assessment from drinking water source to secondary water supply system

The drinking water (DW) supply system is the last line of defense against virus infections for people's DW health. This study systematically evaluated the virus pollution characteristics and human health risks in the entire DW supply systems. The detection frequency range of the virus in DW was 5.30% to 71.21%, and the concentration range at not detected (n.d.) -1.45×105 copies/L. DNA virus like adenovirus was more persistent than RNA viruses like norovirus and enterovirus in the DW system. Drinking water treatment plants (DWTPs) play a crucial role in reducing the target virus with degradation rates ranging from 47.09% to 100% when compared with the removal rates in DW source and secondary water supply (SWS). It was found the persistence and accumulation of the virus in the treated water from DWTPs to the downstream water transmission network. Principal component analysis showed that the virus contamination was positive correlation with water quality indexes like total phosphorus (TP), total nitrogen (TN), dissolved oxygen (DO) but negative correlation with temperature and the dose of free chlorine. Quantitative microbial risk assessment (QMRA) of adenovirus in the SWS showed that the DALYs/person/year of gastroenteritis ranged from 8.11×10-6 to 2.68×10-4 DALYs/person/year. Uncertainty analysis of different distributions of model inputs like virus concentrations showed the risk caused by adenovirus was changed appreciably for different person by using 100,000 Monte Carlo simulations. It is necessary to efficiently remove the virus in the DW systems to ensure human health for the direct ingestion of secondary water supply water.

A Study on the Development of a Filtration System for Drainage Discharge Capacity

This study analyzes the social and economic characteristics of an area affected by chemical emission facilities and proposes policy measures to respond to social disasters such as hazardous chemical emission accidents. Even within the area affected by chemical discharge facilities, social and economic disparities existed depending on the proximity to the chemical discharge facility, child population ratio, and land value. However, the elderly population ratio decreased. It is believed that the presentation of response plans based on the study’s analysis will contribute to protecting people's health and property, which is the ultimate goal of chemical management.

Wastewater Management as a Part of Solution for Water Resources Problem in Erbil City

In Erbil City, municipal wastewater (MWW) is disposed directly without any treatment processes in the natural environment water body and in some places used for irrigation purposes. Untreated MWW causes problems for the environment, and people's health. Water quantity and quality variation produce complications for water sources in Erbil City, Kurdistan Region-Iraq. There is a lack of performing MWW management fundamentals in the area as well. This research aimed to study the MWW management in Erbil City, presenting water resource difficulties and bringing about suitable solutions for the water resource problems, and also to highlight the risk for the poor Management. MWW Data on Erbil municipal (EMWW) water quality parameters were collected and analyzed for the study period (four months), beginning in October 2022 and ending in March 2023. Twelve EMWW quality parameters were captured and tested in the Laboratory, arranged, and compared with MWW disposal criteria and local standards. The following MWW parameters include pH, electrical conductivity (EC), total dissolved salts (TDS), chloride (CL), total solids (TS), total alkalinity, total acidity, chemical oxygen demand (COD), and colour. The results showed that Erbil's MWW characteristics in terms of temperatures ranged between 11-23 °C and in turn, affected biological species activities. Maximum PH value was 7.7. Total alkalinity found in the range from 140 to 178 mg/l. Chloride concentration results showed for October was 62 mg/l and the maximum value was 80 mg/l in November due to the increment in temperature and evaporation. The range of the COD values of sewage water for five months was 246 -773 mg. Erbil's MWW's moderate to medium strength may be treated and utilized for landscaping, fountains, and irrigation, minimizing the need for fresh water from resources like wells and surface water in the Greater Zab River.

Improving Indoor Air Quality: Using Polymate-777A as a Formaldehyde Scavenger to Decrease Formaldehyde Emission in Plywood Panels

Indoor air quality is significantly impacted by volatile organic compounds, with formaldehyde being a prominent concern due to its emission from wood composite products. Formaldehyde emissions from wood composite products is a big concern for the environment and people's health. This study focused at how effective a product called Polymate-777A, the additive used as a formaldehyde scavenger is in reducing the formaldehyde emissions from plywood. This study investigates the efficacy of Polymate-777A, a formaldehyde scavenger, in reducing formaldehyde emissions from plywood panels. Through a series of controlled experiments, it was evaluated the impact of varying concentrations of Polymate-777A on formaldehyde release, utilizing standardized testing methods to quantify emissions. Results indicate that the incorporation of Polymate-777A significantly reduces formaldehyde levels, enhancing the safety and environmental sustainability of plywood products. The Results revels that when 1.5% or more Polymate-777A was used as scavenger for plywood manufacturing, the plywood met the emission standards set by Japan and Europe for formaldehyde emissions. This study suggests that using Polymate-777A could be a good way to reduce formaldehyde emissions from wood products, which would be better for the environment and people's health.

The AI-assisted Traditional Design Methods for the Construction Sustainability: A Case Study of the Lisu Ethnic Minority Village

In recent decades, economic and technical advancements have surged tremendously, accompanied by non-regulatory and unsustainable use of non-renewable assets. The ecological field of toxicology has garnered considerable focus on elucidating the impact of harmful substances on people's wellness. Environmental hazardous chemicals induce many illnesses, posing a heightened danger to youngsters, pregnant women, the elderly, and anyone with preexisting health conditions. Air pollution adversely impacts human health, leading to heightened morbidity and death, necessitating intensified toxicological investigations on industrial air pollution affecting the general populace. It is necessary to develop a computerized Ecological Toxicology-based Air Pollution Management System. Constructive social development is driven by cultural education. It can guarantee a sustainable future, protect national history, and unleash community potential. This study examines Chinese architects' perspectives and understanding of sustainability in village revitalization and conservation. It incorporates traditional Lisu building techniques and materials in Hunan, China. To close research gaps, this study looks at the contributions made by architects to traditional practice integration and environmentally conscious architectural design. This study proposes an IoT-enabled Environmental Toxicology platform for air pollution surveillance, utilizing artificial intelligence (AI) techniques to mitigate the limits of standard monitoring systems and lower total costs, enhancing human wellness. The research examined the intricate interaction between architects' understanding of sustainability, Lisu building techniques and materials, and sustainable architectural designs in village preservation and revitalization programs using path analysis on data from 326 architects in Hunan Province. Lisu building practices and materials strongly correlate with architects' awareness of and attitudes toward sustainability. According to the research, these characteristics are necessary for sustainable architectural solutions that support village revival and preservation. This study has significant theoretical and practical ramifications for academics, lawmakers, and architects. To evaluate the air quality monitoring efficacy of the suggested approach, a comprehensive series of simulation analyses is conducted, and the results are assessed at durations of 5, 15, 30, and 60 minutes. The experimental results demonstrate the superior efficacy of the suggested model compared to current methodologies. These findings could lead to the creation of sustainable design solutions that advance rural development. A thorough overview of upcoming studies on sustainable design approaches in Chinese contexts rounds out this talk.

Locked out of water: a reflection on WaSH access in US prisons

ABSTRACT The United Nations global minimum standards for prisons are termed the ‘Nelson Mandela Rules’ and are based on the humane treatment of incarcerated people. Of the approximately 11.5 million people incarcerated worldwide, over two million are located in the United States (US). Mass incarceration is maintained by political, economic, and societal structures of inequality and discrimination. The lens of safely managed sanitation provides a window into the treatment and lived realities of people who are incarcerated. This article synthesizes the existing literature and builds on this foundational knowledge with accounts from people who have experienced living in the US prison system. Throughout the literature and across these lived accounts we find a severe lack of privacy, emotional distress, consistent Human Rights violations, and evidence of those in positions of power in prisons using control over water and sanitation to enact excessive punishment. Denying these fundamental rights restricts people's health and well-being, and contributes to further dehumanization and trauma, which is detrimental to the individual and to wider society. We find that one route toward revealing the extent of discrimination against incarcerated people, and beginning to make impactful, person-centered change, is focusing on full, safe, and dignified access to WaSH services.

Sports-Related Concussion Among Physically Active Adolescents in the Southeastern United States: Effects on Mental Health During the Pandemic.

Sports-related concussions (SRC) pose risks to young people's physical and mental health. During the COVID-19 pandemic, we studied linkages between youths' SRC experiences and internalizing problems (depression, self-harm, and suicidality) among a representative sample in Southeastern state (n = 4,668 total, n = 547 reported SRC experience). Logistic regressions indicated significant associations between youths' SRC experiences and depression (AOR = 1.32, p < .05), suicidality (e.g., attempted suicide AOR = 2.68, p < .001), and self-harm (AOR = 1.97, p < .001) while controlling for being bullied or teased, gender, age, race, and COVID-19's mental health impact. Contrary to prior findings: (1) SRC associations with self-harm and suicide attempts were consistent across genders; and (2) African American students with SRC were significantly more likely to experience depression, self-harm, suicide planning, and attempts than peers without SRC. Results indicated mental health resilience post-concussion for Latinx youth. Implications advocate population-specific health promotion measures that address vulnerabilities and protective factors while emphasizing SRC education for parents, coaches, and young athletes for timely psychological evaluation and support.

Characteristics and Correlates of Health Information Literacy Among Patients With Type 2 Diabetes and Metabolic Syndrome: A Cross-Sectional Study.

The purpose of the study was to examine the characteristics and the influential effect of individual and social contextual factors on health information literacy among Chinese patients with type 2 diabetes coexisting with metabolic syndrome. Following convenience sampling, a total of 225 patients with type 2 diabetes coexisting with metabolic syndrome were recruited from a tertiary hospital in a suburban area of Beijing, China. Participants' information was gathered through a set of self-reported questionnaires. Descriptive statistics, normality test, correlational analysis, univariate analysis, multiple linear regression, and logistic regression analysis were adopted to examine the potential factors of personal and social contextual resource related to health information literacy based on the health empowerment theory. The health information literacy in this current sample was limited, with a mean score of 16.83 ± 2.96. Correlational analysis showed that self-management knowledge, attitude, and practice for metabolic syndrome; self-efficacy; health problem-solving; resilience; and chronic illness resources were significantly and positively related to health information literacy. Logistic regression analysis showed that self-management knowledge, health problem-solving, and the chronic illness resources were significantly correlated with health information literacy after controlling covariates. Overall, the health information literacy among Chinese patients with type 2 diabetes coexisting with metabolic syndrome is suboptimal. Study findings demonstrated that personal and social contextual resources factors are significantly related to health information literacy. Health care professionals should consider strategies to enhance people's health information literacy level and promote individuals' health problem-solving, enhance chronic illness resources, and improve self-management knowledge when developing tailored interventions.

Relationship of Resilience With Depression, Anxiety, and Stress Among Nursing and Midwifery Students in Qom, Iran, During the COVID-19 Pandemic

Background and Objectives: The COVID-19 pandemic affected physical and mental health of people, including college students. Several studies in Iran have reported high symptoms of depression, anxiety, and stress in college students during the pandemic; however, few studies have investigated their resilience during the pandemic. This study aims to determine the relationship of resilience with anxiety, depression, and stress of nursing and midwifery students in Qom, Iran during the COVID-19 pandemic. Methods: This is a descriptive-correlational study. Participants were 192 nursing and midwifery students of Qom University of Medical Sciences in 2021, who were selected using a simple random sampling method. The instruments included the Corona Disease Anxiety Scale, the Connor-Davidson resilience scale, and the 21-item depression, anxiety, stress scale (DASS-21). The data was analyzed using descriptive statistics and analytical tests of Pearson’s correlation test and regression analysis in SPSS software, version 22. Results: The mean score of anxiety, depression, stress, and total DASS-21 score was 14.6±4.4, 14.48±4.29, 15±4.32, and 32.46±9.88, respectively. The mean total resilience score was 53.5±16.5. There was a significant negative correlation between depression, anxiety, stress, and total DASS-21 score with resilience in students during the pandemic (P&lt;0.001). Conclusion: During the COVID-19 pandemic, nursing and midwifery students’ resilience had a significant relationship with their depression, anxiety, and stress. The lower resilience can increase the stress, depression, and anxiety of nursing and midwifery students.

'I am more stressed if my infection affects others': development of a COVID-19-related stress scale in older people and examination of its validity and associations with mental health risks.

COVID-19 was a collective traumatic event; however, different individuals may have perceived it differently. This study investigated what older people in a collective culture perceived as stressful during COVID-19 and examined how different stressors related to COVID-19 infection and mental health risks. Thirty-six participants from diverse backgrounds engaged in a three-round Delphi study to generate items for a COVID-19-related stress scale for older adults (CSS-OA). Subsequently, 4674 people (aged ≥60 years) participated in a cross-sectional telephone survey; interviewers collected their responses to CSS-OA and information about COVID-19 infection, depressive symptoms, anxiety, loneliness and demographics. Exploratory factor analysis and confirmatory factor analysis were conducted on CSS-OA. A multiple indicator multiple cause (MIMIC) model was used to examine associations between CSS-OA and other measures. The Delphi process generated eight items, all secondary or tertiary stressors related to infection. Exploratory factor analysis revealed a three-factor model, and confirmatory factor analysis confirmed an excellent fit (comparative fit index = 0.99, root mean square error of approximation = 0.06). Pre-existing mental health conditions, having family members/friends infected with COVID-19, loneliness, anxiety and depressive symptoms were associated with higher stress. Conversely, self-infection with COVID-19, older age, being female and living alone were negatively associated with some domains of CSS-OA (all P < 0.05). The Delphi process enhanced our understanding of what older people perceived as stressful, much of which resulted from certain healthcare strategies and reflected cultural influences. These and the MIMIC results highlight the need to balance public health policies with respect to infectious diseases and older people's mental health and quality of life.

Monitoring the Cascade of Monocyte-Derived Macrophages to Influenza Virus Infection in Human Alveolus Chips.

Respiratory viruses ravage the world and seriously threaten people's health. Despite intense research efforts, the immune mechanism underlying respiratory virus-induced acute lung injury (ALI) and pulmonary fibrosis (PF) has not been fully elucidated. Here, the cascade of monocyte-derived macrophages to influenza A virus infection is monitored on an optimized human alveolus chip to reveal the role of macrophages in the development of ALI and PF. We find that viral infection causes damage to the alveolar air-liquid barrier and the release of inflammatory cytokines, which induce the M0 macrophages to gather and polarize to the M1 phenotype at the damaged site through recruitment, adhesion, migration, and activation, leading to ALI. Afterward, M1 macrophages polarize into the M2 phenotype, and then transform into myofibroblasts, followed by enhanced secretion of various anti-inflammatory cytokines and profibrotic cytokines, to promote PF. Our study provides an insight into the pathogenesis of virus-induced ALI and PF, which will assist in the development of therapeutic strategies and drugs for treating influenza and other respiratory virus infections.

COVID-19 drives medical education reform to promote "healthy China 2030" action plan.

In June 2019, the Chinese government proposed the Healthy China Action Plan (2019-2030) development strategy, which focuses on disease prevention and health promotion. It is expected that by 2030, the national health literacy level will be significantly improved, premature mortality caused by major chronic diseases will be significantly reduced, the average healthy life expectancy will be greatly improved, and the main health indicators of residents will enter the ranks of high-income countries. Unfortunately, at the end of 2019, COVID-19 began to break out in Wuhan, China, which had a huge impact on China's economy and people's health. A series of problems in China's health care and medical education were exposed in the prevention and treatment of the epidemic. How to reform medical education and build a medical talent training system with Chinese characteristics is the key to achieving China's Health 2030 strategy. This article will explore the direction of medical education reform in China under the background of the "Healthy China 2030" strategy and the post pandemic era.

Goat Milk Protein-Derived ACE Inhibitory Peptide SLPQ Exerts Hypertension Alleviation Effects Partially by Regulating the Inflammatory Stress of Endothelial Cells.

Hypertension has always posed a severe threat to people's health. Food-derived angiotensin-converting enzyme (ACE)-inhibitory peptides have the potential to both prevent and treat hypertension. In the current investigation, two ACE-inhibitory peptides (SLPQ and PYVRYL) from goat milk were studied for their endothelial effects using EA.hy926 cells. PYVRYL outperformed SLPQ, yet neither impacted cell survival below 200 μg/mL. Investigation of SLPQ's impact on EA.hy926 cell expression revealed 114 differentially expressed genes, with 65 downregulated and 49 upregulated. The genes were enriched in cytokine interactions, coagulation cascades, Hippo signaling, and ECM-receptor interaction. Decreased c-x-c motif chemokine ligand 2 (CXCL2), integrin subunit beta 2 (ITGB2), and fbj murine osteosarcoma viral oncogene homologue (FOS) expression and increased secreted phosphoprotein 1 (SPP1) expression may protect endothelial cells from inflammation. Our findings suggest that beyond ACE inhibition, SLPQ aids blood pressure control by influencing endothelial function, paving the way for its use as an antihypertensive food ingredient.

PRevention Intervention and Support in Mental health for people with aphasia (Aphasia PRISM): protocol and mixed methods analysis plan for two feasibility studies

BackgroundPeople with aphasia commonly experience depression and anxiety. The individual therapy program, Aphasia PRevention Intervention and Support in Mental health (Aphasia PRISM) offers low intensity psychotherapeutic interventions using communication supports. Trained stroke clinicians from disciplines other than psychology (e.g., allied health professional, nurse, doctor) can deliver such interventions. The aim of the planned studies is to test the acceptability, feasibility and preliminary effectiveness of Aphasia PRISM for preventing depression and anxiety and supporting wellbeing in people with aphasia after stroke.MethodThis protocol describes two feasibility studies of the Aphasia PRISM using parallel, convergent, mixed methods designs. Participants will be adults with aphasia after stroke from a metropolitan healthcare site (Study A, pre-post case series, approximate n = 6) and two regional/rural sites (Study B, randomised controlled trial, n = 30; random allocation to either: treatment arm Aphasia PRISM + usual care; or attention control of secondary stroke prevention information + usual care) in Victoria, Australia. Eligible participants will be offered 7 weekly intervention sessions (via telehealth or in person). Other participant groups include stroke clinicians / site managers and family members. Feasibility will be assessed with treatment acceptability ratings (primary outcome) and secondary outcomes such as recruitment rate and participant clinical response. Participant clinical responses to intervention will be collected pre-intervention (baseline), concurrently (4 week acceptability measure), immediately post (8 weeks), follow-up (3 months) and follow-up at 6 months (Study B only). Descriptive statistics will be used to analyse quantitative data based on the type and distribution of data. Reflexive thematic analysis, an inductive approach will be used to analyse qualitative data.DiscussionAphasia PRISM offers the potential for trained stroke clinicians to deliver low intensity psychotherapeutic interventions with communication supports to people with aphasia. Studies A and B were registered with the Australian New Zealand Clinical Trials registry under one registration (ACTRN12620000209998) 20th February 2020.