Introduction: Athletes have been suspected of incurring adverse gastrointestinal (GI) symptomatology. No prior studies have evaluated GI symptoms in college athletes. The aim of our study was to investigate the GI burden of disease in college athletes. Methods: We performed a cross-sectional survey of college club sports athletes at The Ohio State University from November 2017 to January 2018 through an online survey. Tennis, swimming, men's soccer, and men's baseball club teams participated. Demographic and GI symptoms were collected. The primary outcome of interest was determining the overall burden of GI disease. Secondary outcomes included differences between sports and age groups (younger athletes: age 18-21; older athletes: age >21). Results: Twenty-nine athletes participated (13.1% response rate); men's soccer (n: 12; 70.6%) and baseball (n: 9; 17.3%) had the highest response rates. The cohort was predominately male (86.2%), white (86.2%), and did not have a previously diagnosed GI disorder (84%). Abdominal pain (Table 1) was experienced at least ‘rarely' by 62%, most commonly in the pelvic region, with a poor diet triggering the majority of symptoms. The majority reported more than one bowel movement per day, with a fairly normal stool consistency (Table 2). Blood was reported on the toilet paper in the majority of athletes, yet frank hematochezia and/or melena was infrequently reported. NSAIDs were used frequently in 31%; of NSAID users, 55.6% used 400mg at a time and 25.9% reported using 600-800mg at a time. The majority of athletes used NSAIDs on the day of or after competition (Table 3). No differences were noted between baseball and soccer players. Younger athletes trained more hours per week than older athletes, (11-30 hours/week; 81.3% vs. 30.8%). Younger athletes were also more likely to take 600mg or more of NSAIDs on the day of or after competition (40% vs. 0%, p=0.017).2783_A Figure 1 No Caption available.2783_B Figure 2 No Caption available.2783_C Figure 3 No Caption available.Conclusion: College club sport athletes appear to have mild GI symptoms. The majority of these athletes reported infrequent abdominal pain, overall normal bowel movements, and infrequent use of medications. However, many athletes reported bleeding associated with bowel movements, as well as using significant doses of NSAIDs. Further efforts investigating the degree of bleeding may discover undiagnosed GI disease. Additionally, educating college athletes, especially younger ones, on appropriate use of NSAIDs may prevent future GI pathology.