Menopausal Period Research Articles

Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field.

Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment. Some lipoproteins have also been proposed as markers in some endocrine diseases, e.g., thyroid carcinoma. From the scope of endocrine disorders, the largest number of studies explored the lipoprotein changes in polycystic ovary syndrome and in women during the menopausal and peri-menopausal period. Even though the association of thyroid disorders with dyslipidemia is already well studied, new research has delivered some exciting findings about lipoprotein alterations in euthyroid patients with either positive antithyroid peroxidase antibodies or reduced sensitivity to thyroid hormones. The problem of the adverse metabolic profile, including dyslipidemia in hypoprolactinemia has been recognized. Moreover, this review describes other significant discoveries encompassing lipoprotein alterations in disorders of the adrenals, thyroid, parathyroid glands, pituitary, and gonads. The up-to-date knowledge of the influence of endocrine disorders and hormonal changes on serum lipoproteins is prudent as it can significantly impact therapeutic decisions.

Instrumental parameters of bone mineral density in postmenopausal women: combined use of ultrasound densitometry and the FRAX model

Osteoporosis is a systemic widespread disease of the musculoskeletal system that leads to impaired bone microarchitecture with a risk of fractures. The menopause period is one of the leading factors that leads to dysfunction of the RANK/RANKL/OTG signaling pathway, activating systemic inflammation. The purpose of the study was to determine the mineral status of bone tissue in menopausal women with simultaneous assessment of the risk of low-trauma fractures using ultrasound densitometry and the FRAX computerized model. The study included 153 people aged 20 to 89 years (mean age 55.3±15.4 years). Depending on the presence of menopause and gender, the corresponding groups were formed: I - main (menopausal women), II - control (women of reproductive age), III - comparison (men). The results of the study revealed a decrease in bone mineral density in the main group (I), where the T-criterion was -1.45± -1.95, compared with the control group (II) and comparison group (III), where the index was -0.51±0.7 and 0.27±0.72, respectively. The 10-year risk of any osteoporotic fractures according to the FRAX model demonstrates significantly higher risks in group I ([7.4 [4.0-15.0] %) compared to groups II and III, where the risks were 2.7 [2.4 - 3.3] % and 3.2 [2.3 - 3.8] %, respectively, p< 0.0001. As a result of the combined use of ultrasound densitometry and the FRAX model, lower bone mineral density of the radial bones in the main group was found compared to the control and comparison groups. The above results indicate that hypoestrogenism caused by the onset of menopause is a key factor in the development of osteodysmetabolic syndrome.

(181) Female Sexuality During the Menopausal Transition: The Experience of Tunisian women

Abstract Introduction The menopausal transition is a gradual passage from pre-menopause to menopause. It is characterized by hormonal changes that affect a woman's reproductive and sexual health. Understanding the impact of the menopausal transition on sexual functioning is important for providing comprehensive care to these women. Objective Objective: In this study, we aimed to evaluate female sexuality in middle-aged Tunisian women using the female sexual function index (FSFI) Methods This was a descriptive and analytic transversal study, conducted at the Hammam-Lif sexual and reproductive health center over a period of 06 months from February 1st to July 31st, 2022. We included 162 women aged between 40 and 65 years old. We used a validated Arabic version of the Female Sexual Function Index to assess female sexual function. Results The average age of women included in our study was 48.27 years. The majority of questioned women were peri-menopausal, i.e. 40.74%, 35.8% were in pre-menopause and 23.6% were in post-menopause. Moreover, among postmenopausal women, only one patient took hormone replacement therapy. The mean gestity was 3.6 and mean parity was 2.5 in our study population. The majority of women had a gestation greater than or equal to three [0 to 8] and a parity greater than or equal to 2 [0 to 8], i.e. in 80.25% of cases. The mean FSFI score was 18.83 ±7.19, with extremes ranging from 2 to 30.4. The prevalence of sexual dysfunction in our study was as high as 88.9 %. The analysis of our results showed a degradation of the FSFI score from perimenopause to postmenopausal: it went from 21.21±6.4 in pre-menopause, to 18.56±7.33 in perimenopause and 15.65±7.11 in postmenopausal. The difference between the three periods was statistically significant (p=0.030). This decline was statistically significant for three domains namely desire (p=0.033), arousal (p=0.047), and orgasm (p<0.01). Conclusions The prevalence of female sexual dysfunction is quite high and tends to increase with age. The role of healthcare professionals is essential in caring for women and helping them overcome sexual health problems that arise during the menopausal transition period. Disclosure No.

Explanation of the Educational Needs Related to Women's Health During Menopausal Period: A Qualitative Study

Background: Menopause is one of a woman's most crucial life stages. Identifying menopause's educational needs is critical. Objective: This study aims to explain the educational needs of women during menopause. Methods: The current study employs a qualitative content analysis method. The study included 12 women around menopause who were referred to Fatemieh Hospital's menopause clinic in Hamadan in 2020 and seven midwives. Individual semi-structured interviews with open-ended questions were used to collect data for the study. Data analysis was performed by Cheevakumjon method and conceptual content analysis was used to extract the concepts. After reading the text of the data, key sentences and concepts were derived and finally categorized. Results: The mean age of menopausal women and midwives was 54.15±4.24 and 34.35±3.54 years, respectively. In this study, three main themes were found in each of the perspectives of menopausal women (educational needs, expectations from the health system, expectations from others) and nurse-midwives (effective factors in the successful implementation of programs related to the health of menopausal women, obstacles and challenges of successful program implementation, strategies to increase program performance) regarding health needs related to menopause. The experiences of postmenopausal women had 3 themes, 4 categories and 15 subcategories and midwives' point of view was also divided into 3 themes and 5 categories and 14 sub categories. Conclusion: In order to manage the challenges of menopause, education and counseling are needed regarding the physical, mental, psychological and social changes that menopausal women may face. Moreover, to achieve these goals, there is a need for comprehensive support from the relevant politicians.

Primary ovarian leiomyoma in a patient with uterine leiomyoma

A small, unilateral tumor. Most ovarian leiomyomas (OLM) are benign, but can range from benign to borderline with malignant degeneration. In many patients, OLM are asymptomatic and are detected accidentally during surgery. In rare cases, OLM can be accompanied by severe symptoms as their size increases. This situation requires differentiation these formations from malignant ovarian tumors, which is more often observed during the perimenopausal and menopausal periods. Being discussed that the source of OLM is smooth muscle blood vessel cells, so more undiagnosed small asymptomatic OLMs can be expected. This article presents a clinical case of OLM in a 39-year-old woman operated for uterine myoma. In the case we presented the coexistence of uterine fibroids and ovarian leiomyoma, which subsequently received diagnostic confirmation.

Defining the relationship between ovarian adult granulosa cell tumors and synchronous endometrial pathology: Does ovarian tumor size correlate with endometrial cancer?

The main feature of adult granulosa cell tumors (AGCT) is their capacity to secrete hormones, with nearly all of them capable of synthesizing oestradiol. The primary goal of this study is to identify synchronized endometrial pathologies, particularly endometrial cancer, in AGCT patients who had undergone a hysterectomy. The study cohort comprised retrospectively of 316 AGCT patients from 10 tertiary gynecological oncology centers. AGCT surgery consisted of bilateral salpingo-oophorectomy, hysterectomy, peritoneal cytology, omentectomy, and the excision of any suspicious lesion. The median tumor size value was used to define the relationship between tumor size and endometrial cancer. The relationship between each value and endometrial cancer was evaluated. Endometrial intraepithelial neoplasia, or hyperplasia with complex atypia, was detected in 7.3% of patients, and endometrial cancer in 3.1% of patients. Age, menopausal status, tumor size, International Federation of Gynecology and Obstetrics stage, ascites, and CA-125 level were not statistically significant factors to predict endometrial cancer. There was no endometrial cancer under the age of 40, and 97.8% of women diagnosed with endometrial hyperplasia were over the age of 40. During the menopausal period, the endometrial cancer risk was 4.5%. Developing endometrial cancer increased to 12.1% from 3.2% when the size of the tumor was >150 mm in menopausal patients (p = 0.036). Endometrial hyperplasia, or cancer, occurs in approximately 30% of AGCT patients. Patients diagnosed with AGCT, especially those older than 40 years, should be evaluated for endometrial pathologies. There may be a relationship between tumor size and endometrial cancer, especially in menopausal patients.

Cardiometabolic parameters in night workers during the menopausal transition period after melatonin intervention

Cardiometabolic parameters in night workers during the menopausal transition period after melatonin intervention

Effective therapy for menopausal syndrome without hormones and side effects. Illusion? Reality!

The article describes the problems of the menopausal transition period that cause a woman significant discomfort and reduce her quality of life, characterizes the most common methods of treating menopausal syndrome, and suggests possible reasons for their lack of effectiveness. Femoklim, a fundamentally new anti-menopausal drug for the treatment of complications of age-related hormonal changes, is analyzed. It takes due regard to all possible mechanisms of the occurrence of menopausal syndrome, has a complex versatile effect on the female body, and does not provoke the development of cancer.

Features of menopausal period in HIV-positive women

In 2021 in Russia, the proportion of women among HIV-infected patients was 54.6%. In recent years, there has been an increase in the number of female patients of older reproductive age and those in peri- and postmenopause among women living with HIV. Data on the age of onset of menopause and its course in this group of women are contradictory, and clinical recommendations on the features of dispensary observation, the choice of antiretroviral therapy, and the treatment of climacteric syndrome in this group of patients are absent, despite its high frequency and greater intensity of manifestations compared to population indicators. The insufficient amount of research on this topic, low awareness of doctors about the possibilities of prescribing menopausal hormone therapy to HIV-positive patients, and drug interactions between MHT and antiretroviral drugs limit the provision of effective medical care, worsen the quality of life of HIV-positive women, and represent a problem that requires a solution. This article offers a review of modern studies aimed at studying the peculiarities of menopause in women with HIV, the age of its onset, and data on the prescription of MHT. Literature search was conducted on PubMed, and the review includes articles published from 2016 to 2023.

Insomnia in Postmenopausal Women: How to Approach and Treat It?

Insomnia is one of the major complaints of menopausal women with advancing age and may be complexly related to a variety of causes. However, there is still a lack of standards on the general approach and treatment for insomnia in menopausal women. The aim of this review is to summarize recent pathogenic theories of sleep disturbance in the menopausal period and discuss the approach and management of insomnia in postmenopausal women. Sleep disturbances in menopausal women may be associated with physical and psychiatric factors and other comorbid diseases. Careful history taking and multidisciplinary physical and psychosocial evaluation are necessary and, in particular, comorbidities related to sleep disorders, such as obstructive sleep apnea, must be taken into consideration. A unique aspect of insomnia in postmenopausal women is that menopausal symptoms due to hormonal decline can be closely related to sleep disturbances. Therefore, menopausal hormone therapy (MHT) should be considered as the treatment of choice among pharmacological treatments following cognitive behavioral therapy, which is suggested as the first-line treatment in the general population insomnia treatment guidelines. Additionally, melatonin and 5HT-based drugs, which have fewer side effects, along with MHT should be preferentially recommended in menopausal women.

Clinical, Diagnostic and Treatment Characteristics of Trophoblastic Disease in Post-Menopausal Woman: A Case Report and Review of Literature

1.1. Background: Gestational Trophoblastic Disease (GTD) in a heterogeneous group of disorders originating from placenta and between them hydatiform mole, both complete and partial, is the most common condition. Pregnancy in menopause period is an uncommon event but when it occurs the risk of a molar pregnancy is 5-10 times higher. 1.2. Detailed Case Description: This report describes a case of a 54-year-old peri-menopausal patient who accessed our Hospital in August 2023 for persistent metrorrhagia in the last 2 months. Based on ultrasound finding of endometrial cavity entirely occupied by inhomogeneous, vacuolized endometrium with a maximum thickness 83 mm, a diagnostic hysteroscopy with endometrial biopsy is performed: complete mole was the histological examination result. Increased betaHCG value of 338874 mUI/ml was evidenced. An encephalo-thorax-abdomen CT scan confirmed the presence of 12x15 cm diameter uterine neoformation. Encephalic and chest CT scans are negative for secondary tumors. After bilateral LPS hystero-annessiectomy, complete hydatiform mole was diagnosed. A postoperative betaHCG weekly follow-up was indicated and the last value of betaHCG was 8.8 mUI/ml.

Menopause‐induced neurodegeneration of retinal ganglion cells in a model of an acute retinal ischemia in rats

Aims/Purpose: To assess the influence of surgical menopause on the function and survival of retinal ganglion cells in a rat model of optic nerve crush.Methods: A total of 27 rats, aged 8 weeks, were divided into two groups based on the duration between ovariectomy (OVE) and euthanasia. Subgroups consisted of OVE, OVE combined with optic nerve crush (ONC), and ONC alone. All surgical procedures were conducted under general anaesthesia. Menopause was induced through OVE, which involved the surgical removal of ovaries. ONC was performed to induce acute retinal ischemia. Retinal function was evaluated using electroretinography (ERG). Retinas were stained for β3‐tubulin, NeuN, Erα, Erβ, and Iba1. Cell loss ratios were assessed through manual counting using ImageJ software.Results: After a two‐week menopause period, a reduction in retinal interneurons (RI) density was observed, but no significant decline was observed in retinal ganglion cell (RGC) count. The counts for NeuN were 373 ± 58 and 317 ± 55 (healthy vs. OVE, p < 0.02), and for β3‐tubulin were 197 ± 42 and 212 ± 38 (healthy vs. OVE, p > 0.05), respectively. Seven weeks after OVE, menopause affected RI but not RGC, with counts of 404 ± 49 and 378 ± 61 (healthy vs. OVE, p < 0.05), and 286 ± 32 and 287 ± 51 (healthy vs. OVE, p > 0.05) for NeuN and β3‐tubulin, respectively. Following the ONC procedure, the NeuN cell count was 345 ± 28 and 286 ± 40 (ONC and ONC + OVE, respectively, p < 0.0001), and for β3‐tubulin it was 221 ± 28 and 200 ± 37 (ONC and ONC + OVE, respectively, p < 0.05). In the preliminary analysis of ERG, a significant decrease in PhNR amplitudes was observed in the OVE group, while PhNR was severely diminished in the OVE + ONC group.Conclusions: Deprivation of estrogens through surgical menopause leads to accelerated retinal neurodegeneration, primarily affecting retinal interneurons. The absence of estrogens increases the vulnerability of RGCs to insults, resulting in expedited RGC loss during acute retinal ischemia.

Analysis of menopause and application of hormone therapy as therapeutic management

Introduction: Menopause is not a disease, but rather a natural stage in a woman's life. During this period, several physiological changes occur that affect quality of life. Therefore, Hormone Replacement Therapy is considered the first-line treatment. Objective: To analyze the menopausal period and the effectiveness of the application of hormonal therapy as therapeutic management. Methodology: For this research, a literature review, selection of scientific articles and application of the PRISMA method was carried out. Results: 14 publications were obtained according to the inclusion, exclusion and keywords criteria for review. Discussion: Most women present vasomotor symptoms that affect their quality of life, therefore, hormone replacement therapy is the way to compensate for estrogen deficiency. Thanks to important studies carried out in recent decades, a controversy over the benefits and risks has subsided. potentials. Conclusions: Hormonal Therapy is safe in healthy women in the early menopausal period, corroborating that the treatment does reduce symptoms. The treatment is fully recommended for patients where their quality of life is being significantly affected.

Современные лазерные технологии в гинекологической практике: возможности инновационного неодимового лазера

Aim. To summarize a review of modern literature and present a clinical observation of the use of the Magic Gyno Nd:YAG laser for the treatment of vulvovaginal atrophy in postmenopausal patients. Key points. One of the most significant problems of the menopausal period is genitourinary syndrome of menopause (GSM), the symptoms of which have a significant impact on the quality of life and sexual health of most women during menopause and occur in more than 50% of patients. The search and study of new effective and safe methods for treating the symptoms of GSM is an extremely urgent task, the importance of which, taking into account existing demographic and social trends, will only increase in the coming years. In addition to the objective risks associated with hormonal therapy, which is the "gold standard" in the treatment of GSM, it should be noted that for some patients it is contraindicated for medical reasons, and sometimes women themselves do not want to use hormone-containing drugs. Thus, there is a need to select other methods of therapy that will provide long-term symptomatic effect. Based on the available data, treatment of GSM using laser devices may be comparable in effectiveness to local hormonal therapy, and superior in safety. One of the most promising instruments of this class is the Nd:YAG laser, successfully used in cosmetology, ophthalmology, dentistry, surgery, urology, as well as in gynecology. After therapy with a neodymium laser, an improvement in lubrication and elasticity of the tissues of the vulva and vagina, normalization of the pH of the vaginal discharge was shown, as well as a significant reduction in the manifestations of sexual dysfunction and an increase in the quality of sexual life noted by patients. Conclusion. The neodymium laser method in gynecological practice is a new promising method of treatment. Although further randomized controlled trials are required, it has now been successfully used in the treatment of GSM and for patients who are contraindicated for hormonal therapy, or those who do not want to use even topical estrogens due to obsessive stereotypes and unreasonable fears. may become an alternative to local estrogen therapy. Key words: vulvovaginal atrophy, neodymium laser, Nd:YAG laser, genitourinary syndrome of menopause, hormone replacement therapy, estriol, vaginal wall prolapse.

Relationship Between the Level of Knowledge About Menopause with the Level of Menopausal Complaints in Leling Village, Tommo Subdistrict

In the course of her life, women experience many processes of growth and development, until one day growth and development will stop at a stage so that too many changes occur in the function of the female body. These changes will occur as age increases until finally women will reach a point called menopause and at this point anxiety will arise because they feel they are no longer beautiful. In women facing the menopause period, the appearance of psychological symptoms is strongly influenced by changes in the physical-physiological aspects as a result of the reduction and cessation of estrogen hormone production. In women who experience premenopause, complaints that are often felt include: feeling anxious, fearful, irritable, irritable, difficult, concentration, nervous, feeling useless, worthless, stressed and some even experience depression.This research was conducted in Leling Village, Tommo Sub-District, Mamuju Regency from October to November 2022. By using descriptive analytic method using cross sectional study design with a total sample of 33 menopausal women with inclusion criteria: Menopausal mothers who are willing to become respondents and live in Leling village, Tommo sub-district, Mamuju district, menopausal mothers aged 45-54 years, menopausal mothers with good consciousness, not impaired hearing and vision, able to communicate well. Data collection using a questionnaire. Using the Chi-Square Statistical Test with a significance level of α = 0.05. Data analysis was performed by univariate analysis and bivariate analysis on the SPSS program. The results showed that: there was a relationship between the level of knowledge and the level of menopausal complaints in Leling Village, Tommo District, Mamuju Regency, 2022. with a value of p = 0.006 < the value of a = 0.05.

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KECEMASAN WANITA MENOPAUSE DI DESA KOTAYASA

Introduction: In 2020, the Indonesian population will reach 262.6 million people, with the number of womenliving at the age of menopause amounting to 30.3 million people with an average age of 49 years. Women whoexperience the menopause period, there are indications of physical and psychological changes so that womenconsider themselves unattractive, unable to provide sexual satisfaction to their husbands, thus causing anxietyto menopausal women. The purpose of this study was to determine the factors that can affect the anxiety ofmenopausal women in Kotayasa Village.Method: Correlative analytical research design using a cross sectional approach. The research variables wereeducation, age, occupation, socioeconomics and anxiety. The research was conducted from October 2022 to August 2023 in Kotayasa Village. The study sample was 84 menopausal women aged 45-55 years obtainedthrough cluster sampling. The research instruments used knowledge questionnaires and HARS. Data analysisusing spearman rank test.Results: The results showed no significant relationship between education and anxiety (p = 0.466), age andanxiety (p = 0.996), occupation and anxiety (p = 0.689), and socioeconomics and anxiety (p=0.353). However,there was a significant relationship between knowledge and anxiety with a value of p=0.011 (p<0.05).Conclusion: Anxiety of menopausal women is only influenced by knowledge. Future researchers are expectedto analyze other factors associated with anxiety in menopausal women, using other research approaches ormethods to identify factors associated with anxiety in menopausal women.

The Importance of Nutrition in Menopause and Perimenopause-A Review.

Menopause is associated with an increased prevalence of obesity, metabolic syndrome, cardiovascular diseases, and osteoporosis. These diseases and unfavorable laboratory values, which are characteristic of this period in women, can be significantly improved by eliminating and reducing dietary risk factors. Changing dietary habits during perimenopause is most effectively achieved through nutrition counseling and intervention. To reduce the risk factors of all these diseases, and in the case of an already existing disease, dietary therapy led by a dietitian should be an integral part of the treatment. The following review summarizes the recommendations for a balanced diet and fluid intake, the dietary prevention of cardiovascular diseases, the role of sleep, and the key preventive nutrients in menopause, such as vitamin D, calcium, vitamin C, B vitamins, and protein intake. In summary, during the period of perimenopause and menopause, many lifestyle factors can reduce the risk of developing all the diseases (cardiovascular disease, insulin resistance, type 2 diabetes mellitus, osteoporosis, and tumors) and symptoms characteristic of this period.

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review.

Endometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period. About 40% of patients with EAC are linked with obesity and interrelated with hypertension, diabetes mellitus, and high circulating estrogen levels. Proprotein convertase (PC) furin was involved in the progression of EAC. Furin is a protease enzyme belonging to the subtilisin PC family called PC subtilisin/kexin type 3 that converts precursor proteins to biologically active forms and products. Aberrant activation of furin promotes abnormal cell proliferation and the development of cancer. Furin promotes angiogenesis, malignant cell proliferation, and tissue invasion by malignant cells through its pro-metastatic and oncogenic activities. Furin activity is correlated with the malignant proliferation of EAC. Higher expression of furin may increase the development of EAC through overexpression of pro-renin receptors and disintegrin and metalloprotease 17 (ADAM17). As well, inflammatory signaling in EAC promotes the expression of furin with further propagation of malignant transformation. Furin is associated with the development and progression of EAC through the induction of proliferation, invasion, and metastasis of malignant cells of EAC. Furin induces ontogenesis in EAC through activation expression of ADAM17, pro-renin receptor, CD109, and TGF-β. As well, EAC-mediated inflammation promotes the expression of furin with further propagation of neoplastic growth and invasion.

The Influence of Premenopausal and Menopausal Women's Demographic Characteristics on Anxiety and Quality of Life

Introduction: The premenopausal and menopausal periods are natural processes that occur in women. Both of these periods bring about changes in physical, psychological, and social aspects. The symptoms and changes experienced in the body can make women feel fearful, anxious, and lead to changes in their quality of life. The research aims to determine the influence of premenopausal and menopausal women's demographic characteristics on anxiety and quality of life. Methods: This study employed a descriptive design with an analytical observational approach and a cross-sectional design. The study population consisted of community health Center Jagir cadres aged ≥35 years, selected through purposive sampling, with a sample size of 70 respondents. The analysis use the ordinal regression statistical test. Results: Demographic characteristics revealed that the majority were aged 46-55 years (46%), had a high level of education (83%), and were married (81%). The majority experienced mild anxiety (40%) and had good quality of life (67%). The demographic characteristics of women (age, education, and marital status) significantly influenced anxiety and quality of life with a p-value <0.05. The Pseudo R Square values for anxiety were age 0.011, education 0.105, marital status 0.004, and for quality of life were age 0.007, education 0.028, marital status 0.004. Conclusion: Demographic characteristics, including age, education, and marital status, have an impact on anxiety and quality of life with a P Value < 0.05. Providing menopausal syndrome education and husband support is needed in dealing with the pre-menopause period to reduce anxiety and improve quality of life.

Assessment of the glutathione system and the biomolecules oxidation products contribution to the state of free radical homeostasis in women of two ethnic groups with insomnia

Own and literature data showed a change in the free radical oxidation products and indicators of the glutathione system concentration in menopausal women with insomnia. The change in the studied parameters depended on the ethnicity of the patients. The aim of the study was to assess the informative value of these indicators and their contribution to the state of free radical homeostasis in menopausal women of Russian and Buryat ethnic groups with insomnia. Material and methods. The study involved women of the menopausal period of the Russian (n = 136) and Buryat ethnos (n = 94). The women underwent a general clinical examination and a questionnaire. Then they were divided into climacteric phases, control groups and groups with insomnia. Enzyme immunoassay, spectrophotometric and fluorometric methods of analysis were used to determine values of glutathione system and biomolecule oxidation products. The informative value of the studied indicators and their contribution to the state of free-radical homeostasis was assessed with the help of discriminant analysis. Results and discussion. The most informative indicators in the group of Russian women with insomnia in perimenopause were content of advanced glycation end products (AGEs), advanced oxidation protein products (AOPP), products of DNA oxidative modification, oxidized glutathione, glutathione reductase activity; in postmenopause – concentration of AOPP, products of DNA oxidative modification, and glutathione reductase activity. In Buryat perimenopausal women the most informative values were content of AGEs, of reduced and oxidized glutathione and their ratio, and in postmenopause – content of AGEs, of oxidized glutathione and glutathione reductase activity. Mathematical models have been developed that demonstrate the prevalence of the redox balance prooxidant component contribution in Russian ethnic group and the antioxidant component in Buryat ethnic group and allow characterizing patients with insomnia with high accuracy depending on the phase of menopause and ethnicity. Conclusions. In women of the Russian ethnic group with insomnia in the menopausal period, the greatest contribution to the state of free radical homeostasis is made by the products of oxidation of biomolecules, which characterizes the predominance of the processes of disadaptation. In women of the Buryat ethnic group, in response to insomnia in the climacteric period, the components of the glutathione system make the greatest contribution to the state of free radical homeostasis, which characterizes the activation of adaptive capabilities throughout the climacteric period.