BackgroundMeningococcal serogroup B (MenB) is the leading cause of potentially fatal meningococcal disease among United States (US) older adolescents and young adults; college students are at increased risk. Although the Advisory Committee on Immunization Practices (ACIP) recommends that healthy 16–23-year-olds may be vaccinated against MenB, MenB vaccination coverage is low. ObjectiveThis study investigated the impact of a comprehensive multimedia MenB vaccine educational campaign on two-dose MenB vaccine series initiation among college students. MethodsWe implemented a six-week-long (October 11, 2021 – November 19, 2021) educational intervention via a prospective trial on a university campus (the intervention campus), including video broadcasting, student-led campus programming, and printed materials. The control campus was a different university in the same urban setting. ResultsDuring baseline period 1 (August 26, 2019 – November 15, 2019), two students on the intervention campus and three students on the control campus initiated the MenB vaccination series; one student initiated the series on the intervention campus during baseline period 2 (August 27, 2021– October 8, 2021). At least 83 students were exposed to the campaign during the intervention period (October 11, 2021 – November 19, 2021). No students initiated the MenB vaccination series during the intervention period, although one student completed the vaccination series. ConclusionThe campaign did not influence MenB vaccination initiation on the university campus.