Quality Of Life In Men Research Articles

The Impact of Coronavirus Infection on Health-Related Quality of Life in Amateur CrossFit Athletes.

The aim of this study was to assess how the disease, developing over the course of coronavirus infection, affects the quality of life of athletes practicing amateur sports who are not burdened with comorbidities. The study included 102 amateur CrossFit athletes (54 (53%) women and 48 (47%) men) who had been infected with SARS-CoV-2, but were not hospitalized. The training experience of the respondents ranged from 1.5 to 15 years (average: 6.7 ± 3.8 years). The quality of life was assessed with EQ-5D-5L and Clinical COPD Questionnaire (CCQ), which was used to assess the quality of life specific to the respiratory system, and the severity of dyspnea was assessed using the MRC questionnaire. The training experience did not differ statistically significantly between men and women (p = 0.595). The quality of life in men according EQ-5D-5L was statistically significantly higher than in the case of women (0.979 ± 0.028 vs. 0.942 ± 0.073 (p < 0.001), respectively), and in EQ-VAS it was significantly higher in men than in women (85.64 ± 10.4 vs. 72.5 ± 19.36 points (p < 0.001)). The assessment of dyspnea by means of mMRC showed its higher intensity in women than in men. The differences were not statistically significant (p = 0.195). In men, a significantly lower result of the quality of life was noted in the CCQ questionnaire: 0.71 ± 0.57 vs. 1.14 ± 0.84 points (p = 0.009). The HRQOL, which surveyed amateur CrossFit after COVID-19, was higher in men than in women. People practicing strength- and strength-endurance-based sports rated their quality of life as the highest. Most of the subjects observed a slight intensification of dyspnea. The findings can be used for future healthcare measures to be applied in the population of CrossFit athletes.

New Razor Technology Improves Appearance and Quality of Life in Men With Pseudofolliculitis Barbae

Pseudofolliculitis barbae (PFB) consists of ingrown hairs leading to papules, pustules, and discomfort. This prospective, 12-week clinical study aimed to assess the appearance of males with razor bumps and shaving irritation when using a new razor technology with 2 blades separated by a bridge feature (SkinGuard [Procter & Gamble]). The impact on participants' shave-related itching, burning, and stinging severity, as well as quality of life (QOL), also was assessed. In men with PFB, shaving with the test razor at least 5 times per week over a 12-week period improved the appearance and QOL of males with razor bumps and shaving irritation compared with baseline.

Predictors and Moderators of Quality of Life in Male Users of Anti-Aging Products.

For most individuals, changes occurring during the aging process may cause dissatisfaction and concerns regarding body image, with implications on quality of life (QoL). The aim of this study was to assess the contribution of sociodemographic and psychological variables and the type of anti-aging products/treatments on men's QoL, as well as to evaluate the moderating role of aging perceptions in the relationship between psychological morbidity and QoL. This study used a cross-sectional design and included a sample of 111 male participants who used anti-aging cosmetic products/aesthetic treatments. Participants were assessed on body image, self-esteem, psychological morbidity, aging perceptions, traits of perfectionism, and QoL. Results suggested that psychological morbidity and perceptions of the aging process as chronic negatively contributed to QoL, and emotional representations of aging moderated the relationship between psychological morbidity and QoL. According to the findings, psychological intervention programs to improve QoL should focus on men with higher levels of psychological morbidity and more negative emotional responses to the aging process.

Quality of life (QoL) in patients with heart failure with preserved ejection fraction (HFpEF): a systematic review

Abstract Introduction Heart failure with preserved ejection fraction (HFpEF) is associated with significant clinical unmet need as mortality and morbidity rates are high despite current treatments. Patient-reported quality of life (QoL) is an important and clinically relevant endpoint in patients with HF so understanding the impact of HFpEF on QoL is essential. Purpose The aim of this systematic review was to identify and summarize data on QoL in HFpEF. Methods Systematic searches of Medline, Medline Epub Ahead of Print (In-Process &amp; Other Non-Indexed Citations), Embase, and EBM Reviews were conducted in October 2021. Congress proceedings from the past 3 years and reference lists of included publications were also searched. Publications were screened against eligibility criteria by title/abstract and then by full text. Eligibility criteria included clinical studies of any design reporting baseline QoL in adults with HFpEF published from 2016 onwards. Results The electronic database search identified 6,403 articles on HFpEF. After screening, 35 full publications reporting HFpEF and QoL were included. Study designs included observational cohort (n=17), cross-sectional (n=3), and post-hoc analyses of interventional studies (n=15). Tools used to measure QoL included KCCQ (n=17), MLHFQ (n=12), EQ-5D-VAS (n=8), SF-12 (n=2), SF-36 (n=2), and EHFSQ-1 (n=1). Health-state utility values (HSUVs) were captured using EQ-5D in four studies. HSUVs in HFpEF ranged from 0.67–0.74, indicating a substantial QoL burden. Eleven studies using various instruments compared QoL in patients with HFpEF vs non-HFpEF (Table 1). Of these, five reported statistically significantly poorer QOL in HFpEF vs non-HFpEF, one reported statistically significantly poorer QOL in non-HFpEF vs HFpEF and five found no statistically significant difference between HF subtypes. Four studies compared QoL in men vs women with three reporting statistically significantly worse QoL in women. Three studies examined the impact of comorbidities, and all reported statistically significantly poorer QoL in patients with comorbid atrial fibrillation, diabetes, or metabolic syndrome. Two studies examined the effect of age; one reported that, vs elderly patients (age ≥85 years), younger patients (age ≤55 years) with HFpEF had statistically significantly worse QoL despite having fewer comorbidities; in contrast, the second study reported that younger patients (age ≤55 years) had statistically significantly better QoL than elderly patients (age ≥75 years). Two studies reported on hospitalizations, with one reporting no difference in QoL between patients who had previously been hospitalized and those who had not and the other reporting that readmission for HF correlated with QoL. Conclusions QoL burden among HFpEF patients is substantial. QoL may be affected by age, comorbidities, gender, and prior hospitalization, and may be associated with poorer outcomes. QoL in HFpEF is generally poorer than in non-HFpEF. Funding Acknowledgement Type of funding sources: Private company. Main funding source(s): AstraZeneca

Multilevel interventions to address sexual health challenges in men with prostate cancer

Background: Men treated for prostate cancer (PCa) experience post-treatment sexual dysfunction, including decreased libido and erectile dysfunction. Sexual health issues are expected following the diagnosis and treatment of PCa, which impairs the quality of life in men. Aim: This article proposes multilevel interventions to address the men’s sexual healthcare (SHC) gaps following PCa diagnosis and treatments. Setting: The setting of this article is the radiation oncology environment within the context of the sexual health of men with PCa. Methods: A qualitative retrospective study design was adopted in this article as the authors revisited the previously published data. The authors methodically analysed qualitative data using deductive and inductive approaches to expand and operationalise the first author’s 2017 psychosexual counselling guidelines. Results: Four levels of multiple-level interventions were identified and further expanded into seven nonpharmacological interventions to improve SHC in men with PCa post-radiotherapy. These levels of interventions include the patient, peer support, provider and system levels. Conclusion: It is hoped that these interventions will contribute to the sexual well-being of men with PCa through this nonpharmacological interventional approach. Contribution: This article provides pragmatic interventions to address the challenging and unspoken concerns of men undergoing treatment for PCa in the ROD. Methodologically, it advances deductive and inductive analyses for rich interpretative analysis.

Testosterone and quality of life in patients with dilated cardiomyopathy.

Testosterone is an important factor that influences the quality of life in men. The purpose of this study is to evaluate how testosterone level impacts the quality of life in patients with dilated cardiomyopathy. This cross-sectional single-center included 97 male patients with dilated cardiomyopathy, in whom serum testosterone was measured. Health-related quality of life was measured using the translated validated version of the Kansas City Cardiomyopathy Questionnaire (KCCQ-12). We used correlation and multivariable regression to assess the association between KCCQ-12 score, serum testosterone level, and clinical and paraclinical variables. The mean age of study participants was 58 (range 29-88). The mean LVEF was 25 ±8.61%. The average total serum testosterone level was 3.13 ±2.72 (range 0.19-13.5 ng/ml). The median global KCCQ-12 score was 44.8 (6.2-90.6) representing a poor to fair impairment in quality of life. There was an inverse correlation between the KCCQ-12 score and NYHA class (Pearson coefficient r = 0.847 p<0.001) and a direct correlation with LVEF (r=0.445, p<0.001). Also, the KCCQ-12 score correlated with hemoglobin level (r=0.214, p=0.037) and plasmatic creatinine level (r=-0.296 p= 0.004). In multivariable regression, the independent predictors of health-related quality of life were testosterone, LVEF, and NYHA class. The results of this study showed for the first time a significant direct relationship between serum testosterone levels and quality of life in patients with dilated cardiomyopathy.

Home-based Exercise Influence On Circulating Cytokines, Functional Capacity And Quality Of Life In Men With Prostate Cancer Under Active Surveillance

PURPOSE: To investigate the impact of a home-based exercise program in men with PCa. METHODS: Fifteen men with PCa under active surveillance completed 24 weeks of home-based exercise (HBE), combining aerobic and body-weight based exercises. Aerobic exercise included 5 days of walking for 30 minutes at 40-60% of the participant’s heart rate reserve. Body-weight based exercises were performed 3 times per week consisting of 3 sets of 15 reps of bodyweight squats, inclined push-ups, and hip thrusts. Baseline and end of study assessments were done. Blood was collected to measure circulating eotaxin, IFNγ, IL-12, IL-1a, IL-5, IL-6, TNF-α, and VEGF (pg/mL; Millipore Sigma, Billerica, MA). A 6-minute walk test (6MWT) was done to measure physical function. The Short form 36 (SF-36) and Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) were used to quantify changes in quality of life (QoL). T-tests were performed with significance set to p < 0.05. RESULTS: Of the 15 men consented, 9 men completed the intervention (40% attrition due to COVID). Participants were 72.0 ± 8.52 yrs old, 85.31 ± 6.41 kg with BMI of 27.77 ± 2.93 kg/m2. A tendency was observed for improved 6MWT distance (Pre: 382.7 ± 108.1 m; Post: 466.7 ± 73.78; p = 0.08). Non-significant reductions were seen in circulating of IFNγ (Pre: 152.9 ± 312.7; Post: 118.9 ± 258.8; p = 0.08) and VEGF (Pre: 125.2 ± 198.7; Post: 80.29 ± 124.3; p = 0.06). Several other biomarkers showed relevant, though not significant, decreases as well, including IL-12 (Pre: 28.69 ± 32.06; Post: 23.92 ± 19.38; -16.6%), IL-1a (Pre: 78.76 ± 183.3; Post: 65.55 ± 147.6; -16.8%), IL-6 (Pre: 23.71 ± 45.64; Post: 21.24 ± 45.18; -10.4%), and TNF-α (Pre: 24.58 ± 35.4; Post: 19.71 ± 20.76; -19.8%). Significant differences were identified in the SF-36 for role limitation due to emotional problems (Pre: 85 ± 15.1; Post: 96.7 ± 7.0; p = 0.003) and the FACIT subscales for physical wellbeing (Pre: 3.7 ± 0.2; Post: 1.3 ± 1.5; p < 0.001) and emotional wellbeing (Pre: 3.7 ± 0.3; Post: 1.5 ± 0.9; p < 0.001). CONCLUSIONS: : Despite the loss of participants due to COVID-19 protocols limiting in person research visits, the results show promising indications that HBE can be effective in reducing cytokines, increasing functional capacity and promoting QoL in men with PCa. Further investigation is needed with a powered sample.

Testosterone Replacement Therapy in the Aged Male: Monitoring Patients' Quality of Life Utilizing Scoring Systems.

Hypogonadism has been associated with significant deterioration of well-being. In the aging male, late-onset hypogonadism affects sexual life, mental health, levels of energy, lower urinary tract symptoms and, therefore, quality of life may be found significantly deteriorated. Testosterone replacement or supplementation therapy has been found efficient to reverse the adverse effects of hypogonadism and improve quality of life. Scales and questionnaires assessing the general health, urinary symptoms, sexual health, and cognition can provide a thorough assessment of the clinical syndrome, optimize treatment, assist the follow-up, and facilitate referrals to other specialties depending on the chief complaint. A systematic assessment might combine several tools, but the optimal ones and the exact usage is unknown. In this narrative review, we are flipping through the literature presenting the available tools per domain for the assessment of quality of life in men on testosterone replacement therapy and we discuss the optimal usage.

Structural model of the relationship between physical activity and students' quality of life: Mediating role of body mass index and moderating role of gender.

BackgroundAs a country’s future leaders and pioneers, University students must live with healthy habits. In order to achieve a healthy lifestyle, Physical activity and Quality of Life can serve as suitable indices to study. The purpose of the study was to clarify how physical activity (PA), Body mass index (BMI) and gender relate to the quality of life (QOL) of students of Medical Sciences University by using a structural equation model.MethodsThe research was a cross-sectional study. The number of participants was 225 students of the University. The participants answered three questionnaires, including Demographic, International Physical Activity Questionnaire (IPAQ short form), and Quality of Life Questionnaire (SF-12), BMI was calculated by anthropometric measures, as well. The Structural equation model (SEM) method was employed. The Fitness of the proposed pattern was measured using the following indexes: chi-square/degree of freedom ratio (CMIN/DF), Normed Fit Index (NFI), comparative fit index (CFI), the goodness of fit index (GFI), and standardized root mean squared residual (SRMR). In the analysis the significant level was considered as P < 0.05.ResultsPA (r = -0.726, P<0.001) and QOL (r = -0.405, P<0.001) have significantly inverse relationship with BMI, whereas the QOL and PA were proven to be positively related (r = 0.357, P<0.001). Moreover, the results signify gender as a moderator in the relationship between PA and QOL (Δχ2 (10) = 19.903, P = 0.030) and also the mediatory role of BMI among students. BMI affects the QOL in men (P < 0.001, β = -0.307) more in compare to women women (P = 0.324, β = -0.158).ConclusionStudy findings supported the research hypothesis. Gender exhibited moderating role in the relationship between PA and QOL, considering the mediating role of BMI.

전립선 비대증 남성의 건강관련 삶의 질 예측요인

Objectives This study is a descriptive correlation study to confirm the predictive factors of lower urinary tract symptoms and disease-related characteristics perceived by the subject on the health-related quality of life of men with Benign prostate hypertrophy. Methods This study was conducted on a total of 113 patients aged 45 or older who were diagnosed with prostate hypertrophy at a general hospital urology out patient department in U-si, Gyeonggi-do, who could understand, respond to, and communicate with the questionnaire. The collected data were analyzed with SPSS/WIN 23.0. Results As a result of a Stepwise regression analysis to explore predictors of health-related quality of life of subjects, lower urinary tract symptoms (==-.65, p&lt;000) as a predictor of health-related quality of life in men with Benign prostate hypertrophy was the highest, followed by sleep time (==.17 p&lt;008). It was identified as (Adjusted R2=.57). Conclusions As a result of this study, the predictive factors affecting the health-related quality of life of men with prostate hypertrophy were investigated as lower urinary tract symptoms and sleep time. In order to improve the health-related quality of life of prostate hypertrophy cyst, it is believed that intervention and education programs for the management of lower urinary tract symptoms should be developed. In addition, it is necessary to approach the improvement of self-management capabilities for the prevention of symptoms and diseases of prostate hypertrophy men who help alleviate and improve lower urinary tract symptoms.

Which Type of Exercise During Radiation Therapy Is Optimal to Improve Fatigue and Quality of Life in Men with Prostate Cancer? A Bayesian Network Analysis

ContextPhysical exercise in men with prostate cancer (CaP) has shown benefits in improving cancer-related fatigue (CRF) and quality of life (QoL) during radiation therapy. However, types of exercises that are more effective are not well understood. Evidence acquisitionWe searched PubMed, Web of Science, and ClinicalTrials.gov up to November 2021 to identify potentially relevant studies. Randomized controlled trials (RCTs) testing the effects of exercise training on CRF, QoL, and treatment-related toxicities in patients with CaP undergoing radiation therapy were included. The quality of individual studies was evaluated using the Tool for the assEssment of Study qualiTy and reporting in Exercise (TESTEX) scale. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation method. A meta-regression analysis was conducted to test the study-level covariates. A random-effect network meta-analysis was conducted based on a Bayesian model. Evidence synthesisEight RCTs with 466 participants were included. Exercise achieved significant improvements in CRF (standardized mean difference [SMD] = 1.24, 95% confidence interval or CI [0.43, 2.06], I2 = 93%) and QoL (SMD = 1.40, 95% CI [0.05, 2.75], I2 = 95%). Based on the meta-regression and Bayesian model, combined moderate-intensity continuous training aerobic exercise and resistance exercise (MICT/RES) showed the highest probability of ranking first in terms of CRF and QoL improvement, but the results of QoL were unstable. Exercise training also had a positive effect on urinary toxicities (SMD = –0.53, 95% CI [–0.79, –0.27], I2 = 0%). A subgroup analysis indicated that MICT/RES might be the most promising exercise modality for reducing intestinal toxicities (SMD = –1.76, 95% CI [–2.32, –1.20]). ConclusionsMICT/RES might be superior to any other types of exercise at reducing CRF. MICT/RES was more effective on significantly mitigating urinary and intestinal toxicities. Patient summaryIn prostate cancer (CaP) survivors during radiation therapy, exercise training is an effective and safe intervention to reduce cancer-related fatigue (CRF) and improve quality of life (QoL), and should be prescribed as a rehabilitation option for clinical management. As for the types of exercises, moderate-intensity continuous training aerobic exercise and resistance exercise seem to be the most effective interventions to reduce CRF, improve QoL, and mitigate treatment-related symptoms.

A narrative review of pelvic floor muscle training in the management of incontinence following prostate treatment.

Background and ObjectiveUrinary incontinence following prostate treatment (IPT) is a common complication with corresponding negative impacts on quality of life. Pelvic floor muscle training (PFMT) is a non-invasive treatment strategy to treat combat this clinical issue, and has been recognized by medical associations globally and increasingly supported by large bodies of literature. Accordingly, many studies demonstrate a significant benefit of pelvic floor muscle training to continence status and quality of life in men with incontinence following prostate treatment. However, related research is limited by variety in treatment regimens, outcome measures, and study designs, with unclear impact on treatment success. We aim to provide a brief overview of pathology and incidence of incontinence following prostate surgery and an understanding how PFMT is currently used to treat and prevent this clinical consequence.MethodsA comprehensive literature search was conducted utilizing PubMed, Medline, and Google Scholar. Search criteria included systematic reviews and randomized control trials published in the year 2000 to present. References of resulting studies were further analyzed to identify further articles of relevance. Keywords searched included: “post-prostatectomy incontinence”, “pelvic muscle strengthening”, “Benign Prostatic Hyperplasia”, and “pelvic floor muscle training”. Peer-reviewed publications that demonstrated a novel addition to the existing body of literature on this subject were included.Key Content and FindingsUpon review of the current research landscape, PFMT is largely supported in treatment of IPT. Analysis of current literature on this subject demonstrates heterogeneity in protocols, measures of treatment success, and patient numbers. Nevertheless, benefits to continence and quality of life are noted across an expansive body of literature and as such, PFMT is therefore recommended as an important part of the treatment algorithm following radical prostatectomy.ConclusionsPFMT is an important and effective part of the treatment algorithm in the prevention and treatment of IPT. Additional research is needed to more extensively assess PFMT’s role in treating this clinical consequence, especially following other prostate surgeries.

The Effect of Salvage Radiation Therapy on Survival, Functional Outcomes, and Quality of Life in Men with Persistent Prostate-specific Antigen After Robot-Assisted Radical Prostatectomy: Which Patient Benefits More?

PurposeThe aim of this study was to evaluate the effect of salvage radiation therapy (sRT) on survival, functional outcomes, and quality of life in men with persistent prostate-specific antigen (PSA >0.1 ng/mL) after a robot-assisted radical prostatectomy (RARP) and reveal subgroups that benefit more from sRT. Methods and MaterialsData of 3409 patients who underwent RARP was retrieved from a high-volume institute database, and 313 patients with persistent PSA were included in further analyses. Patients who received sRT and those who did not were compared after propensity score matching. Progression-free survival (PFS), metastasis-free survival (MFS), androgen deprivation therapy (ADT)-free, cancer-specific survival, and overall survival, as well as patient-reported outcomes were the endpoints. Multivariable Cox regression models were developed to reveal treatment effect sizes for the subgroups. ResultsThe overall persistent PSA rate was 9.2%, and the median follow-up time after RARP was 4.5 years (interquartile range, 2.7-7.9 years). The sRT was associated with improved PFS (hazard ratio [HR]: 0.29; P < .001), ADT-free survival (HR: 0.34; P < .001), MFS (HR: 0.39; P = .001), cancer-specific survival (HR: 0.34; P = .03), and overall survival (HR: 0.24; P = .001). Positive surgical margins (HR: 0.26; P < .001 for ADT-free survival), advanced pathological T stage (HR: 0.24; P < .001 for PFS) and positive lymph nodes (HR: 0.15; P = .001 for MFS), and lower Gleason score (HR: 0.15; P = .001 for PFS) were associated with marked survival benefits of sRT. Bowel symptoms were observed more frequently in patients who had sRT with or without ADT compared with patients with persistent PSA but no sRT (34.3% vs 19.2%; P = .01). Early sRT (<6 months after surgery) was associated with bothering incontinence (P < .001) and bowel symptoms (P = .03). ConclusionsPersistent PSA after a radical prostatectomy is still a common challenge in the robotic surgery era. sRT provides clear survival benefits for all endpoints, especially with unfavorable locoregional factors but a low Gleason score.

Quality of life in low-income men after surgical castration for metastatic prostate cancer.

To compare health-related quality of life in men who underwent surgical vs. medical castration for metastatic prostate cancer. We analyzed data from a prospective cohort of men enrolled in a statewide public health program that provides care for prostate cancer among low-income, uninsured men from 2001 to 2020. Outcome measures included the RAND SF-12 and the UCLA Prostate Cancer Index (PCI) at baseline and every 6 months. We used generalized estimating equations to assess the independent impact of surgical vs. medical castration on health-related quality of life. Among men with metastatic prostate cancer, 27 underwent orchiectomy, and 274 underwent medical castration. Median cohort age at enrollment was 61.3 years (IQR 56-65); 239 (79%) men had less than a high school education. Average follow-up was 8 months (range 0-45) since study enrollment. Seventy percent of patients within the surgical castration group had their orchiectomy prior to study enrollment (median months since orchiectomy at study enrollment was 9 months, IQR 1-43). Similarly, 59% of patients within the medical castration group had begun ADT prior to study enrollment (median months since ADT initiation at study enrollment was 4 months, IQR 1-12). The majority (66%) had metastatic disease at diagnosis. The 2 groups did not differ in age, race/ethnicity, education, monthly income, baseline PSA, Gleason score, or percent metastatic at diagnosis. SF-12 domains did not differ between those who underwent surgical vs. medical castration (on average throughout follow-up, physical component difference -2.0, 95% CI -8.0-3.9 and mental component difference -1.0, 95% CI -5.4-+3.4). Patients treated with orchiectomy reported better urinary function than those who underwent medical castration (+16 point, 95%CI 5.3-26). Surgical castration did not negatively impact general or disease-specific quality of life. The finding of improved urination after orchiectomy merits further inquiry. This may inform urologists' discussion of surgical vs. medical options for men with castration-sensitive metastatic prostate cancer.

P-017 Impact of yoga intervention on immunosenescence, fertility potential and quality of life in men with Rheumatoid arthritis

Abstract Study question Can a yoga intervention bring about alterations in immune aging, fertility potential and quality of life in men with Rheumatoid arthritis? Summary answer Yoga not only reduces disease severity, minimizes usage of drugs but also reduces the rate of immune aging and cellular aging. What is known already The complex mechanism of Rheumatoid arthritis with infertility in men involves interactions between endocrine, immune, and reproductive systems. Association of autoimmunity with dysregulated androgen (hypogonadism) levels may cause transient infertility in men. Furthermore, usage of disease-modifying antirheumatic drugs (DMARDs) like cyclophosphamide, methotrexate, sulphasalazine etc. may result into decreased quantity and quality of sperm, mitochondrial dysfunctions, reduced fertility potential and ultimately permanent infertility. These drugs can cross blood-testis-barrier and induce changes in sperm impairing spermatogenesis. Complementary and alternative medicine like yoga reduces seminal oxidative stress and its consequences like DNA fragmentation in sperm nuclear/mitochondrial genome. Study design, size, duration Fifty males with RA were enrolled in this 12-week prospective, open-label, single-arm exploratory study, designed to explore the impact of yoga intervention on immunosenescence, fertility potential and quality of life (QoL). Participants/materials, setting, methods The participants were evaluated for pre (day 0) and post (12th week) levels of inflammatory markers: IL-6, IL-17A, TGF-β and TNF-α. T cell sub-set populations along with their aged T cell profiles for immunosenescence as well as telomere length and telomerase activity for cellular aging were studied. Seminal reactive oxygen species (ROS), DNA fragmentation index (DFI) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels were estimated as per WHO 2010 guidelines. QoL was measured by WHOQOL-BREF Scale. Main results and the role of chance There was significant reduction in mean levels of TNF-α, IL-6, IL-17A and elevation in TGF-β after 12 weeks. A significant reduction was seen in seminal ROS levels, 8-OHdG and DFI as well. There was a significant decline in aged T cell populations after yoga. There was no change seen in the telomere length but there was an improvement in the telomerase activity. The participants showed significant improvements in QoL after 12 weeks. Limitations, reasons for caution Compliance of patients for Yoga intervention was poor, hence we enrolled large number of patients to achieve the desirable sample size. Wider implications of the findings Adoption of yoga intervention holds the key to maintaining immune homeostasis, reduction of inflammation, reduction in the rate of cellular aging, improved overall QoL, and its associated consequences associated with physical, mental, and reproductive health. Trial registration number N/A

Low quality of life in men with chronic prostatitis-like symptoms

BackgroundChronic prostatitis (CP) can impair health-related quality of life (QOL), but the full impact of CP, including the impact of CP-like symptoms in men who have no CP diagnosis (CPS), is unknown. We estimated the impact of diagnosed CP (DCP) and CPS on Health-related QOL.MethodsFrom a representative nationwide survey of men aged 20–84 in Japan, we determined the prevalence of DCP and also of CPS. For CPS, we used Nickel’s criteria, which were used previously to estimate the prevalence of CP and are based on the NIH Chronic Prostatitis Symptom Index. To test the robustness of Nickel’s criteria, we used two other definitions of CPS (two sensitivity analyses). We measured QOL with the Short-Form 12-Item Health Survey. We compared the participants’ QOL scores with the national-norm scores, and with the scores of men who had benign prostatic hyperplasia (BPH).ResultsAmong the 5 010 participants, 1.4% had DCP and 3.7% had CPS. The sensitivity analyses resulted in CPS prevalence estimates of 3.1% and 4.5%. CPS was particularly common in younger participants (5.7% of those in their 30 s had CPS). QOL was very low among men with CP: In most areas (domains) of QOL, their scores were more than 0.5 standard deviation below the national-norm mean. Their mental-health scores were lower than those of men with BPH. The lowest scores among all 8 QOL domains were in role-functioning.ConclusionsCP is common, but it is underdiagnosed, particularly in younger men. Whether diagnosed or only suspected, CP’s impact on QOL is large. Because CP is common, and because it substantially impairs individuals’ QOL and can also reduce societal productivity, it requires more attention. Specifically, needed now is a simple tool for urologists and for primary care providers, to identify men, particularly young men, whose QOL is impaired by CP.

Association between domains of quality of life and patients with Klinefelter syndrome: a systematic review.

ObjectiveKlinefelter syndrome (KS) is the second-most prevalent chromosomal disorder in men, though late diagnosis is very common and 50–75% of men remain undiagnosed. Evidence suggests that men with KS have impaired quality of life (QoL) but research on how the diagnosis of KS is associated with different QoL domains and what factors influence patients’ QoL is limited. This study aimed to provide a systematic review of the published evidence on factors that influence QoL in men with KS.DesignSystematic review and meta-analysis with narrative synthesis.MethodsMedline, Cochrane, Embase, Psychinfo, CINAHL, BASE and relevant publication reference lists were searched in January 2021. Eligible studies included randomised control trials, cohort studies, cross-sectional studies and epidemiology studies on KS and its effect on QoL and all domains of World Health Organisation (WHO) Quality of Life 100 (WHOQOL-100). Clinical studies with no date restriction published in English were included.ResultsThematic analysis was completed on 13 studies, with a meta-analysis of intelligence quotient completed on 7 studies. Twelve out of the 13 studies suggested that KS negatively affected the QoL outcomes and KS was associated with impairments in physical, psychological, level independence and social relationship domains of WHOQOL-100. Meta-analysis suggested that men with KS have significantly lower full-scale Intelligence Quotient vs controls (P < 0.00001).ConclusionsThis is the first evidence synthesis of QoL in men with KS. Current evidence suggests that combined physical and psychological impairments affect men with KS who also experience impairments in relationships and independence in society. Further research is needed to identify factors that influence the QoL in men with KS.

Effect of Central Stability and Dynamic Neuromuscular Stabilization Exercises on Pain, Flexibility, Balance, Muscle Endurance and Quality of Life in Men With Nonspecific Chronic Low Back Pain

Background: Study on the effectiveness of new methods of low back pain treatment is very important due to its high prevalence. There is no consensus on the most effective treatment for low back pain, despite the existence of different treatments options. Objective: This study aims to assess the effect of 8 weeks of dynamic neuromuscular stabilization (DNS) and core stability (CS) exercises on pain, hamstring flexibility, balance, abdominal muscle strength, and quality of life (QoL) in men with chronic low back pain. Methods: Participants were 20 men with non-specific low back pain, randomly divided into two groups of DNS (Age=47.8±9.82 years, BMI=25.8±2.9 kg/m2) and CS (Age=42.4±11.8 years, BMI=28.1±13.1 kg/m2). Subjects performed exercises for 8 weeks. Before and after exercises, their pain, hamstring flexibility, static and dynamic balances, abdominal muscle strength, and QoL were assessed. For data analysis, the paired t-test and analysis of covariance were used, considering a significance level of P&lt;0.05. Results: Both training methods improved pain, abdominal muscle strength and static balance. The CS exercise significantly improved hamstring muscle flexibility, and DNS exercise significantly improved QoL. The comparison between the two methods showed no significant difference in any study variables. Conclusion: Both CS and DNS exercises can be used in designing the interventions for patients with chronic low back pain.

608-P: Intersectional Identities, Social Risk Factors, and Quality of Life in Men and Women with Diabetes

Background: More than 34 million adults ≥18 years have diabetes in the U.S. Adverse social conditions associated with poor health, or social risk factors, contribute to poorer access to care, quality of care, and clinical outcomes for adults with diabetes. Intersectionality, defined as having multiple marginalized/disadvantaged social identities that reflect larger-scale inequalities and systems of oppression, may contribute to diabetes disparities. The study objective was to assess differences in the relationship between intersectionality and social risk factors between men and women with diabetes. Methods: Data of 2,476 adults (weighted sample = 1,144,573) from the Behavioral Risk Factor Surveillance System (BRFSS) were analyzed. The outcomes were physical and mental health quality of life, and the predictor was intersectionality summed as Non-Hispanic White, age ≥65 years, unemployment, less than high school education, and income &amp;lt;$25K. Covariates included comorbidities, insurance, region, and metropolitan statistical area. Logistic regression models were found for each of the outcomes to assess their independent association with intersectionality. Results: In the fully adjusted model, women with 3+ intersecting social identities were 4x more likely to have poorer physical health (OR=4.13 (95% CI 0.54, 7.73)) compared to women reporting no intersectionality. Men with food insecurity were 5x more likely to have poorer mental health (OR=4.93, 95% CI 1.02, 8.84) than men without food insecurity, whereas women with food insecurity were 3x more likely to have poorer mental health (OR=2.56, 95% CI 0.61, 4.51) compared to women without food insecurity. There were no significant associations between intersectionality and housing instability in this sample. Conclusions: These findings suggest the need for understanding the influence of intersectionality among women with diabetes and social risk factors, especially food insecurity, among men and women with diabetes. Disclosure J.S.Williams: None. A.Thorgerson: None. M.N.Ozieh: None. L.E.Egede: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (K24DK093699, R01DK118038, R01DK120861 and R21DK123720)

Impact of Hypogonadism on Quality of Life in Men with Coronary Artery Disease

Today, the issue of improving care for patients with cardiovascular diseases is particularly acute, because despite all the achievements of modern medicine, they remain one of the leading causes of disability and mortality in Europe and the world. Despite the fact that many factors have been established that affect the prognosis and course of cardiovascular diseases, such as arterial hypertension, smoking, gender, obesity, age, diabetes mellitus, obesity, metabolic disorders, etc.,[1] their search continues. So, the factor influencing the course of cardiovascular diseases is the presence of androgen deficiency in men. According to studies [2],[3],[4],[5],[6] conducted in world practice, there is evidence that androgen deficiency has a negative impact on the course of cardiovascular diseases, in particular coronary artery disease. However, this issue requires further study. The aim of the study was to study the possible impact of androgen deficiency on the quality of life in men with coronary heart disease.