Memory For Pictures Research Articles

Association of Potentially Damaging De Novo Gene Variants With Neurologic Outcomes in Congenital Heart Disease

Neurodevelopmental disabilities are commonly associated with congenital heart disease (CHD), but medical and sociodemographic factors explain only one-third of the variance in outcomes. To examine whether potentially damaging de novo variants (dDNVs) in genes not previously linked to neurodevelopmental disability are associated with neurologic outcomes in CHD and, post hoc, whether some dDNVs or rare putative loss-of-function variants (pLOFs) in specific gene categories are associated with outcomes. This cross-sectional study was conducted from September 2017 to June 2020 in 8 US centers. Inclusion criteria were CHD, age 8 years or older, and available exome sequencing data. Individuals with pathogenic gene variants in known CHD- or neurodevelopment-related genes were excluded. Cases and controls were frequency-matched for CHD class, age group, and sex. Heterozygous for (cases) or lacking (controls) dDNVs in genes not previously associated with neurodevelopmental disability. Participants were separately stratified as heterozygous or not heterozygous for dDNVs and/or pLOFs in 4 gene categories: chromatin modifying, constrained, high level of brain expression, and neurodevelopmental risk. Main outcomes were neurodevelopmental assessments of academic achievement, intelligence, fine motor skills, executive function, attention, memory, social cognition, language, adaptive functioning, and anxiety and depression, as well as 7 structural, diffusion, and functional brain magnetic resonance imaging metrics. The study cohort included 221 participants in the post hoc analysis and 219 in the case-control analysis (109 cases [49.8%] and 110 controls [50.2%]). Of those 219 participants (median age, 15.0 years [IQR, 10.0-21.2 years]), 120 (54.8%) were male. Cases and controls had similar primary outcomes (reading composite, spelling, and math computation on the Wide Range Achievement Test, Fourth Edition) and secondary outcomes. dDNVs and/or pLOFs in chromatin-modifying genes were associated with lower mean (SD) verbal comprehension index scores (91.4 [20.4] vs 103.4 [17.8]; P = .01), Social Responsiveness Scale, Second Edition, scores (57.3 [17.2] vs 49.4 [11.2]; P = .03), and Wechsler Adult Intelligence Scale, Fourth Edition, working memory scores (73.8 [16.4] vs 97.2 [15.7]; P = .03), as well as higher likelihood of autism spectrum disorder (28.6% vs 5.2%; P = .01). dDNVs and/or pLOFs in constrained genes were associated with lower mean (SD) scores on the Wide Range Assessment of Memory and Learning, Second Edition (immediate story memory: 9.7 [3.7] vs 10.7 [3.0]; P = .03; immediate picture memory: 7.8 [3.1] vs 9.0 [2.9]; P = .008). Adults with dDNVs and/or pLOFs in genes with a high level of brain expression had greater Conners adult attention-deficit hyperactivity disorder rating scale scores (mean [SD], 55.5 [15.4] vs 46.6 [12.3]; P = .007). The study findings suggest neurodevelopmental outcomes are not associated with dDNVs as a group but may be worse in individuals with dDNVs and/or pLOFs in some gene sets, such as chromatin-modifying genes. Future studies should confirm the importance of specific gene variants to brain function and structure.

The effect of survival processing on memory for pictures depends on how memory is tested

ABSTRACT Two experiments investigated the effects of survival processing on memory for pictures of objects. In experiment 1, participants were presented with 32 pictures of common objects and rated them for their relevance to a survival scenario, a moving home scenario, or for pleasantness. In a surprise recall test, participants in the survival condition recalled more of the verbal labels of the objects than participants in the moving and pleasantness conditions. In experiment 2, participants rated 64 pictures of objects in survival, moving home, or pleasantness conditions. Memory for visual detail was assessed using a forced-choice recognition test in which participants had to decide which of two highly similar pictures was the one they rated at study. In contrast to the results of experiment 1, correct recognition scores were highest in the pleasantness condition and lowest in the survival condition. This pattern suggests that survival processing enhances memory for objects but not for precise visual detail. The findings are consistent with the view that rating objects for their survival value directs attention to the potential uses of the objects. They also emphasise the importance of the match between encoding and retrieval processes in the survival processing paradigm.

Changes in Medial Prefrontal Cortex Mediate Effects of Heart Rate Variability Biofeedback on Positive Emotional Memory Biases

Previous research suggests that implicit automatic emotion regulation relies on the medial prefrontal cortex (mPFC). However, most of the human studies supporting this hypothesis have been correlational in nature. In the current study, we examine how changes in mPFC-left amygdala functional connectivity relate to emotional memory biases. In a randomized clinical trial examining the effects of heart rate variability (HRV) biofeedback on brain mechanisms of emotion regulation, we randomly assigned participants to increase or decrease heart rate oscillations while receiving biofeedback. After several weeks of daily biofeedback sessions, younger and older participants completed an emotional picture memory task involving encoding, recall, and recognition phases as an additional measure in this clinical trial. Participants assigned to increase HRV (Osc+) (n = 84) showed a relatively higher rate of false alarms for positive than negative images than participants assigned to decrease HRV (Osc−) (n = 81). Osc+ participants also recalled relatively more positive compared with negative items than Osc− participants, but this difference was not significant. However, a summary bias score reflecting positive emotional memory bias across recall and recognition was significantly higher in the Osc+ than Osc− condition. As previously reported, the Osc+ manipulation increased left amygdala-mPFC resting-state functional connectivity significantly more than the Osc− manipulation. This increased functional connectivity significantly mediated the effects of the Osc+ condition on emotional bias. These findings suggest that, by increasing mPFC coordination of emotion-related circuits, daily practice increasing heart rate oscillations can increase implicit emotion regulation.

Normative data for logographic and lexical Japanese paired associates

The current study aimed to provide normative paired-associate data for an unexplored logographic language system (Japanese). 240 participants with a mean age of 21.8 (SD = 3.6) were randomly allocated to one of three conditions in an independent groups design: logographic (Japanese symbol - English word), lexical (Japanese word - English word), or abstract paired associates (Japanese symbol - Japanese word). Participants underwent three study-test trials in each condition. Recall accuracy was found to increase across trials whilst relative item difficulty (correlations between trials in each condition) remained similar. A simultaneous multiple regression revealed that Japanese symbol stroke count was the only reliable and significant predictor of recall accuracy. Metacognitive measures, when correlated with recall accuracy, showed that participants were generally aware of how well they had learned the paired associates. Based on prior research into memory for pictures and words, we hypothesized that the recall accuracy of participants in the logographic condition would exceed that of those in the lexical condition. This hypothesis was rejected following a post hoc independent t-test comparing the two groups. This study provides a thorough normative data set that can be customized by researchers for diverse purposes in addition to novel insights, such as revealing participants’ recall accuracy for abstract paired associates for which they had no previous semantic representations.

Spatial and temporal massive memory in humans

It is well known that humans have a massive memory for pictures and scenes.1,2,3,4 They show an ability to encode thousands of images with only a few seconds of exposure to each. In addition to this massive memory for "what" observers have seen, three experiments reported here show that observers have a "spatial massive memory" (SMM) for "where" stimuli have been seen and a "temporal massive memory" (TMM) for "when" stimuli have been seen. The positions in time and space for at least dozens of items can be reported with good, if not perfect accuracy. Previous work has suggested that there might be good memory for stimulus location,5,6 but there do not seem to have been concerted efforts to measure the extent of this memory. Moreover, in our method, observers are recalling where items were located and not merely recognizing the correct location. This is interesting because massive memory is sometimes thought to be limited to recognition tasks based on sense of familiarity.

Polygenic risk score for Alzheimer’s disease and APOE ε4 status in relation to cognitive decline: a population‐based study of individuals followed over 16 years.

AbstractBackgroundPolygenic risk scores for Alzheimer’s disease (AD‐PRS) have been associated with incident AD and dementia. However, few long‐term studies have examined the effect of AD‐PRSs, and the interaction with APOE ε4 status, on cognitive performance over time in the general population.MethodA population‐based sample of 855 participants born 1930 were examined at age 70, 75, 79, and 85 years. AD‐PRSs that surpassed four P value thresholds (P<5e‐8, P<1e‐5, P<1e‐3, P<1e‐1) were generated based on information from recent genome‐wide association studies. Cognitive performance was measured at all examinations using a composite global cognitive score based on five psychometric tests (Thurstone’s Picture Memory, immediate recall of 10 words, Block Design, PSIF [perceptual speed], and Mini‐Mental State Examination score). Linear mixed effect models with random intercepts and slopes were used to analyze the effect of AD‐PRSs and APOE ε4 status on cognitive performance. The models included sex*age, AD‐PRS*age, APOE ε4 status*age, and 10 principal components to correct for population stratification. Analyses were repeated in samples without prevalent and incident dementia.ResultThe interaction‐term 5e‐8 AD‐PRS*age (β=‐0.2, P=.03) and APOE ε4 status*age (β=‐0.2, P=.02) were associated with cognitive decline. The results remained in those without prevalent and incident dementia (the 5e‐8 AD‐PRS*age: β=‐0.2, P=.02, APOE ε4 status*age: β=‐0.2, P=.007). No association was observed between AD‐PRSs that surpassed P value thresholds >5e‐8 and cognitive performance over time (1e‐5 AD‐PRS*age: β=‐0.06, P=.08, 1e‐3 AD‐PRS*age: β=‐0.03, P=.3, and 1e‐1AD‐PRS*age: β=‐0.02, P=.6). Further, neither APOE ε4 status nor AD‐PRSs were associated with cognitive performance at baseline (APOE ε4 status: β=‐0.9, P=.3, the 5e‐8 AD‐PRS: β=0.6, P=.5, 1e‐5AD‐PRS: β=0.5, P=.2, 1e‐3 AD‐PRS: β=0.5, P=.1, and 1e‐1 AD‐PRS: β=0.2, P=.6).ConclusionWe found an effect of a 5e‐8 AD‐PRS and APOE ε4 status on cognitive decline in individuals from the general population followed over 16 years, regardless of dementia diagnosis. These results contribute with additional knowledge to identify individuals at increased risk of cognitive decline, which may be important to implement personalized prevention as early as possible.

Encoding-phase orientation toward thematic content over perceptual style benefits picture memory

ABSTRACT Orienting toward the meaning versus perceptual features of an experience benefits subsequent memory. Yet given that past work encouraged these orientations with different tasks, it is not clear if this memory benefit is solely due to internal processing factors versus external task-related ones. Moreover, it remains unclear how this benefit generalises from verbal to detailed picture memory. Here, we developed a novel paradigm that cued participants’ attention to thematic (story) or stylistic (artist style) dimensions of storybook-style illustrations during a repeat-detection task. Afterwards, participants completed a recognition memory test with studied illustrations and lures along thematic and stylistic dimensions. In contrast to past work, both orienting tasks were identical except for the dimension participants were cued to attend to. Furthermore, our thematic and stylistic dimensions enabled us to separately examine memory quality along each dimension. We found that thematic attention yielded superior memory for studied illustrations over stylistic orientations. False alarms to lures varied by dimension and attention: errors were greater to thematic than stylistic lures overall and stylistic attention elevated false alarms to stylistic lures. Our results show that semantic encoding orientations enhance detailed picture memory, without a cost to memory quality along semantic or perceptual dimensions of experience.

Measuring memory is harder than you think: How to avoid problematic measurement practices in memory research.

We argue that critical areas of memory research rely on problematic measurement practices and provide concrete suggestions to improve the situation. In particular, we highlight the prevalence of memory studies that use tasks (like the "old/new" task: "have you seen this item before? yes/no") where quantifying performance is deeply dependent on counterfactual reasoning that depends on the (unknowable) distribution of underlying memory signals. As a result of this difficulty, different literatures in memory research (e.g., visual working memory, eyewitness identification, picture memory, etc.) have settled on a variety of fundamentally different metrics to get performance measures from such tasks (e.g., A', corrected hit rate, percent correct, d', diagnosticity ratios, K values, etc.), even though these metrics make different, contradictory assumptions about the distribution of latent memory signals, and even though all of their assumptions are frequently incorrect. We suggest that in order for the psychology and neuroscience of memory to become a more cumulative, theory-driven science, more attention must be given to measurement issues. We make a concrete suggestion: The default memory task for those simply interested in performance should change from old/new ("did you see this item'?") to two-alternative forced-choice ("which of these two items did you see?"). In situations where old/new variants are preferred (e.g., eyewitness identification; theoretical investigations of the nature of memory signals), receiver operating characteristic (ROC) analysis should be performed rather than a binary old/new task.

The influence of memory for impressions based on behaviours and beliefs on approach/avoidance decisions

ABSTRACT Recent work has shown that memory for various types of information associated with social targets (impressions based on behaviours and political ideology) influences decisions to approach or avoid those same targets. The current study was intended to better understand the extent that memory for other types of details associated with targets (beliefs and behaviours) affects subsequent approach/avoidance decisions. In this investigation, participants formed impressions of social targets represented by a picture and a sentence (a belief in Experiment 1; either a belief or behaviour in Experiment 2). Later, memory for the impressions and sentences associated with each target was tested. Finally, participants decided whether they would want to approach or avoid each target. Results demonstrated that accurate memory strongly influenced approach/avoidance decisions for targets associated with different types of information (beliefs; behaviours), although there was no difference in the effect of memory between beliefs and behaviours. Overall, results suggest an important role of memory in decisions to approach or avoid others.

Directed forgetting of pictures of everyday objects.

Directed forgetting is a laboratory task in which subjects are explicitly cued to forget certain items and remember others. Volitional control over the contents of memory has been used to study clinical disorders, with successful intentional control of memory being a hallmark of a healthy mind. Yet the degree of volitional forgetting over the content of visual long-term memory is unclear when compared to words. Different kinds of visual stimuli (e.g., abstract symbols, line drawings, scenes) may not equally be susceptible to voluntary control in memory, and intentional forgetting studies have shown both twice as much forgetting of pictures compared to words (think/no-think task) and half as much forgetting of pictures compared to words (directed forgetting task). In the present study, we systematically test volitional control over pictures of everyday objects using item-method directed forgetting procedures. We find that subjects are able to intentionally prioritize memory for pictures cued as to be remembered over pictures cued to be forgotten. Here we show that directed forgetting effects are observed using pictures of everyday objects (albeit to a weaker extent compared to directed forgetting of words), suggesting increased confidence for generalization of directed forgetting literature to real-world applications. However, we caution clinical applications of intentional memory control until the underlying direction causing this effect (upregulation of remember-cued items or downregulation of forget-cued items) is known.

EPQuant: A Graph Neural Network compression approach based on product quantization

Graph Neural Networks (GNNs) have been widely used in graph analysis due to their strong performance on a wide variety of tasks. Unfortunately, as the size of graphs keeps growing, large graphs can easily consume Terabytes, and training on such graphs may take days. The high memory footprint limits the usage of GNNs on resource-constrained devices like smartphones and IoT devices. Hence, reducing the storage cost, training time, and inference latency is highly desirable. In this work, we apply Product Quantization (PQ) on GNNs for the first time to achieve superior memory capacity reduction. To alleviate the processing burden caused by PQ and improve compression performance, we propose Enhanced Product Quantization (EPQ). It reduces the input graph data, which tends to dominate memory consumption, and accelerates clustering in PQ. Moreover, an efficient quantization framework11Github repository:https://github.com/Lyun-Huang/EPQuant for GNNs is proposed, which combines EPQ with Scalar Quantization (SQ), to achieve improved compression performance and computation acceleration on off-the-shelf hardware, enabling the deployment of GNNs on resource-constrained devices. In addition, the proposed quantization framework can be applied to the existing GNNs without too much porting effort. Extensive experimental results show that the proposed quantization scheme can achieve 321.26× and 184.03× memory capacity compression for input graph data and overall storage, respectively. This impressive memory reduction can come with an accuracy loss of less than 1%.

Musical emotions affect memory for emotional pictures

Music is widely known for its ability to evoke emotions. However, assessing specific music-evoked emotions other than through verbal self-reports has proven difficult. In the present study, we explored whether mood-congruency effects could be used as indirect measures of specific music-evoked emotions. First, participants listened to 15 music excerpts chosen to induce different emotions; after each excerpt, they were required to look at four different pictures. The pictures could either: (1) convey an emotion congruent with that conveyed by the music (i.e., congruent pictures); (2) convey a different emotion than that of the music, or convey no emotion (i.e., incongruent pictures). Second, participants completed a recognition task that included new pictures as well as already seen congruent and incongruent pictures. From previous findings about mood-congruency effects, we hypothesized that if music evokes a given emotion, this would facilitate memorization of pictures that convey the same emotion. Results revealed that accuracy in the recognition task was indeed higher for emotionally congruent pictures than for emotionally incongruent ones. The results suggest that music-evoked emotions have an influence on subsequent cognitive processing of emotional stimuli, suggesting a role of mood-congruency based recall tasks as non-verbal methods for the identification of specific music-evoked emotions.

QOL-18. Neuropsychological screening in a pediatric neuro-oncology multidisciplinary clinic.

Abstract BACKGROUND: The purpose of this project was to examine the usefulness of neuropsychological screening in a multidisciplinary clinic for neuro-oncology populations and determine whether a brief evaluation can adequately screen children for cognitive dysfunction or psychiatric comorbidities. METHODS: Thirty-one children or young adults with a history of CNS tumor had neuropsychological screening as part of their multidisciplinary clinic visit. This screening evaluation consisted of clinical interview, neuropsychological testing, and the completion of emotional/behavioral checklists. Our neuropsychological test battery included the Kaufman Brief Intelligence Test-Second Edition (KBIT-2) and the NIH Toolbox Fluid Cognition Composite, which consists of 6 subtests - flanker task, working memory, processing speed, oral reading, card sort, and memory. RESULTS: Over a 15-month period 31 children, adolescents, and young adults with CNS tumors were seen in our neuropsychology screening clinic. Females made up 39% of the sample. The average age was 12.7 years (range=5–24 years). The average time to complete neuropsychological testing was 60.3 minutes. Thirty-six percent did not have any new neuropsychological diagnoses, 42% had one new diagnosis, 19% had two new diagnoses, and 3% had three new diagnoses. The most common new diagnoses were mild or major neurocognitive disorder (mild=29%, major=6%), anxiety (32%), ADHD (10%), and mood disorder (13%). Neurocognitive test scores were mostly in the average range (Verbal-IQ=97.7; Nonverbal-IQ=95.3; Total IQ=96.2; Flanker T-Score=46.1; Working Memory T-Score=44.0; Card Sort T-Score=43.7; Picture Memory T-Score=48.5). Processing speed and fluid cognition composite scores for the group were in the low-average range (Processing Speed T-Score=42.7; Fluid Cognition Composite T-Score=41.4). Behavioral health recommendations were needed for 71% of this sample. Educational recommendations were needed for 58%. CONCLUSIONS: Brief neuropsychological screening completed as part of multidisciplinary clinics for pediatric neuro-oncology patients was efficient and useful in identifying neuropsychological diagnoses in children and assisted with informing necessary behavioral health and academic interventions.

A Study of English Learning Vocabulary Detection Based on Image Semantic Segmentation Fusion Network.

College students learn words always under both teachers' and school administrators' control. Based on multi-modal discourse analysis theory, the analysis of English words under the synergy of different modalities, students improve the motivation and effectiveness of word learning, but there are still some problems, such as the lack of visual modal memory of pictures, incomplete word meanings, little interaction between users, and lack of resource expansion function. To this end, this paper proposes a stepped image semantic segmentation network structure based on multi-scale feature fusion and boundary optimization. The network aims at improving the accuracy of the network model, optimizing the spatial pooling pyramid module in Deeplab V3+ network, using a new activation function Funnel ReLU (FReLU) for vision tasks to replace the original non-linear activation function to obtain accuracy compensation, improving the overall image segmentation accuracy through accurate prediction of the boundaries of each class, reducing the intra-class error in the prediction results. The accuracy compensation is obtained by replacing the original linear activation function with FReLU. Experimental results on the Englishhnd dataset demonstrate that the improved network can achieve 96.35% accuracy for English characters with the same network parameters, training data and test data.

Does multisensory study benefit memory for pictures and sounds?

Studies have found a multisensory memory benefit: higher recognition accuracy for unimodal test items that were studied as bimodal items than for those studied as unimodal items. This is a surprising finding because the encoding specificity principle predicts that memory performance should be better with greater overlap between processing during study and test. We used Thelen, Talsma, and Murray's (2015) method who previously found a multisensory memory benefit. Items were presented as unimodal (picture or sound) or bimodal (picture and sound) items in a continuous recognition task in which only one modality was task-relevant. In four experiments we obtained little evidence for a difference in memory performance between items studied as unimodal or bimodal stimuli, but there was a benefit of study-test overlap in format if sound was the task-relevant modality. Task-induced attention for the irrelevant modality or response bias may have played a role in previous studies. We conclude that the multisensory memory benefit may not be a general finding, but rather one that is found only under conditions that induce participants to pay attention to the task-irrelevant modality.

Multi-domain Cognitive Testing: A Biomarker for Classifying the Cognitive Status of Mild Cognitive Impairment and Alzheimer's Disease.

Cognition is impaired in Alzheimer's disease (AD) and patients with mild cognitive impairment (MCI) with varying levels of magnitude. The present study aimed to identify a biomarker for classifying MCI and AD using multi-domain cognitive testing. This was a cross-sectional study. 26 AD patients, 28 MCI patients and 25 controls were recruited. Cognitive assessment of different domains was done using standard questionnaires and cognitive function tests. Cognitive task scores were compared between the groups using multivariate analysis of variance (MANOVA). Patients with AD had significantly lower MMSE, CDR, cognitive task scores compared to controls and MCI. Cognitive scores of all tasks for MCI were significantly less than controls, except MMSE and digits forward score. ROC analysis showed that picture memory had 100% sensitivity, 91.6% specificity for AD and 88.4% sensitivity, 92.5% specificity for MCI. Word memory had 92.3% specificity, 100% specificity for AD and 80.7% specificity, 84.6% specificity for MCI. The global cognitive tools are less specific in bringing out the differences especially between MCI and control. Limitation of MMSE, heterogeneity of MCI and differential impairment of various domains of cognition, demands the inclusion of multi-domain cognitive evaluation especially picture and word memory tasks with high sensitivity and specificity into the existing diagnostic protocol. ROC results also suggested the continuum of cognitive impairment and MCI as a transitional stage leaving more scope on the quantum of research required for intervention to halt the structural and functional decline.

Multisensory synchrony of contextual boundaries affects temporal order memory, but not encoding or recognition

We memorize our daily life experiences, which are often multisensory in nature, by segmenting them into distinct event models, in accordance with perceived contextual or situational changes. However, very little is known about how multisensory boundaries affect segmentation, as most studies have focused on unisensory (visual or audio) segmentation. In three experiments, we investigated the effect of multisensory boundaries on segmentation in memory and perception. In Experiment 1, participants encoded lists of pictures while audio and visual contexts changed synchronously or asynchronously. After each list, we tested recognition and temporal associative memory for pictures that were encoded in the same audio-visual context or that crossed a synchronous or an asynchronous multisensory change. We found no effect of multisensory synchrony for recognition memory: synchronous and asynchronous changes similarly impaired recognition for pictures encoded at those changes, compared to pictures encoded further away from those changes. Multisensory synchrony did affect temporal associative memory, which was worse for pictures encoded at synchronous than at asynchronous changes. Follow up experiments showed that this effect was not due to the higher dimensionality of multisensory over unisensory contexts (Experiment 2), nor that it was due to the temporal unpredictability of contextual changes inherent to Experiment 1 (Experiment 3). We argue that participants formed situational expectations through multisensory synchronicity, such that synchronous multisensory changes deviated more strongly from those expectations than asynchronous changes. We discuss our findings in light of supportive and conflicting findings of uni- and multi-sensory segmentation.

Determinants of quality, specificity, and stability of emotional episodic memories in a fine-dining context

For theoretical and practical reasons, it is of great interest to understand how accurate and persistent episodic memories of enjoyable experiences are formed and maintained, for example, in the context of gastronomy and other instances of experience design. Here, we investigated factors that might affect the quality (a measure of coherence) of immediate and long-term emotional episodic memories of individual dishes of a long and complex dinner in a fine-dining restaurant. We also assessed long-term recognition memory for pictures of the dishes. Intra-class correlations revealed good immediate emotional episodic memory, which remained stable over three months. Contributing factors to these kinds of memory were assessed with path modelling. The quality of emotional episodic memory was enhanced by the hedonic intensity of the most valued dishes during the meal and was impaired with the hedonic intensity of the least valued dishes. Enjoying the final dish positively affects emotional memory after the experience. Interestingly, when diners reported to have been distracted from the meal, presumably by communicating with their meal companions about the food, it had a positive effect on the long-term emotional episodic memory. Personality traits of the diners had no substantial impact on either type of memory. Alcohol intake during the meal modestly affected recognition memory but – interestingly – had no statistically significant effect on emotional episodic memory. Altogether, this study provides novel information about the main determinants of the precision and temporal stability of emotional episodic memory and nonemotional recognition memory for a meal. These findings contribute to the psychological foundations of designing memorable experiences in gastronomy and other areas. Implications for gastronomyKnowing what factors may determine whether a gastronomic experience would be memorable to diners is the holy grail of any chef. The design of a gastronomic experience should provide intense emotional moments to the diners aiming to increase the quality of emotional memory of those moments. Different factors contribute to this stability, for instance, how the diner interacts with the food and the food itself. In this regard, serving in a dining course very tasty and less delicious dishes thereafter can enhance the memorability of the former, but not so much of the latter, as it may be disturbing for the diner. Critically, enjoying the final dish positively affects emotional memory after the experience. In addition, most gastronomic events are shared with companions. Far from being a distracting element, social relationships in a table seem to increase the memorability of the experience, as communication deeply elaborates and reinforces memory traces. In the reinforcement of emotional memories for foods, alcohol has a negligible effect. Although our findings have been obtained in a fine-dining context, the implications of our current findings might be generalizable to other, more standard contexts. The critical point is to focus on having positive specific episodes rather than having a positive global valuation. All these outcomes would converge to increase the probability of repeating the gastronomic experience, regardless of whether it is a high-level restaurant or a standard one.

The Effect and Mechanism of Transcranial Direct Current Stimulation on Episodic Memory in Patients With Mild Cognitive Impairment.

ObjectiveThis study aimed to investigate the efficacy of transcranial direct current stimulation (tDCS) on episodic memory in patients with mild cognitive impairment (MCI) and analyze the neural mechanism of tDCS therapy from the perspective of neuroelectrophysiological parameters.MethodsForty MCI patients were recruited and randomly divided into a sham group (n = 20) and a tDCS group (n = 20). Patients in the tDCS group were treated with a tDCS instrument for 20 min, once a day, for 5 days. Patients in the sham group were treated with sham stimulus. Montreal Cognitive Assessment Scale (MoCA), Wechsler Memory Scale (WMS), and event-related potential (ERP) (amplitude and latency of P300 wave) were comparatively assessed between the two groups at pre-treatment, 5 days and 4 weeks post-treatment points.ResultsThe two groups showed no significant difference in any of the assessed parameters at pre-treatment (P > 0.05). At 5 days post-treatment, memory quotient (MQ) score in the tDCS group significantly increased (P < 0.05), scores of picture memory, visual regeneration, logical memory, memory span, visual regeneration-delay, and logical memory-delay were significantly increased compared to pre-treatment (P < 0.01). The P300 amplitude significantly increased, and its latency significantly shortened (P < 0.01). Four weeks post-treatment, the scores of MQ and visual regeneration-delay in the tDCS group increased, compared to pre-treatment (P < 0.05); picture memory, visual regeneration, logical memory, memory span, and logical memory-delay improved (P < 0.01); the P300 amplitude increased, and its latency shortened (P < 0.01). At 5 days and 4 weeks post-treatment points, the tDCS group, compared with the sham group (P < 0.01), exhibited greater scores of MQ, picture memory, visual regeneration, logical memory, memory span, visual regeneration-delay, and logical memory-delay, increased P300 amplitude, and shortened P300 latency. Similarly, the tDCS group showed higher MQ scores at 5 days post-treatment (P < 0.05) and 4 weeks post-treatment (P < 0.01). Before treatment and after 5 days of treatment, P300 amplitude and latency difference were positively correlated with MQ difference (P < 0.05).ConclusiontDCS improved episodic memory in MCI patients, and the effect lasted for 4 weeks. Changes in ERP (P300) suggested that tDCS could promote changes in brain function.

Sometimes it helps to be taken out of context: Memory for objects in scenes

ABSTRACT It is well known that humans demonstrate massive and surprisingly rich recognition memory for objects and/or scenes and that context typically aids retrieval of episodic memories. However, when we combine picture memory for 100 objects with the context in the form of a background scene, we find that irrelevant contexts lead to substantial impairments of object memory. Twelve experiments used a standard long-term, picture memory paradigm. Backgrounds could be semantically consistent or inconsistent scenes or simple arrays of objects. In all cases, the target object to be remembered was clearly marked by an outline box. Backgrounds were always known to be irrelevant, but, nevertheless, significantly reduced old/new discrimination for target objects. Interference from the scene was apparently unavoidable, suggesting that the seemingly effortless encoding that makes it easy to store scenes into memory, makes it hard to avoid interference with the encoding and recognition of objects placed in or on those scenes.