Crew Members Research Articles

Dietary Rhythmicity and Mental Health Among Airline Personnel

Misaligned dietary rhythmicity has been associated with metabolic diseases; however, its association with mental health remains largely unexplored. To examine the association between dietary rhythms and the mental health condition of shift workers, specifically airline crew members. This cross-sectional study analyzed data collected from the Civil Aviation Health Cohort of China, an ongoing large-scale health survey of pilots, flight attendants, and air security officers employed by major airline companies in China. Participants aged 18 to 60 years were invited through text messages to complete a web-based survey. The data collection period was December 2022 to March 2023. Statistical analysis was performed from July 24, 2023, to April 12, 2024. Data on timing of breakfast and dinner on workdays and rest days, daily time windows for food intake, and meal and eating jet lags were collected and calculated. Anxiety and depressive symptoms were measured using the 7-item Generalized Anxiety Disorder Assessment and the 9-item Patient Health Questionnaire. Multivariate logistic regressions were performed to evaluate the associations of anxiety and depression with meal timing, eating window time, meal jet lag (ie, delayed meals), and eating jet lag (ie, delayed eating). All models were adjusted for individual socioeconomic, demographic, and lifestyle characteristics. Of the 22 617 participants (median [IQR] age, 29.1 [26.3-33.7] years; 13 712 males [60.6%]), 1755 (7.8%) had anxiety and 2768 (12.2%) had depression. After controlling for confounding factors, having dinner after 8 pm on morning-shift days was associated with increased odds of anxiety (adjusted odds ratio [AOR], 1.78; 95% CI, 1.53-2.05) and depression (AOR, 2.01; 95% CI, 1.78-2.27), compared with consuming dinner before 8 pm. Similar results were observed on night-shift days and rest days. An eating window of less than 12 hours was associated with reduced odds of anxiety (AOR, 0.84; 95% CI, 0.75-0.93) and depression (AOR, 0.81; 95% CI, 0.75-0.89) on morning-shift days; the results remained significant on rest days. Delayed dinner on morning-shift days was associated with increased odds of anxiety (AOR, 1.32; 95% CI, 1.13-1.54) and depression (AOR, 1.39; 95% CI, 1.22-1.58). On night-shift days, delayed dinner was associated with higher odds of anxiety (AOR, 1.22; 95% CI, 1.06-1.39) and depression (AOR, 1.21; 95% CI, 1.08-1.36). On morning-shift days, delayed eating rhythms were associated with higher odds of depression (AOR, 1.35; 95% CI, 1.13-1.61), whereas advanced eating rhythms were associated with lower odds of anxiety (AOR, 0.78; 95% CI, 0.70-0.87). This cross-sectional study found that meal timing, long eating window, and meal jet lags were associated with increased odds of depression and anxiety. These findings underscore the need for interventions and supportive policies that help mitigate the adverse implications of shift work and irregular working hours for the mental health of shift workers.

The Impact of Vessel/Ship Noise on the Productivity and Well-being of Maritime Crew: A Holistic Examination

This comprehensive survey examines the impact of vessel/ship noise on the productivity and well-being of 500 maritime crew members. The study explores the multifaceted repercussions of regular exposure to ship-related noise on both the operational efficiency and overall health of seafarers. Through an extensive examination of existing literature and first-hand assessments, the research delves into the physiological and psychological effects of vessel noise on crew members. Statistical Package for the Social Sciences (SPSS) and descriptive geometry were utilized to analyse the field response data. Additionally, it evaluates the potential implications for maritime safety and productivity. Investigated noise levels range from 60 to 110 dB, observed productivity ranges from 40 to 90%, and well-being ranges from 60 to 95%. The findings from this survey offer valuable insights to the maritime industry, illuminating the complex relationship between ship noise, crew well-being, and operational performance. Keywords: Maritime Noise Impact, Crew Well-being, Holistic Examination, Productivity Challenges and Vessel Sound Effects.

Predicting muscle function and mass with electrical impedance myography: A study in rat analogs of micro- and partial gravity

IntroductionSpaceflight results in marked muscle atrophy and a corresponding loss in muscle strength. Methods to evaluate spaceflight-induced changes to muscle size and strength are difficult to achieve within the tight confines of spacecrafts. Therefore, convenient methods to non-invasively monitor muscle that are predictive of actual muscle function are critical for future missions to ensure the health and safety of crew members. PurposeEvaluate the ability of non-invasive in vivo electrical impedance myography (EIM) combined with statistical models to predict muscle size and strength in rodent models of micro- and partial gravity. MethodsMale and female Fisher rats (N = 120), half gonadectomized, were divided into three different weightbearing (WB) conditions of 40 animals each, including 0%WB (0 % of weight-bearing, simulated microgravity), 40%WB (40 % of weight-bearing, simulated Martian gravity), and 100%WB (100 % of weight-bearing, full weight-bearing controls). Rats remained in designated interventions for 28 days. Afterward, rats underwent a series of musculoskeletal strength assessments and measurement of EIM. Rats were then euthanized and gastrocnemius tissues collected. Machine-learning (ML) algorithms were applied to full spectrum EIM data to predict various muscle parameters. Results40%WB and 0%WB rats had lower grip strength and plantar flexion compared to 100%WB. Correspondingly, 40%WB and 0%WB also had reduced gastrocnemius mass compared to 100%WB. EIM resistance values demonstrated a dose-dependency response, with greater resistance values associated with reduced gravitational load. ML-enhanced EIM yielded strong predictions of muscle plantar flexion force and muscle mass, with root mean squared errors of 18.4 % of 22.0 %, and R2 values of 0.87 an 0.88, respectively. ConclusionML-enhanced EIM may be a helpful tool to non-invasively monitor muscle changes predictive of muscle force production and mass during exposure to reduced gravity.

Optimizing translucent multilayer membrane for lunar habitats: A design study

In the recently boosted scenario, the eventual settlement in extreme extra-terrestrial environments, notably the Moon and Mars, stands as critical objective driving the forefront of space exploration endeavours: the possibility of realizing a lunar settlement is currently under study by NASA Artemis Program and others active subjects in the aerospace sector (Schrunk et al., 2008) [1]. As mission duration tends to increase, the wellness of crew members emerges as a stronger concern, affecting the habitat features and driving the design towards solutions that still must face environmental constraints. A wide exploration in the aerospace field has been conducted, starting from the experience accumulated in more than 50 years of experimentation and activity on board of the active and decommissioned space stations.In recent years, several pioneering concepts for human living structures on our satellite have been proposed, with an extensive adoption of transparent inflatable or deployable shells. Even if these proposals can lead the way for optimized solution identification, the technical characterization of these shells has not been extensively explored yet, and it represents a mandatory step in the path for achieving the best possible prototype to be built on the Moon surface. Our research aims to assess the viability of employing transparent or translucent inflatable-type envelopes within the harsh conditions of extra-terrestrial environments.The research background has been extensively investigated in order to identify best practices and promising solutions, which have been proposed here. Where no previous tests were conducted, traditional Earth-related engineering tools where utilized. The result of this work is a multilayer membrane to be deployed through internal air pressurization, with the correct size of each of the composing layers calculated by employing multi-physics simulations employing multi-physics simulations and computational.The outcome of this work represents not a definitive design, but an introductive experience with the aim to launch wider investigations to reach higher TRLs. Finally, we aimed to identify the limits of this research that need to be addressed in order to make an inflatable multilayer membrane feasible to be adopted for long permanent human missions on the Moon.

Navigating the Skies: Unraveling Communication Challenges in Diverse Aviation Accidents

Effective communication is the lifeline of aviation safety, serving as the cornerstone for preventing accidents, mitigating crises, and ensuring seamless coordination among diverse stakeholders within the complex and dynamic aviation environment. The aim of this study is to provide a qualitative analysis of the 10 fatal accidents in aviation history and incidents and accidents that occurred in the past 10 years registered by the National Transportation Safety Board (NTSB). The content analysis of the reports of the fatal accidents and reports of the 48 events identified in the accident database search revealed themes such as miscommunication between flight crew members, challenges in emergent situations, and communication breakdowns with ATC. These findings align with existing literature, emphasizing the pivotal role of communication in aviation safety. The study offers recommendations to invest in CRM training, standardized phraseology, and advanced communication technologies for aviation safety. Future research directions include exploring human-machine interaction, artificial intelligence, and communication in Unmanned Aerial Systems. Moreover, grounded in these findings, airline companies can infer practical implications such as improved safety, operational efficiency, stress reduction, cost savings, regulatory compliance, and trust-building, thereby emphasizing the industry's commitment to continuous improvement in navigating the complexities of aviation communication.

Effect of Experience and Professional Role on Psychophysiological Stress Response in an Underwater Evacuation Training

Background: This research aimed to analyze the effect of experience and professional role on psychophysiological stress response in underwater evacuation training. Methods: We analyzed 36 participants (39.06±9.01 years), divided into two different groups; 17 crew members (38.6±7.2 years) and 19 medical members (39.5±10.5 years). modifications in the rating of perceived exertion, subjective stress perception, heart rate, blood oxygen saturation, cortical arousal, heart rate variability, spirometry, isometric hand strength, and short-term memory before and after underwater evacuation training were analyzed. Results: The maneuver produced a significant increase in SSP, RPE, IHS, FVC, and SatO2 at different moments of the intervention, being higher in crew members. Conclusions: We found that the underwater evacuation training produced an anticipatory anxiety response, and an increase in autonomous sympathetic nervous system modulation not affecting strength capacities, cortical arousal, and memory independently of the aircraft role (medical or crew).

The actual issues of detection of risk factors and prevention of myocardium infarction in sailors

In Russia, increases morbidity of myocardial infarction. The statistics of recent years demonstrate failure in meeting target indicators of national programs on reducing number of deaths from this disease. At that, able-bodied population is in high risk zone and their professional activity is under influence of large combination of risk factors of myocardial infarction. This risk area covers profession of seafarer that is characterized by irregular work schedule, high levels of stress and mental tension, low physical activity or, contrariwise, increased working loads, unbalanced diet, isotherm stress and interaction with harmful substances. Besides that, situation is aggravated by limited set of first medical aid measures at exacerbation of disease in view of remoteness from hospitalization centers. Thus, considering high mortality rate from myocardial infarction, it is extremely important for ship crews to have full and timely information about diagnostic, symptomatic and prevention of this disease. The article examines statistics data of morbidity and mortality of myocardial infarction in population of the Russian Federation on the basis of Rosstat data and target indicators of the National project "Health Care". The risk factors of myocardial infarction established by INTERHEART studies are analyzed. The specifics of work conditions of crew members of marine vessels are established. The collection of professional modifying risk factors was selected. The recommendations for their correction were developed to enhance efficiency of primary preventive measures and to decrease morbidity and mortality among seafarers.

Economic Dynamics of Urban Fishermen in Muarareja: The Death of Fish Auction Places

This study examines the closure of the Fish Auction Place (TPI) in Muarareja, which was caused by debt agreements between fishermen and fish traders for boat purchases. The closure of the TPI has led to fishermen losing access to a competitive sales platform and becoming dependent on the traders' markets. The research method used was qualitative with a case study approach, through semi-structured interviews, direct observation, and documentation. The research participants included 6 skippers or fishermen who own ships, 5 crew members (ABK), 6 collectors or traders, and 3 mothers who make salted fish around the TPI. Data collection was carried out from June 1 to August 28, 2023. The purpose of the study was to analyze changes in the dynamics of patron-client relationships among fishermen in Muarareja and to examine the economic and social impacts of the closure of the TPI. The results showed that the closure of the TPI changed the mechanism of buying and selling fish to be more closed to patrons (traders), which significantly affected the social and economic dynamics of urban fishermen. Based on these findings, it is recommended to examine the effectiveness of alternative programs such as fishermen's cooperatives or micro-loans, and further research is needed on the revitalization of the TPI to improve the overall welfare of fishermen. In the context of public policy, it is also necessary to consider strategies that strengthen the capacity of fishermen in facing increasingly complex global economic challenges. This research is expected to provide significant theoretical and practical contributions to the field of sociology, especially economic sociology.

Promosi Kesehatan Penyakit Menular Dan Tidak Menular Pada SMPLB Menggunakan Metode Permainan Edukatif Flash Card

ABK (Children with Special Needs) are children who have physical, intellectual and emotional characteristics that are lower or higher than normal children their age. ABK can also be defined as children who have weaknesses and disabilities. Limited knowledge of crew members, especially in maintaining health, can reduce the health status of ABK. The community service carried out is one of the interventions that can be provided, the focus of the problem is regarding understanding infectious and non-infectious disease using the flash card educational game method. This health promotion aims to increase ABK knowledge about health so that they can reduce morbidity rates due to infectious and non-infectious disease. Using educational flash card games is one of innovations used in community service, adapting the learning by playing method. The level of knowledge of the 30 respondents was proven to have increased, which was measured through pre and post test questionnaires. The average post test score increased or was higher after providing health education using educational flash card games, namely from 37.7 to 65.6. There was an increase in understanding and knowledge of SMPLB students and students about infectious and non-infectious disease by 53.3% after being given health education using the flash card educational game method. The flash card educational games method is effective for use in the teaching and learning process and also as innovation in delivering material in community service to ABK respondents.

Physical Attractiveness and Social distance Perception in Service Encounters- Evidence from a Developing County

Physical Attractiveness (PA) is an essential factor affecting consumer response (CR) in service encounters (SE). Using an experimental design, the purpose of the study is to demonstrate the physical attractiveness (PA) of a service representative's effects (CR) in the context of consumer satisfaction, service quality perception, and likability of the service representative. The study investigated the complex underlying mechanism between these two variables by analyzing the mediating role of social distance perceptions (SDP), and the moderating role of consumer’s physical attractiveness (CPA) and gender. The context of the study is the Airline Industry of Pakistan. The data of the study was collected through scenario based self-administered questionnaires from in-flight 385 passengers using non-probability sampling (voluntary response sampling) from. Analyzing the results of the study it is predicted that high PA has a positive effect on CR. Hence it is also important to take the consumer’s perspective into consideration, as this perspective gives rise to situations under which the beauty premium notion might not hold. The results of the study revealed that a consumer’s gender and his/her own level of PA is an important determinant of how he/she reacts to the attractiveness of the representative. Results can provide significant insights to Airline companies to strategize the recruitment and deployment of cabin crew members in accordance with the level of the customer’s gender and his/her own (PA).

Legal challenges of regulating cross-border nuclear pollution from ship ballast water under the background of fukushima wastewater release and China’s response

The Japanese government has initiated plans to release water contaminated The international community has yet to fully recognize the accelerated spread of nuclear-contaminated water through ship ballast water along the Japanese route. This increases the risk of nuclear exposure for crew members and poses ecological and environmental contamination risks to port waters, inland seas, and rivers. The lack of international attention to the marine nuclear safety crisis caused by nuclear pollution from ballast water, along with the absence of corresponding legal prevention and control mechanisms and technical safeguards, remains a critical issue. From the perspective of international law, preventing the spread of Fukushima wastewater through ship ballast water faces numerous legal challenges, including disputes over the applicability of conventions, the jurisdiction of international organizations, and mechanisms for cross-border accountability for marine nuclear pollution. As a major shipping nation adjacent to Japan, China faces significant risks of nuclear pollution from ballast water along the Japanese route. To counter such risks, it is recommended to propose measures through the International Maritime Organization to elevate international attention. Moreover, refining ballast water regulatory frameworks, establishing monitoring and warning mechanisms specific to nuclear pollution from ballast water, improving the technical capabilities of ballast water treatment systems, and promoting international cooperation in monitoring marine environments and preventing pollution are also advisable.

Perancangan Sistem Alarm Kebisingan untuk Kapal Penangkap Ikan Berbasis Arduino Uno dengan Sensor KY-037

Fishermen are highly susceptible to hearing impairment due to prolonged exposure to the high-intensity noise of boat engines. While numerous studies have investigated the noise intensity levels of boat engines, no research has been conducted on noise warning alarm systems for fishing boats. Therefore, this study aims to develop a sound noise alarm system based on Arduino Uno with a KY-037 sensor for fishing boats, which is expected to reduce the potential for hearing impairment among fishermen. This research employs a quantitative descriptive approach, with data collected through experimental methods and analyzed by comparing noise level data at various engine speeds. The results of the noise level measurements of boat engines at the Fish Landing Base (PPI) in Cikidang, Pangadaran Regency, indicate that the majority of fishermen are safe from hearing impairment due to engine noise, as most boats there are small, with a Gross Tonnage (GT) capacity of under 5 GT. The risk of hearing impairment emerges for boats with a capacity of 11 GT running at a maximum engine speed of 1600 rpm, producing noise levels up to 84 dB. Thus, it is recommended that crew members use earplugs.

Communicating in English as a Second Language Aboard a European Cruise Line: An Autoethnographic Sketch

Working aboard an international cruise ship that travels to Europe is an exciting adventure with the many wonderful ports of call to visit, exquisite dining experiences, and a multitude of crew members who come from different countries. Because they have to serve foreign guests, crewmembers speak English frequently. This paper is an autoethnographic sketch of a pianist who works in an international cruise line and befriends a Polish musician who has English language issues such as inability to pronounce correct English words and phrases, excessive use of non-verbal cues in communication, and a generally low English comprehension level, but with an inquisitive spirit to learn the second language, the two communicators manage to foster a mutual understanding. Narratives are drawn from self-reflections, analyzed and interwoven as a self-culture assemblage of cross-cultural communication. Results of the study reveal that interpersonal communication hovers within diverse cultural settings despite certain language impediments, emphasizing that the English language as a second language spoken by both second language speakers tends to eliminate speech anxiety. European crew members mingling with multi-cultural individuals establish good interactive skills while fostering good relationships while they learn practical English in the exercise of their daily duties.

Delayed Pressure Urticaria Associated With Altitude Chamber Training Responsive to Cyclosporine and Omalizumab.

Delayed pressure urticaria (DPU) is a subset of chronic inducible urticaria. It is characterized by the formation of wheals anytime between 30 minutes and 24 hours after stimulus exposure of localized pressure application. In this case report, we discuss a military flight crew member with no significant past medical history who developed DPU following rapid decompression in an altitude chamber. The chamber training included an uneventful ascent to 45,000 feet, higher than he had been previously, and a rapid decompression. About 16 hours later, he developed pruritic swelling of his hands and feet, along with diffuse deep nodular swelling, erythematous plaques, and erythematous nodules. His DPU was refractory to monotherapy treatment with antihistamines, and he continued to develop lesions in weight-bearing areas. Control of symptoms was achieved through combination treatment of a second-generation antihistamine, a leukotriene receptor antagonist, and an immunosuppressant (cyclosporine). His waiver to return to flight status was denied while on cyclosporine. He was transitioned to a monoclonal antibody that binds free immunoglobin E (omalizumab) with resolution of symptoms and was cleared to return to active duty.

Fatigue Among Cabin Crew and Work-Life Balance: A Qualitative Study in the Turkish Context

In the context of literature review, it can be observed that information regarding the fatigue levels of cabin crew generally relies on quantitative data obtained from the flight crew. Considering that cabin crew members also have their own personal lives, it is believed that managing work fatigue and achieving work-life balance are crucial for them to sustain their lives in a healthy manner. However, it is rarely investigated in the literature what the views of cabin crew members are regarding fatigue and what strategies can be employed to reduce fatigue. Therefore, in order to better understand the causes and consequences of cabin crew fatigue, participants' experiences related to fatigue and how fatigue affects work-life balance were examined through semi-structured interviews using phenomenological analysis. Twenty cabin crew employees participated in the study. The analysis revealed three main themes titled "Perception of fatigue in cabin crew members, The impact of fatigue on work-life balance and Strategies for coping with fatigue" along with eight sub-themes that elucidate these themes. Based on the findings, recommendations are provided at the individual and organizational levels to reduce fatigue in cabin crew members, ensure work-life balance, and enhance productivity.

Adaptation Strategy of Migrant Crew on Taiwanese Fishing Vessels

This study aims to analyse the adaptation strategies used by migrant crew members on Taiwanese fishing vessels in facing the risks they face. The research's risks include heavy workloads, hazardous work environments, health, and forced labour exploitation. The research method used is a qualitative analysis using primary data from interviews with seven resource persons who are migrant crew members on Taiwanese fishing boats. The study results show that migrant crew members use various adaptation strategies to deal with the risks they face on fishing boats. These adaptation strategies include a more effective division of labour, the use of better technology or equipment to reduce physical burdens, joining a community of fellow migrant workers, and the fight for decent work rights. In addition, migrant crew members also use an adaptation strategy from the beginning of recruitment by choosing the departure process through the official route. This research makes an essential contribution to understanding how migrant crew members cope with the risks they face on Taiwanese fishing vessels. The practical implications of this study are the importance of paying attention to the welfare and work rights of migrant crew members and expanding understanding of the importance of adaptation strategies in increasing their resilience in often challenging and high-risk work environments.

Maritime Industry and the Cyber-‘Iceberg’

The maritime industry is embracing cyber technology. The proliferation of digitalisation in the shipping industry is apparent, as any modern vessel today is a complex cyber-physical-mechanically engineered system. The digital incorporation of operational technology (OT) and information and communication technology (ICT) systems in network and control systems has resulted in complex integrated shipping vessels. As most modern vessels utilise the internet to communicate with those on shore, it is true to say that shipping today has adopted cyber technology to enhance the efficiency of its operations. It is also true that the modern shipping industry has become totally dependent on cyber technologies for its future existence. Along with the integration of ICT and cyber-related technologies came numerous cybersecurity threats. These risks need to be identified and mitigated. If not properly addressed, these underlying cybersecurity threats can lead onto disasters of all different kinds. This paper discusses the integration of (ICT) and cyber-related technologies in the maritime and shipping industry, the related cybersecurity threats encountered and why these should be mitigated. It also suggests how senior management and the crew members can contribute in assisting to safeguard shipping vessels from these ever-present cybersecurity threats.

Evaluating infectious disease outbreak potential and mitigation effectiveness on cruise ships

The cruise ship sector is a major part of the tourism industry, and an estimated over 30 million passengers are transformed worldwide each year. Cruise ships bring diverse populations into proximity for many days, facilitating the transmission of respiratory illnesses. The objective of this study is to develop a modeling framework to inform the development of viable disease risk management policies and measures to control disease outbreaks on cruises. Our model, parameterized and calibrated using the data of the COVID-19 outbreak on the Diamond Princess cruise ship in 2020, is used to assess the impact of the mitigation measures such as mask wearing, vaccination, on-board and pre-traveling testing measures. Our results indicate mask wearing in public places as the cheapest and most affordable measure can drop the number of cumulative confirmed cases by almost 50%. This measure along with the vaccination by declining the number of the cumulative confirmed cases by more than 94% is the most effective measure to control outbreaks on cruises. According to our findings, outbreaks are more predominant in the passenger population than the crew members, however, the protection measures are more beneficial if they are applied by both crew members and passengers. Regarding the testing measure, pre-traveling testing is more functional than the on-board testing to control outbreaks on cruises.

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

The SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92, L-44, L-3 days), during (Flight Day: FD1, FD2, FD3), and after (Return: R + 1, R + 45, R + 82, R + 194 days) spaceflight, spanning a total of 289 days across 2021-2022. The collection process included venous whole blood, capillary dried blood spot cards, saliva, urine, stool, body swabs, capsule swabs, SpaceX Dragon capsule HEPA filter, and skin biopsies. Venous whole blood was further processed to obtain aliquots of serum, plasma, extracellular vesicles and particles, and peripheral blood mononuclear cells. In total, 2,911 sample aliquots were shipped to our central lab at Weill Cornell Medicine for downstream assays and biobanking. This paper provides an overview of the extensive biospecimen collection and highlights their processing procedures and long-term biobanking techniques, facilitating future molecular tests and evaluations.As such, this study details a robust framework for obtaining and preserving high-quality human, microbial, and environmental samples for aerospace medicine in the Space Omics and Medical Atlas (SOMA) initiative, which can aid future human spaceflight and space biology experiments.

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

Spaceflight can change metabolic, immunological, and biological homeostasis and cause skin rashes and irritation, yet the molecular basis remains unclear. To investigate the impact of short-duration spaceflight on the skin, we conducted skin biopsies on the Inspiration4 crew members before (L-44) and after (R + 1) flight. Leveraging multi-omics assays including GeoMx™ Digital Spatial Profiler, single-cell RNA/ATAC-seq, and metagenomics/metatranscriptomics, we assessed spatial gene expressions and associated microbial and immune changes across 95 skin regions in four compartments: outer epidermis, inner epidermis, outer dermis, and vasculature. Post-flight samples showed significant up-regulation of genes related to inflammation and KRAS signaling across all skin regions. These spaceflight-associated changes mapped to specific cellular responses, including altered interferon responses, DNA damage, epithelial barrier disruptions, T-cell migration, and hindered regeneration were located primarily in outer tissue compartments. We also linked epithelial disruption to microbial shifts in skin swab and immune cell activity to PBMC single-cell data from the same crew and timepoints. Our findings present the inaugural collection and examination of astronaut skin, offering insights for future space missions and response countermeasures.