Melting Point Test Research Articles

Potential anticancer activity of Mn (II) complexes containing arginine dithiocarbamate ligand on MCF-7 breast cancer cell lines

IntroductionCancer refer to genetic changes in the DNA structure accompanied by abnormal growth of normal cells, and resulting in the death of these structures, and is a disease currently recognized as a major cause of mortality globally. Chemotherapy plays important role in breast cancer management. Non-toxic metals have been developed to replace the highly toxic cisplatin, an example being Manganese. Furthermore, Ligands have displayed great capabilities in the determination of anticancer properties, and an essential agent exploited in drug development is arginine dithiocarbamate. Therefore, this study was conducted to examine the anticancer potentials of Mn (II) arginine dithiocarbamate. MethodsThe synthesis and spectroscopic analysis of the Mn (II) Arginine dithiocarbamate complex was successfully carried out. Then, the complexes were characterized through the employment of the UV-Vis, FT-IR, as well as the melting point tests, and subsequently analyzed for anticancer activities through in vitro means. The compound was produced from UV-Vis spectrum at 246 and 385 nm wavelengths and IR spectrum at wave numbers 354-499 cm−1. ResultsThe results revealed the cytotoxicity of Mn (II) Arginine dithiocarbamate against the MCF-7 cell line, observed from a significant change in the morphology of the cancer cells with IC50 value of 211.53 μg/mL. ConclusionThe compound, Mn (II) Arginine dithiocarbamate has effective anticancer potentials against MCF-7 cancer cells.

PEMANFAATAN EKSTRAK BIJI KESUMBA KELING ( Bixa orellana L) SEBAGAI PEWARNA ALAMI PADA SEDIAN LIPSTIK

Lipstick (Lipstick) is a cosmetic sedan that is used to color the lips with an artistic touch so as to enhance aesthetics in facial makeup. One of the plants that can be used as natural dyes is kelumba keling (Bixa orellana L). Kesumba rivet contains bixsin and nonbixin compounds, which can be used as natural dyes that have the potential as antioxidants. The aim of this study is to utilize kelumba keling as a natural coloring agent in lipstick sedans.Making Keeling keumba seed extract by maceration using 70% ethanol as a solvent. The formulation was made by means of a lipstick base added with variations in the concentration of kesumba keling seed extract 18%, 20%, 22%. Tests carried out on a lipstick sedan made include organoleptic test, irritation test, PH test, melting point test, lipstick sediment test , during storage for 30 days.The results of the test of the lipstick extract of the kesumba rivet seed in the stable orange color organoleptic test can be seen in the irritation test of the non-irritating lipstick sedan, at the melting point test at 51oC for 15 minutes formulation F0, F1, F2, F3 the lipstick made can melt, at Sedian rub test was carried out 5 times basting. In this study it can be concluded that the kesumba keling seed extract can be used as a natural coloring agent in lipstick sedans. Kata Kunci : Biji Kesumba Keling, Lipstik, Evaluasi lipstik

Synthesis and properties of zwitterionic gemini surfactants for enhancing oil recovery

In this paper, a series of double quaternary ammonium salts zwitterionic gemini surfactants YLZ-0–YLZ-4 has been synthesized for the oilfield of high reservoir temperature, high salinity, and even a low API (crude oil density) proportion, which have all increased the difficulties of oil recovery. The products were characterized by IR, ESI-MS, elemental analysis and melting point tests and their physicochemical properties were tested, including solubility, surface tension, critical micelle concentration (CMC), wettability, interfacial tension, salt tolerance, divalent cations tolerance, emulsification, adsorption and flooding experiment.The CMC of the surfactant YLZ-3 is 0.0178%, and it has the best effect of changing the wettability of the rock surface; Under the condition of high salinity injection water in the oilfield, the interfacial tension of YLZ-3 solution reached an ultra-low value of 0.0053 mN/m at the concentration of 0.1% (wt%). Furthermore, YLZ-3 can enhance oil recovery by 9.48% in laboratory flooding experiment.

FORMULATION AND EVALUATION OF LIPSTICK, ROUGE AND EYE SHADOW USING COLORED PIGMENT FROM THE EXTRACT OF PIPER BETEL AND ACACIA CATECHU

The present work was aimed to formulate various cosmetic formulations comprising of extract of Piper betel and Acacia catechu and limestone as a coloring agent to minimize the side effect(s) associated with the use of synthetic colorants. Different natural ingredients such as bees wax, carnauba wax, white soft paraffin, castor oil, strawberry essence, rice starch and lemon juice were used to formulate herbal lipstick, rouge, and eye shadow along with the extracted color. Different evaluation tests were carried out to evaluate the prepared formulations such as color, texture, pH, perfume stability, melting point, breaking point, softening point, surface anomalies, aging stability, thixotrophy and skin irritation test. The results of the evaluation tests revealed that melting point of the prepared lipstick formulation was in the range of 61-63oC. The breaking point of all the prepared lipstick formulations was in the range of 30 – 33 g. Force of application was noted to be good for all the formulations. Thixotrophy character was observed in the range of 9.2 ±0.3 to 9.6 ±0.1. Softening point was found to be in the range 52.33 to 60.330C. Eye shadow and rouge showed good adhesion property and proper color dispersion with melting point of 480C. Patch test on the volunteers showed no signs of skin irritation. The results of the study confirmed that the color extracted from Piper betel and Acacia catechu may prove to be an attractive option and act as a substitute for synthetic colorants in various cosmetic formulations.

Synthesis of novel caffeic acid derivatives and their protective effect against hydrogen peroxide induced oxidative stress via Nrf2 pathway

AimThis study was aimed to synthesize novel caffeic acid derivatives and evaluate their potential applications for the treatment of oxidative stress associated disease. Main methodsCaffeic acid sulfonamide derivatives were synthesized by coupling sulfonamides to the backbone of caffeic acid and fully characterized by melting point test, FT-IR, MS, NMR, UV–vis and n-octanol–water distribution assay. Their free radical scavenging ability was evaluated using DPPH assay and cytotoxicity against A549 cells were determined by MTT assay. The protective effect of these derivatives against hydrogen peroxide (H2O2) induced oxidative injury was assessed in A549 cells from cell viability, production of reactive oxygen species (ROS) and malondialdehyde (MDA), alternation of antioxidase activities, and expressions of Nrf2 and its target genes. Key findingsSix novel caffeic acid sulfonamide derivatives were obtained. The derivatives showed better liphophilicity than the parent caffeic acid. CASMZ, CAST and CASQ exhibited similar DPPH scavenging capability as caffeic acid, while the protection of hydroxyl groups on the benzene ring with acetyl groups caused decrease in radical scavenging activity. No inhibitory effect on the proliferation of A549 cells were observed up to a concentration of 50 μM. Pre-treatment of cells with these derivatives strongly inhibited H2O2 induced decrease of cell viability, reduced the production of ROS and MDA, promoted antioxidase activities, and further upregulated the expression of Nrf2 and its target genes. SignificanceCaffeic acid sulfonamide derivatives were synthesized with simple reactions under mild conditions. They might protect cells from H2O2-induced oxidative injury via Nrf2 pathway.

Isolation and Characterization of Flavonoids from Black Glutinous Rice (Oryza Sativa L. Var Glutinosa)

This study aims to isolate and characterize the isolated flavonoid compounds from glutinous rice (Oryza Sativa L. Var Glutinosa). The method that used was maserasi with methanol solvent, multilevel fractionation with n-hexane and ethyl acetate. The separation of chemical components using column chromatography and tested its purity by melting point test and TLC. Characterization of isolated flavonoids using color reagents (H2SO4, NaOH, Mg-HCl), KKt-2A, UV-Vis and FT-IR. The powder (amorphous) flavonoid isolation results have a melting point of 236.5-237.8 oC. Flavonoid powder added H2SO4 produces a yellow color, with NaOH producing a violet color, and Mg-HCl produces a red color. KKt-2A with a BAA developer has Rf 0.49 and 15% acetic acid having Rf 0.09. The UV-Vis spectrum shows maximum absorption at 532 nm wavelength. The results of powder analysis (amorphous) flavonoid using FT-IR showed absorption at wave number 3.330,40 cm-1, 2838,96 cm-1, 1,656,23 cm-1, 1,421,85 cm-1, 1,112,25 cm-1, 1,019,27 cm-1 and 697,76 cm-1. According to those data it can be concluded that flavonoids that isolated have the form of powder (amorphous) which belong to anthocyanin group that have o-diOH on ring B and have a conjugated double bond.Keywords- Black Sticky Rice, Flavonoid, Fractionation, FT-IR, Maserasi, UV-Vis.

FORMULASI SEDIAAN LIPSTIK EKSTRAK DAUN JATI (Tectona grandis L., f.) SEBAGAI ZAT PEWARNA

Teak leaves (Tectona grandis L., f) include familia verbenaceae that have strong antioxidant activity. The color of the teak leaves is caused by the flavonoid that is antosianidin. Anthocyanidin is a pigment that can be used as a natural dye and can replace synthetic dyes. The purpose of this study was to formulate lipstick preparations using dyes contained in teak leaves and to determine the effect of variation of teak leaf extract concentration. The type of research used is experimental research. This research covers teak leaf extraction using maseration method. Lipstick is made in 3 formulas. Formula I with concentration 5%, formula II 7% concentration and formula III 9% concentration. Lipstick that has been made then tested by physical properties including organoleptc test, homogeneity test, pH test, melting point test, and hardness test. The resulting lipstick is stable, red brick, brownish and light brown. The melting point of lipstick preparation containing teak leaf extracts with concentration of 5%, 7% and 9% were 55,670C; 57,330C and 58,670C, respectively, while the pH of lipstick preparations were respectively 6; 5 and 4. Hardness of lipstick preparations with concentrations of 5%, 7% and 9% were 87 grams, 97 grams and 112 grams, respectively. The conclusion of the research showed that the lipstick formulation of teak leaf extract can be used as a dye and there is influence of variation of teak leaf extract concentration.

The physical properties and stability of purple yam (Ipomoea batatas (L.) Lam ) lipstick

The purple yam (Ipomoea batatas (L) Lam) has a useful anthocyanin as a natural dye which safer compare to the synthetic dyes. Anthocyanins have the antioxidant effect that can capture free radicals. The purpose of this study was to assess the effect of purple yam extract in various concentrations on the physical properties and physical stability of lipstick. Lipstick was made in three formulas that is L01, L02, L03. To evaluate the quality of the product, the physical properties, and stability test for purple yam lipsticks were conducted. Physical properties test consisted of organoleptic tests, melting point test, hardness test, homogeneity test, the Pap test, and pH test. Lipstick stability tests were performed by stored lipstick for 30 days at room temperature 25 °C, then observed the change of shape, color, and odor during storage. “W” a top market leader lipstick in Indonesia was used as a control. Observed data of melting point, strength, and pH of lipstick were analyzed using One Way ANOVA and continued with Tukey. Organoleptic data, homogeneity, topicality and lipstick stability were described descriptively. The results showing no significant differences between lipstick L01, L02, L03 in organoleptic, homogeneity, pH and lipstick physical stability. However, when comparing with W lipstick, there is a significant difference in the melting, hardness and smearing points between L01, L02, L03 lipstick with W lipstick. It was concluded that purple yam extract may influence the physical properties of lipstick in particular melting point and hardness of lipstick. Although it has no effect on the stability of purple yum lipstick.

FORMULASI SEDIAAN LIPSTIK EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa) SEBAGAI PEWARNA DAN MINYAK ZAITUN (Olive oil) SEBAGAI EMOLIEN

Islam is a beautiful religion and loves beauty. The using of a lipstick is to form a lip in an attractive appearance and to protect the lips from dryness with no side effects. The use of rosella as a dye and olive oil as an emollient in the formulation of the preparations due to the red pigments of anthocyanin in rosella (Hisbiscus sabdariffa l.) and olive oil can be used as an emollient to keep the moisture of the lips. The purpose of this study was to make a lipstick with a good stability. The simplisia of rosella flowers was macerated in ethanol 96%. The components of the lipstick used are cera alba petroleum jelly, aba, Cetyl alcohol, lanolin, titanium dioxide, nipagin, oleum rosae, olive oil and extracts of flowers rosella with concentrations of 0%, 2%, 4%, 6%, 8%, 10%. The lipstick mixture was then tested including: homogeneity, stability, grease, melting point and pH tests. Test a fondness and irritation test performed on the 25 panelists. The results showed that the concentrations of rosella extract 0% did not cause any color or white, the concentration of 2%-4% color posed red fade, the concentration of 6% was red, the concentration of 8%-10% was dark red. Concentration of the extract of 0%-4% did not experience the color change (stable) in a storage room temperature for 30 days. As for the material of 6%-10% color lipstick changes slowly, due to the occurrence of oxidation on lipstick. The result of fondness and irritation tests are that in the preparation of 1, 2, 3, 4, 5 and 6 does not cause irritation, itching and skin redness on the skin.

Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative

Acethydrazide was modified by addition of benzaldehyde refluxing in ethanol to obtain a new product: N’-Benzylideneacethydrazide. The new product obtained was complexed with Iron (II) and Copper (II) salt. The result of the FT-IR analysis of acethydrazide, N’-Benzylideneacethydrazide and its complexes were compared to ascertain the possible points and mode of coordination to the metal (II) centre. The shift in the absorption band of the N’-Benzylideneacethydrazide (N'-BA) from 3337 cm-1 (N-H) to 3462 cm-1 and 3406 cm-1 (N-H) in the spectra of the Fe(II) and Cu(II) complexes respectively, indicates the coordination of the N’-Benzylideneacethydrazide to the metal ion via O and N atoms of the carbonyl and amide functional groups. The products were further characterized by UV/Visible spectroscopic technique and other physical measurements like melting point and solubility test.

Identification of mothball powder composition by float tests and melting point tests

Introduction: The aim of the study was to identify the composition, as either camphor, naphthalene, or paradichlorobenzene, of mothballs in the form of powder or tiny fragments by float tests and melting point tests.Methods: Naphthalene, paradichlorobenzene and camphor mothballs were blended into powder and tiny fragments (with sizes <1/10 of the size of an intact mothball). In the float tests, the mothball powder and tiny fragments were placed in water, saturated salt solution and 50% dextrose solution (D50), and the extent to which they floated or sank in the liquids was observed. In the melting point tests, the mothball powder and tiny fragments were placed in hot water with a temperature between 53 and 80 °C, and the extent to which they melted was observed. Both the float and melting point tests were then repeated using intact mothballs. Three emergency physicians blinded to the identities of samples and solutions visually evaluated each sample.Results: In the float tests, paradichlorobenzene powder partially floated and partially sank in all three liquids, while naphthalene powder partially floated and partially sank in water. Naphthalene powder did not sink in D50 or saturated salt solution. Camphor powder floated in all three liquids. Float tests identified the compositions of intact mothball accurately. In the melting point tests, paradichlorobenzene powder melted completely in hot water within 1 min while naphthalene powder and camphor powder did not melt. The melted portions of paradichlorobenzene mothballs were sometimes too small to be observed in 1 min but the mothballs either partially or completely melted in 5 min. Both camphor and naphthalene intact mothballs did not melt in hot water.Conclusions: For mothball powder, the melting point tests were more accurate than the float tests in differentiating between paradichlorobenzene and non-paradichlorobenzene (naphthalene or camphor). For intact mothballs, float tests performed better than melting point tests. Float tests can identify camphor mothballs but melting point tests cannot. We suggest melting point tests for identifying mothball powder and tiny fragments while float tests are recommended for intact mothball and large fragments.

Air gasification of biogas-derived digestate in a downdraft fixed bed gasifier

Digestate is a byproduct from biomass anaerobic digestion process. Gasification of dried digestate to produce gasesous product might be a promising route. In this work, air gasification of digestate with high ash content was performed in a downdraft fixed bed gasifier at temperature varying from 600°C to 800°C and air equivalence ratio (ER) ranging from 0.25 to 0.30. The ash melting properties were firstly detected by the Intelligent Ash Melting Point Test, and the by-products (biochar and ash) were analyzed.The results showed that no ash slagging was observed and therefore it is feasible to operate digestate gasification under 800°C and ER ranging from 0.25 to 0.30. High temperature favored gas production, 800°C is proposed for digestate gasification in the present study. ER with a medium value improved gas quality and cold gas efficiency (CGE), and the optimal LHV of 4.78MJ/Nm3 and CGE of 67.01% were obtained with ER of 0.28. High ER favored the increase of gas yield and decrease of tar concentration, and the optimal gas yield of 2.15 Nm3/kg and tar concentration of 1.61g/Nm3 were achieved with ER of 0.30. Improved molar ratio of H2/CO varying from 1.03 to 1.08 was obtained at 800°C, indicating gaseous product has the potential for chemical synthesis processes (1<H2/CO<2). The byproducts biochar and ash could be applied on land as fertilizer.

Preparation and In vitro Evaluation of Naproxen Suppositories.

The aim of this work was to develop the best formulations for naproxen suppositories. The effects of different bases and surfactants on the physicochemical characteristics of the suppositories were determined by several tests such as weight variation, melting point, assay, hardness, and release rate. All formulations met the standard criteria for tested physicochemical parameters; weight variation (97-112%), content uniformity (97-105%), melting point (4.66-8.7 min) and hardness tests (>5400 g). Based on release rate studies, hydrophilic, and lipophilic bases without surfactants were not suitable bases for naproxen suppository. Amongst the formulations containing surfactants only Witepsol H15 with 0.5% w/w of Tween 80 and Witepsol W35 with 0.5% of cetylpyridinium chloride were suitable and released nearly complete drug during 30 and 60 min, respectively. This study demonstrates the effects of incorporation of known agents on the in vitro release characteristics of naproxen suppository.

Ethyl-2-(3,5-Dihidroxyfenol): Phloroglucinol derivatives as potential anticancer material

Ethyl-2-(3,5-dihidroxyfenol) based phloroglucinol compounds have been synthesized. Ethyl-2-(3,5-dihidroksifenol) were synthesized by reacting phloroglucinol with ethyl 2-chloro acetate in excess. Phloroglucinol reaction using 2-chloro ethyl acetate was carried out under reflux for 24 hours at a temperature of 56 oC. The reaction products were identified by a thin layer chromatography and were characterized by melting point test. Analysis of the structure of the products was obtained by FTIR spectrophotometer, H-NMR, and 13C-NMR. The result of the reaction between phloroglucinol and 2-chloro ethyl acetate was brownish black solid, and has a melting point of 191 oC. Based on the structural analysis by FTIR, 1H-NMR and 13C-NMR, the reaction product was a mixture of compounds which is ethyl 2- (3,5-dihidroksifenol) acetate, ethyl-2-(2,4,6-trioxocyclohexyl) acetate, and the rest of phloroglucinol which can not react.

Prototyping and characterisation of a variable stiffness actuation mechanism based on low melting point polymer

With the advent of automation and robotic systems, flexible robotic manipulators are becoming increasingly popular in various applications where safe interaction with surrounding environments is needed. This project aims to investigate stiffness varying technology for a class of flexible manipulators with the aim of online changing manipulator stiffness. We propose and develop a stiffness varying mechanism based on low melting point polycaprolactone (PCL), characterise it and test out together with extensive experiments. The proposed mechanism is further integrated into a tendon-driven flexible manipulator and it successfully changed the overall stiffness of the manipulator. This paper mainly involves design improvement, modelling, characterisation and hands-on experiments.

Prototyping and characterisation of a variable stiffness actuation mechanism based on low melting point polymer

With the advent of automation and robotic systems, flexible robotic manipulators are becoming increasingly popular in various applications where safe interaction with surrounding environments is needed. This project aims to investigate stiffness varying technology for a class of flexible manipulators with the aim of online changing manipulator stiffness. We propose and develop a stiffness varying mechanism based on low melting point polycaprolactone (PCL), characterise it and test out together with extensive experiments. The proposed mechanism is further integrated into a tendon-driven flexible manipulator and it successfully changed the overall stiffness of the manipulator. This paper mainly involves design improvement, modelling, characterisation and hands-on experiments.

A comparative UV−HPLC analysis of ten brands of ibuprofen tablets

ObjectiveTo investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets (400 mg) purchased from pharmacies in Benin City, Nigeria. MethodsThe drug samples were subjected to uniformity of weight, crushing strength, friability, melting point, disintegration and dissolution tests following acceptable and official protocols. The ibuprofen content was determined using UV and high performance liquid chromatography method. ResultsCrushing strength values of the drug samples ranged between 6 and 16 kp while the disintegration times were between 7.43 and 10.40 min (for uncoated tablets) and 3.25–37.32 min (for coated tablets). Friability values were less than 1% and the melting points of recrystallized ibuprofen from the samples ranged from 73.5 to 76.0 °C. The amount of ibuprofen released within 1 h ranged between 18% and 102% and two brands failed the content of active ingredient in the UV method of assay while all the brands passed the test using HPLC. ConclusionsIbuprofen (400 mg) tablets marketed in Benin City, Nigeria vary in pharmaceutical quality.

Synthesis, characterization, and mechanism studies of bis(imino)pyridine ligands and their Cr(III) compounds

Two new bis(imino)pyridine ligands L1, L2 (L1 = 2,6-bis[1-(4-bromophenylimino)]pyridine, L2 = 2,6-bis[1-(4-methylphenylimino)]pyridine) have been prepared. Their compounds [CrCl3L1] (I) and [Cr(Cl)(μ-Cl)(L2′)]2 (II) (L2′ = 6-bis(6-methylquinoline)pyridine) for olefin oligomerization were obtained by hydrothermal methods, during which L2′ was appeared from L2, and characterized by elemental analysis, single-crystal X-ray analysis (CIF files CCDC nos. 1025448 (I),1025447 (II)), IR spectra and melting point test. Compound I is a mononuclear compound, while compound II, bridged with the chlorine atoms, is a binuclear compound. The transformation mechanism between L2 and L2′ is also studied, and the possible reason is due to the presence of the electron-donating groups as substituents on L2. The subsequent studies on that will be carried on.

Synthesis and Toxicity Assessments Some Para-methoxy Chalcones Derivatives

Chalcones is a very interesting compounds because it is known to have various of biological activities such as antimicrobial, antifungal, anticancer, antimalarial, antioxidant, antitumor, anti-inflammatory and antidepressant. Moreover, natural and synthetic compounds of chalcones have roles as precursors for other compounds. Therefore, many chalcones become model structures of target compounds by researcher. In this research, methoxy chalcones derivatives have been synthesized using stirrer method and using base catalyst NaOH. The synthesized results obtained are (E)-3-(4-isoprophylphenyl)-1-(4’-methoxyphenyl)prop-2-en-1-one (1), (E)-1-(4’-methoxyphenyl)-3-p-tolylprop-2-en-1-one (2) and (E)-3-(3-bromophenyl)-1-(4’-methoxyphenyl)prop-2-en-1-one (3). The purity of all compounds have been tested using TLC, melting point test, analytical HPLC. Then they are characterized using UV, FTIR, 1H-NMR and MS spectroscopy. The toxicity assessments of the novel compounds were done by Brine Shrimp Lethality Test (BSLT) method. The all compounds showed very good activity with LC50 value<200 μg/mL.

Coaxial Electrospinning as a Process to Engineer Biodegradable Polymeric Scaffolds as Drug Delivery Systems for Anti-Inflammatory and Anti- Thrombotic Pharmaceutical Agents

Abstract Objective: Blend electrospinning has been acknowledged as a cost-effective technique for the production of fibrous scaffolds, suitable for various biomedical applications. Coaxial electrospinning is a method variant that results in core-shell structures with advantages, such as delayed diffusion and protection of sensitive biomolecules. The aim of this work was to evaluate how different process and solution parameters affect the structural, mechanical and physical properties of the fibers, created by polycaprolactone (PCL). In addition, acetylsalicylic acid (ASA) that was used as a model anti-inflammatory and anti-thrombotic agent, was loaded within the fiber meshes in order to compare release kinetics between fibers produced by conventional blend and coaxial electrospinning. Methods: Scanning electron microscopy (SEM) was used to investigate the structural and morphological characteristics of the fibers. The fibers’ hydrophilicity was investigated using contact angle measurements while the electrical conductivity of the polymeric solutions and the thermal properties of the fibers were also evaluated. Differential scanning calorimetry (DSC) was used to determine the fibers’ melting point and mechanical tensile tests were performed in order to study the mechanical properties of the fibers. Moreover, UV-vis spectroscopy was used to determine the release kinetics of ASA. Results: The results indicated that increasing the concentration of PCL led to thicker and less aligned fibers. Furthermore, the physicochemical characterization did not reveal significant changes during the process. Coaxially electrospun fibers that were loaded with ASA exhibited a slower and sustained, biphasic release profile compared to blend electrospun fibers with 34% of ASA released during the first 8h and 97% in total after 3 months. Conclusion: Taken together, fibrous meshes created by coaxial electrospinning using PCL, can be tailor-made by a careful optimization of all the process and solution parameters, in order to fit the scope of specific applications in the fields of biomedical engineering and drug delivery.