Melastoma Malabathricum Research Articles

GC-MS analysis, adme toxicity and in silico studies of some isolated compounds from Melastoma malabathricum leaves against SPLA2 inhibition

The bioactive components of Melastoma malabathricum leaves and the chemical compositions of ethanol-based M. malabathricum leaf extract were studied using gas chromatography-mass spectrometry (GC-MS) analysis. Twelve compounds obtained were: phthalic acid hept-4-yl isobutyl ester, oleic acid, n-hexadecanoic acid, melezitose, hexadecanoic acid methyl ester, hexadecanoic acid ethyl ester, D-mannose, 9,10 secocholesta-5,7,10(19) triene-3,24,25, triol, (3β,5Z,7E), 2-myristynoyl pantetheine, propanamide, 3-[3,5di(tetra-butyl)-4hydroxyphenyl]-N-(2hydroxyethyl), cholesta 4,6- dien-3-ol and desulphosinigrin. These compounds were characterized and analyzed for sPLA2 inhibition by molecular docking using the standard inhibitors. Among these, 2-myristynoyl pantetheine showed better interactions with sPLA2 lIA enzyme with ‘e’ value of -8.62 (PubChem id: 535560), followed by desulphosinigrin (-7.19) and D-mannose (-4.96). ADME toxicity studies proved that 2-myristynoyl pantetheine is better for in vivo administration. The 2-myristynoyl pantetheine was found to exhibit anti-inflammatory activity.

Traditional healing practices of Pnar and War communities in West Jaintia Hills District of Meghalaya, Northeast India

Pnar and War are the most predominant and oldest ethnic community in the West Jaintia Hills of Meghalaya; they have faith on the medicinal plants for their primary health care. Information about the ethno medicinal uses of several plants were collected through interview of the local respondents following the standard ethno medicinal methods. Statistical tools, informant consensus factors (FIC) and fidelity level (FL) were used to analyze the importance of ethnomedicinal plants. The present investigation revealed 70 plant species belong 64 genera, under 44 family were being used against different ailments, which were classified into 11 groups. The results of the FIC value of blood related disease category had the greatest agreement =1.0), followed by Urinogenetal disease (0.90), Antidote (0.85), Dermatological, fungal and bacterial infections (0.82). The highest FL values were gastrointestinal, parasitic and hepatobiliary (Melastoma malabathricum, 95.83%), followed by external injuries and bleeding (Centella asiatica, 94.11%), oral, dental and otorhinolaryngolgical problems (Curcuma longa, 91.66%).

The Potency of Senggani (Melastoma malabathricum L) Leaves in Repair of Pancreatic Beta Cells for Diabetes Mellitus Patients: A Narrative Review

Diabetes mellitus is often caused by damage to pancreatic beta cells which play a role in secreting insulin in the body. Damage to pancreatic beta cells causes the body to lack insulin. Dipeptidyl peptidase-4 (DPP-4) is a peptidase enzyme complex located on the surface of the cell membrane. Inhibition of the DPP4 enzyme will increase blood GLP-1 levels and induce regeneration of pancreatic beta cells. Senggani leaf (Melastoma malabathricum) boiled water is believed by the people of the Ciamis area to be used as a diabetes medicine. There have been many studies and reviews related to Senggani (Melastoma malabathricum) and its potential. This review focuses on the discussion of Senggani as an antidiabetic by analyzing the reduction in glucose levels and the repair ability of pancreatic beta cells. The results of the literature study that show that senggani leaves have the ability to reduce blood glucose levels and repair activity of pancreatic beta cells through the DPP-4 enzyme inhibition mechanism supported by molecular docking simulation data. There are 12 active compounds that have a binding site similarity above 50% with the comparison compound vildagliptin. Rutin is the best active compound which has a 100% similarity of the binding site. Based on in vivo research and toxicity analysis on the admetsar database, senggani leaf extract and active compounds of senggani leaves have low toxicity, making it safe to be used as antidiabetic herbal preparations.

Formulation and Stability Test of Cream Ethanol Extract Senduduk Leaves (Melastoma malabatricum L.) On Burn Healing of Male White Mice

Burns are tissue damage caused by contact with heat sources such as fire, chemicals, electricity and radiation. This study aims to find a new burn drug from senduduk leaves (Melastoma malabathricum L.) with a form of standard cream preparation type M/A. The viscous extract of the leaves of senduduk is carried out by a characterization test and screening test, then formulated in the form of cream with a concentration of 2.5%, 5%, and 7.5%. Standard cream type M/A formulated with senduduk leaf extract was evaluated and tested for the stability of the preparation. Mice were burnt with a heated metal plate, then smeared with the cream of senduduk leaf extract and the diameter was measured using a calliper by measuring the four sides of the wound diameter and averaging it to obtain the proportion of wound closure. The percentage of wound closure was analyzed at D-1 to D-11 treatment. The results showed that the ethanol extract of senduduk leaf cream preparation with a concentration of 7.5% was more effective in healing burns with an average diameter of 0.20 cm of final burns and the proportion of wound healing was 99% compared to the concentration of senduduk leaf extract cream preparation which was other. The results of the burn test showed that the ethanol extract of senduduk leaf cream with a concentration of 7.5% was efficacious in healing wounds in mice.

Melastoma malabathricum stem bark acetone extract as an anti-bacterial agent against Streptococcus mutans

Melastoma malabathricum, also known as 'senduduk' in Malaysia, has been used as traditional medicine for diseases such as toothache, dysentery, haemorrhoids and stomachache. Therefore, the objective of this study is to investigate the biological activity of Melastoma malabathricum stem bark extracts (MMSBE) towards Streptococcus mutans. This investigation involved a few methods, which at first is the determination of minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC). Next is by analyzing the time-kill curve, anti-biofilm activity, scanning electron and transmission electron microscopic analyses. Later, next-generation sequencing (NGS) was done to determine differential regulation genes of treated and non-treated S. mutans. Lastly, confirmation of differential regulation genes was done by RT-PCR analysis. As for the results, M. malabathricum stem bark acetone extract (MMSBAE) showed the greatest inhibition concentrations towards S. mutans, followed by M. malabathricum methanol extract (MMSBME). Values of MIC and MBC (MMSBAE) were 1.25 mg/mL and 5 mg/mL. Meanwhile, MIC and MBC values of MMSBME were 5 mg/mL and 40 mg/mL. MMSBAE was chosen to further analyze its anti-bacterial activity against S. mutans. Time kill curve analysis found that MMSBAE possessed bacteriostatic properties against S. mutans. Besides, SEM and TEM analyses revealed that there were some changes to S. mutans cell morphology after treated with MMSBAE while Next gene sequencing analysis revealed significant (p<0.05) gene expression with multiple targets by MMSBAE, which caused inhibition of S. mutans biofilm formation activity. As for the conclusion, this study highlights the potential of MMSBAE as a new promising anti-S. mutans agents.

EKSPLORASI TUMBUHAN OBAT DI HUTAN PENELITIAN UNIVERSITAS BORNEO TARAKAN SEBAGAI BAHAN AJAR BERUPA BOOKLET UNTUK SISWA KELAS X SMK KESEHATAN KALTARA TARAKAN

This study aimed to determine the types of medicinal plants in the forest area of the Borneo Tarakan University and produce a product in the form booklet that are suitable for use. The type of this research was Research and Development (R D) which uses the development model of Borg and Gall (1983) and is only carried out up to the fifth stage. The results showed that 15 species were found, Kayu putih (Melaleuca leucadendron L.), Paku picisan (Drymoglossum pilloselloides L.), Karamunting (Melastoma malabathricum L.), Resam (Dicronopteris linearis L.), Pandan (Pandanus Sp.), Paku kawat (Lycopodium cernuum L. ), Congkok (Molineria capitulate L.), Jintan (Plectranthus amboinicus L.), Kantong semar (Nepenthes ampullaria), Anggrek tanah (Bromheadia finlaysoniana L.), Hiring-Hiring (Scleria sumatrensis Retz.), Lengkuas (Alpinia galangal L.), Paku tanduk (Platycerium bifurcatum), Paku sarang burung (Asplenium nidus L.), Paku kasak (Blechnum orientale L.). The result of research development in the form booklet were resulted scores validation from that are 86.6% (very feasible), material experts at 80% (feasible), practitioners at 100% (very feasible) and the percentage of student response tests at 94.5% (very interesting. The concluded of this research is the medicinal booklet with medicinal properties in the Borneo Forest Tarakan Research Forest Area is feasible to be used as teaching material for grade X SMK students.Keywords: Medicinal Plants, Booklet

Reducing Sugar, Total Phenolic Content, and Antioxidant Potential of Nepalese Plants.

The aim of the present study was to investigate the reducing sugar, total phenolic content, and in vitro antioxidant activity of 70% (v/v) ethanolic extract of seven medicinal plants grown in Nepal. The reducing sugar content and total phenolic content were determined by 3,5-dinitrosalicylic acid (DNSA) and the Folin–Ciocalteu method, respectively. The in vitro antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The reducing sugar content of the studied plant samples ranged from 6.89 ± 2.44 to 674.13 ± 2.43 mg GE/g dry extract weight and the total phenolic content ranged from 14.87 ± 0.41 to 281.71 ± 1.47 mg GAE/g dry extract weight. The reducing sugar and total phenolic content were found highest in Ficus glaberrima. Antioxidant activity was found highest in Melastoma malabathricum (IC50value = 6.27 μg/mL), followed by F. glaberrima (IC50value = 11.7 μg/mL). A positive and significant correlation was found between (i) total phenolic content and reducing sugar content and (ii) total phenolic content and antioxidant activity. The present study is the first study for the analysis of reducing sugar content of selected plants and for the scientific exploration of F. glaberrima. The present result suggests that the various parts of these studied plants could be assumed as a rich source of biologically active compounds and considered beneficial for the food and pharmaceutical industries.

MELASTOMA MALABATHRICUM L. EXTRACTS-BASED INDICATOR FOR MONITORING SHRIMP FRESHNESS INTEGRATED WITH CLASSIFICATION TECHNOLOGY USING NEAREST NEIGHBOURS ALGORITHM

As a maritime country, shrimp commodity production in Indonesia is very high and continues to increase. However, because shrimp is a perishable food, we need a detection device. This is because conventional methods that are widely used by the community in detecting freshness of shrimp are only based on the smell. Of course, this is a problem when shrimp are packed in closed containers. In this paper, a method for detecting shrimp is proposed using the Melastoma malabathricum L. - based label indicator. The high content of flavonoids in the extracts allows the changing the colour of the label from red to grey due to the interaction between the label with the OH- group that arises from the shrimp spoilage process. The colour that appears on the label indicator will correlate with the level of shrimp freshness. By increasing detection effectiveness, the classification is performed using the nearest-neighbours algorithm, which is equipped with an image processing mechanism in the form of colour quantization. There are four classifications used to express the quality of shrimp, namely "acceptable," "just acceptable," "unacceptable," and "more unacceptable." The accuracy of applying this method is 71.9%, with the majority of detection errors occurring in the "acceptable" class. Based on these results, it can be stated that the label indicators prepared in this study are very promising to be developed into intelligent packaging components.

Optimization of Gelling Agents and Emulsifiers in Emulgel Bases, and Physical Evaluation of Emulgel containing Sepabang (Melastoma malabathricum L.) Leaves Extract

Sepabang (Melastoma malabathricumshot L.) leaf contains a group of phenolic compounds and has a very strong antioxidant activity so it is potentially to be developed in the form of pharmaceutical preparations. The purpose of this research is to optimize and formulate an emulgel containing Sepabang leaf extract that physically stable. Emulgel preparations are formulated using carbopol and hydroxyprophylmethylcellulose as gelling agents and Tween 60 – Span 60 and combination of triethanolamine and stearic acid as emulsifiers, with a concentration of methanol extract of Sepabang leaves of 0.25%. Physical characteristics of emulgel preparations include pH value, viscosity determination, and spreadability test evaluated at room temperature for 4 weeks. The physical stability test is done by the Freeze Thaw method for 6 cycles, of which 1 cycle consists of 48 hours at 4°C and 48 hours at 40°C. The results showed that the Sepabang emulgel that meet physical characteristic and stability parameters are F1 with HPMC as gelling agents and Tween 60-Span 60 3% as emulsifiers.

The presence of potentially invasive alien plant species in Laiwangi-Wanggameti National Park and vicinity, Sumba, Indonesia

The study was aimed at providing data on the presence of potentially invasive alien plant species in Laiwangi-Wanggameti National Park and vicinity. The study was conducted using the taxonomic data collection methods, which took place in Laiwangi-Wanggameti National Park and vicinity, East Sumba, Indonesia. The plant material was collected for herbarium specimens and shipped to Herbarium Bogoriense for processing and identification. One hundred and four species of plants were collected in Laiwangi-Wanggameti National Park and vicinity. Of those collections, three invasive alien plant species were identified in the national park: Austroeupatorium inulifolium, Melastoma malabathricum, and Thespesia lampas. Another one was Jatropha gossypiifolia found outside the national park.

Antibacterial Activity Test of the Ethanol in Leaves Extract of Senduduk (Melastoma malabathricum L.) Against Escherichia coli and Staphylococcus aureus

Senduduk (Melastoma malabathricum L.) is one of the wild plants used as traditional medicine. Senduduk leaves are used as a medicine for sprue, boils, diarrhea and smallpox. The purpose of this study was to determine the antibacterial activity of the ethanol extract of senduduk leaves of the against Escherichia coli and Staphylococcus aureus. Senduduk leaves extracted by maceration using 96% ethanol solvent. Antibacterial activity testing is carried out using the diffusion method using paper discs.This experiment was repeated three times using concentrations of 20%, 40%, 60% and 80%.Ethanol extract of the senduduk leaves contains flavonoids, saponins, tannins and steroids/triterpenoids. The test results showed that the ethanol extract of the leaves has antibacterial activity against Escherichia coli and Staphylococcus aureus which is characterized by the inhibition zone formed around the disc paper. In Escherichia coli bacteria the smallest inhibition zone at a concentration of 20% with a diameter of inhibition zone 11 mm and the largest diameter of the inhibitory zone at a concentration of 80% with a diameter of inhibition zone 19 mm. whereas for the smallest inhibitory zone Staphylococcus aureus bacteria at a concentration of 20% with an inhibition zone diameter of 12.6 mm and the largest inhibitory zone dameter at a concentration of 80% with a diameter of the inhibitory zone 21,3 mm.The results of the study concluded that the ethanol extract of Senduduk leaves has antibacterial activity against Escherichia coli and Staphylococcus aureus.

Antibacterial and antibiofilm analyses of Melastoma malabathricum leaves extract against Streptococcus mutans on tooth surfaces

Antibacterial and antibiofilm analyses of Melastoma malabathricum leaves extract against Streptococcus mutans on tooth surfaces

Optical characterization and concentration-dependent antibacterial activity of silver nanoparticles (AgNPs) using aqueous Melastoma malabathricum extract against Staphylococcus aureus

The approach towards green synthetic methods has been enormously encouraged to synthesise nanoparticles for various uses. In this study, the one-pot synthetic method was adapted to synthesise silver nanoparticles (AgNPs) using Melastoma malabathricum (M. malabathricum) aqueous extract. The formation of AgNPs was confirmed by observing the results obtained by optical characterisation methods. The plasma resonance band along with shoulder at 375 nm and 595 nm, respectively, in Uv-Visible spectra supported the conversion of silver (Ag) to AgNPs reduced by functional groups present in the plant extract. The size of AgNPs was 31 nm and cubic in shape as confirmed by X-ray diffractometry (XRD) using Scherer equation. X-Ray Fluorescence (XRF) results also confirmed the presence of silver. The FTIR characterisation confirmed the presence of reducing functional groups. The antibacterial activity of AgNPs against Staphylococcus aureus (S. aureus) was carried out by disc diffusion method with increasing concentration of AgNPs, and enhanced inhibition zone was observed. The AgNPs obtained can be further explored against different bacterial strains and can a potential candidate as an antibacterial agent using the green synthetic approach.

Antioxidant Activity and Physicochemical Properties Changes of Melastoma Malabathricum (L.) And Syzygium Caryophyllatum (L.) Fruit during Ripening

ABSTRACT Antioxidant activity and physicochemical properties of Melastoma malabathricum (L.) and Syzygium caryophyllatum (L.) fruit were determined in line with the progressive color development in three maturity stages (MS) such as unripe (MS1-green), intermediate (MS2-light purple) and ripe (MS3-blackish-purple). Antioxidant values in terms of total phenol content, ferric reducing antioxidant power, 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, and oxygen radical absorbance capacity, as well as physicochemical properties, were increased significantly (P <0.05) with the ripening while decreasing titratable acidity and firmness of both fruits significantly (P <0.05). Color measurements pertaining to lightness (L*) and yellowness (b*) of both fruits were decreased while increasing the redness (a*) significantly (P <0.05).

Contrasting growth responses to aluminium addition among populations of the aluminium accumulator Melastoma malabathricum.

Aluminium (Al) hyper-accumulation is a common trait expressed by tropical woody plants growing on acidic soils. Studies on Al accumulators have suggested that Al addition may enhance plant growth rates, but the functional significance of this trait and the mechanistic basis of the growth response are uncertain. This study aimed to test the hypothesis that differential growth responses to Al among populations of an Al accumulator species are associated with variation in biomass allocation and nutrient uptake. We conducted two experiments to test differential responses to the presence of Al in the growth medium for seedlings of the Al accumulator shrub Melastoma malabathricum collected from 18 populations across Peninsular Malaysia. Total dry mass and relative growth rate of dry mass were significantly greater for seedlings that had received Al in the growth medium than for control plants that did not receive Al, but growth declined in response to 5.0 mM Al addition. The increase in growth rate in response to Al addition was greater for a fast-growing than a slow-growing population. The increase in growth rate in response to Al addition occurred despite a reduction in dry mass allocation to leaves, at the expense of higher allocation to roots and stems, for plants grown with Al. Foliar concentrations of P, K, Mg and Ca increased in response to Al addition and the first axis of a PCA summarizing foliar nutrient concentrations among populations was correlated positively with seedling relative growth rates. Some populations of the Al hyper-accumulator M. malabathricum express a physiological response to Al addition which leads to a stimulation of growth up to an optimum value of Al in the growth medium, beyond which growth declines. This was associated with enhanced nutrient concentrations in leaves, which suggests that Al accumulation functions to optimize elemental stoichiometry and growth rate.

Root architecture, rooting profiles and physiological responses of potential slope plants grown on acidic soil.

Globally, there has been an increase in the frequency of landslides which is the result of slope failures. The combination of high intensity rainfall and high temperature resulted in the formation of acidic soil which is detrimental to the healthy growth of plants. Proper plant coverage on slopes is a prerequisite to mitigate and rehabilitate the soil. However, not all plant species are able to grow in marginal land. Thus, this study was undertaken to find a suitable slope plant species. We aimed to evaluate the effect of different soil pH on root profiles and growth of three different potential slope plant species namely, Melastoma malabathricum, Hibiscus rosa-sinensis and Syzygium campanulatum. M. malabathricum showed the highest tolerance to acidic soil as it recorded the highest plant height and photosynthetic rate. The root systems of M. malabathricum, H. rosa-sinensis and S. campanulatum were identified as M, VH- and R-types, respectively. The study proposed M. malabathricum which possessed dense and shallow roots to be planted at the toe or top of the slope while H. rosa-sinensis and S. campanulatum to be planted in the middle of a slope. S. campanulatum consistently recorded high root length and root length density across all three types of soil pH while M. malabathricum showed progressive increase in length as the soil pH increased. The root average diameter and root volume of M. malabathricum outperformed the other two plant species irrespective of soil pH. In terms of biomass, M. malabathricum exhibited the highest root and shoot dry weights followed by S. campanulatum. Thus, we propose M. malabathricum to be planted on slopes as a form of soil rehabilitation. The plant species displayed denser rooting, hence a stronger root anchorage that can hold the soil particles together which will be beneficial for slope stabilization.

EFFECT OF KARAMUNTING LEAF EXTRACT (Melastoma malabathricum L.) ON GLUCOSYLTRANSFERASE ENZYME OF Streptococcus mutans

ABSTRACTBackground: Karamunting leaf extract has secondary metabolite compounds such as tannin, flavonoid, and phenol that have antibacteria potential to be used as an alternative to mouthwash in addition to Chlorhexidine 0.12% to lower the incidence of tooth caries. Caries is caused by several important virulence factors, including Streptococcus mutans Glucosyltransferase (GTF) enzyme. Karamunting leaf extract can inhibit the work of GTF enzyme by precipitating, denaturing protein and damaging cell walls. Inhibition of Streptococcus bacteria enzyme activity will decrease plaque formation, thus decreasing the potential of dental caries. Objective: The purpose of this study was to determine the effect of Karamunting leaf extract and 0,12% Chlorhexidine on Glucosyltransferase enzyme activity of Streptococcus mutans. Methods: This study used true experimental design with post test only with control group design using 7 groups, including Karamunting leaf extract group with 5%, 10%, 15%, 20%, and 25% concentrations to determine the activity of S. mutans GTF enzyme. Results: The results showed that Karamunting leaf extract with 20% concentration was able to decrease the activity of Glucosyltransferase enzyme in Streptococcus mutans. Conclusion: Karamunting leaf extract affects Streptococcus mutans Glucosyltransferase enzyme activity. Keywords: Chlorhexidine 0,12%, Glucosiltransferase, Melastoma malabathricum L., Streptococcus mutans.

Reducing the Effects of Blood Sugar Infusion of Melastoma Malabathricum L. in Mus Musculus

This study aims to determine the blood sugar-lowering effect of Melastoma malabathricum L. infusion on Mus musculus. The research design used was an experimental laboratory carried out in the pharmacology laboratory of the Ho Chi Minh City University. This study used 15 male mice which were divided into 5 groups consisting of group I as negative control by giving aquadest, groups II, III, IV were given infusion of Melastoma malabathricum L. respectively 0.1 g/ml, 0.2 g/ml, and 0.4 g/ml, and group V as a positive control with glibenclamide suspension. The results showed that statistical testing using the SPSS program showed a significant difference (p &lt;0.05), which means that senggani leaf infusion had a significant effect on reducing blood sugar levels in mice and the most optimal was 0.4 g/ml infusion.

Plants Diversity in Small Rubber Plantations at Segamat, Johor

Species richness in rubber plantations varies considerably with regards to production and management activities. This research was conducted to identify the diversity and richness of common plants in rubber plantations at Segamat, Johor. To answer the question of how rubber plantations owned by local smallholders affects the plant diversity, quadrat random method with 5 x 5 m plotting site was established in three different aged of rubber plantations at Segamat area which are Kg. Sedeng, Kg. Logah and Kg. Jawa. Each of the locations consisted of 10 sampling quadrats making a total of 30 quadrats. The results showed there are a total of 41 species belonging to 36 genera and 24 families in the 30 plots of the three plantations. The most dominant families were Rubiaceae, Euphorbiaceae and Asteraceae. The plants diversity were documented in rubber plantations at different location to record the number of species, the species evenness, similarity index, species richness, abundance parameter and important value index (IV i ). As for all three locations, the plants species were moderately diverse as the value of Shannon Diversity Index (H’) moving closer to Hmax but all the plotted area within three location showed higher evenness in species distribution. Based the result from density and frequency of abundance parameter, Asystasia gangetica species was the common species in all plantations. For the IV i , there was only one species with absolute dominance (higher than 10%) which was Asystasia gangetica with value 13.62% for overall location at Segamat, Johor. In conclusion, the most common species in the smallholder rubber plantations at Segamat, Johor was Asystasia gangetica, Bridelia tomentosa, Ageratum conozoides, Caryota mitis and Melastoma malabathricum. The rubber plantations adopting a minimal or natural management approach were dominated by common weed species and invasive plants. Despite the benefits of maintaining high species diversity for sustaining the gene pool, improving management practices is beneficial to improve yield and productivity.

Mechanical properties of contaminated concrete inhibited by Areca catechu leaf extract as a green corrosion inhibitor

The most significant characteristic of corrosion inhibitors is to create chemical stability, when considering the fact that it affects concrete properties simultaneously. mild steel corrosion in 1 M HCl was studied in the presence different concentrations of Acacia longifolia, Areca catechu, Melastoma malabathricum, Elaeis guineensis and Cocos nucifera as green inhibitors and sodium nitrite (SN) as chemical inhibitor. Effects of green inhibitor utilized in this research has been investigated through conducting various tests on ordinary concrete, contaminated concrete and contaminated concrete modified with SN inhibitor and Areca catechu was found as the most efficient green inhibitor which was concluded through corrosion of mild steel and nitrogen content tests. The ordinary concrete has been contaminated by adding 5% magnesium sulphate and 5% sodium chloride by mixing water while casting. Results showed that the optimum percentage of A. catechu over concrete was 2% achieved by compressive, tensile and flexural strength test has been conducted at 7 and 28 days. Both chemical and green inhibitor showed acceptable compressive, tensile and flexural strength in contaminated concrete, while A. catechu added concrete showed superior performance when compared to SN.