Medium-scale companies often operate in dynamic and competitive business environments. Faced with market changes and new opportunities, timely and accurate strategic decisions are key to maintaining and enhancing the competitiveness of the company. This research aims to examine the role of ChatGPT in business information systems to support strategic decision-making in medium-scale enterprises. The research method employed is a literature review with a qualitative approach and descriptive analysis. Descriptive analysis will be used to present information from systematically selected articles from Google Scholar within the timeframe of 2014-2024. The study results indicate that in the continuously evolving digital era, medium-scale companies increasingly rely on technology to address increasingly complex business challenges. One innovation playing a significant role in today's business landscape is the presence of ChatGPT. As an artificial intelligence model capable of understanding and generating text naturally, ChatGPT has a significant impact on business information systems and supports strategic decision-making in these companies.