Medium Intensity Research Articles

Quality of Life and Symptoms of Hospitalized Hematological Cancer Patients

Patients with hematological malignancies undergo intensive treatment and prolonged hospitalization, thus having a variety of physical and psychosocial symptoms and worse quality of life (QOL). This study aimed to assess the QOL and investigate the symptoms of hospitalized hematological cancer patients. A cross-sectional study was conducted in the hematology clinics and day units of two general hospitals of Heraklion, Crete. Adult patients with hematological malignancy and an adequate understanding of the Greek language participated. A demographic questionnaire, the European Organization for Research and Treatment for Cancer quality assessment questionnaire (EORTC QLQ-C30), and the MD Anderson Symptom Inventory (MDASI) were used. The sample consisted of 120 patients—42.5% were women, with a mean age of 65.6 years. The mean time from diagnosis was 33 months. The global health status of QoL had an average value of 47.1. The highest levels of QOL were found in the subscale of cognitive function (72.8) and the lowest in the role function (46.1). For the EORTC QLQ-C30 symptoms scale, the lowest score was found in nausea-vomiting (11.0) and the highest in fatigue (59.1). In the MDASI, in part I (core symptoms), higher levels but also medium intensities were reported at fatigue (78.3%, mean 3.5), drowsiness (65.0, mean 3.3), and distress (65.8%, mean 2.8). In part II, enjoyment of life (85.8%, mean 5.1) had the highest, and relation with other people (67.5%, mean 3.7) had the lowest scores. The increase in the severity of the core symptoms (part I) was related to females (rho = 0.193, p <0.05) and comorbidities (rho = 0.220, p < 0.05). It was also associated with a significant decrease in all functional domains and increased fatigue (rho = 0.571, p < 0.05) in the EORTC QLQ-C30 questionnaire. The increased global health status was related to males (rho = −0.185, p < 0.05) and physical functioning with younger age (rho = −0.331, p < 0.05), higher education (rho = 0.239, p < 0.05), fewer months from diagnosis (rho = −0.199, p < 0.05), and low comorbidity (rho = −0.209, p < 0.05). Finally, multiple linear regression analysis revealed that the total average symptom score of the MDASI was the most significant factor influencing the global health status of the EORTC QLQ-C30 (β = −4.91, p < 0.001). The increased global health status of the EORTC QLQ C30 was not significantly related (p > 0.05) to the social characteristics of the patients, such as education or employment, which requires further validation. The QoL of hematological cancer patients significantly decreases during treatments due to a considerable number of symptoms that must be taken into consideration for high-quality, individualized care.

Studying the X-ray absorption characteristics of Centaurus X-3 using nearly 14 years of MAXI/GSC data

Centaurus X-3 is a persistent high-mass X-ray binary with the long-term light curve from the source exhibiting orbit-to-orbit intensity variations with no apparent superorbital periodicity. We used sim 13.5 years of MAXI /GSC data to study the long-term behaviour of X-ray absorption caused by the stellar wind from the companion star and any absorbing structures present in the binary. We used orbital-phase-resolved spectroscopy to study the variation in the photoelectric absorption along the line of sight of the source for both the intensity-averaged data and intensity-resolved data after dividing all the data binned with orbital period into three intensity levels. We find an asymmetric variation in the photoelectric absorption along the line of sight across an orbit of the source. The orbital-phase-resolved spectra show a clear increase in photoelectric absorption after $ orb 0.5, which deviates from a spherically symmetric stellar wind model. The flux of Cen X-3 shows significant variation between consecutive orbits. An intensity-resolved spectral analysis of the source was performed, followed by an intensity-resolved and orbital-phase-resolved spectral analysis, which showed that at the medium and high intensity levels, the orbital-phase-resolved photoelectric absorption is slightly asymmetric with respect to mid-phase ($ orb =$ 0.5). The asymmetry is very pronounced at the lowest intensity level and cannot be explained by a spherically symmetric wind from the companion star. The differences in the orbital phase-dependence of absorption for different intensity levels suggest that the presence of an accretion wake, photoionization wake, or tidal stream is more prominent at a lower intensity level for Centaurus X-3 than at a higher intensity level.

The use of argon plasma coagulation in ruptured hemorrhagic syndrome (Mallory-Weiss syndrome) complicated by ongoing bleeding

Objective: to evaluate the efficacy and safety of argon plasma coagulation for endoscopic hemostasis in Mallory-Weiss syndrome. Materials and methods: on the basis of a clinical observation of a patient admitted to the emergency department of the State Budgetary Healthcare Institution of the Moscow Region of the Children’s Central City Hospital with complaints of vomiting of scarlet blood, dark stools, weakness, dizziness. The patient underwent emergency EGDS. Results: According to the EGDS data, a linear mucosal rupture was detected in the lower third of the esophagus along the posterior wall with a transition to the stomach cardia along the lesser curvature, about 8-9 cm long (5 cm in the esophagus, 3-4 cm in the stomach), up to 2 cm deep. -3 mm, from the rupture there is a flow of scarlet blood of medium intensity, in the bottom of the defect, fibers of the submucosal and muscular layers were determined. Endoscopic hemostasis was performed: argon plasma coagulation of the rupture of the mucous membrane of the esophagus and stomach. Against the background of endoscopic treatment by argon plasma coagulation in a patient with a long rupture, hemostasis was achieved and surgical treatment was avoided, which could aggravate the condition and lengthen the treatment time. Conclusions: Argon plasma coagulation as a non-contact method of hemostasis has a limited penetration depth and is safer and more effective than other (contact) electrocoagulation methods, where, as a rule, it is difficult to control the depth of exposure. The use of this method improves the efficiency of endoscopic hemostasis, reduces economic costs, and reduces the patient’s stay in bed.

Low-Frequency Magnetic Incremental Permeability for the Non-destructive Evaluation of Hardness Profile After Carburization Treatment with Large Case Hardening Depth

Carburization treatment with large case hardening depth is a technical process to enhance steel parts' surface hardness and wear resistance. Accurate evaluation of this metallurgical treatment is crucial to prevent critical mechanical failures. Low-frequency magnetic incremental permeability (LF-MIP) emerges as a non-destructive surface technique well-suited for this purpose in the case of ferromagnetic parts. Although correlations between magnetic indicators obtained through LF-MIP characterization and deep carburization treatment have been demonstrated, they remain qualitative. In this study, we propose an innovative method to assess the entire hardness profile based on LF-MIP characterization. Experimental results and simulation data are integrated into a reference chart used for post-processing, enabling the prediction of hardness profiles for specimens in a blind test. With a relative Euclidean distance of less than 6% between the method's predictions and destructive tests conducted on specimens treated with medium, deep, and intense intensities, we consider the method validated.

Work of ART: Profiling the First 100 Patients Discharged Home From an Acute Hospital with the Active Recovery Team (ART)

Abstract Background The Active Recovery Team (ART) is a new therapy lead rehabilitation team that offers supported discharge and admission avoidance from a large acute hospital. This interdisciplinary team consists of a physiotherapist, occupational therapist, medical social worker and two therapy assistants. ART accepts referrals from all services within the hospital including the emergency department. Methods As ART is a new service, a retrospective audit of the first 100 patients who discharged on the pathway was completed. Demographics included age, sex, referring specialty, presenting complaint, frailty (measured by the Clinical Frailty Score) and level of input received. ART use the coding of low, medium and high intensity to describe the intervention provided based on dosage (visits) and complexity. Results Most (67%) of the group were female and mean age was 77 years. Only 8% were pre-frail (CFS 0-3), 86% were living with mild to moderate frailty (CFS 4-6) and 6% considered severely frail (CFS 7-9). The type of intervention patients received was 31% low, 33% medium and 36% high intensity. Referrals came from a range of specialties, but the highest percentage of referrals were from emergency medicine (29%), medicine (20%), orthopaedics (18%) and geriatric medicine (16%). Most (53%) initially presented post a fall at home. Most frequent reason for ART referral (78%) was that the patient was discharging home not at their functional baseline but had potential to an achieve a specific goal(s) with further input (most frequently within domains of mobility indoors/outdoors, transfers, stairs and activities of daily living). Conclusion This is an effective pathway that improves the transition from hospital to home. ART offer patients an opportunity for further rehabilitation at home with continuity of care from the acute hospital. Future work will examine the impact of ART on length of stay, readmission rate and explore patient satisfaction with this service.

Zonulin — effective biomarker for the diagnosis of intestinal lesions in patients with nonalcoholic fatty liver disease in COVID‑19

The SARS‑CoV‑2 virus mainly attacks the respiratory system, but can also affect several organs, in particular, causing gastrointestinal symptoms such as vomiting, diarrhea or abdominal pain in the early stages of the disease. Intestinal dysfunction leads to a change in intestinal microorganisms and an increase in the content of inflammatory cytokines. Liver dysfunction is also relatively common in patients with coronavirus disease 2019 (COVID19). Objective — to investigate the efficacy of zonulin in determining intestinal damage in patients with nonalcoholic fatty liver disease with COVID‑19. Materials and methods. The study included 76 patients with non‑alcoholic fatty liver disease (NAFLD) who had complaints indicating intestinal disorders during the outpatient stage of follow‑up after ­COVID‑19. From the anamnesis, it was found that all examined patients had a confirmed diagnosis of infection with SARS‑CoV‑2 virus. All patients had a mostly mild course of COVID‑19, which did not require hospitalization. Patients with NAFLD were divided into two groups depending on defecation violation: group I — 36 patients who, after an acute respiratory infection caused by the SARS‑CoV‑2 virus, developed periodic diarrhea (on average, in (38.7±5.2) days after a negative PCR result for SARS‑CoV‑2 virus); group II — 40 patients with constipation, which began to bother on average in (86.9±7.4) days after a negative PCR result. The control group included 20 practically healthy individuals. The level of zonulin was determined in blood serum and faeces by enzyme‑linked immunosorbent assay. Patients underwent faecal culture to assess the quantitative and qualitative composition of the colon microflora. Results. During the anthropometric examination, overweight and first‑degree obesity were detected more frequently in patients of both groups: overweight was diagnosed most frequently in patients of group I (38.9%) and first‑degree obesity in patients of group II (35.0%). The microbiological examination of faeces in both groups of patients revealed a decrease in the number of bifidus and lactobacilli, as well as Enterococcus and E. coli with normal enzymatic properties. In group I patients, Citrobacter and Staphylococcus were statistically significantly (p <0.05) more often detected in increased concentrations in faeces, whereas in group II patients Enterobacter, Klebsiella and Clostridium were detected (p <0.05). Significant changes were found in the analysis of zonulin levels in both serum and faeces in patients with NAFLD after COVID‑19. Serum zonulin levels in patients of group I increased 6.5‑fold, and in patients of group II—8.6‑fold (p <0.001). An increase in the concentration of zonulin in the faeces was also detected — by 7.5 and 9.7 times, respectively (p <0.001). A correlation was established between the level of zonulin in both blood serum and faeces and a decrease in the number of bifidus and lactobacilli in faeces in patients of both groups. Also, a strong correlation was found between the number of Enterobacter, Klebsiella and Clostridium and a medium intensity correlation between the number of Staphylococcus in the faeces in patients of group ІІ. In patients of group І, a correlation was found between the number of Staphylococcus and Citrobacter. The level of zonulin (both in blood serum and faeces) directly depended on changes in body mass index in the patients we examined, namely, overweight in patients of group І and obesity of the first degree in patients of group ІІ. Conclusions. In patients with NAFLD after COVID19, changes in the quantitative and qualitative composition of the colon microflora were found in the intestinal lesions, including a decrease in the number of bifidobacteria and lactobacilli, as well as an increase in the content of Staphylococcus and Citrobacter in the faeces in patients with predominant diarrhoea and Enterobacter, Klebsiella and Clostridium in patients with predominant constipation. An increase in the level of zonulin in the blood serum and faeces in patients with NAFLD after ­COVID‑19 was detected. A more pronounced deviation from the norm was found in patients of group ІІ (with complaints of constipation). A direct correlation was established between the level of zonulin in the blood serum and faeces and changes in the quantitative and qualitative composition of the colon microflora, as well as an increase in body mass index in patients with NAFLD after ­COVID‑19.

Biomagnetismo medicinal na hepatite autoimune: um estudo de caso

Autoimmune Hepatitis (AIH) is a chronic and severe inflammatory disease of the liver caused by loss of tolerance to hepato-specific autoantigens, and the identification is made by applying diagnostic scores. It is characterized by an increase in serum aminotransferases - aspartate aminotransferase (AST) and alanine aminotransferase (ALT), immunoglobulin G, autoantibodies, where triggering agents appear that confuse the immune system that recognizes components of some hepatocytes as antigens. In this study, Medicinal Biomagnetism (BM) was applied, which is a treatment method developed by Dr. Isaac Goiz Durán (1941-2021), whose technique consists of applying a pair of medium intensity magnets -1,000 to 7,500 Gauss, with opposite polarities that resonate with each other and aim to depolarize the dysfunction magnetic field called Biomagnetic Pair (BMP). The magnetic resonance generated by the static magnetic fields, identifies and restores the electron spin of the biochemical elements that support the hydrogenion potential (pH) distortion. The objectives os this study were: to investigate whether there was any change in the clinical and laboratory signs of the patient undergoing BM and to investigate the applicability of the technique in her clinical evolution; compare possible changes in saliva pH before and after therapy; observe whether there were changes in liver enzymes during the treatment period; find out whether during the treatment the hepatologist indicated a reduction in the dosage of the medication in view of the clinical/laboratory improvement; and if there was an improvement in symptons. Through the analysis of the medical records, it was observed that the BM tecnique made it possible to improve the clinical/laboratory status of the patient with AIH.

Hypomethylation in promoters of PGC-1α involved in exercise-driven skeletal muscular alterations in old age.

Exercise training can significantly improve skeletal muscle mitochondrial function and has been proven to be highly relevant to alterations in skeletal muscle DNA methylation. However, it remains unclear whether late-in-life exercise has an effect on promoter methylation of PGC-1α, a key regulator of mitochondrial biogenesis. Here we employed two distinct exercise modalities, constant medium intensity exercise training (CMIT) and high-intensity interval exercise training (HIIT), to investigate their impacts on PGC-1α expression and methylation regulation in skeletal muscle of aged mice. The results revealed a notable decrease in PGC-1α expression in skeletal muscle of aged mice, accompanied by elevated methylation levels of the PGC-1α promoter, and increased DNA methyltransferase (DNMT) protein expressions. However, both forms of exercise training significantly corrected PGC-1α epigenetic changes, increased PGC-1α expression, and ameliorated skeletal muscle reduction. Furthermore, exercise training led to elevated expression of proteins related to mitochondrial biogenesis and energy metabolism in skeletal muscle, improving mitochondrial structure and function. In conclusion, late-in-life exercise improved skeletal muscle function, morphology, and mitochondria biogenesis, which may be associated with hypomethylation in promoters of PGC-1α and increased content of skeletal muscle PGC-1α. Notably, there was no clear difference between HIIT and CMIT in PGC-1α expression and skeletal muscle function.

Ecophysiology of Mediterranean Chestnut (Castanea sativa Mill.) Forests: Effects of Pruning Studied through an Advanced IoT System

Chestnut (Castanea sativa Mill.) forests in the Mediterranean region are facing increasing abandonment due to a combination of factors, ranging from climate change to socioeconomic issues. The recovery of chestnut ecosystems and their preservation and valorization are key to ensuring the supply of the wide spectrum of ecosystem services they provide and to preventing detrimental environmental shifts. The study’s objective was to provide evidence on the effects of different management options on the ecophysiology of chestnut forests, with diverse pruning intensities (low, medium, and high intensity versus no pruning) tested in an abandoned chestnut stand in central Italy with the aim of recovering and rehabilitating it for fruit production. Innovative Internet of Things (IoT) ‘Tree Talker’ devices were installed on single trees to continuously monitor and measure ecophysiological (i.e., water transport, net primary productivity, foliage development) and microclimatic parameters. Results show a reduction in water use in trees subjected to medium- and high-intensity pruning treatments, along with a decrease in the carbon sequestration function. However, interestingly, the results highlight that trees regain their usual sap flow and carbon sink activity at the end of the first post-pruning growing season and fully realign during the following year, as also confirmed by the NDVI values. As such, this paper demonstrates the efficacy of recovering and managing abandoned chestnut forests, and the initial setback in carbon sequestration resulting from pruning is rapidly remedied with the advantage of reviving trees for fruit production. Additionally, the reduced water demand induced by pruning could represent a promising adaptation strategy to climate change, bolstering the resilience of chestnut trees to prolonged and intensified drought periods, which are projected to increase under future climate scenarios, particularly in the Mediterranean region.

Climatic and anthropogenic deflation change factors in the territory of Belarus and their regional features

The present study deals with the analysis of the frequency and recurrence of extreme deflation phenomena in the territory of Belarus. The deflation intensity was estimated using meteorological data. 810 cases of dust storms and drifting snow were recorded in the country in the period of 1961–2022, of which 238 had low intensity, 213 – medium intensity and 359 – high intensity. The deflation phenomenon dynamics was analyzed: in the period of 1961–2000 the number of cases decreased gradually, but after 2000 there was an increase in dust storms. The growth of deflation repeatability corresponds to ongoing current climate changes. The spatial zoning of the country by deflation intensity was conducted based on the relief, the composition and structure of cover deposits, and the conditions of economic development of the area. The zones are presented as follows: with low deflation intensity (central Belarusian hills and ridges, northern and eastern regions of the country), medium (central regions of the country) and high (Belarusian Polesie, Grodno, Volkovysk and Slonim uplands with adjacent plains and lowlands).

Comparison between junior and recreational based on internal and external load response in soccer

The characteristics of soccer games tend to be at medium and high intensity. Measurement of heart rate response and activity profile can be used to assess the physical condition performance of players in planning the right program. The purpose of this study was to analyze the differences between heart rate response and activity profile in junior and recreational soccer players. The sampling technique used was purposive sampling. 24 male soccer players (12 junior Aged 11.58 ± 0.28 Years, 142.25 ± 8.74 cm, 34.5 ± 6.42 kg) and (12 recreational Aged 32.7 ± 1.38 Years, 170.67 ± 3.92 cm, 73.42 ± 5.33 kg) underwent simulation game sessions of 15 minutes each recorded using Polar Verity Sense and Catapult One to capture internal and external load data. Data were analyzed using the Mann-Whitney U Test to determine the difference between the heart rate of junior and recreational players. The results showed that there was a significant difference between HRavg in junior players (166.1 ± 17.2) and recreation (155.3 ± 10.5) as well as HRmax in junior players (193.1 ± 12.3) and recreation (176.0 ± 10.0) (p < 0.05). In addition, in the variable top speed (6.20 ± 0.68) and also maximal acceleration (4.52 ± 0.39) there is a significant difference (p < 0.05). This study concludes that there is a significant difference in heart rate response, but in the activity profile only the top speed and maximal acceleration variables between soccer players. Keywords: heart rate response, activity profile, junior and recreational soccer players

Comparison of non-invasive magnetomyography to Brink score for assessment of pelvic floor muscle strength.

Objective.Levator ani muscles undergo significant stretching and micro-trauma at childbirth. The goal was to assess the neuromuscular integrity of this muscle group by means of magnetomyography (MMG) and correlate with Brink score-a commonly used digital assessment of pelvic floor muscle strength.Approach.Non-invasive MMG data was collected on 22 pregnant women during rest and voluntary contraction of the pelvic-floor muscles (Kegels). The mean amplitude and power spectral density (PSD) of the Kegels were correlated to Brink pressure score.Main Results.The modified Brink pressure score demonstrated medium correlations (⩾0.3) with MMG amplitude and PSD with the average Kegel of medium intensity and rest. Data showed that the 'resting state' of the pelvic floor is, in actuality, quite dynamic and may have implications for pelvic floor disorder propensity postpartum.Significance.These results confirm the ability of non-invasive MMG to reliably capture pelvic floor contraction as these signals correlate with clinical measure.

Exploring effects of light intensity on sustainability indicators in finishing pig production

With an ongoing transition towards the use of Light Emitting Diodes, more knowledge is needed on which light settings optimise sustainability parameters in pig production. We studied the effects of four light intensities on social, environmental and economic sustainability indicators, including ammonia emissions, space use, pen fouling, weight gain, carcass quality, perception of the stockkeeper, costs of the light system, and use of drinking water, electricity and medicines. Light treatments included a low (45 lux), medium (198 lux) and high (968 lux) uniform intensity, and a spatial gradient treatment ranging from 71 lux in the front to 330 lux in the back of each pen. The latter treatment aimed to improve the space use of functional areas. A total of 448 growing-finishing pigs were studied on a commercial farm using two consecutive batches of four rooms containing eight pens with seven pigs. Light intensity influenced some aspects of space use and pen fouling. For example, the proportion of pigs lying in the resting area was higher in the high and medium light intensity treatment than in the low intensity and gradient treatment. Moreover, the high-intensity treatment resulted in more fouling with faeces in the feeding area compared with the low-intensity and the gradient treatment. Ammonia emissions were higher in the gradient than in the low intensity treatment (not measured in medium and high intensity treatment). Furthermore, light intensity did not affect weight gain, carcass quality, water use and medicine use. The stockkeeper was content to work in all light conditions, but slightly preferred the medium intensity due to optimal visibility. Concerning economic performance, the costs of the light system and electricity use increased in the following order: low intensity, gradient, medium intensity, and high intensity. In conclusion, contrary to expectation the spatial gradient did not notably improve space use or reduce pen fouling, but rather increased ammonia emissions in comparison with uniform light. This is likely because the gradient could not be applied in an optimal way in the existing housing conditions. Among the other sustainability indicators, mainly electricity use and costs of the light system differed per treatment. These aspects can be improved by further optimising the number of light sources needed per pen to achieve the targeted intensities.

Particulate matter hinders the development and reproduction of predatory mites of Euseius finlandicus (Acariformes: Phytoseiidae)

The foliage of the small-leaved lime (Tilia cordata) is characterised by the nerve axils being grown by non-glandular trichomes, which trait contributes to the enhanced retention of the particulate matter (PM). This fact may disturb the ecological service of T. cordata related to the structure of its leaves, which is to provide acarodomatia (micro-shelters) for the predatory mites of the Phytoseiidae family. Phytoseiids are natural enemies of a variety of plant pests, widely applied in integrated pest management (IPM). Their occurrence is largely related to acarodomatia in which these mites hide, feed, reproduce, and develop. For the first time, the influence of PM deposition within spaces typically occupied by phytoseiids is investigated. Experimental populations of Euseius finlandicus were reared on T. cordata leaves in the progressive PM-pollution. The results showed that the values of life table parameters of the predator depended significantly on the level of PM deposition on leaves. Contrary to clean leaves from the control, the medium and high contamination intensities significantly reduced the daily (by 47% and 70%, respectively) and the total fecundity (by 62% and 77%, respectively) of females which, in turn, resulted in a decreased net reproductive rate (by 67% and 81%, respectively), intrinsic rate of increase (by 40% and 55%, respectively) and finite rate of increase (by 8% and 10%, respectively) of E. finlandicus. The pre-ovipositional period was prolonged, while the oviposition duration was shortened and the mites matured longer. In high pollution level the mortality of phytoseiids was boosted by 19% and some females were observed with pollutant lumps adhered to the idiosoma. Also, significant shares of juvenile forms (13%) and adult females (25%) made attempts to escape from highly contaminated experimental arenas. The implications of PM retention on the shelter vegetation are discussed in the context of IPM and ecological services.

Crystal structure of catena-poly[[methanoldioxidouranium(VI)]-μ-2-[5-(2-oxidophen-yl)-1H-1,2,4-triazol-3-yl]acetato-κ2 O:O'

In the title complex, [U(C10H7N3O3)O2(CH3OH)] n , the UVI cation has a typical penta-gonal-bipyramidal environment with the equatorial plane defined by one N and two O atoms of one doubly deprotonated 2-[5-(2-hy-droxy-phen-yl)-1H-1,2,4-triazol-3-yl]acetic acid ligand, a carboxyl-ate O atom of the symmetry-related ligand and the O atom of the methanol mol-ecule [U-N/Oeq 2.256 (4)-2.504 (5) Å]. The axial positions are occupied by two oxide O atoms. The equatorial atoms are almost coplanar, with the largest deviation from the mean plane being 0.121 Å for one of the O atoms. The benzene and triazole rings of the tetra-dentate chelating-bridging ligand are twisted by approximately 21.6 (2)° with respect to each other. The carboxyl-ate group of the ligand bridges two uranyl cations, forming a neutral zigzag chain reinforced by a strong O-H⋯O hydrogen bond. In the crystal, adjacent chains are linked into two-dimensional sheets parallel to the ac plane by C/N-H⋯N/O hydrogen bonding and π-π inter-actions. Further weak C-H⋯O contacts consolidate the three-dimensional supra-molecular architecture. In the solid state, the compound shows a broad medium intensity LMCT transition centred around 463 nm, which is responsible for its red colour.

The effect of <i>Streptococcus mutans</i>, <i>Candida albicans</i> and other cariesogenic factors on the concentration of cathelicidin LL-37 in oral fluid in children with early childhood caries

BACKGROUND: Human antimicrobial peptides play a significant role in innate immunity. In the oral cavity salivary glands and mucosal epithelium produce human antimicrobial peptides, including defensins and cathelicidin LL-37. Cathelicidin is the most significant peptide protecting against different types of infections, controls the activity of commensal bacteria and prevents colonization and growth of pathogenic bacteria. AIM: To determine the concentration of cathelicidin LL-37 in the oral fluid of children 2–5 years old and the oral hygiene index depending on some of the parameters and intensity of the carious process in the oral cavity. MATERIALS AND METHODS: The study was conducted in a group of children aged 2-5 years old; the concentration of catelicidine in the oral fluid was determined by enzyme immunoassay. Moreover, the concentration of Streptococcus mutans in saliva, the presence of Candida albicans in dental plaque, oral hygiene index and the concentration of 25-hydroxycalciferol in venous blood were assessed in these children. RESULTS: The stydy revealed the dependence of the concentration of cathelicidin in the oral fluid on the intensity of the carious process in children as well as on the concentration of Streptococcus mutans in saliva, the presence of Candida albicans in plaque and poor oral hygiene. CONCLUSIONS: It was found that in children with high intensity of caries, the concentration of antimicrobial peptide LL-37 is twice lower than in children with low and medium intensity of early childhood caries.

Physical exercise as a key element in the behavioral treatment of type 2 diabetes - the extent to which patients follow recommendations

Introduction and purpose Diabetes is a set of metabolic disorders whose common, characteristic feature is the occurrence of hyperglycemia. Elevated glycemia levels result from impaired insulin secretion and/or defects in its action. In type 2 diabetes, we have modified risk factors such as improper diet, reduced physical activity, and obesity. In the context of these reversible factors, intervention in patients' lifestyle, with particular emphasis on physical activity, seems advisable. To investigate the implementation of recommendations for the treatment of type 2 diabetes, relating to physical activity as a component of behavioral treatment of diabetes. Materials and methods. Author's survey covering patients' knowledge about their disease, needs and expectations regarding education. The questionnaire examines the physical activity of patients newly diagnosed and already treated for type 2 diabetes. Results. The most frequently undertaken exercise was of medium intensity in the form of walking or "Nordic walking". This was also more likely to be intensified. Patients choosing this type of activity practiced it much more often and more regularly than other types of activity. Running and cycling were other activities undertaken by the patients, although in the younger group of patients. Patients who enjoyed physical exercise were more likely and willing to do it and it was more regular. Conclusions. Patients were reluctant to undertake physical exercise and usually did not treat it as an integral part of treatment. Usually, it was not a very intense effort. They also rarely intensified it when the diagnosis was made. Most of the respondents did not understand the role of exercise in the treatment process and its impact on sugar levels.

Effects of vineyard inter‐row management on soil physical properties and organic carbon in Central European vineyards

AbstractThe intensity and frequency of inter‐row management in vineyards are highly diverse and depend on local environmental conditions and the wine grower's attitude and experience. Reasons for different management include water conservation, weed and pest control, biological activity promotion and soil fertility and biodiversity preservation. We studied different soil cover management in 16 paired vineyards located at eight sites in the Leithaberg and Carnuntum regions of eastern Austria. To this end, we compared inter‐rows with medium intensity (Periodically Mechanically Disturbed) and low intensity (Permanent Green Cover). We investigated the effects of these different management intensities on soil organic carbon, bulk density, saturated and unsaturated hydraulic conductivity, pore size distribution and percolation stability in the upper soil layer from 3 to 8 cm. Soil organic carbon and percolation stability were significantly higher and soil bulk density was significantly lower in vineyards with permanent green cover. No significant differences were observed for saturated hydraulic conductivity, pore size distribution and plant available water. This may be attributed to a minor effect as a result of the time lag of up to 2 years since the last tillage. Regression analysis to predict plant‐available water for local vineyard soils also showed that texture, total organic carbon and bulk density were suitable predictor variables. These results suggest that both investigated inter‐row management systems support a good soil structure for winegrowers. Organic carbon content and parameters interacting with organic carbon may still be improved with permanent vegetation cover systems; however, the positive effects on plant available water are limited.

Adults in Low and Medium Intensity Group Pain Management Programs Achieve Similar Clinically Significant Outcomes: A Quasi-Experimental Study

Adults in Low and Medium Intensity Group Pain Management Programs Achieve Similar Clinically Significant Outcomes: A Quasi-Experimental Study

Summarizing physical performance in professional soccer: development of a new composite index

The aims of this study were to create a composite index to measure the overall players’ physical performance in professional soccer matches and analyze the effect of individual playing time and positional differences on this composite index. A total of 830 official matches from LaLiga men’s first division and Spanish Copa del Rey were analyzed, which resulted in 24,980 match observations collected from 1138 male players (forwards, n = 286; midfielders, n = 441; defenders, n = 411). The physical performance variables, which represent the locomotor demands, were collected using electronic performance tracking systems. A Partial Least-Squares Structural Equation Model (PLS-SEM) was used to measure performance. The PLS-SEM output had three significant latent components, which explained 95% of the initial variability, that were related to the acceleration-specific performance (component 1), high-intensity running-related variables (component 2), and medium intensity actions variables (component 3). Also, a linear regression analysis was used to explore relationships between playing activity time (hours—X axis) and the composite index (10-point scale—Y axis), in which a strong and positive correlation was observed between individual playing time and the composite index (r = 0.76; p < 0.001; R2 = 0.58). Also, significant positive correlations were observed in forwards (r = 0.85; p < 0.001; R2 = 0.74), midfielders (r = 0.80; p < 0.001; R2 = 0.64), and defenders (r = 0.67; p < 0.001; R2 = 0.45). However, significant differences between playing positions with a small effect size (p < 0.05; eta-squared = 0.01) were found. From a practical perspective, this study may serve as a reference for sports performance practitioners to create a composite index that measures the overall players’ physical performance. The instructions to create this index are available in the manuscript.