This work is focused on the numerical modeling of steady, laminar, heat and mass transfer by MHD mixed convection from a semi-infinite, isothermal, vertical and permeable surface immersed in a uniform porous medium in the presence of thermal radiation and Dufour and Soret effects. A mixed convection parameter for the entire range of free-forced-mixed convection is employed and the governing equations are transformed into non-similar equations. These equations are solved numerically by an efficient, implicit, iterative, finite-difference scheme. The obtained results are checked against previously published work on special cases of the problem and are found to be in excellent agreement. A parametric study illustrating the influence of the thermal radiation coefficient, magnetic field, porous medium inertia parameter, concentration to thermal buoyancy ratio, and the Dufour and Soret numbers on the fluid velocity, temperature and concentration as well as the local Nusselt and the Sherwood numbers is conducted. The obtained results are shown graphically and the physical aspects of the problem are discussed.