The objective of this study was to show the different ways medicinal herbs are used by the indigenous people in Port Harcourt metropolis (07 °3′ E, 04° 51′ N) in the Niger Delta region, Nigeria. One hundred and fifty structured questionnaires were administered, including oral interviews to herbal practitioners and users located at different parts of the city. Also, three popularly known herbal companies—Emiola naturalist care, Yem-Kem international herbal center, and Abiola medical herbal center—were included as they are healthcare providers, especially the medium income group. The results showed that a total of 83 plant species were recorded and classified according to their family, botanical, common, and local names. Also, the plant part used, mode of preparation, and type of ailment cured were included. The most frequently used plant parts were leaves followed by barks, roots, and fruits and with malaria fever as the most treated ailment. Deforestation, agricultural expansion, and fire were noted as the most important factors threatening the availability of these plants. The authors are of the opinion that paying special attention to the medicinal plants found in the area through conservation may help to amplify their role in the healthcare system, poverty alleviation, and environmental protection.