Medium Effect Size Research Articles

Issues Behind the Measurement of Political Orientation

Abstract: Given the limited research addressing the construct and content validity of single-item and multiple-item measures of political orientation (PO), we investigated the effect sizes in the relationship between PO and variables categorized into multiple dimensions using a meta-analysis of 511 independent effect sizes from 108 articles published from 2012 to 2022. Multiple-item measures of PO that included economic items had a large effect size ( r = .55 ~ .75) in their association with variables in the economic, environmental, and traditionalism dimensions, whereas we found small effect sizes ( r = .23 ~ .24) between single-item PO and variables in the economic and environmental dimensions and a medium effect size ( r = .31) between single-item PO and variables in the traditionalism dimension. Based on the pooled data consisting of all multiple dimensions’ data subsets, we found medium effect sizes ( r = .35 ~ .39) for multiple-item measures of PO and a small effect size ( r = .27) for single-item PO. Our content analysis of 30 multiple-item measures of PO showed that over 80% of multiple-item measures were grounded in US and/or Western countries’ political contexts and samples and 50% of them did not measure economic aspects of PO. We discuss implications for future research.

Evaluation of the Pregnancy to Parenthood program: A dyadic intervention for mothers with perinatal mental disorders and their infants.

Dyadic interventions targeting maternal mental health and the mother-infant relationship in the perinatal period are critical due to the potential consequences of perinatal mental illness and relational disturbance for the mother, the infant, and their family. This paper describes the Pregnancy to Parenthood (P2P) model of care, a dyadic mother-infant community-based program designed to support vulnerable families in Western Australia in the context of an identified need to build workforce capacity. A pragmatic service evaluation study was conducted by analyzing routine clinical data collected from 105 dyads who completed pre- and post-intervention measures, including the Edinburgh Postnatal Depression Scale (EPDS), Perinatal Anxiety Screening Scale (PASS), and the Mother Object Relations Scale-Short Form (MORS-SF). Reliable change index and cut-off analyses indicated a clinically reliable pre-post reduction in perinatal depressive and anxiety symptoms for 71% and 68% of the sample, respectively. Significant pre-post improvements with medium effect sizes (r=-.46, r=-.32) were found for caregiving representations on the MORS-SF, suggesting representations became more balanced. These results provide provisional evidence that the P2P model of care may be effective in improving maternal mental health and caregiving representations. Further research is required to evaluate the efficacy of P2P in relation to enhancing family well-being, and to inform policy and mental health service development.

Study protocol of an exercise and nutrition intervention for ovarian cancer patients during and after first-line chemotherapy (BENITA) - a randomized controlled trial.

In ovarian cancer frequently reported side effects are muscle wasting and malnutrition, leading to frailty, decreased health-related quality of life (HRQoL), and cancer-related fatigue (CRF). Both often begin during first-line chemotherapy and develop progressively into a refractory state, if left untreated. Primary objective is to evaluate effectiveness of a newly developed app-based exercise and nutrition program under non-standardized conditions of clinical routine. We hypothize that patients who receive an individually tailored exercise and nutrition program for six months will have improved physical performance compared to patients who receive usual care. This is a multicenter randomized controlled open-label trial comparing an intervention group receiving a six-month exercise and nutrition intervention and a control group receiving usual care. Primary endpoint is the change in 6-Minute Walk Test (6MWT) from baseline to T2 (26 weeks after baseline) as a measure of physical functioning. Secondary endpoints include patients' utilization and adherence to the nutrition program (MEDAS), their malnutrition risk (NRS2002), as well as patients' HRQoL (see Table1). Using the two-sample t-test with a two-sided type I error of 5% and 80% power, a medium effect size of Cohen's d = 0.50 can be demonstrated with a minimum of 128 participants (64 per group). With a conservatively estimated dropout rate of 30%, 182 patients will be recruited. Patients who are included must be over 18 years of age, be diagnosed with ovarian cancer, cancer of fallopian tubes, or peritoneal cancer, FIGO stages II-IV, receive surgery and chemotherapy (adjuvant or neoadjuvant). Exclusion criteria are an ECOG status greater than 2, inadequate proficiency in German, or physical or mental impairments hindering the implementation of the program or execution of study procedures. In case of success, the project contributes in the long term to (i) improving medical care (diagnosis, psychoeducation, patient orientation, and empowerment), (ii) reducing the burden of disease and promoting physical autonomy for patients, and (iii) being incorporated into relevant guidelines. The study was registered at ClinicalTrials.gov (NCT06250686).

Local Language Explanation-Infused Learning Material (LLE) and Activity-Based Formative Assessment (AFA): Enhancing Mathematics Learning

The study employed mixed-method research, specifically a pre-experimental case study, to explore the influence of implementing local language explanation-infused learning material (LLE) and activity-based formative assessment (AFA) on mathematics learning. The t-test for dependent samples was used to analyze the influence of LLE and AFA on students' mathematics learning. Thematic analysis of the data from informal interviews, focus group discussions, and observations was used to support the findings. The participants were 38 Grade 9 students from one of the public secondary high schools in the Philippines, identified through purposive sampling and selection criteria. The findings showed that using LLE and AFA significantly improves mathematics learning along with illustrating, modeling, and problem-solving with small to medium effect sizes. The thematic analysis results show that the use of LLE is helpful for students to study independently because they find the lessons more straightforward to understand. The use of AFA helps students enjoy learning through individual and group activities, leading to the development of analytical and critical thinking. The study recommends integrating local languages into instructional materials, providing teacher training on LLE and AFA, ensuring resources of adequate sort for formative assessments, and strengthening monitoring mechanisms to enhance the implementation of these practices in the classroom.

Parental emotion socialization and parent-child attachment security: A meta-analytic review.

Although parental sensitivity is an established determinant of children's attachment security, effect sizes are modest, suggesting other aspects of parenting that might support secure attachment. Parental emotion socialization (ES) has been proposed as a parenting domain that is theoretically linked to secure parent-child attachment. The goal of this meta-analysis was to evaluate the strength of the relations between parental ES and attachment security in children under the age of 18. We conducted three meta-analyses assessing the links of supportive parental ES, nonsupportive parental ES, and parental elaboration with attachment security assessed with behavioral, representational, and questionnaire measures (ks = 9-11 samples; Ns = 576-1,763 participants). The relation between supportive ES and security was significant but very small (r = .06). The relation between nonsupportive ES and security was not significant (r = -.05). Parental elaboration emerged as a key correlate of secure attachment, with a medium effect size (r = .24), similar to the relation between sensitivity and attachment security. The findings underscore the need for further research to elaborate on the role of ES in the development of attachment. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Dimensionality, reliability, and validity of the Finnish version of the pain catastrophizing scale in chronic low back pain.

The 13-item pain catastrophizing scale (PCS) is the most commonly used measure of pain catastrophizing. A validated Finnish version of the PCS has previously been unavailable. The objectives were to translate the original English version of the PCS into Finnish (PCS-FI), then to evaluate (i) structural validity of the PCS-FI with a confirmatory factor analysis (CFA), (ii) internal reliability with Cronbach's alpha, Omega, and Omega hierarchical, (iii) convergent validity with measures of well-being, quality of life, sleep quality, symptoms of central sensitization, and anxiety, and (iv) known-groups validity between participants with chronic low back pain (CLBP) and pain-free controls. The translation process was performed with established guidelines. The PCS-FI was psychometrically validated using 92 participants with CLBP and 53 pain-free controls. Structural validity with CFA supported a bifactor solution. However, low reliability was found for the three specific factors (ω h ranging from 0.14 to 0.18) compared to the general factor (ω h = 0.88) suggesting that only the total score should be used. Convergent validity analysis showed satisfactory correlations and medium effect sizes with the other patient-reported outcome measures. Participants with CLBP had significantly higher total PCS-FI scores than pain-free controls. The PCS-FI appears to be a valid and reliable instrument for assessing pain-related catastrophizing in Finnish-speaking populations. Ethical approval for this study was obtained from the Research Ethics Committee of the Northern Savo Hospital District, identification number 2131/2022, on the 31st of January 2022.

Investigating the Prevalence of Hypercalciuria in Children Aged 2-16 Years With Asymptomatic Microscopic Hematuria in 2020 in Tehran Children's Medical Center.

The prevalence of hypercalciuria in children is 3%-10% globally and up to 35% in the United States. Hypercalciuria in children has many presentations; it causes different metabolic disorders and can negatively affect a child's growth. It also increases the risk of low bone mineral density and urinary tract infections. In addition, it is the most widespread cause of persistent microscopic hematuria. Changes in the diet and medications in cases of advanced stage can be useful to prevent further complications. This study aimed to determine the prevalence of hypercalciuria and to investigate its relationship with different factors in children aged 2-16 years with asymptomatic microscopic hematuria in 2020 in the Children's Medical Center hospital. This retrospective cross-sectional study was performed in a population of children aged 2-16 years old with asymptomatic microscopic hematuria who were referred to the Children's Medical Center clinic in 2020. Data such as age, sex, serum creatinine level, and proteinuria were extracted from the patient's medical records, and their relationship with hypercalciuria was analyzed using logistic regression analysis. According to the inclusion criteria, 166 children with asymptomatic microscopic hematuria (72 boys and 94 girls) were included in this study. The prevalence of hypercalciuria (ratio of random urine calcium to creatinine more than 0.2) in these patients was estimated at 25% with a confidence interval of 18%-32%. In order of prevalence, the most common conditions accompanying microscopic hematuria were kidney stones, urinary tract infections, and proteinuria. The age of patients with hypercalciuria was 2 years younger on average. Each year of age increase and every 5 years of age increase between the ages of 2 and 16 years reduced the chance of hypercalciuria in this category of patients by 12% and 45%, respectively. Our findings also showed that children with a positive history of kidney stones were about 2.2 times more likely to have hypercalciuria than their counterparts, which is considered a medium effect size. Our results showed that hypercalciuria in children with hematuria is significantly related to younger age and a positive history of kidney stones.

The effects of photobiomodulation and transcutaneous electrical nerve stimulation on chronic neck pain: A double-blind, randomized, sham-controlled trial

BackgroundPhotobiomodulation (PBM) and transcutaneous electrical nerve stimulation (TENS) are used to reduce neck pain. ObjectiveTo investigate the immediate and 1-month post-treatment effects of 10 treatment sessions of PBM and TENS delivered over 2 weeks on pain intensity in individuals with neck pain. MethodsIndividuals with neck pain were randomized into four groups: PBM+TENS, PBM, TENS, and Sham. Primary outcome: pain intensity at rest. Secondary outcomes: pain intensity during movement, pressure pain threshold (PPT), temporal summation (TS), conditioned pain modulation (CPM), cervical range of motion (ROM), psychosocial factors, drug intake for neck pain, and global perceived effect (GPE). All outcome assessments were made pre- and post-treatment. Mean differences and 95 % confidence intervals were calculated for between-group comparisons. ResultsA total of 144 participants were recruited. No significant between-group difference was observed for pain intensity at rest, TS, CPM, ROM, psychosocial factors, and drug intake. The PBM+TENS showed a reduction in pain intensity during movement and GPE compared to the PBM (MD: 1.0 points; 95 % CI: 0.0, 2.0; MD: 2.0 points; 95 % CI: 1.0, 3.0) and Sham (MD: 2.0 points; 95 % CI: 1.0, 3.0; MD: 2.0 points; 95 % CI: 1.0, 3.0) groups. PBM+TENS presented a medium effect size to increase local PPT compared to PBM and Sham groups. TENS presented a medium effect size to increase local PPT compared to PBM and Sham groups. TENS presented a medium effect size to increase distant PPT compared to other groups. ConclusionsThe use of PBM or TENS was not effective for reducing pain intensity at rest. The combination of PBM and TENS was effective in improving pain intensity during movement, local hyperalgesia, and the GPE. TENS reduced local and distant hyperalgesia.

Efficacy of brief cognitive behavior therapy in improving symptoms, functioning, and adherence to treatment in patients with bipolar disorder in remission: A randomized control study

Background: Residual symptoms in individuals with bipolar disorder (BD) in remission are common, and they contribute to significant functional impairment and distress. The incomplete efficacy of pharmacological treatments and improvements in psychotherapeutic approaches has led to renewed interest in psychotherapy for this disorder. However, there are fewer studies addressing the same. Aim: The study aims to examine brief CBT (cognitive behavior therapy) in addressing the residual symptoms in BD. Method: A two-group randomized control design with multiple assessments (pre, post, and 3-month follow-up) was adopted. The sample consisted of 30 patients each in the intervention and Treatment As Usual (TAU) groups selected from the outpatient services of a tertiary mental health hospital. The variables studied were interepisodic symtpoms, functioning, and adherence to treatment using the tools of Beck Depression Inventory-II, Young Mania Rating Scale, and Beck Anxiety Inventory. The intervention group received a brief integrated CBT of 8–10 sessions conducted weekly over 2–3 months. The TAU group received treatment as usual and brief weekly telephonic contact. Results: A significant difference was seen across the time points between the groups on all the variables. Significant changes in within group scores was noted in the intervention group on depressive and anxiety symptoms, medication adherence, and dysfunctional attitudes compared to the TAU group. However, there was no significant change in the functioning in both the groups. Larger within group effect sizes for anxiety, dysfunctional attitudes and emotion regulation, medium effect sizes for depression, and quality of life and small effect sizes for manic symptoms and medication adherence were found in the intervention group. Depression severity had a significant moderating effect on therapy outcomes. Conclusion: The study shows effectiveness of brief CBT in reducing residual symptoms in the patients with BD. A longer-term follow-up would validate the findings.

Weighted Vest Combined With Vibrotactile Stimulations Decrease the Sympathetic Activity: A Repeated Measures Study.

Mental and neurological disorders are a growing global concern, further intensified by the COVID-19 pandemic. Stress management techniques, such as deep pressure therapy, have gained attention, with weighted vests commonly used for anxiety relief. However, there is limited scientific evidence supporting their efficacy. This study aimed to rigorously assess the effectiveness of a weighted vest incorporating vibrotactile stimulation in reducing anxiety by measuring physiological indicators-pulse rate and skin conductance (SC)-as well as subjective comfort ratings. A total of 30 final-semester college students participated in the study. Participants wore a vibrotactile-weighted vest, and both pulse rate and skin conductance (SC) were measured to gauge anxiety levels. Additionally, participants rated their comfort using a Comfort Rating Scale (CRS). Changes in pulse rate and SC were statistically analyzed, and effect sizes (Cohen's d) were calculated to assess the magnitude of the intervention's impact. The weighted vest with vibrotactile stimulation resulted in a significant reduction in both pulse rate (dpulse = 0.23-0.62) and SC (dsc = 0.32-0.66), indicating a small to medium effect size in anxiety reduction. Subjective evaluations of the vest using the CRS revealed low scores on discomfort-related items, with participants rating unfavorable statements between 1.5/10 and 4.6/10, suggesting overall comfort during use. This study provides compelling evidence that vibrotactile-weighted vests effectively reduce anxiety, as indicated by both physiological measures and subjective comfort ratings. The findings support the potential of this intervention as a formal therapeutic tool for stress and anxiety reduction. Further research may explore long-term effects and broader applications in clinical settings.

A Meta-analysis of Horticultural Therapy Programs for Older Adults with Dementia

Background and objective: This study analyzed the effect size of each element to secure the expertise of horticultural therapy programs for older adults with dementia.Methods: This study conducted a meta-analysis to analyze the effectiveness of horticultural therapy programs for older adults with dementia using 'horticulture' as a search term. To this end, 29 articles were selected and analyzed from a total of 147 articles published between 2003 and 2022.Results: First, the overall effect size of horticultural therapy for older adults with dementia was .522, which is statistically significant. This is considered a medium effect size according to Cohen's (1988) criteria for effect size. Second, the group size, a variable related to the number of subjects, showed the largest effect size when the group had 21–30 participants, and the number of sessions per week showed the largest effect size when the number of sessions was once a week, followed by twice a week, and so on. The effect size was largest when the total number of sessions was 21 or more, and when each session was conducted for 90-120 minutes.Conclusion: This study examined previous studies related to horticultural therapy programs for older adults with dementia through a meta-analysis and presented the results of a systematic effect size analysis. The significance of this study is that it summarized the factors that have a large effect and quantified the effect sizes so that it can be used in various horticultural therapy programs for older adults with dementia.

Effects of Vegan and Omnivore Diet on Post-Downhill Running Economy and Muscle Function

Objectives The objective of this study was to examine the difference between the extent of muscle damaging exercise on muscle function variables of vegans and omnivores. Methods Twenty recreationally trained participants completed the study. Participants were assigned to either vegan (n = 10) or omnivore (n = 10) groups. Subjects completed a consent visit followed by 2 visits consisting of running exercise sessions and test familiarization. They returned to the laboratory for visit 4 3-5 days after visit 3 to complete the testing battery. Following the testing, the participants performed a downhill run on the treadmill at −15% grade and approximately 70% of their speed at VO2peak and repeated the testing battery upon completion. Participants were asked to track their food intake. Visits 5, 6, and 7 took place 24, 48, and 72 h following the downhill running protocol, respectively, and consisted of the same testing battery used during visit 4. The detection of differences was performed using two-way (group x time) mixed factorial ANOVA with repeated measures. Results No group x time interactions were noted for running economy or any of the dependent variables. Main effects of time were found for muscle thickness (p<.001) with small effect sizes (d=-0.194 to d=-0.265), pain pressure threshold (p=.002) with medium effect sizes (d=.460 to d=.461), NPRS scale (p<.001) with large effect sizes (d = -0.776 to d=-1.520), and jump height (p<.002) with small to medium effect sizes (d=.304 to d=.438). Nutritional analysis compared the two groups revealed no difference (p>.05) between relative intake of macronutrients and that both exceeded typical recommendations for protein (vegan group − 1.4 g/kg, omnivore group − 1.6 g/kg). Conclusion The lack of differences in recovery between the groups suggests that nutritional adequacy may play a role in recovery. Recovery from downhill running might be influenced by several factors beyond diet, such as exercise protocol intensity, individual fitness levels, and age.

Enhancing sleep and mood in depressed adolescents: A randomized trial on nurse-led digital cognitive behavioral therapy for insomnia

BackgroundDespite the effectiveness of digital cognitive behavior therapy for insomnia (dCBT-I) in treating comorbid insomnia and depression, its accessibility and high dropout rates among adolescents and young adults remain significant limitations. A potential solution could be nurse-led dCBT-I. This study evaluates the feasibility and efficacy of nurse-led dCBT-I in reducing insomnia symptoms and improving mood in adolescents and young adults with depression. AimsOur objective was to evaluate the feasibility and effectiveness of a nurse-led dCBT-I in reducing insomnia severity among adolescents and young adults with depression. MethodsA parallel-group randomized controlled trial involved 40 adolescents and young adults aged 14 to 24 with major depressive disorder and insomnia. They were assigned to receive either a nurse-led 6-week dCBT-I or usual care. The study evaluated outcomes such as insomnia severity, depression severity, and sleep parameters. Measurements were taken at baseline, immediately after the intervention (6 weeks), and during a follow-up at 18 weeks. ResultsThe intention-to-treat analysis was performed using a generalized linear mixed model (GLMM). Results indicated that, compared to the control group, participants in the intervention group exhibited a significant reduction in insomnia severity at the 18-week follow-up, with a large effect size (Cohen's d = −0.965, p < 0.001). Additionally, the intervention group demonstrated a significant decrease in depression severity both at the end of the intervention (Cohen's d = −0.686, p = 0.001) and at the 18-week follow-up (Cohen's d = −0.508, p = 0.011), indicating a medium effect size. ConclusionsNurse-led dCBT-I is an effective treatment for adolescents and young adults with depression and insomnia.

The effectiveness of teaching human evolution to 14-15-year-olds in Slovenia Učinkovitost poučevanja evolucije človeka pri 14-do 15-letnikih v Sloveniji

In Slovenia, human evolution is first taught in biology classes to 14–15-year-old students. For many of them, this will be the only contact with this topic at school. The objective was to determine how much knowledge students acquired about human evolution. Data were collected with a questionnaire using a 5-point Likert scale. The participants were 13–14-year-olds who had not yet learned about human evolution (the control group) and 15–16-year-olds who had learned about human evolution one year earlier in biology classes (the experimental group). The results show that students significantly improved their knowledge of human evolution with small to medium effect sizes. Students knew very well that modern humans are the only species of humans today and that they did not live at the same time as dinosaurs. The achievements were low on the following topics: modern humans lived at the same time as Neanderthals and mammoths, and modern humans did not evolve from Neanderthals. To the problematic topics, attention should be paid to teacher education and the primary school curriculum. There were few correlations between the knowledge of human evolution, acceptance of evolution, religiosity, and attitudes toward biology.

Comparison of two different stretching strategies to improve hip extension mobility in healthy and active adults: a crossover clinical trial

ObjectiveTo improve hip flexor flexibility, the commonly used hip extension stretch focuses on advancing the pelvis forward in a half-kneeling position, targeting only hip extension. This study aimed to compare the effectiveness of this traditional stretch with a new technique incorporating posterior pelvic tilt.MethodsA randomized crossover clinical trial was conducted with in 26 healthy, physically active individuals (52 hips), aged 22.50 ± 4.10 years. Each participant performed both the hip extension stretch and the posterior pelvic tilt stretch (26 hips), with one technique applied to each limb: the posterior pelvic tilt stretch on one limb and the hip extension stretch on the other limb (26 hips). The reactive hip flexor test and active knee extension test were measured pre and post stretching techniques. A repeated measures ANOVA was performed to assess differences between groups.ResultsThere was a significant group-by-time interaction with a medium effect size for the variable related to reactive hip flexor force (F = 4.775, p = 0.034, η2p = 0.087). The posterior pelvic tilt stretch had a statistically significant mean difference of 4.85 N·m (p = 0.003; 95%CI: 1.74; 7.96) compared with the hip extension stretch (mean difference = 0.06 N·m (p = 0.969; 95%CI-3.05; 3.17). No significant differences were found for active knee extension (p > 0.05).ConclusionsThe results showed that the posterior pelvic tilt stretching technique was effective in reducing the hip reactive flexor force when compared to conventional hip extension stretch.

Rapid Effects of MDMA Administration on Self-Reported Personality Traits and Affect State: A Randomized, Placebo-Controlled Trial in Healthy Adults

ABSTRACT 3,4-methylenedioxymethamphetamine (MDMA) assisted therapy has been shown to be a safe and effective treatment for PTSD and emerging research suggests a change in personality traits may be a factor in treatment response. Most prior research on MDMA and personality has focused on cross-sectional comparisons of MDMA users and non-users; as such, well-controlled research assessing personality and affective states change following MDMA vs placebo administration is needed. In the current pre-registered study, we investigated the impact of MDMA administration on five-factor model (FFM) traits and affective states before and 48 h after drug administration in a randomized, placebo-controlled study of healthy adults (N = 34). Statistical significance was not observed for the four a priori hypotheses; however, medium effect sizes were found between MDMA administration and trait Openness and Positive Affect 48 h following drug administration, compared to placebo (d = .79 and .51, respectively). This study provides initial results to help guide future well-powered studies with large samples and longer follow-up timepoints to continue to investigate how MDMA impacts personality and emotional experience, which may inform optimization of MDMA treatment approaches.

Known-Group Validity and Sensitivity to Change in the Sensory-Motor Dysfunction Questionnaire in Individuals with Neck Pain: A Pilot Study

Background/Objectives: Sensorimotor dysfunction is often reported in individuals experiencing neck pain, irrespective of severity and chronicity. The treatment of neck dysfunction has been found to positively impact sensorimotor integration (SMI), thereby improving sensorimotor function. However, no patient-reported outcome measure has been validated for discrimination between healthy individuals and neck pain patients with disordered SMI, nor has there been documentation of positive change in SMI following neck pain treatment.The purpose of this study was to administer the Sensory-Motor Dysfunction Questionnaire (SMD-Q), for the purposes of: (1) known-group validity between individuals without and with chronic neck pain (CNP) or subclinical neck pain (SCNP); (2) assess the questionnaire’s capacity to quantify changes in altered SMI following a tailored treatment plan. Methods: Part 1—Known Group Validity: The SMD-Q was administered to 30 neck pain (13 with CNP, and 17 with SCNP), and 30 healthy participants. Part 2—Sensitivity to Change: The SMD-Q was re-administered to neck pain participants following their tailored treatment plans (SCNP—8-weeks and CNP—12 weeks). Results: The SMD-Q can discriminate between healthy and neck pain participants (p ≤ 0.001), and may be sensitive to showing treatment effects (ηp2 = 0.162; large effect size (ES)), but the sample size was too small to determine if it can discriminate treatment effects between groups (ηp2 = 0.070; medium ES). Conclusions: Differing degrees of disordered SMI can be discriminated by the SMD-Q, but further research is needed to determine its sensitivity to treatment.

A Person-Based Web-Based Sleep Intervention Aimed at Adolescents (SleepWise): Randomized Controlled Feasibility Study.

Adolescents are advised to sleep 8-10 hours per night; however, most do not sleep for this recommended amount. Poor adolescent sleep is associated with detrimental health outcomes, including reduced physical activity, risk-taking behaviors, and increased depression and anxiety levels, making this an important public health concern. Existing interventions targeting adolescent sleep are often unsuccessful or their effectiveness unclear, as they are frequently noninteractive, time-consuming, and lack a strong theoretical foundation; highlighting an urgent need for innovative interventions deemed acceptable by adolescents. The main objective of this study was to determine the acceptability, feasibility, and preliminary impact of a web-based person-based sleep intervention (SleepWise) on adolescent sleep quality. Participant incentivization was also explored to understand its impact on engagement, acceptability, and sleep quality. A feasibility trial was conducted to test the feasibility, acceptability, and preliminary impact of SleepWise on adolescent sleep quality, developed based on the person-based approach to intervention development. In total, 90 participants (aged 13-17 years) from further education institutions and secondary schools were recruited for two 2-arm randomized controlled trials. One trial (trial 1) was incentivized to understand the impact of incentivization. Acceptability and sleep quality were assessed via questionnaires, and a mixed methods process evaluation was undertaken to assess participant engagement and experience with SleepWise. Engagement was automatically tracked by SleepWise, which collected data on the date and time, pages viewed, and the number of goals and sleep logs completed per participant. Semistructured interviews were carried out to gain participant feedback. Participants in both trials reported high levels of acceptability (trial 1: mean 21.00, SD 2.74; trial 2: mean 20.82, SD 2.48) and demonstrated similar levels of engagement with SleepWise. Participants in trial 1 viewed slightly more pages of the intervention, and those in trial 2 achieved their set goals more frequently. Improvements in sleep quality were found in both trials 1 and 2, with medium (trial 1) and large (trial 2) effect sizes. A larger effect size for improvement in sleep quality was found in the nonincentivized trial (d=0.87), suggesting that incentivization may not impact engagement or sleep quality. Both trials achieved acceptable recruitment (trial 1, N=48; trial 2, N=42), and retention at 5 weeks (trial 1: N=30; trial 2: N=30). Qualitative findings showed that adolescents lead busy lifestyles, which may hinder engagement; however, participants deemed SleepWise acceptable in length and content, and made attempts at behavior change. SleepWise is an acceptable and potentially efficacious web-based sleep intervention aimed at adolescents. Findings from this study showed that incentivization did not greatly impact engagement, acceptability, or sleep quality. Subject to a full trial, SleepWise has the potential to address the urgent need for innovative, personalized, and acceptable sleep interventions for adolescents. OSF Registries osf.io/yanb2; https://osf.io/yanb2.

Genetic Prediction Modeling in Large Cohort Studies via Boosting Targeted Loss Functions.

Polygenic risk scores (PRS) aim to predict a trait from genetic information, relying on common genetic variants with low to medium effect sizes. As genotype data are high-dimensional in nature, it is crucial to develop methods that can be applied to large-scale data (large and large ). Many PRS tools aggregate univariate summary statistics from genome-wide association studies into a single score. Recent advancements allow simultaneous modeling of variant effects from individual-level genotype data. In this context, we introduced snpboost, an algorithm that applies statistical boosting on individual-level genotype data to estimate PRS via multivariable regression models. By processing variants iteratively in batches, snpboost can deal with large-scale cohort data. Having solved the technical obstacles due to data dimensionality, the methodological scope can now be broadened-focusing on key objectives for the clinical application of PRS. Similar to most methods in this context, snpboost has, so far, been restricted to quantitative and binary traits. Now, we incorporate more advanced alternatives-targeted to the particular aim and outcome. Adapting the loss function extends the snpboost framework to further data situations such as time-to-event and count data. Furthermore, alternative loss functions for continuous outcomes allow us to focus not only on the mean of the conditional distribution but also on other aspects that may be more helpful in the risk stratification of individual patients and can quantify prediction uncertainty, for example, median or quantile regression. This work enhances PRS fitting across multiple model classes previously unfeasible for this data type.

Meta-analysis: Correlation between academic stress and sleep quality in urban living

Purpose: Sleep quality is essential because it is associated with quality of life. It plays a vital role in good health and well-being throughout life. This study aims to see whether there is a correlation between academic stress and sleep quality among urban students. Method: This research uses a meta-analysis research method. This meta-analysis research uses 15 article of literature (2012-2024). Result: Based on the results of the meta-analysis, it can be seen that there was an effect size correlation between academic stress and sleep quality, which was classified into a medium effect size (r=0.454, p=&lt;0.001, 95% CI=-0.288 – 0.619). Conclusion: So it can be concluded that there is a significant relationship between academic stress and sleep quality. This research highlights the importance of managing time to minimize academic stress affecting sleep patterns.