Abstract Background iSIMPATHY is an EU INTERREG VA funded project, delivering quality clinical care in primary care (Republic of Ireland (ROI) and Scotland) and in secondary care (Northern Ireland). The approach is interdisciplinary, collaborative and centred around pharmacist-led medicines reviews. iSIMPATHY recognises patients as key partners in their own health. iSIMPATHY addresses the challenges posed by polypharmacy and adherence, identified by the WHO as a priority area to focus on to reduce severe, avoidable medication related harm. Methods In July 2021, a survey was conducted to obtain structured feedback about GPs and Pharmacists’ experiences of the iSIMPATHY project in participating GP practices in Ireland. The survey identified issues to be addressed and informed the evaluation of the project. Survey topics included barriers and facilitators to success of the project, overall impression and visions for the future for pharmacist roles in primary care in ROI. Results 33% GPs and 100% Project Pharmacists responded to the survey. They agreed that iSIMPATHY is: Having a positive effect on patient safety, patient quality of life, satisfaction, knowledge and understanding, adherence and quality of patient careImpacting positively on GP job satisfaction, knowledge and understandingPharmacist knowledge and skills, capacity to carry out and follow up on reviews (time available) and pharmacist communication with the patient are facilitating project successProject funding and support, including training of the pharmacists, was felt by most to be a facilitator of project successAll are not only in favour of the continuation of pharmacy presence in their practice beyond the life of this project but they would encourage integration of more clinical pharmacy roles within the primary care setting in the future. Conclusion GPs and pharmacists find the iSIMPATHY approach overwhelmingly positive. The project is perceived to benefit patients and GPs and there is unanimity in support for the clinical pharmacist role in project practices and more broadly in Ireland.