Medication Compliance Research Articles

British South Asian ancestry participants views of pharmacogenomics clinical implementation and research: a thematic analysis

BackgroundSouth Asian ancestry populations are underrepresented in genomic studies and therapeutics trials. British South Asians suffer from multi-morbidity leading to polypharmacy. Our objective was to elucidate British South Asian ancestry community perspectives on pharmacogenomic implementation and sharing pharmacogenomic clinical data for research.MethodsFour focus groups were conducted (9–12 participants in each). Two groups were mixed gender, while one group was male only and one was female only. Simultaneous interpretation was available to participants in Urdu and Bengali. Focus groups were recorded and abridged transcription and thematic analysis were undertaken.ResultsThere were 42 participants, 64% female. 26% were born in the UK or Europe. 52% were born in Bangladesh and 17% in Pakistan. 36% reported university level education.Implementation of pharmacogenomics was perceived to be beneficial to individuals but pose a risk of overburdening resource limited systems. Pharmacogenomic research was perceived to be beneficial to the community, with concerns about data privacy and misuse. Data sharing was desirable if the researchers did not have a financial stake, and benefits would be shared.Trust was the key condition for the acceptability of both clinical implementation and research. Trust was linked with medication compliance. Education, outreach, and communication facilitate trust.Conclusions (Significance and Impact of the Study)Pharmacogenomics implementation with appropriate education and communication has the potential to enhance trust and contribute to increased medication compliance. Trust drives data sharing, which would enable enhanced representation in research. Representation in scientific evidence base could cyclically enhance trust and compliance.

43 A Qualitative Study to Establish a Culture Specific Presurgical Psychological Screening for Patients with Degenerative Spinal Disease in Taiwan

Objective:Presurgical psychological screening (PPS) is a procedure for mitigating possible unfavorable outcomes after spinal surgery. Although the effectiveness of PPS on degenerative spinal diseases has been investigated in Western studies, a potential cultural influence on PPS is still unknown. This study thus aims to explore the experiences of Taiwanese people before spinal surgery and tries to establish culture-specific components of PPS in Taiwan.Participants and Methods:A total of five participants aged from 44–69 with degenerative spinal diseases were eligible in this study. All participants visited a neurosurgical outpatient clinic for potential surgical treatment, and each participant underwent an one-hour semi-structured interview before surgery. The demographical information, medical history, psychological status (e.g., personality traits and emotional disturbances) and considerations to make a surgical decision, were recorded and further analyzed following the rule of grounded theory.Results:Four major components with 21 sub-components were reported when deciding to receive a surgical treatment for their spinal diseases, including disease-related considerations, medical information, self-concept and interpersonal relations. In terms of disease-related aspects, patients concerned about etiology, symptomatology, impacts, coping strategies and rehabilitation methods. As for medical information, patients paid more attention on medical compliance, the relationship with medical system, attitude for treatment, expectation to surgical outcomes, medical decisions and medical information. As for the self-concept, patients considered more on the impacts of disease on self-concept, strategies of emotional regulations and personality traits. In terms of interpersonal relations, patients reported more on the supportive resources, patterns of interpersonal activities and impacts of interpersonal relations on medical decisions. Additionally, other specific factors, such as past negative experiences (e.g., chronic insomnia, experiences of psychological counseling), litigation, physical punishment in childhood and social roles, were also reported.Conclusions:Like previous findings, our results supported that the interpersonal relations and doctor-patient relationship in PPS were important considerations before surgery, while we further evidenced that influences of family members on medical decision is determinant and unique in this culture.

(202) Use of Long-Acting Injectable Paliperidone to Increase Medication Compliance in Individuals with ESRD and Schizophrenia

(202) Use of Long-Acting Injectable Paliperidone to Increase Medication Compliance in Individuals with ESRD and Schizophrenia

The Role of The Pharmacist in The Success of Tuberculosis (Tb) Treatment in Jeneponto Regency

Tuberculosis (TB) is an infectious disease caused by the bacterium called Mycobacterium tuberculosis leading to the inflammation of the lung parenchyma. This study aims to determine the effect of counseling on drugs and disease on TB patients and Medication Supervisors (PMO) as well as to determine the effect of PMO in increasing TB patient compliance with monitoring of each respondent. This study used two instruments, the first instrument was the TB-P10 instrument to measure the knowledge of respondents and PMO with pre and post-monitoring. The second instrument was MARS-5, given to the respondent and PMO to see how the respondent's compliance after therapy. Based on the results of the analysis of the paired t-test, it is known that the significance so it can be concluded that there is an average difference between the pre-test and post-test knowledge levels of PMO, which means that there is an effect of pharmacist counseling interventions to respondents and PMO in improving their knowledge. Meanwhile, the performance of PMO in increasing patient medication compliance showed a good performance with 48 patients (96%) who adhered to taking medication, while the poor performance was 2 patients who did not adhere to taking medication (4%). Based on the results of the analysis of the Wilcoxon test, it is known that the significanc, so it can be concluded that there is a relationship between PMO performance on patient medication compliance with clinical outcomes in the presence of patient weight gain and negative final of AFB results.

The Association Between Mild Cognitive Impairment and Medication Non-adherence Among Elderly Patients With Chronic Diseases.

Medication adherence is essential for optimizing treatment outcomes in elderly patients who frequently contend with multiple chronic diseases requiring pharmacological interventions. Mild cognitive impairment (MCI) is a prevalent cognitive disorder among the elderly population, but its impact on medication adherence among elderly patients is still uncertain. This cross-sectional study aimed to investigate the impact of MCI on medication adherence among elderly patients. A cross-sectional study of 436 elderly patients with common chronic diseases aged 60 years and above was conducted. Medication adherence was measured using the Morisky Medication Adherence Scale-8 (MMAS-8). MCI was screened, and cognitive status was assessed using the Mini-Mental State Examination (MMSE) questionnaire. Multivariate logistic regression analysis was performed to identify independent risk factors of medication non-adherence. Among these elderly patients, 212 (48.6%) had poor medication compliance, and 181 (41.5%) had MCI. Preliminary analyses showed a significant association between MCI and medication non-adherence among elderly patients (odds ratio (OR)=3.95, 95% confidence interval (95%CI)=2.63-5.92, P<0.001). Multivariate logistic regression analysis showed that MCI was independently associated with the risk of medication non-adherence among elderly patients (adjusted OR=2.64, 95%CI=1.64-4.24, P<0.001). Additionally, adverse drug reaction and poor evaluation of medication effects were also independently associated with medication non-adherence in elderly patients (P<0.05). Findings from this cross-sectional study proved the substantial adverse impact of MCI on medication adherence among elderly patients, and MCI was an independently influential factor of medication non-adherence. Identifying the MCI status early and providing interventions to enhance medication adherence are undoubtedly essential for optimizing healthcare outcomes in elderly patients.

Uses of AI in Field of Radiology- What is State of Doctor &amp; Pateints Communication in Different Disease for Diagnosis Purpose

Over the course of the past ten years, there has been a rising interest in the application of AI in radiology with the goal of improving diagnostic practises. Every stage of the imaging workflow might potentially be improved by AI, beginning with the ordering of diagnostic procedures and ending with the distribution of data. One of the disadvantages of utilising AI in radiology is that it can disrupt the doctor-patient contact that takes place during the diagnostic procedure. This research synthesis examines how patients and clinicians engage with AI in the process of diagnosing cancer, brain disorders, gastrointestinal tract, and bone-related diseases. [S]ome of the diseases that are studied include cancer, brain disorders, and gastrointestinal tract. Researchers began their investigation of several databases in 2021 and continued their work until 2023. Some of the databases that were examined include PubMed, Embase, Medline, Scopus, and PsycNet. The search terms "artificial intelligence" and "intelligence machine" as well as "communication," "radiology," and "oncology diagnosis" were utilised. It has been demonstrated that artificial intelligence can help medical professionals make more accurate diagnoses. Medical compliance can be enhanced with good training in doctor-patient diagnosis communication, and future research may assist boost patients' trust by informing them of the benefits of AI. Both of these things are important for the delivery of quality medical care.&#x0D; GRAPHICAL ABSTRACT&#x0D; &#x0D;

Hepatocellular Carcinoma: Surveillance, Diagnosis, Evaluation and Management.

Hepatocellular carcinoma (HCC) ranks fourth in cancer-related deaths worldwide. Semiannual surveillance of the disease for patients with cirrhosis or hepatitis B virus allows for early detection with more favorable outcomes. The current underuse of surveillance programs demonstrates the need for intervention at both the patient and provider level. Mail outreach along with navigation provision has proven to increase surveillance follow-up in patients, while provider-targeted electronic medical record reminders and compliance reports have increased provider awareness of HCC surveillance. Imaging is the primary mode of diagnosis in HCC with The Liver Imaging Reporting and Data System (LI-RADS) being a widely accepted comprehensive system that standardizes the reporting and data collection for HCC. The management of HCC is complex and requires multidisciplinary team evaluation of each patient based on their preference, the state of the disease, and the available medical and surgical interventions. Staging systems are useful in determining the appropriate intervention for HCC. Early-stage HCC is best managed by curative treatment modalities, such as liver resection, transplant, or ablation. For intermediate stages of the disease, transarterial local regional therapies can be applied. Advanced stages of the disease are treated with systemic therapies, for which there have been recent advances with new drug combinations. Previously sorafenib was the mainstay systemic treatment, but the recent introduction of atezolizumab plus bevacizumab proves to have a greater impact on overall survival. Although there is a current lack of improved outcomes in Phase III trials, neoadjuvant therapies are a potential avenue for HCC management in the future.

A 13-item Health of the Nation Outcome Scale (HoNOS-13): validation by item response theory (IRT) in patients with substance use disorder

BackgroundThe Health of the Nation Outcome Scale (HoNOS) is a widely used 12-item tool to assess mental health and social functioning. The French version has an added 13th item measuring adherence to psychotropic medication. The aim of the current study is to uncover the unknown pattern of the new item 13 and to compare the unidimensional and multidimensional fit of the new HoNOS-13 using Item Response Theory (IRT). This research question was studied among inpatients with substance use disorder (SUD).MethodsSix hundred and nine valid questionnaires of HoNOS-13 were analyzed using unidimensional (one-factor) and multidimensional (two-factor) IRT modeling.ResultsThe multidimensional model suggesting a first factor capturing psychiatric/impairment-related issues and a second factor reflecting social-related issues yielded better goodness-of-fit values compared to the unidimensional solution. This resulted in an improvement of all slope parameters which in turn translates to better discriminative power. Significant improvement in item location parameters were observed as well. The new item 13 had a good discriminative power (1.17) and covered a wide range of the latent trait (− 0.14 to 2.64).ConclusionsWe were able to validate the 13-item questionnaire including medication compliance and suggest that the HoNOS-13 can be recommended as a clinical evaluation tool to assess the problems and treatment needs for inpatients with SUD. Interestingly, the majority of item response categories are endorsed by respondents who are below and above the average levels of HoNOS. This indicates that the scale is able to discriminate between participants both at the low and at the high ends of the latent trait continuum. More importantly, the new item 13 has a good discriminative power and covers a broad range of the latent trait below and above the mean. It therefore has the desired profile of a good item and is a useful measure for the assessment of mental health and social functioning.Trial registration ClinicalTrials.gov, Identifier: NCT03551301. Registered: 11.06.2018. Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03551301.

Pharmacist Involvement in Mental Health Treatment

Mental health disorders constitute a significant public health concern, with a growing recognition of the need for integrated, comprehensive approaches to their management and treatment. Pharmacists, as essential members of the healthcare team, have a unique opportunity to contribute to the care of patients with mental health conditions. This review critically examines the multifaceted role of pharmacists in mental health treatment, encompassing their involvement in medication management, patient education, and collaborative care models. Pharmacists play a pivotal role in ensuring the safe and effective use of psychotropic medications, offering expertise in drug selection, dosing, monitoring, and assessing medication adherence. Their involvement in medication reconciliation and management of drug interactions can significantly enhance patient safety and optimize treatment outcomes. Moreover, pharmacists can provide valuable education to patients and caregivers regarding medication adherence, potential side effects, and strategies for managing adverse reactions, thereby promoting medication compliance and improving overall treatment efficacy. Furthermore, the integration of pharmacists within collaborative care teams has demonstrated promising outcomes in the delivery of holistic mental health services. Through their interdisciplinary collaboration, pharmacists facilitate effective communication among healthcare providers, enabling comprehensive treatment planning and the identification of potential pharmacotherapeutic interventions. This collaborative approach fosters a patient- centered care model, emphasizing the importance of individualized treatment plans tailored to each patient’s unique needs and preferences. Additionally, the expanding role of pharmacists in mental health screenings, early intervention initiatives, and community-based support programs serves to promote mental health awareness and reduce the stigma associated with mental illness. By actively engaging with patients and communities, pharmacists contribute to the development of accessible mental health services and resources, thereby fostering a more inclusive and supportive healthcare environment.

Rates and correlates of medication non-adherence behaviors and attitudes in adult patients with early psychosis.

Literature on antipsychotic medication adherence in early psychosis primarily assessed adherence behaviors and focused on young patients. There is a paucity of research investigating negative medication attitude and its determinants in the early illness course, particularly in older-aged sample. We aimed to examine prevalence and correlates of medication non-adherence behaviors and negative medication attitudes separately in adult patients with early psychosis. One hundred ninety-nine Chinese early psychosis patients aged 26-55years who had received three-year treatment for first psychotic episode in Hong Kong were examined. Assessments encompassing socio-demographics, premorbid adjustment, clinical and treatment profiles, self-stigma and therapeutic alliance were conducted. Patients were evaluated with Medication Compliance Questionnaire, which is a modified Chinese-translated version of Medication Adherence Rating Scale and includes items measuring adherence behaviors and attitudes towards medications. Rates of medication non-adherence and negative attitude towards medications were 38.7% and 50.8%, respectively. Multivariate regression analysis showed that more severe positive symptoms, greater self-stigma and negative medication attitude were independently associated with medication non-adherence. Negative attitude towards medications was significantly associated with younger age, higher educational attainment, diagnosis of other psychotic disorders, poorer insight, greater self-stigma and less satisfaction with communication with healthcare staff, which represented an index reflecting suboptimal therapeutic alliance. Antipsychotic non-adherence and negative medication attitudes are frequently observed in adult early psychosis patients. Our findings indicate that poor insight, elevated self-stigma and suboptimal therapeutic alliance may constitute potential treatment targets for promoting medication adherence and rectifying negative medication attitudes in the early illness stage.

Relationship between Knowledge, Attitudes, and Motivation and Compliance to Taking Anti-Tuberculosis Medication on the Pulmonary TB Patient

Tuberculosis (TB) is a deadly infectious disease worldwide. The annual number of global TB sufferers seeking treatment has increased from around 6 million people in 2015 to 7.1 million people in 2019. Geographically, most TB cases occurred in the Southeast Asian region, one of which is Indonesia. Many factors affect the success and compliance with treatment programs, including knowledge, attitudes, perceptions, and individual motivation. Increased knowledge can lead to changes in one's perceptions, attitudes, or habits. This research contribution analyzes the relationship between knowledge, attitudes, and motivation with compliance to taking anti-tuberculosis medication in pulmonary TB patients at RSUD Dr. Soekardjo, Tasikmalaya City. Furthermore, this research is a descriptive analytical-correlational research with a cross-sectional approach. The sample of this study was 60 respondents (aged 20-80 years) consisting of outpatients at the TB Polyclinic at RSUD Dr. Soekardjo in October-November 2022. The instrument used to measure the variables of knowledge, attitudes, motivation, and medication compliance is a questionnaire. The relationship between the variables was carried out using the Chi-Square statistical test. Based on the research results, it was obtained that 95% (57) of the respondents had good knowledge, 73% (44) of the respondents had good attitude, 72% (43) had good motivation, and 51.7% (31) of the respondents were adherent in taking medication. Furthermore, based on the results of statistical analysis using the Chi-Square test it showed that attitude and motivation variables were not significantly related to medication compliance (p-value &gt;0.05), while the level of knowledge was significantly related to medication compliance (p-value &lt; 0.05). It was further concluded that the level of knowledge of the respondents shows a significant relationship with compliance to taking OAT medication at Dr. Sukarno Hospital.

Medical ethics and compliance amongst physician groups: a self-assessed survey in a hospital in Southeast Nigeria.

Being a doctor remains a moral enterprise as he is expected to make some medical decisions based on ethical principles during encounter with patients. The objective of this study was to investigate the knowledge and application of medical ethical principles amongst physician groups in a Hospital in Enugu, Nigeria. This was a cross-sectional self-assessed study conducted amongst medical doctors in five specialty groups in a teaching hospital in Enugu, Nigeria.Descriptive and inferential statistics were used to summarize the items and determine whether significant differences on knowledge and application of medical ethics existed amongst the physician groups in the treatment of patients. Observance and compliance with medical ethical conduct was highest among doctors that were aged 55 years and above. In sex, male doctors had higher ethical conduct compliance than female doctors. Comparing the doctors by rank, medical officers, consultants and senior registrars respectively had the highest ethical conduct. Knowledge and practice of medical ethics were mostly deficient among younger Nigerian and female doctors. Remedying the situation will require better curricula both at the undergraduate and post-graduate medical school programmes for doctor trainees. Requiring certification in bioethics for license renewal will also help in resolving and improving the knowledge gap.

A nomogram for predicting mild cognitive impairment in older adults with hypertension

BackgroundHyper- and hypotension increase the risk of cognitive dysfunction. As effective control of blood pressure can reduce the risk of mild cognitive impairment (MCI), early risk assessment is necessary to identify MCI in senile hypertension as soon as possible and reduce the risk of developing dementia. No perfect risk-prediction model or nomogram has been developed to evaluate the risk of MCI in older adults with hypertension. We aimed to develop a nomogram model for predicting MCI in older patients with hypertension.MethodsWe selected 345 older patients with hypertension in Xixiangtang District, Nanning City, as the modeling group and divided into the MCI (n = 197) and non-MCI groups (n = 148). Comparing the general conditions, lifestyle, disease factors, psychosocial and other indicators. Logistic regression was used to analyze risk factors for MCI in older hypertensive patients, and R Programming Language was used to draw the nomogram. We selected 146 older patients with hypertension in Qingxiu District, Nanning City, as the verification group. The effectiveness and discrimination ability of the nomogram was evaluated through internal and external verification.ResultsMultivariate logistic regression analysis identified 11 factors, including hypertension grade, education level, complicated diabetes, hypertension years, stress history, smoking, physical exercise, reading, social support, sleep disorders, and medication compliance, as risk factors for MCI in older patients with hypertension. To develop a nomogram model, the validity of the prediction model was evaluated by fitting the curve, which revealed a good fit for both the modeling (P = 0.98) and verification groups (P = 0.96). The discrimination of the nomogram model was evaluated in the modeling group using a receiver operating characteristic curve. The area under the curve was 0.795, and the Hosmer–Lemeshow test yielded P = 0.703. In the validation group, the area under the curve was 0.765, and the Hosmer–Lemeshow test yielded P = 0.234.ConclusionsWe developed a nomogram to help clinicians identify high-risk groups for MCI among older patients with hypertension. This model demonstrated good discrimination and validity, providing a scientific basis for community medical staff to evaluate and identify the risk of MCI in these patients at an early stage.

The Relationship between Knowledge and Family Support with Tb Patient Drinking Compliance in Kudungga Hospital

Tuberculosis is an infectious disease mostly caused by Mycobacterium tuberculosis. There are various species of Mycobacterium, including Mycobacterium africanum, Mycobacterium bovis and Mycobacterium leprae, known as Acid Resistant Bacteria (BTA). The recovery or success of this treatment is determined by several factors, especially adherence to taking medication. Family support greatly supports the successful treatment of pulmonary TB patients by always reminding sufferers to take medicine, deep understanding of patients who are sick and encouraging them to remain diligent in treatment. This study used a purposive sample technique with a cross-sectional study design. The sample size in this study was 76 people. The results of the statistical test using the chi-square test obtained a p-value = 0.033 (Knowledge on Medication Compliance), p-value = 0.002 (Family Support with Medication Adherence). There is a relationship between Knowledge and Family Support with Compliance with Taking Medication for TB Patients at Kudungga Hospital.

Carer involvement in medication adherence: carer views and experiences of facilitating medication adherence using pharmacy-filled multi-compartment medication compliance aids and other methods of adherence support-a questionnaire survey.

Unpaid carers are an increasing proportion of the UK population. One of the many ways in which they help those they care for is assisting with medication adherence. Many older adults have medicines dispensed in pharmacy-filled multi-compartment medication compliance aids (pMCAs). However, evidence suggests that pMCAs may increase medication-related harm, and little is known about the interaction between the user, medication adherence systems and the carer. To explore the views of carers supporting older adults to manage their medications with and without a pMCA. A researcher-administered questionnaire survey of carers supporting older adults to manage their medicines with or without a pMCA. Participants were recruited from inpatient wards, outpatient clinics and community services in central London. Responses were analysed by two independent researchers to identify overarching themes. Eighty-eight unpaid carers were interviewed and responses were categorised according to the medication adherence method used; 47 supported a user with a pMCA and 41 supported without a pMCA. The main themes were: Time, Responsibility and Mistakes, Waste and Sustainability, and Polypharmacy, with sub-themes of design of multi-compartment medication compliance aids, organisation and reassurance. Supporting medication adherence puts considerable burden on carers regardless of whether a self- or pharmacy-filled medication compliance aid is used or not. Prescribers could alleviate this burden through regular medication review by considering the prescribing frequency and duration and medication rationalisation. Redesign of both pMCAs and systems surrounding their use could also help reduce carer's burden and environmental burden.

Level of Knowledge of Hypertension Patients and Compliance with Treatment at Sirnajaya Health Center

Background: Uncontrolled hypertension is the most common and important risk factor for cardiovascular diseases, which can lead to complications or even death. Uncontrolled hypertension can be caused by noncompliance with hypertension medication instructions. One factor contributing to the disobedience of hypertension medication instructions is the level of knowledge on hypertension. Purposes: This study analyzed the correlation between patients’ hypertension knowledge and hypertension medication compliance in Sirnajaya Health Center, Bekasi, West Java, Indonesia. Methods: A cross-sectional study was conducted among 62 hypertension patients in Sirnajaya Health Center in December 2022. They were asked to answer the Hypertension Knowledge-Level Scale (HK-LS) questionnaire and the Morisky Medication Adherence Scale-8 (MMAS-8) to assess their hypertension knowledge and compliance with the hypertension medication. The chi-squared test was used to determine the correlations between the variables. Results: There were 36 respondents (58.1%) with low knowledge and 39 respondents (62.9%) with low medication compliance. Analysis through the chi-squared test reveals a correlation between knowledge level and medication compliance (p &lt;0.001). Conclusion: There was a correlation between hypertension knowledge and compliance in consuming hypertension medication among the hypertension patients of Sirnajaya Health Center, Bekasi, West Java, Indonesia.

Criminal law protection on juvenile crimes with bipolar disorders

BackgroundBipolar disorder refers to a type of mood disorder that includes both manic or mild manic episodes and depressive episodes in clinical practice. Compared with a single disease, comorbidities typically have characteristics such as severe symptoms, long course of disease, severe social function impairment, high risk of suicide, and poor prognosis. Minors are prone to engage in criminal behavior under the influence of bipolar disorder. This study will use group psychological counseling combined with criminal law protection education to intervene and treat underage patients.Subjects and Methods80 underage bipolar disorder patients were selected and divided into two groups according to a random number table method: the control group received group psychological counseling for intervention, while the research group received group psychological counseling combined with communication training and nursing. The improvement of the condition, self-care ability, depression, mania, quality of life, medication compliance, and social adaptability scores of the two groups of patients were compared.ResultsThe results showed that before the intervention, there was no statistically significant difference in the improvement of the condition, self-care ability, depression, mania, quality of life, medication compliance, and social adaptation scores between the two groups. After 12 weeks of intervention, the improvement score of the study group’s condition and self-care ability score were higher than that of the control group.ConclusionsThe combination of group psychological counseling and criminal law protection education can enhance the treatment effect of underage bipolar disorder patients, improve their quality of life, alleviate negative emotions, and achieve better nursing outcomes.

Prevalence and Factors Associated with Medication Nonadherence in Patients with Major Psychiatric Disorders in Southern India

Abstract Objectives: Historically, nonadherence to medication has been a major problem faced by health care workers while treating chronic illnesses. Nonadherence to psychotropic medications is known to be associated with poorer treatment outcomes, remarkable risk, and cost to the medical system in managing psychiatric illness. For care providers, partial compliance or discontinuation of medications represents the difficulty of maintaining treatment successes over time. In this study, we intended to assess medication adherence and to understand the reasons for nonadherence in patients with major psychiatric disorders in southern India. Methods: This is a cross-sectional observational study, done from January to June 2023. With the International Classification of Diseases 10th Revision diagnosis, we assessed patients with psychotic disorders, bipolar affective disorders, and major depressive disorder. The Medication Adherence Rating Scale (MARS) was used to assess medication adherence. The patients also completed copies of semi-structured questionnaire on their sociodemographic characteristics, their medications, and reasons for nonadherence. Results: A total of 147 subjects were assessed. We found that 68.0% of subjects were poorly adherent to the treatment based on MARS, and that only 32.0% of them were strictly adherent to the treatment. The reasons for poor adherences to the medication treatment were carelessness or forgetfulness (21.8%), adverse effects of the medications (16.3%), and the perception of the subject of feeling better (15.6%). Conclusion: More than two thirds of the subjects was found to be non-adherent to the medications. Assessing various reasons for medication adherence will help find strategies to improve medication adherence and thus outcome of the treatment.

Compliance level to Tuberculosis prophylaxis in patients undergoing therapy with tumor necrosis factor-alpha inhibitors: a cross-sectional study.

Tumor necrosis factor-alpha (TNF-α) inhibitors are used to treat autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, and inflammatory bowel disease. However, patients using TNF-α inhibitors are at a high risk of developing tuberculosis. Therefore, this study aimed to evaluate the compliance level of patients who were prescribed TNF-α-based tuberculosis prophylactic treatment. The study included 135 patients who were followed up at a tuberculosis dispensary between December 2020 and June 2021 and agreed to participate in the study. The study was conducted after obtaining necessary permissions from the institution, ethics committee, and patients. Data were collected using a questionnaire and evaluated using the Medication Adherence Report Scale (MARS). The MARS scale scores range from 5 to 25, with high scores indicating a high level of "medication compliance level". Of the included patients, 42.2% were females, 46.7% were primary school graduates, and their mean age was 43.75±11.86 years. Additionally, 35.6% of patients had ankylosing spondylitis, among whom 54.1% had a disease duration of 1-5 years and 57.8% had been using TNF-α inhibitors for a year. Of the patients taking isoniazid (INH) for tuberculosis prophylaxis, 47.4% missed their prescribed INH doses, with "forgetfulness" being the reason in 28.9% of these patients. The patients had a mean MARS score of 15.71±6.18. Patients using TNF-α inhibitors were found to have "moderate" compliance levels for INH-based prophylactic therapy. It is recommended that the compliance levels of patients and factors influencing their compliance should be regularly monitored.

Music Therapy in Pediatric Asthma: A Short Review.

Music therapy (MT) is a common modality that performs a complementary and integrative role along with standard treatments for many pediatric diseases. This article briefly reviewed the effects of MT on children aged 5-11 years old and adolescents with asthma from previous studies, specified its functional target towards asthma symptoms, and sorted out the design and investigation of selected research. Medline/PubMed, Embase, SportDis-cus, Cochrane Library, Teacher Reference Centre, Web of Science, Academic Search Complete, PsycARTICLES, and Scopus were queried for experimental and observational studies published between 1990 and 2021. Then, researchers showed that MT lessened patients' asthma symptoms, improved medication compliance, pulmonary function, and quality of life, and helped children and their parents manage anxiety and depression. This article may serve as a reference for clinical research for pediatric asthma therapies and lay the foundation for future research on MT and its clinical practice.