general practitioners (GP) in primary care. The aim of this study was then to measure the impact of STOPP criteria during primary care consultation on PIM. Methods.– Twenty GPs have been involved in the study and ask for using STOPP criteria for 10 consecutive elderly patients (> 75years) whowere takingat leastfivedifferentdrugs. The rateof PIMaccording to STOPP criteria was measured before and after consultation and the Medication Appropriateness Index (MAI) score assessing thequality of prescribingwasused for statistical comparisonbefore and after intervention. Results.– The number of PIM decreased according to STOPP criteria for nearly half of the patients (46.9%) and the mean MAI score decreased by 39.1% (P<0.001). The improvement in MAI according to STOPP is mainly related to the number of medication regardless the age (≥50years) of medical doctors. The use of STOPP also allowed an improvement of all prescriptions (globalMAI decreased by 14.3%, P<0.001). Conclusions.– This is the first study showing a reduction of PIMwith STOPP criteria in primary care. These results need to be confirmed by a randomized-control study; it should be then appropriate to promote the use of STOPP criteria in primary care, during an annual consultation dedicated to drug medication reviewing.