This paper aims to discussion on the application of International Organization for Standardization (ISO) 45001 in hospitals. With the spread of COVID-19 globalization, the occupational health and safety problems of many medical staff have become international commonalities. There are a lot of articles talking about how to protect medical staff, including World Health Organization (WHO), however most of them are focus on the details, which lack of system methodology and standardized model. By analyzing the Occupational Health and Safety (OH&S) risks faced by medical staff during the COVID-19, the importance of International Organization for Standardization (ISO) 45001 application in hospital industry is put forward. Firstly, the paper adopt a theoretical foundation by which or through which hospital can better manage medical staff’s occupational health and safety risks and improve their overall performance. Secondly, this paper uses Plan-Do-Check-Act (PDCA) model to hospitals, which provides a framework for hospital to plan what they need to do. Thirdly, from the ISO 45001 perspectives to explore how to solve the current occupational health problems faced by medical staff and adopt relevant programs to protect occupational health and safety of medical staff, thus promoting the healthy and sustainable development of individuals and hospitals. Findings-ISO 45001 can plays an important role in the occupational health and safety of medical staff. It is of great and urgent to instruct hospitals how to scientifically and effectively identify hazards (COVID-19), evaluate their risks and take corresponding prevention and control measures. Therefore it can promote the health and well-being of medical staff. The occupational health and safety management of medical staff in hospitals is also a concrete manifestation of their active fulfillment of social responsibilities. Originality/value: This paper offers an standardized angle to address the risks of occupational health and safety of medical staff during the spread of COVID-19. As for the application of ISO 45001, this paper provides some suggestions based on china’s practice and experience, which through the angles of theoretical research methods include high level structure, Plan-Do-Check-Act (PDCA) model and man, machine, material, Method, Environment (4M1E) model.