Janus medical protective clothing (MPC) with asymmetric wetting properties can enhance the comfort of healthcare workers by transporting sweat from the skin to exterior surfaces. However, these textiles fail to promptly remove heavy sweat (e.g., several liters), resulting in soaked fabrics and reduced comfort. Herein, inspired by superabsorbent polymers (SAPs) and lotus leaves, we propose a bump-liked MPC (BPC) for profuse perspiration management. The fabrics can enable unidirectional sweat transport through the inner Janus fabric layer and sustained absorption of large amounts of sweat by the median layer of SAPs. The bump-liked structure can store SAPs and adapt them to swelling. An external polydimethylsiloxane (PDMS)-coated layer can effectively block water, blood, and ethanol from penetrating the skin (synthetic blood contact angle, 118°; anti-blood penetration resistance, 4.8 kPa), thereby ensuring excellent protective properties. More importantly, BPC possesses an unrivalled sweat removal rate of 5.9 ml cm−2 min−1, which is three orders of magnitude higher than the human sweat rate during high-intensity exercise. This work addresses the dual challenge of profuse perspiration management and resistance to liquid penetration, which represents a promising direction for improving the thermal-moisture comfort of medical protective clothing.