Medical Products Research Articles

A Framework for Future Analysis of Ophthalmology Fellowships in Iran: Call for Action, Implications and Recommendations.

Ophthalmology fellowship is focusing on the educational advancement, medical research progress and academic productivity by transforming general ophthalmologists into superior clinical capacities in ophthalmology. There is a vast majority of ophthalmologists who wish to undertake fellowship degrees. The fellowship programs have several benefits for ophthalmologists and medical institutions. However, the expansion of ophthalmic fellowships has resulted in a greater number of ophthalmology visits, the possibility of unnecessary subspecialty eye examinations, induced demand and increasing eye-care costs. Moreover, sub-specialized ophthalmic services are not accessible to patients in remote regions. This can lead to a degree of inequity in the provision of healthcare services in the healthcare system. The massive expansion of fellowships in ophthalmology is revitalizing the necessity for evaluation of the need for post-residency education and providing effective planning for the future of the ophthalmic human-resource for eye health. This narrative review includes an integration and descriptive summary of the existing evidence on trends and different aspects that affect the future of ophthalmic fellowship education. Moreover, we pinpointed challenges such as maintaining standards in fellowship education, keeping an efficient production of graduates, and improving productivity in both patient care and education. We explored potential solutions to overcome these challenges. The 7-step framework for future analysis suggested here includes Determining educational needs and desired outcomes, Evaluating the current status of fellowship education, determining the gaps, and appropriate solutions, analyzing possible future trends and their impact on ophthalmology practice, investing in virtual educational technology, developing new educational horizons by foresight expert panels, and human-resource planning.

Advanced Technologies in Radiation Research.

The U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, Advanced Technologies in Radiation Research (ATRR), which focused on the use of advanced technologies under development or in current use to accelerate radiation research. This meeting report provides a comprehensive overview of the research presented at the workshop, which included an assembly of subject matter experts from government, industry, and academia. Topics discussed during the workshop included assessments of acute and delayed effects of radiation exposure using modalities such as clustered regularly interspaced short palindromic repeats (CRISPR) - based gene editing, tissue chips, advanced computing, artificial intelligence, and immersive imaging techniques. These approaches are being applied to develop products to diagnose and treat radiation injury to the bone marrow, skin, lung, and gastrointestinal tract, among other tissues. The overarching goal of the workshop was to provide an opportunity for the radiation research community to come together to assess the technological landscape through sharing of data, methodologies, and challenges, followed by a guided discussion with all participants. Ultimately, the organizers hope that the radiation research community will benefit from the workshop and seek solutions to scientific questions that remain unaddressed. Understanding existing research gaps and harnessing new or re-imagined tools and methods will allow for the design of studies to advance medical products along the critical path to U.S. Food and Drug Administration approval.

Deepstacked-AVPs: predicting antiviral peptides using tri-segment evolutionary profile and word embedding based multi-perspective features with deep stacking model

BackgroundViral infections have been the main health issue in the last decade. Antiviral peptides (AVPs) are a subclass of antimicrobial peptides (AMPs) with substantial potential to protect the human body against various viral diseases. However, there has been significant production of antiviral vaccines and medications. Recently, the development of AVPs as an antiviral agent suggests an effective way to treat virus-affected cells. Recently, the involvement of intelligent machine learning techniques for developing peptide-based therapeutic agents is becoming an increasing interest due to its significant outcomes. The existing wet-laboratory-based drugs are expensive, time-consuming, and cannot effectively perform in screening and predicting the targeted motif of antiviral peptides.MethodsIn this paper, we proposed a novel computational model called Deepstacked-AVPs to discriminate AVPs accurately. The training sequences are numerically encoded using a novel Tri-segmentation-based position-specific scoring matrix (PSSM-TS) and word2vec-based semantic features. Composition/Transition/Distribution-Transition (CTDT) is also employed to represent the physiochemical properties based on structural features. Apart from these, the fused vector is formed using PSSM-TS features, semantic information, and CTDT descriptors to compensate for the limitations of single encoding methods. Information gain (IG) is applied to choose the optimal feature set. The selected features are trained using a stacked-ensemble classifier.ResultsThe proposed Deepstacked-AVPs model achieved a predictive accuracy of 96.60%%, an area under the curve (AUC) of 0.98, and a precision-recall (PR) value of 0.97 using training samples. In the case of the independent samples, our model obtained an accuracy of 95.15%, an AUC of 0.97, and a PR value of 0.97.ConclusionOur Deepstacked-AVPs model outperformed existing models with a ~ 4% and ~ 2% higher accuracy using training and independent samples, respectively. The reliability and efficacy of the proposed Deepstacked-AVPs model make it a valuable tool for scientists and may perform a beneficial role in pharmaceutical design and research academia.

Cannabis donation as a harm reduction strategy: a case study

BackgroundThe United States (US) continues to experience unprecedented rates of overdose mortality and there is increased need to identify effective harm reduction practices. Research from Canada describes cannabis donation through harm reduction agencies as an adjunctive strategy to mitigate the negative consequences of more harmful drugs. This case study describes the operational logistics, feasibility, and potential benefits of a cannabis donation program that was operated through a harm reduction program in rural Michigan.Case presentationWe applied a community driven research approach to gather information from harm reduction program staff about the implementation and evolution of cannabis donation efforts in Michigan. We also examined 20-months (September 2021 through May 2023) of administrative data from a cannabis company to compare the sale and donation of cannabis products. Ten cannabis-experienced harm reduction clients received cannabis donations, with clinical staff determining client interest and appropriateness, and providing weekly pick-up or delivery. To expand product availability and sustainability, we examined administrative data from a commercialcannabis company that volunteered to provide donations. This administrative data suggests that while flower products constitute most of the adult and medical sales, edible, oil, and topical products predominated donations. Further, cost analysis suggests that donations represent only 1% of total gross sales and account for much less than the expected yearly donation amount.ConclusionsResearch suggests there is potential to reduce alcohol and drug use related harms of more dangerous substances through substitution with cannabis. This case study is the first to document cannabis donation as a harm reduction practice in the US and suggests potential for sustainability dependent on state laws. Findings from this case study provide a starting point for inquiry into cannabis donation as a harm reduction strategy in the US; future research is needed to fully understand the individual-level outcomes, public health impacts, necessary legal regulations, and best practices for cannabis donation programs through harm reduction organizations.

Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon and disrupted intestinal function. Ramulus mori (Sangzhi) alkaloids (SZ-A), derived from twigs of mulberry, were approved by the National Medical Products Administration in 2020 for treating type 2 diabetes mellitus. Accumulated evidence has confirmed that SZ-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation, indicating its potential to address inflammation in UC. However, the treatment of UC faces challenges due to low drug delivery efficiency and short retention time. To overcome these challenges, an injectable and adherent in-situ thermo-sensitive hydrogel containing SZ-A was developed for rectal drug delivery, utilizing the thermo-sensitive polymers Poloxamer 407 and 188. The thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32 ± 0.5 °C, a short gelation time of 64 s, a pH range of 7–10, high moisturizing capability exceeding 90%, and moderate mechanical strength of 4–5 s. In a rat model with UC, the in situ thermo-sensitive hydrogel significantly extended the retention time at the colonic site and enabled sustained release after rectal administration. Symptoms of UC were markedly reduced following rectal administration of SZ-A thermo-sensitive hydrogel. Furthermore, the release of inflammatory factors, such as interleukin-1β (IL-1β), IL-6, IL-18, tumor necrosis factor-α (TNF-α), and transforming growth factor-β1 (TGF-β1), significantly decreased in the SZ-A thermo-sensitive hydrogel group. The integrity of the colonic mucosal barrier was significantly enhanced following the application of SZ-A thermo-sensitive hydrogel. In conclusion, rectal administration of SZ-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms, inhibited the secretion of inflammatory factors, and promoted the repair of the colonic mucosal barrier. This approach holds promise as a potential treatment for UC.

Effect of NaClO disinfectant treatment on the yields, components and combustion characteristics of typical medical waste pyrolysis products

Medical waste with pathogenic bacteria is infectious and toxic, which could cause significant harm to the environment and human health without being adequately disposed of. Pyrolysis-incineration coupled technology can realize the rapid and efficient treatment of medical waste while reducing the generation of pollutants. Whereas, the NaClO disinfection treatment, which is a necessary process prior to transfer and disposal of medical waste, has not been sufficiently described in terms of its effect on the pyrolysis yield and components characteristics of medical waste. This study clarified the influence mechanism of NaClO disinfection treatment on the yields, components, and combustion characteristics of pyrolysis products derived from typical medical waste (cotton swab sticks, masks, and latex gloves). The results showed that NaClO disinfection treatment induced depolymerization of the internal structure of the polymer and increased pyrolysis tar and syngas at 400 °C. In addition, NaClO disinfection treatment reduced syngas quality, which was attributed to generating more CO2 and inhibiting alkynes gas production under medium-low pyrolysis temperatures. Furthermore, the condensation or cyclization of light components into heavy components in the tar increased the average double-bond equivalents and oxygen content, which was detrimental to tar ignition and combustion. Moreover, the combustion performance of char was improved because there was a tendency for the conversion of graphitic carbon to fatty carbon in the char. These findings elucidate the feasibility of pyrolysis-incineration coupled technology for the fast and effective treatment of medical waste.

The Plethora of Microbes with Anti-Inflammatory Activities.

Inflammation, which has important functions in human defense systems and in maintaining the dynamic homeostasis of the body, has become a major risk factor for the progression of many chronic diseases. Although the applied medical products alleviate the general status, they still exert adverse effects in the long term. For this reason, the solution should be sought in more harmless and affordable agents. Microorganisms offer a wide range of active substances with anti-inflammatory properties. They confer important advantages such as their renewable and inexhaustible nature. This review aims to provide the most recent updates on microorganisms of different types and genera, being carriers of anti-inflammatory activity.

Age-appropriate design of domestic intelligent medical products: An example of smart blood glucose detector for the elderly with AHP-QFD Joint KE

BackgroundIn response to the rise of intelligent products and the increasing prevalence of urban "empty nesters," we have developed a product specifically tailored for elderly diabetic patients. This product fulfils functional requirements and addresses stylistic preferences, contributing to the age-friendly evolution of home intelligent medical devices, particularly in intelligent blood glucose monitoring. MethodsOur approach commenced with a comprehensive user experience analysis to ascertain the needs of elderly users regarding home blood glucose meters. This involved constructing a hierarchy of user demands, followed by analysing and prioritising these needs. Utilizing Quality Function Deployment (QFD), we aligned user requirements with design specifications, identifying specific product functionalities and service design elements. Further, we employed Kansei Engineering (KE) to select sample designs that resonate with the concept of sensual imagery, leading to the derivation of specific modelling intentions. Combining these design elements, we proposed product design strategies and conducted practical case studies. The effectiveness of these designs was then assessed through fuzzy evaluation methods, allowing for user feedback. ResultsEmploying the Analytic Hierarchy Process for goal analysis, along with Quality Function Deployment theory and Kansei Engineering, we developed a home intelligent blood glucose meter catered to the elderly. This device not only meets its users' physiological and psychological needs but also provides an operationally convenient, health-conscious, and aesthetically pleasing experience. ConclusionsThis methodology enhances the age-appropriate design of home-based smart glucose monitors for the elderly, offering innovative insights and optimization strategies for designing elderly-centric smart medical products.

An Efficient Low‐Cost Device for Sampling Exhaled Breath Condensate EBC

AbstractWhile exhaled breath condensate EBC is not yet used in routine clinical diagnostics and disease monitoring, recent publications indicate that exhaled air and EBC contain a wide range of molecular biomarkers that are characteristic of various medical conditions. This includes evidently lung disorders such as asthma, COPD, and cystic fibrosis, but also diabetes and several types of cancer go along with specific biomarkers exhaled from the airways. In addition, EBC samples can be collected in a non‐invasive way and, due to their small volume, they can be easily stored frozen between collection and analysis. Several home‐made EBC‐collection systems for research purposes are documented in literature while there are also a few systems from commercial suppliers that are not yet certified as medical products. In this work, a novel collection device is presented in which the EBC is condensed and frozen inside stainless steel tubes, tightly surrounded by an aluminum cylinder that is precooled in a kitchen freezer. The device is low cost, easy to use by patients at home or in a clinic, and its collection efficiency of up to 500 µL min−1 of respiration is on the high side.

An Innovative approach to Improve the Quality of Pharmaceuticals approach using Cloud Computing

INTRODUCTION: Pharmaceuticals evolve alongside advancing technology driven by ongoing research and pharmaceutical companies’ production of new medications. Ongoing research and adjustment are necessary for various aspects of the pharmaceutical sector, such as patient understanding, drug testing, manufacturing, and communication of complex concepts through technology. OBJECTIVES: This paper discusses the intersection of cloud computing, technological advancements, and healthcare applications. METHODS: The Azure Cloud facilitates data processing, customer and patient engagement, employee and care team empowerment, clinical and operational optimisation, and healthcare digital transformation in the pharmaceutical industry. The integration of Microsoft Azure cloud technologies inside the pharmaceutical industry is examined in this research. RESULTS: Analysing how Internet of Things (IoT) sensors and the Industrial Internet of Things (IIoT) are used in pharmaceutical manufacturing and logistics, benefits in drug research, production monitoring and supply chain optimisation are highlighted. CONCLUSION: Cloud computing's potential to facilitate General Data Protection Regulation compliance, improve security, and promote innovation is explored.

Pre-Experimental Assessment of Uranyl Nitrate Solution Irradiation in Kartini Reactor Facilities

Medical radioisotope production using neutron irradiation via fission reaction requires a sufficient neutron source. The Kartini reactor has been proposed and studied to become a neutron source for radioisotope production under the Subcritical Assembly for 99Mo Production (SAMOP) project, which uses uranyl nitrate solution as the irradiation target. A full-scale experiment involving a liquid fission product is difficult to conduct and requires facility rearrangement to reduce the risk of contamination. Although a small-batch experiment is safer to perform, a pre-experimental assessment is necessary to address the practicality of production and the accompanying problems. The goals of this assessment are (1) to characterize the Kartini reactor irradiation facilities’ flux through experiment and Monte Carlo benchmark simulation, (2) to predict the irradiation product inventory in relation to the variation of uranium concentration and the measured flux, and (3) to predict the irradiated sample gamma spectrum reading using high-purity germanium detector simulation. The irradiation simulation uses natural uranium as a control parameter, which caused the irradiation inventory dominated by actinides from transmutation. The simulation also presents the possibility of instant small-batch 99Mo production using the measured Lazy Susan facilities’ flux from a neutronic perspective. The qualitative assessment of the predicted irradiation inventory and its spectrum reading from different sample concentrations are discussed along with the recommendation and possible action to improve the experiment or future production process.

Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice

Carrimycin (CA), sanctioned by China's National Medical Products Administration (NMPA) in 2019 for treating acute bronchitis and sinusitis, has recently been observed to exhibit multifaceted biological activities, encompassing anti-inflammatory, antiviral, and anti-tumor properties. Despite these applications, its efficacy in sepsis treatment remains unexplored. This study introduces a novel function of CA, demonstrating its capacity to mitigate sepsis induced by lipopolysaccharide (LPS) and cecal ligation and puncture (CLP) in mice models. Our research employed in vitro assays, real-time quantitative polymerase chain reaction (RT-qPCR), and RNA-seq analysis to establish that CA significantly reduces the levels of pro-inflammatory cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6), in response to LPS stimulation. Additionally, Western blotting and immunofluorescence assays revealed that CA impedes Nuclear Factor Kappa B (NF-κB) activation in LPS-stimulated RAW264.7 cells. Complementing these findings, in vivo experiments demonstrated that CA effectively alleviates LPS- and CLP-triggered organ inflammation in C57BL/6 mice. Further insights were gained through 16S sequencing, highlighting CA's pivotal role in enhancing gut microbiota diversity and modulating metabolic pathways, particularly by augmenting the production of short-chain fatty acids in mice subjected to CLP. Notably, a comparative analysis revealed that CA's anti-inflammatory efficacy surpasses that of equivalent doses of aspirin (ASP) and TIENAM. Collectively, these findings suggest that CA exhibits significant therapeutic potential in sepsis treatment. This discovery provides a foundational theoretical basis for the clinical application of CA in sepsis management.

The Impact of Regulatory Reforms in China on Drug Lag: The Role of Clinical Development Strategies.

In recent years, there has been significant focus on China's new drug lag, but relevant research is limited. This study explores the reasons for drug lag by assessing the impact of reforms in China's drug review system, particularly focusing on the influence of clinical development strategies. This study selected drugs first launched in the United States between 2017 and 2022, examining absolute and relative lag between China and the first-launch country (including submission and review lag). These delays with drugs approved in the European Union and Japan during the same period were compared with uncover the roots of delays in China, further identifying potential factors that could reduce these delays. The results indicate that the National Medical Products Administration (NMPA) has a longer relative lag compared with the European Medicines Agency (EMA) and the Pharmaceuticals and Medical Devices Agency (PMDA). The submission lag time of the NMPA significantly surpasses that of the EMA and PMDA, whereas the review lag time of the NMPA exceeds that of the PMDA but falls short of the EMA. Focusing on clinical trial strategies, bridging trials and multiregional clinical trials (MRCTs) are typically required by the NMPA in East Asia, resulting in longer clinical delay time. Whereas the EMA and PMDA primarily require international MRCTs in Europe and America, with a clinical delay of < 5 months. It is evident that there is a significant gap in clinical trial durations between China and other countries. Further optimization of clinical trial management is necessary to address the lag for new drugs in China.

Maternal and perinatal health research during emerging and ongoing epidemic threats: a landscape analysis and expert consultation

IntroductionPregnant women and their offspring are often at increased direct and indirect risks of adverse outcomes during epidemics and pandemics. A coordinated research response is paramount to ensure that this...

Machine Learning Prediction Model: A Case Study of Urban Transport of Medical and Pharmaceutical Products

Machine Learning Prediction Model: A Case Study of Urban Transport of Medical and Pharmaceutical Products

Rheumatoid arthritis: Appraisement of the new security warnings for JAK-inhibitors

Januskinase-Inhibitors (JAKI) are highly effective substances (JAKi) for the treatment of rheumatoid arthritis (RA). In terms of efficiency in reduction of disease activity and induction of remission they are partially prior to biologic (b) DMARDs. Presently the four substances tofacitinib, baricitinib, upadacitinib and filgotinib are approved for the treatment of RA. The prospective controlled ORAL-SURVEILLANCE-trial investigated the safety of tofacitinib in comparison to TNF-inhibitors. Current results now show that treatment with tofacitinib might be associated with an increased risk for cardiovascular events, thromboembolism and certain malignancies. Affected are patients >65y, current or former smoker and, regarding cardiovascular events, patients who already had such an event. On the basis of this trial the Committee for Medical Products for Human Use (CHMP) of the European Medicines Agency (EMA) formulated actual recommendations for prescription of JAKi in order to reduce the risk of severe undesirable effects. These apply not only for tofacitinib but as well for all other JAKI named above, as a class effect was supposed. The data and their consequences are discussed and evaluated in this work.

Cross-sectional survey of sources of information accompanying veterinary product advertisements in two professional print publications.

Veterinarians should be able to easily access scientific evidence about medical products and devices to incorporate into their clinical decision making. While the characteristics and quality of supporting information accompanying device and pharmaceutical advertisements have been studied in human medicine, little is known about this topic in veterinary medicine. The aim of this study was to characterise the supporting information provided by manufacturers of prescribed products, tests or devices in promotional material found in two commonly read UK-based veterinary publications. Advertisements contained in issues of two veterinary periodicals published between July 2017 and July 2018 were analysed for advertisement and product characteristics and for items of accompanying information. Literature searches were conducted to assess the availability of peer-reviewed sources of information on advertised products. A minority (16%) of the 451 analysed advertisements were accompanied by references to peer-reviewed literature, despite the availability of scientific literature for many of the products advertised. This study sampled two professional publications over a narrow time period. There may be insufficient evidence being provided to veterinary professionals via marketing features; this may limit the accessibility of scientific information for clinical decision making around advertised products.

Intelligent, Flexible Artificial Throats with Sound Emitting, Detecting, and Recognizing Abilities.

In recent years, there has been a notable rise in the number of patients afflicted with laryngeal diseases, including cancer, trauma, and other ailments leading to voice loss. Currently, the market is witnessing a pressing demand for medical and healthcare products designed to assist individuals with voice defects, prompting the invention of the artificial throat (AT). This user-friendly device eliminates the need for complex procedures like phonation reconstruction surgery. Therefore, in this review, we will initially give a careful introduction to the intelligent AT, which can act not only as a sound sensor but also as a thin-film sound emitter. Then, the sensing principle to detect sound will be discussed carefully, including capacitive, piezoelectric, electromagnetic, and piezoresistive components employed in the realm of sound sensing. Following this, the development of thermoacoustic theory and different materials made of sound emitters will also be analyzed. After that, various algorithms utilized by the intelligent AT for speech pattern recognition will be reviewed, including some classical algorithms and neural network algorithms. Finally, the outlook, challenge, and conclusion of the intelligent AT will be stated. The intelligent AT presents clear advantages for patients with voice impairments, demonstrating significant social values.

EU27 regional trade networks for medical products in fight against Covid-19 pandemic: Quantifying vulnerability and self sufficiency in critical inputs.

The Covid-19 pandemic spread fast due to a lack of vaccines and a severe shortage of medical products to treat and combat the disease. Many studies have focused on the characteristics of extant global supply chains and trade networks that are determined by globalization drives for production to low-cost countries and the technological complexity of products with many components distributed globally. This, along with the lockdown of many sectors and national policies that divert exports for domestic use, are reasons for lack of access, especially, in Western countries to these products. Governments adopted policies that aim to mitigate vulnerability to imports of critical medical products that include self-sufficiency measures such as increased domestic production, stockpiling and reduction of exports. However, there is as yet no quantitative way to assess if a country's vulnerability to critical imports has been reduced by such drives for self-sufficiency, when other countries in the trade network follow similar policies. For this we develop a Google PageRank style centrality measure based on the Markose-Giansante eigen-pair method for a specially constructed global bilateral trade network to assess the vulnerability of net importers of critical medical products when they attempt to mitigate it by regional or domestic buffers. We use the network vulnerability centrality measure to quantify the regional self-sufficiency for EU27 countries over 2019-2021 for four Covid-19 critical medical products, viz. facemasks, personal protective equipment, ventilators and hand sanitizers. Despite, growth in value and share of intra-EU regional trade in most of these products by 2021, some countries did not achieve the reduction of vulnerability centrality.

Plasma-induced Polymerization and Grafting of Acrylic Acid on the Polypropylene Nonwoven Fabric Using Pulsed Underwater Diaphragm Electrical Discharge

Polypropylene (PP) nonwovens are used in many hygiene, healthcare and medical products due to their low cost, high chemical resistance and inertness. From an economic point of view, PP textiles would be used as an excellent support material in regenerative medicine or tissue engineering, but here surface functionalization is necessary to ensure cell adhesion and proliferation. Acrylic acid (AAc) is an excellent source of carboxylic-rich (-COOH) coatings suitable for this purpose, but their multistep preparation is time-consuming. Plasma polymerization provides an excellent solution to this demanding procedure since the process of polymerization and grafting to the substrate takes place simultaneously. Here, we propose a relatively fast and effective method for AAc plasma polymerization by using a pulsed underwater diaphragm electrical discharge operated in an aqueous solution consisting of AAc. AAc layers are successfully grafted onto PP nonwovens, which are continuously rewound through the slit where the plasma is generated. The presence of plasma polymerized AAc layer in the fibrous structure of PP nonwoven was monitored by SEM, FTIR and XPS measurements. Additionally, the improved wettability and adhesion characteristics were investigated by the critical wetting surface tension (CWST) method, the standard method of strike-through time (STT) and „tape-peel“ test. Resulting AAc modified PP nonwoven possesses hydrophilic character, enhanced adhesion and a considerable amount of -COOH groups on the surface. Although after the washing test the FTIR and XPS results indicated a lower concentration of the carboxylic groups, the CWST and STT measurements confirmed the stable hydrophilic character of the PP nonwovens surface.