Chronic fatigue is one of the most common syndromes in the clinical practice of medical doctors of various specialties. However, issues of criteria for distinguishing chronic fatigue from physiological fatigue, differential diagnosis of reactive asthenia, secondary fatigue syndrome and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as a distinct nosological form can be challenging for physicians. The provision of care to patients with ME/CFS is negatively impacted by the lack of accurate and up-to-date knowledge about the disease among healthcare professionals. Even if doctors are compassionate, they often do not know how to make a diagnosis or what can be done to improve the well-being of patients. Currently, this problem is especially relevant due to the increased risk of developing ME/CFS after suffering from a new coronavirus infection, COVID-19. This article presents a modern approach to the diagnosis of ME/CFS, set out in consensus recommendations that were developed in 2021 independently by groups of experts on the diagnosis and treatment of this disease in European countries and the USA, and taking into account the recommendations of domestic specialists.
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