Zero-watermarking in medical images is an emerging field that focuses on calculating the invisible data (key) using medical imagery to ensure data integrity and authenticity without compromising diagnostic accuracy. This paper introduces a robust zero-watermarking technique leveraging the Collatz and Fresnelet Transforms. The Forward Collatz Transform (FCT) is initially applied to create a secure and encrypted embedding pattern for medical images. Subsequently, the Fresnelet Transform (FT) is employed, offering superior localization and frequency selectivity. From the fresnelet values, we extract two strongest Oriented FAST and Rotated BRIEF (ORB) points to enhance watermark robustness, resulting in a 64-bit perceptual image hash. Our approach adopts a dual-layer security strategy by combining FCT and Cyclic-Shift-Transformation (CST) methods, significantly fortifying the protection of watermark image data. The watermark can be efficiently extracted using the Inverse Collatz Transform (ICT). A comprehensive performance analysis evaluates our system under single, double, and multiple attacks on medical images. Our experiments clearly show that our system outperforms existing methods in medical image watermarking, demonstrating its resilience against various manipulations. This approach can significantly improve data security and reliability in medical imaging applications.