Medical Diagnosis Support System Research Articles

Generative adversarial U-Net for domain-free few-shot medical diagnosis

• We proposed a new data augmentation method for few-shot medical diagnosis. • The proposed method can be used in different modality medical image data. • Extensive experiments are conducted to demonstrate the superior of the proposed method. In interactive remote medical diagnosis, medical diagnosis support system plays an important role in the pre-screening stage. Deep learning methods are widely used in such system especially medical imaging area to provide an initial diagnosis to support medical professional. However, the shortage of annotated medical images is one of the biggest challenges in the field of medical image computing. Without a sufficient number of training samples, deep learning based models are very likely to suffer from over-fitting problem. The common solution is image manipulation such as image rotation , cropping, or resizing. Those methods can help relieve the over-fitting problem as more training samples are introduced. However, they do not really introduce new images with additional information and may lead to data leakage as the test set may contain similar samples which appear in the training set. To address this challenge, we propose to generate diverse images with generative adversarial network . In this paper, we develop a novel generative method named generative adversarial U-Net, which utilizes both generative adversarial network and U-Net. Different from existing approaches, our newly designed model is domain-free and generalizable to various medical images. Extensive experiments are conducted over eight diverse datasets including computed tomography (CT) scan, pathology, X-ray, etc. The visualization and quantitative results demonstrate the efficacy and good generalization of the proposed method on generating a wide array of high-quality medical images.

Concatenation of Pre-Trained Convolutional Neural Networks for Enhanced COVID-19 Screening Using Transfer Learning Technique

Coronavirus (COVID-19) is the most prevalent coronavirus infection with respiratory symptoms such as fever, cough, dyspnea, pneumonia, and weariness being typical in the early stages. On the other hand, COVID-19 has a direct impact on the circulatory and respiratory systems as it causes a failure to some human organs or severe respiratory distress in extreme circumstances. Early diagnosis of COVID-19 is extremely important for the medical community to limit its spread. For a large number of suspected cases, manual diagnostic methods based on the analysis of chest images are insufficient. Faced with this situation, artificial intelligence (AI) techniques have shown great potential in automatic diagnostic tasks. This paper aims at proposing a fast and precise medical diagnosis support system (MDSS) that can distinguish COVID-19 precisely in chest-X-ray images. This MDSS uses a concatenation technique that aims to combine pre-trained convolutional neural networks (CNN) depend on the transfer learning (TL) technique to build a highly accurate model. The models enable storage and application of knowledge learned from a pre-trained CNN to a new task, viz., COVID-19 case detection. For this purpose, we employed the concatenation method to aggregate the performances of numerous pre-trained models to confirm the reliability of the proposed method for identifying the patients with COVID-19 disease from X-ray images. The proposed system was trialed on a dataset that included four classes: normal, viral-pneumonia, tuberculosis, and COVID-19 cases. Various general evaluation methods were used to evaluate the effectiveness of the proposed model. The first proposed model achieved an accuracy rate of 99.80% while the second model reached an accuracy of 99.71%.

A Novel COVID-19 Diagnosis Support System Using the Stacking Approach and Transfer Learning Technique on Chest X-Ray Images.

COVID-19 is an infectious disease-causing flu-like respiratory problem with various symptoms such as cough or fever, which in severe cases can cause pneumonia. The aim of this paper is to develop a rapid and accurate medical diagnosis support system to detect COVID-19 in chest X-ray images using a stacking approach combining transfer learning techniques and KNN algorithm for selection of the best model. In deep learning, we have multiple approaches for building a classification system for analyzing radiographic images. In this work, we used the transfer learning technique. This approach makes it possible to store and use the knowledge acquired from a pretrained convolutional neural network to solve a new problem. To ensure the robustness of the proposed system for diagnosing patients with COVID-19 using X-ray images, we used a machine learning method called the stacking approach to combine the performances of the many transfer learning-based models. The generated model was trained on a dataset containing four classes, namely, COVID-19, tuberculosis, viral pneumonia, and normal cases. The dataset used was collected from a six-source dataset of X-ray images. To evaluate the performance of the proposed system, we used different common evaluation measures. Our proposed system achieves an extremely good accuracy of 99.23% exceeding many previous related studies.

Development of a decision support system tool to predict the pulmonary function using artificial neural network approach

SummaryThe spirometry is considered a preclinical tool for the evaluation of the respiratory system. The formal lung volumes measurement and health status lung system are made using spirometry. Artificial neural network (ANN) has been introduced in solving complex problems in a large number of different settings, including medical diagnosis support system as predictive power. An objective of this research was intended to investigate the development of a new decision support system (DSS) using ANN modeling approaches and algorithms to predict pulmonary function in people. The spirometry data and general characteristics, anthropometric data, and body composition parameters (N = 130) were obtained from subjects. The classification of pulmonary function was performed by the multi‐layer perceptron (MLP) model. Findings show that the MLP model is capable of classifying respiratory abnormalities in different people. The ANN model was totally 93.6%, 92.3%, 84.6%, and 91.5% successful in correctly classified in training, validation, test, and all data, respectively. Also, a DSS tool was created that allows the evaluation and classification of the results of spirometry data. It appears that ANNs are useful in classification pulmonary function.

A novel medical diagnosis support system for predicting patients with atherosclerosis diseases

Abstract Atherosclerosis diagnosis is an indistinct and complex cognitive process. Artificial intelligence methods, such as machine learning algorithms, have proven their efficiency in Medical Diagnosis Support Systems (MDSS). In this paper, we developed a novel machine learning MDSS to boost the diagnosis of cardiovascular diseases. Our study performed using 835 patient medical records that suffer from atherosclerosis, usually caused by coronary artery diseases (CAD), collected from three databases. The system input layer includes several input variables based on three databases, the Cleveland heart disease, Hungarian, and Z-Alizadeh Sani databases. Seven independent classification methods are applied to assess the system: Artificial Neural Network (ANN), K-Nearest Neighbor (KNN), Support Vector Machine (SVM), Decision Tree (DT), Naive Bayes (NB), Classification Ensemble (CE), and Discriminant Analysis (DA) algorithms. The robustness of the proposed methods was evaluated through several performance measures. The results showed that the proposed MDSS reached an accuracy of (98%), which is a higher accuracy than the existing approaches. These results are a promising step toward facilitating large-scale clinical diagnostics for atherosclerosis diseases.

Supervised Machine Learning Based Medical Diagnosis Support System for Prediction of Patients with Heart Disease

Supervised Machine Learning Based Medical Diagnosis Support System for Prediction of Patients with Heart Disease

Exploring healthcare professionals' understanding and experiences of artificial intelligence technology use in the delivery of healthcare: An integrative review.

The integration of artificial intelligence (AI) into our digital healthcare system is seen as a significant strategy to contain Australia's rising healthcare costs, support clinical decision making, manage chronic disease burden and support our ageing population. With the increasing roll-out of 'digital hospitals', electronic medical records, new data capture and analysis technologies, as well as a digitally enabled health consumer, the Australian healthcare workforce is required to become digitally literate to manage the significant changes in the healthcare landscape. To ensure that new innovations such as AI are inclusive of clinicians, an understanding of how the technology will impact the healthcare professions is imperative. In order to explore the complex phenomenon of healthcare professionals' understanding and experiences of AI use in the delivery of healthcare, an integrative review inclusive of quantitative and qualitative studies was undertaken in June 2018. One study met all inclusion criteria. This study was an observational study which used a questionnaire to measure healthcare professional's intrinsic motivation in adoption behaviour when using an artificially intelligent medical diagnosis support system (AIMDSS). The study found that healthcare professionals were less likely to use AI in the delivery of healthcare if they did not trust the technology or understand how it was used to improve patient outcomes or the delivery of care which is specific to the healthcare setting. The perception that AI would replace them in the healthcare setting was not evident. This may be due to the fact that AI is not yet at the forefront of technology use in healthcare setting. More research is needed to examine the experiences and perceptions of healthcare professionals using AI in the delivery of healthcare.

Investigating the impacting factors for the healthcare professionals to adopt artificial intelligence-based medical diagnosis support system (AIMDSS)

Compared to the booming industry of AIMDSS, the usage of AIMDSS among healthcare professionals is relatively low in the hospital. Thus, a research on the acceptance and adoption intention of AIMDSS by health professionals is imperative. In this study, an integration of Unified theory of user acceptance of technology and trust theory is proposed for exploring the adoption of AIMDSS. Besides, two groups of additional factors, related to AIMDSS (task complexity, technology characteristics, and perceived substitution crisis) and health professionals’ characteristics (propensity to trust and personal innovativeness in IT) are considered in the integrated model. The data set of proposed research model is collected through paper survey and Internet survey in China. The empirical examination demonstrates a high predictive power of this proposed model in explaining AIMDSS adoption. Finally, the theoretical contribution and practical implications of this research are discussed.

Cuckoo-search based Intuitionistic Fuzzy Clustering Algorithm

Clustering plays an important role in the fields like medical diagnosis, pattern recognition and decision support systems. Fuzzy clustering allows an object to be a part of various clusters with various membership values. Intuitionistic fuzzy set helps in making useful decisions by adding another parameter called hesitancy which contributes to the uncertainties present in the data. This work focuses on the effective usage of Intuitionistic fuzzy clustering algorithm by hybridizing it with the most famous optimization algorithm called Cuckoo Search. The results are compared to Fuzzy C Means and Intuitionistic Fuzzy C Means algorithms. The resulting clusters are found to be of more efficient in terms of intra cluster distances minimized to a great extent and thus leading to an effective diagnosis.

Embedding Ethical Principles in Collective Decision Support Systems

The future will see autonomous machines acting in the same environment as humans, in areas as diverse as driving, assistive technology, and health care. Think of self-driving cars, companion robots, and medical diagnosis support systems. We also believe that humans and machines will often need to work together and agree on common decisions. Thus hybrid collective decision making systems will be in great need. In this scenario, both machines and collective decision making systems should follow some form of moral values and ethical principles (appropriate to where they will act but always aligned to humans'), as well as safety constraints. In fact, humans would accept and trust more machines that behave as ethically as other humans in the same environment. Also, these principles would make it easier for machines to determine their actions and explain their behavior in terms understandable by humans. Moreover, often machines and humans will need to make decisions together, either through consensus or by reaching a compromise. This would be facilitated by shared moral values and ethical principles.

Feature projection k-NN classifier model for imbalanced and incomplete medical data

Many datasets, especially various historical medical data are incomplete. Various qualities of data can significantly hamper medical diagnosis and are bottlenecks of medical support systems. Nowadays, such systems are often used in medical diagnosis. Even great number of data can be unsuitable when data is imbalanced, missing or corrupted. In some cases these troubles can be overcome by machine learning algorithms designed for predictive modeling.Proposed approach was tested on real medical data and some benchmarks dataset form UCI repository. The liver fibrosis disease from a medical point of view is difficult to treatment and has a significant social and economic impact. Stages of liver fibrosis are diagnosed by clinical observation and evaluations, coupled with a so-called METAVIR rating scale. However, these methods may be insufficient, especially in the recognition of phase of the disease. This paper describes a newly developed algorithm to non-invasive fibrosis stage recognition using machine learning methods – a classification model based on feature projection k-NN classifier. This solution allows extracting data characteristics from the historical data which may be incomplete and may contain imbalance (unequal) sets of patients. Proposed novel solution is based on peripheral blood analysis without using any specialized biomarkers, and can be successfully included to medical diagnosis support systems and might be a powerful tool for effective estimation of liver fibrosis stages.

A cooperative semi-supervised fuzzy clustering framework for dental X-ray image segmentation

Dental X-ray image segmentation (DXIS) is an indispensable process in practical dentistry for diagnosis of periodontitis diseases from an X-ray image. It has been said that DXIS is one of the most important and necessary steps to analyze dental images in order to get valuable information for medical diagnosis support systems and other recognition tools. Specialized data mining methods for DXIS have been investigated to achieve high accuracy of segmentation. However, traditional image processing and clustering algorithms often meet challenges in determining parameters or common boundaries of teeth samples. It was shown that performance of a clustering algorithm is enhanced when additional information provided by users is attached to inputs of the algorithm. In this paper, we propose a new cooperative scheme that applies semi-supervised fuzzy clustering algorithms to DXIS. Specifically, the Otsu method is used to remove the Background area from an X-ray dental image. Then, the FCM algorithm is chosen to remove the Dental Structure area from the results of the previous steps. Finally, Semi-supervised Entropy regularized Fuzzy Clustering algorithm (eSFCM) is opted to clarify and improve the results based on the optimal result from the previous clustering method. The proposed framework is evaluated on a real collection of dental X-ray image datasets from Hanoi Medical University, Vietnam. Experimental results have revealed that clustering quality of the cooperative framework is better than those of the relevant ones. The findings of this paper have great impact and significance to researches in the fields of medical science and expert systems. It has been the fact that medical diagnosis is often an experienced and case-based process which requests long time practicing in real patients. In many situations, young clinicians do not have chance for such the practice so that it is necessary to utilize a computerized medical diagnosis system which could simulate medical processes from previous real evidences. By learning from those cases, clinicians would improve their experience and responses for later ones. In the view of expert systems, this paper made uses of knowledge-based algorithms for a practical application. This shows the advantages of such the algorithm in the conjunction domain between expert systems and medical informatics. The findings also suggested the most appropriate configuration of the algorithm and parameters for this problem that could be reused by other researchers in similar applications. The usefulness and significance of this research are clearly demonstrated within the extent of real-life applications.

1-4 グリッドコンピューティングと循環器疾患治療診断支援システム

1-4 グリッドコンピューティングと循環器疾患治療診断支援システム

A Medical Diagnosis Support System with Signs, Symptoms and Clinical Laboratory Data

A Medical Diagnosis Support System with Signs, Symptoms and Clinical Laboratory Data