Medical Cosmetology Research Articles

Preparation and Properties of the Sodium Hyaluronate Composite Hydrogel for Medical Cosmetology.

As society advances, an increasing number of people are focusing on the antiaging process of the body and seeking ways to maintain youthful facial features. Intradermal injection has been used to effectively improve the rough and wrinkled skin, playing a role in skin rejuvenation. However, the main component of intradermal injection products is cross-linked sodium hyaluronate (SHA), which has biological toxicity and potential carcinogenicity. In this study, amino acids were used as hyaluronidase inhibitors and combined with non-cross-linked SHA to prepare a synergically stable SHA composite hydrogel. The effects of amino acids on the viscosity and enzyme activity of the hydrogel were investigated. To determine the stability and antioxidant properties of the composite hydrogel, the effects of the introduction of stabilizer and antioxidant on the hydrogel properties were systematically studied. The results of the in vitro study showed that the introduction of amino acids effectively reduced the activity of hyaluronidase, addressing the problem of rapid hydrolysis and the short half-life of SHA hydrogel invivo. In addition, the results revealed that NaCl stabilizer, niacinamide, and vitamin B12 antioxidants effectively maintained the stability and antioxidant properties of the hydrogels. In vivo results showed that SHA composite hydrogels had no irritating effect on the skin, and the subcutaneous experiments of mice showed that SHA composite hydrogel still retained a high content after 4 weeks. Therefore, the SHA composite hydrogels have promising applications in the field of medical cosmetology.

Recent Developments in Using Microneedle Patch Technology as a More Efficient Drug Delivery System for Treating Skin Photoaging.

Skin photoaging, resulting from prolonged exposure to ultraviolet (UV) radiation, is characterized by intricate biological changes involving oxidative damage and structural alterations. Despite an increasing demand for effective interventions, the current therapeutic options for treating skin photoaging are limited. We discovered through literature data search on PubMed that recent research has shifted its focus to the application of microneedle patches as an innovative approach to address this concern. Microneedle patches, serving as a novel transdermal delivery system, exhibit the potential to deliver bioactive substances such as cytokines, cellular vesicles, gene fragments and even alive algae to mitigate the effects of skin photoaging. This review aims to provide a comprehensive overview of recent advancements in research about utilizing microneedle patches for the treatment of skin photoaging and potential future directions in leveraging microneedle patches as clinical therapeutic agents for skin rejuvenation. Ultimately, we believe that microneedle patches have a broader application prospect in the fields of medical cosmetology and anti-photoaging.

Engineering a durable BDDE cross-linked collagen filler for skin rejuvenation

Skin aging, characterized by reduced regeneration, chronic inflammation, and heightened skin cancer risk, poses a significant challenge. Collagen fillers have emerged as a potential solution for skin rejuvenation by stimulating collagen regeneration. However, their clinical efficacy is limited by inherent instability and vulnerability toin vivodegradation by collagenase. Chemical cross-linking presents a promising approach to enhance stability, but it carries risks such as cytotoxicity, calcification, and discoloration. Here, we introduce a highly durable 1,4-butanediol diglycidyl ether (BDDE) cross-linked collagen filler for skin rejuvenation. BDDE effectively cross-links collagen, resulting in fillers with exceptional mechanical strength and injectability. These fillers demonstrate favorable stability and durability, promoting proliferation, adhesion, and spreading of human foreskin fibroblast-1 cellsin vitro. In vivostudies confirm enhanced collagen regeneration without inducing calcification. BDDE cross-linked collagen fillers offer promising prospects for medical cosmetology and tissue regeneration.

Simulated skin model for in vitro evaluation of insertion performance of microneedles: design, development, and application verification

Microneedles, as a new efficient and safe transdermal drug delivery technology, has a wide range of applications in drug delivery, vaccination, medical cosmetology, and diagnostics. The degree of microneedles penetration into the skin determines the reliability of the delivery dose, but its evaluation is not yet well-established, which is one of the major constraints in the commercialization of microneedles. In this paper, a novel visual simulated skin model was developed with reference to the physical properties of real skin. The simulated skin model was well-designed and its prescription was optimized to make the thickness, hardness, elasticity, and other parameters close to those of real skin. It not only meets the need to assess the degree of insertion of microneedles but also provides a visual observation of the insertion state of microneedles.

의료미용 종사자의 WLB가 조직몰입과 조직성과에 미치는 영향

Recently, as a positive link between an organization and individuals, ‘work-life balance’ has been taken as a top priority among employees. In fact, people have desired to improve the quality of life in diverse fields as work-life balance regulates their lives and ensure a happy life. This study attempted to investigate the influence of work-life balance on organizational commitment and organizational performances against medical cosmetology workers to provide basic data needed to improve their working environments. For this, a questionnaire survey was performed against estheticians, nursing assistants and patient care coordinators who work at skin and plastic surgery clinics and hospitals across the country from July 27 to August 12, 2023. Among a total of 310 questionnaires distributed, 303 copies excluding 7 poorly answered ones were used for final analysis, and the results found the followings: First, work-life balance had a positive influence on organizational commitment with statistical significance. Second, work-life balance revealed a positive effect on organizational performances with statistical significance. It is anticipated that the above results would be available in developing training programs for work-life balance against medical beauty workers and those in other sectors.

The aspects of the use of cosmetology services nomenclature in medical organizations

Aim – to study the practice of use of the cosmetology services nomenclature in medical organizations. Material and methods. The Clinic of beauty and health "New Life" (Samara, Russia) was the base of the study. We analyzed its business practices and made a review of regulatory documents and scientific literature on the use of cosmetology services nomenclature. The analytical method and the content analysis method were applied. Results. Currently, there is a situation when one medical cosmetology service is called differently in various documents related to medical care provision: in medical documentation, in the contract for the provision of medical services, in informed voluntary consent to medical intervention and other documents, defining medical services in different terms. Conclusion. For responsible professional communication and awareness of generally accepted methods of diagnosis, treatment and prevention in the provision of medical care in the "cosmetology" profile, it is necessary to unify the terminology of cosmetology services within the current nomenclature of medical services.

Directed osteogenic differentiation of human bone marrow mesenchymal stem cells via sustained release of BMP4 from PBVHx-based nanoparticles

Bone Morphogenetic Protein 4 (BMP4) is crucial for bone and cartilage tissue regeneration, essential in medical tissue engineering, cosmetology, and aerospace. However, its cost and degradation susceptibility pose significant clinical challenges. To enhance its osteogenic activity while reducing dosage and administration frequency, we developed a novel long-acting BMP4 delivery system using poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) (PBVHx) nanoparticles with soybean lecithin-modified BMP4 (sBP-NPs). These nanoparticles promote directed osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through sustained BMP4 release. sBP-NPs exhibited uniform size (100–200 nm) and surface charges, with higher BMP4 entrapment efficiency (82.63 %) compared to controls. After an initial burst release within 24 h, sBP-NPs achieved 80 % cumulative BMP4 release within 20 days, maintaining levels better than control BP-NPs with unmodified BMP4. Co-incubation and nanoparticle uptake experiments confirmed excellent biocompatibility of sBP-NPs, promoting hBMSC differentiation towards osteogenic lineage with increased expression of type I collagen, calcium deposition, and ALP activity (> 20,000 U/g protein) compared to controls. Moreover, hBMSCs treated with sBP-NPs exhibited heightened expression of osteogenic genetic markers, surpassing control groups. Hence, this innovative strategy of sustained BMP4 release from sBP-NPs holds potential to revolutionize bone regeneration in minimally invasive surgery, medical cosmetology or space environments.

Bioflavonoids in medical cosmetology

Bioflavonoids in medical cosmetology

Hydrogel Based on Riclin Cross-Linked with Polyethylene Glycol Diglycidyl Ether as a Soft Filler for Tissue Engineering.

Hydrogels composed of natural polysaccharides have been widely used as filling materials, with a growing interest in medical cosmetology and skin care. However, conventional commercial dermal fillers still have limitations, particularly in terms of mechanical performance and durability in vivo. In this study, a novel injectable and implantable hydrogel with adjustable characteristics was prepared from succinoglycan riclin by introducing PEG diglycidyl ether as a cross-linker. FTIR spectra confirmed the cross-linking reaction. The riclin hydrogels exhibited shear-thinning behavior, excellent mechanical properties, and cytocompatibility through in vitro experiments. Furthermore, when compared with subcutaneous injection of a commercial hyaluronic acid hydrogel, the riclin hydrogels showed enhanced persistence and biocompatibility in Balb/c mice after 16 weeks. These results demonstrate the great potential of the riclin-based hydrogel as an alternative to conventional commercial soft tissue fillers.

Expert consensus on the clinical application of narrow-band intense pulsed light (2024 edition)

The continuous innovation of medical cosmetology technology promotes the rapid development of aesthetic medicine. Narrow-band intense pulsed light (NB-IPL), which is developed based on conventional intense pulsed light, is a more accurate, efficient, and safer technique on clinical application. In order to promote more professionalization and standardization of the clinical application of NB-IPL, a panel of clinical experts in plastic surgery, dermatology and other fields developed the consensus based on the evidence-based medicine, clinical practice, and authoritative guidelines of other disciplines. The consensus panel discussed the indications, treatment parameters, contraindications, and precautions for the clinical application of NB-IPL and would serve as a reference for clinicians, nurses, teaching and research personnels engaged in plastic and cosmetics related work.

The Chemical Constituents and Application Status of Radix Astragali

Radix Astragali, a highly renowned herbal medicine, boasts a venerable history within the realm of the traditional Chinese medicine. Its abundant therapeutic value has elicited widespread scholarly attention. This paper summarizes the chemical composition and pharmacological effects of the Radix Astragali and explores its application status in aquaculture and medical cosmetology. Radix Astragali is rich in chemicals. Flavonoids, saponins and astragalus polysaccharides are the main active components of Radix Astragali. These ingredients have many pharmacological effects, such as antioxidant, anti-inflammatory, antitumor, and immunomodulatory effects. In addition, Radix Astragali as a feed additive can improve the growth and development, and reproductive function and immune health of livestock and poultry. In the medical beauty industry, Radix Astragali has also been developed into a product with effects such as the sun protection and skin repair. These studies provide a basic basis for the research and application of astragalus and its active ingredients.

The mechanism and application of computer-assisted full facial skin imaging systems.

Computer-assisted full facial imaging systems are currently among the most widely used skin analysis instruments in dermatology and medical cosmetology. These systems offer objective quantitative evaluation of facial skin conditions, and as they are non-invasive, play an important role in assessing dermatological conditions such as pigmentation, inflammation, vascular diseases, skin texture, the severity of ageing, and therapeutic follow-up. Although computer-assisted full facial imaging systems enable quantitative analysis in the scope of medical treatment and cosmetic evaluation, their results may considerably vary because of the influence of environmental and postural factors for improper operation. Furthermore, manual observation is sometimes necessary for experimental work for more accuracy, and familiarity with the imaging principles and application points is necessary to best apply this technique. This report aims to discuss and interpret these systems' imaging mechanisms and explore the primary issues with their application.

Application of Auricular Cartilage Scaffold Combined With L-Shaped Prosthesis in Asian Rhinoplasty.

Rhinoplasty is a common surgical procedure in medical cosmetology. From patients with saddle nose deformity to beauty seekers with low and short noses, this surgery is mainly sought to improve the nose's appearance. To investigate the effect of modified auricular cartilage scaffold combined with L-shaped prosthesis in rhinoplasty. This retrospective study included 54 patients who underwent auricular cartilage augmentation rhinoplasty with L-shaped implants in our hospital from July 2018 to July 2021. The function of nasal ventilation and olfaction was inspected. As a result, the degree of nasal tip protrusion and the changes in the superior lip angle of columella were improved. The patients' satisfaction was measured a year after the surgery. Patients who underwent auricular cartilage augmentation rhinoplasty with L-shaped prosthesis were satisfied with the surgery outcomes. Using a protective auricular cartilage scaffold combined with an L-shaped implant for augmentation rhinoplasty reduced the shortage of the application and reinforced the stability of the auricular cartilage augmentation rhinoplasty. At >12 months follow-up, there were no serious adverse effects on nasal ventilation and olfactory function in any of the patients. The presented method made full use of auricular cartilage so that it reduced the harvest of the cartilage. Besides, it achieved the remarkable lift of the nose tip, thus simulating the appearance of costal cartilage rhinoplasty. Furthermore, the risk of implant exposure was efficiently reduced, making it worthy of clinical application.

Exosomal microRNAs from Mesenchymal Stem Cells: Novel Therapeutic Effect in Wound Healing.

Wound healing is a complicated biological process that leads to the regeneration of damaged skin tissue. Determining the methods to promote wound healing has become a hot topic in medical cosmetology and tissue repair research. Mesenchymal stem cells (MSCs) are a group of stem cells with the potential of self-renewal and multi-differentiation. MSCs transplantation has a broad application prospect in wound healing therapy. Many studies have demonstrated that the therapeutic capacity of MSCs is mainly mediated by paracrine actions. Exosomes (EXOs), which are nanosized vesicles carrying a variety of nucleic acids, proteins and lipids, are an important component of paracrine secretion. It has been demonstrated that exosomal microRNAs (EXO-miRNAs) play a key role in the function of exosomes. In this review, we focus on current research on miRNAs from MSC-derived exosomes (MSC-EXO miRNAs) in terms of sorting, releasing and function and their effects on inflammation regulation, epidermal cell function, fibroblast function, and extracellular matrix formation. At last, we discuss the current attempts to improve the treatment of MSC-EXO-miRNAs. Many studies have demonstrated that MSC-EXO miRNAs play a key role in promoting wound healing. They have been shown to regulate inflammation response, enhance epidermal cell proliferation and migration, stimulate fibroblast proliferation and collagen synthesis, and regulate extracellular matrix formation. Besides, there have been a number of strategies developed to promote MSC-EXO and MSC-EXO miRNAs for wound healing treatment. Utilizing the association of exosomes from MSCs with miRNAs may be a promising strategy to promote trauma healing. MSC-EXO miRNAs may provide a new approach to promote wound healing and improve the quality of life for patients with skin injuries.

Enhanced Luminescence of Long-Wavelength Broadband Near-Infrared Germanate Phosphors.

Long-wavelength broadband near-infrared (NIR) phosphors have attracted considerable interest in the fields of medical cosmetology and organic detection because of their special emission band. Herein, Ca2GeO4(CGO): Cr4+ NIR phosphor, presenting a broadband emission with longer wavelength ranging from 1100 to 1600 nm, has been synthesized. Further, the luminescence intensity and quantum efficiency of Cr4+ could be obviously improved via the energy transfer from Eu3+ to Cr4+. The energy transfer is dominated by the dipole-dipole mechanism, which can be inferred from the spectra and the decay curves. Furthermore, in order to evaluate the potential application, an NIR phosphor-converted light-emitting diode (pc-LED) based on blue chip has been prepared. Consequently, CGO: Eu3+, Cr4+ exhibits proper output power and wider half-width than the NIR LED chip, indicating its great prospect for long-wavelength NIR pc-LED applications.

Psychosocial characteristics of patients in a cosmetology clinic: results of a non-sample study

The relevance of the study is determined by the rapid development of medical cosmetology, which, unlike plastic surgery, has not been studied at all in psychological and sociological terms, although the effect of facial skin defects on the emotional state, social success, quality of life is beyond doubt, and their elimination significantly affects psychological well-being. patients. A practicing dermatologist-cosmetologist conducted a non-selective clinical and socio-psychological study of 188 patients (mean age 39.12+0.81 years) of a cosmetology clinic. The author’s structured interview and the medico-sociological scale «Level of social frustration» were used. According to 50 parameters, women with mild, moderate and significant severity of cosmetic problems were compared. Statistical methods of analysis were used (Pearson’s χ2 and ANOVA). An analysis of clinical data showed a relationship between the severity of a facial skin defect and its nature (symptoms), age, comorbid pathology, and treatment efficacy. Social positions (educational and labor status, nature of professional activity), significant spheres of personal relations (to oneself, to persons of the opposite sex, family relations, the presence and nature of mental trauma) were studied. Among the psychological and social characteristics, the characteristics of the family sphere, the reasons for visiting the clinic, and the patient›s subjective assessment of the impact of the cosmetic problem on the quality of life have a statistical relationship with the severity of the cosmetic problem and the age of the patients. The results are compared with the data of modern world literature. The limitations of the study associated with the use of non-standardized methods, which are relevant, however, to the tasks of a screening non-selective survey, are noted. The prospects for further studies of patients of the clinic for non-surgical correction of appearance using psychometric (standardized) methods are outlined.

Current Research of Botulinum Toxin Type A in Prevention and Treatment on Pathological Scars.

Dermatologists have been looking for ways to improve wound healing and postoperative scar appearance. The safety and efficacy of botulinum toxin type A (BTXA) in the prevention and treatment on pathological scars have become the current research hotspot since it was approved by the US FDA in medical cosmetology in 2002. This article aims to provide an overview of the clinical research, limitations, and application prospects of BTXA in the prevention and treatment of traumatic or postoperative pathological scars, which can provide a reference and better understanding of relevant studies. The current research progress was summarized and discussed, with new problems and research ideas being proposed ranging from the molecular mechanism of BTXA in preventing and treating pathological scars to its clinical application via investigation and reference research. BTXA is effective in relieving itching and pain associated with pathological scars, limiting scar hyperplasia along with preventing scar contracture, but the specific mechanism is still not clear. Most of the clinicians have confirmed the clinical effectiveness of BTXA in the prevention and treatment of pathological scars, yet its mode of action and combination therapy need more research.

Investment Value Analysis and Regulatory Trends in China's Medical Cosmetology Industry

With the rapid rise of the Internet celebrity economy and the live broadcasting industry, medical beauty has become a hot spot sought after by consumers and operators with its advantages of low risk and fast start-up. However, considering that China's medical beauty industry started late compared with other developed countries, both the social foundation and the theoretical research foundation are relatively weak to cultivate the medical cosmetology industry to become a truly valuable investment track, we must analyze and study. Given the recent rise of the medical beauty industry in the capital market, many investors and consumers lack understanding and analysis of the medical beauty industry. This paper first analyzes the development status and trend of the medical cosmetology industry from the perspective of investment. Analyze the investment value of several listed companies in the medical beauty industry from a macro and micro perspective. Second, analyze the current problems in the beauty industry and regulatory measures.

Hyaluronic acid injection in the auricular base for the aesthetic correction of lying ears: A retrospective study

BackgroundEars play an important role in facial profiles. Lying ears are not perceived favorably in Asian cultures; therefore, surgical procedures are implemented to adjust this defect. However, surgery has complications and requires recovery time. We introduced a hyaluronic acid (HA) injection technique to aesthetically improve ear prominence. MethodsThis retrospective study examined 25 Chinese patients aged 20–47 years with congenital lying ears who received HA injections in the auricular base at Shanghai Ninth People’s Hospital and Hangzhou Yijie Medical Cosmetology Clinic between November 2019 and December 2022. The average injection volume was 6.32 ​± ​1.22 mL in the auricular base unilaterally, and the follow-up time ranged from 6 to 24 months. Morphological measurement data were recorded. Two-dimensional (2D) and three-dimensional (3D) images were obtained to evaluate the effects. ResultsAll patients showed improvements in ear prominence. The cranioauricular angle (CAA) increased from 22.24° ​± ​4.53° to 65.90° ​± ​5.38° immediately post-injection and was maintained at 49.18° ​± ​4.74° 6 months later. The ear projection (EP) increased from 14.75 ​± ​2.72 mm to 26.26 ​± ​2.94 mm immediately post-injection and was 22.51 ​± ​2.68 mm after 6 months. No serious complications were noted. ConclusionHA injection in the auricular base effectively corrected the lying ears and aesthetically optimized the facial profile. It also had a face-lift effect that made the face look younger and more compact. The injection procedure was minimally invasive and required no recovery period. The effect was maintained for a long time and was satisfactory.

Biocompatible Triple-Helical Recombinant Collagen Dressings for Accelerated Wound Healing in Microneedle-Injured and Photodamaged Skin

Skin rejuvenation procedures such as microneedling and laser resurfacing have gained global popularity in medical cosmetology, leading to acute skin wounds with persistent pain, erythema, and edema. A variety of dressings have been explored to repair these postoperative skin injuries; however, their inadequate biocompatibility and bioactivity may raise concerns about undesirable efficacy and complications. Herein, we developed biocompatible and nonirritating triple-helical recombinant collagen (THRC) dressings for accelerated healing of microneedle-injured and photodamaged acute skin wounds. Circular dichroism (CD) measurements of THRC from various batches exhibited triple-helical structure characteristics of collagen. Cell experiments using L929 fibroblasts revealed that THRC dressings possess superior biocompatibility and bioactivity, significantly elevating the proliferation and adhesion of fibroblasts. In vivo, skin irritation tests of New Zealand rabbits demonstrated that the THRC dressings are gentle, safe, and non-irritating. Histological analysis of the animal model studies in photodamaged skin wounds using H&E and Masson’s trichrome staining revealed that 4 days of treatment with the THRC dressings effectively healed the damaged dermis by accelerating re-epithelialization and enhancing collagen deposition. In vivo studies of microneedle-injured rat defects showed that THRC dressings of varying concentrations exhibit the same rapid epithelialization rates at 48 h as commercial bovine collagen dressings. The highly biocompatible and bioactive recombinant collagen dressings may provide an advanced treatment of acute skin wounds, indicating attractive applications in postoperative care of facial rejuvenation.