Osteogenesis imperfecta (OI) is a genetic disorder primarily characterized by an impairment in the synthesis of type I collagen, leading to bone fragility, frequent fractures, scoliosis, short stature, and other symptoms. The disease is mostly inherited from parents to children, and its severity can vary significantly. This article describes the approach to treatment and therapy outcomes for 10 children with osteogenesis imperfecta. Objective — сomplex examination of pediatric patients with OI, treatment with bisphosphonates and further support by multidisciplinary team of specialists for therapy evaluation. Materials and methods. The treatment was aimed to minimize the frequency of fractures and improve the quality of life of patients. Key aspects of the treatment included: medicinal treatment (bisphosphonates were used to reduce bone resorption, thereby increasing bone mass and reducing bone fragility, as well as vitamin D and calcium, administered to support normal bone mineralization); physical therapy (included exercises to develop muscle strength, coordination, and joint mobility, minimizing the risk of injury); and management by a multidisciplinary team (consultations with an orthopedist, psychologist, and other specialists as needed). Results and discussion. The treatment results were positive, showing a reduction in the frequency of fractures and improvements in functionality and quality of life. Conclusions. Over the course of 11 months, the significant reduction in medical complications and improvements in the overall health status of the study participants have been noticed, demonstrating the importance of a comprehensive approach to the treatment of osteogenesis imperfecta.