The article presents the features of the implementation of the Regulations on internal quality control and safety of medical activities in the Clinical Hospital of the Federal Medical Institution «Medical and Sanitary Unit of the Ministry of Internal Affairs of the Russian Federation in Moscow». To implement this line of activity, a person responsible for this type of control was appointed, medical workers improved their qualifications on the issues of examination of the quality of medical care and quality control and safety of medical activities. The peculiarity of the implementation and implementation of internal control was associated with a large number of structural units and a bed fund. A regulation on interaction with the medical commission of a medical organization has been created. The general functions of the internal control system, the medical commission and the examination of the quality of medical care are defined.