Introduction: Type 2 Diabetes Mellitus (T2DM) has established itself as a silent pandemic with devastating multiorgan involvement. The only way forward is to nip it at its bud by proactive screening at every available circumstance. There are many types of cost-effective screening tools available at national and international level. Indian Diabetic Risk Score (IDRS) developed by Madras Diabetes Research Foundation (MDRF) is one of them. The sensitivity of this simple non-invasive tool has been studied mostly in the Southern part of India. Aim: To study the screening accuracy of the IDRS among Outpatient (OPD) attending adults at a tertiary health care setup. Objective: To screen the OPD attending adults aged between18 -60 years for risk of T2DM by IDRS score and check its sensitivity and specificity by univariate, bivariate and Receiver Operating Characteristic (ROC) Curve analysis taking Random Blood Sugar (RBS) as control. Method: A cross-sectional study was carried out on OPD attending patients at a Medical college in central India. A total of 101 subjects were screened over a one-month period by purposive sampling method and their pertinent sociodemographic information along with RBS was collected in addition to IDRS data. Data coding and analysis was done in SPSS version 20. Result: The participants mean age was 38.65±12.54), literacy rate at (63;62.4%).and male representation at 56 (56.5%). The prevalence of high risk, moderate risk and low risk for diabetes among participants as per IDRS were found to be 19.8 %,55.4% and 24.8 % respectively. 11 subjects (10.89%) recorded a RBS levels ? 140 mg/dl. The area under the ROC curve was in the acceptable range (.7-.8). Fixing the IDRS core ? 35 (moderate risk zone) the predicted risk of T2DM had a sensitivity of 90% and specificity of 64%. Conclusion: IDRS may be considered as a viable screening method for OPD attending patients in central India for risk evaluation in asymptomatic cases. How to cite this article: Barjatya P, Mishra BN, Panwar NKS, Chouhan DS. Study of Effectiveness of IDRS as a Screening tool in OPD attending Adults at a Medical College Hospital in Central India. J Adv Res Med Sci Tech 2019; 6(3&4): 19-24. DOI: https://doi.org/10.24321/2394.6539.201908