The concept of ethics goes back to the time of Hippocrates, the Greek physician from the IV century BC. The basic principle of Hippocrates was: Primum non nocere (First, not to harm). That principle has become the foundation of high ethics, which manifested itself in Hippocrates's relation towards his patients. The interest and welfare of patients is the primary and main goal of medical practice. Health care professionals most often take the updated version of The Hippocratic Oath - the Declaration of Geneva. The Declaration emphasizes the importance of the obligation to provide professional health assistance, regardless of religious affiliation, race, social standing and political beliefs. Professional knowledge must not be used contrary to basic laws of humanity. Besides the doctor-patient relationship, the doctor-doctor relationship is also very important .There are certain countries and associations where the term 'ethical' is identified with the term 'collegial'. Element for criticism that defines the doctor-doctor relationship, is the competition that exists among the doctors of medicine engaged in private practice. Competition can be considered as a natural state or social interaction, which is a result of the inevitable coexistence of equal interest, and a justified battle to take a better place in the hierarchy. However, the spread of intolerance, baseless accusations and other things that may damage the reputation and moral integrity of health professionals are not allowed. This does not refer to the right of each health professional to publicly present his/ her critical opinion, as long as it is done in the spirit of tolerance, and is in the best interest of science or the profession. One of the special aspects of medical ethics is the doctor-patient relationship. There are several current issues that remain open, concerning this relationship: medical fault and the causes of unfavorable outcomes of the treatment, the duty of doctors to inform patients about the diagnosis, outcome after the treatment, therapy and the risks that go with it (so the patient can decide whether to accept the therapy), the responsibility for the damage caused by medical appliances and injections. Doctor-patient relationship, that once used to be full of respect, is replaced by fear and distrust, and patients are encouraged to seek the help from the lawyers. Nowadays, there are two concepts in medical practice: the defensive medicine and evidence-based medicine. The defensive medicine always takes into account the possibility of a judicial process and sometimes applies unnecessary diagnostic and therapeutic procedures. Evidence-based medicine justifies its actions by existence of valid scientific evidences. What is the solution? Kind behavior towards the patient, but firm attitude based on knowledge and determination, is the way one should follow in order to improve modern medicine, or in other words, Lege Artis, at any cost.