Peach is one of the most important fruit crops in the world with wider ecological adaptation which has been cultivated in sub-tropical to temperate climates. In spite of its economic importance, its production has been affected by various abiotic and biotic factors. Therefore, the objective of this study was to assess the effect of non-selective herbicides against peach weeds. Treatments consisted of three post emergence non selective herbicides; Glynosh @ 1.75kg/ha, Glynosh @1.75 L ha<sup>-1</sup>, Glyphosate@ 2L ha<sup>-1</sup> along with weedy check that were laid out in RCBD with three replications. The field was infested with nine weed species in which five species were annual weeds, three species were perennial weeds and one species was under category of biennial. The maximum relative weed density (17.38) was calculated from<i> Cynodon dactylon </i>L<i>. </i>while minimum (3.90) number was observed from <i>Centella asiatica L</i>. The result also showed that application of all herbicides had no statistically significant differences on <i>Bidens pilosa L., Medicago polymorpha L., Palntago lanceoleta L. and Raphanus raphanistrum L. </i>except for weedy check<i>. </i>In addition, application of Glyphosate IPA 480gm. /lit, 48% SL and Glyphosate produced statistically no significant differences on the remaining weed species<i>. </i>Application of all herbicides revealed statistically no significant differences in terms of weed dry weight while better weed control efficiency and fruit yield was obtained from application of Glyphosate IPA 480gm. /lit, 48% SL at all experimental sites. Furthermore, there is no phytotoxicity was observed due to candidate herbicide if applied with great care in between row planted peach. Thus, Glynosh 1.75 L/ha is recommended for control of various annual and perennial weeds in peach.