Objective: To summarize the nursing experience of a patient with postoperative intrathoracic hemorrhage after thoracoscopic-assisted resection of the right upper mediastinal tumor through the original incision. Methods: Summarize the main points of nursing care of postoperative intrathoracic hemorrhage after thoracoscopic mediastinal surgery, including observation and nursing when internal hemorrhage occurs after operation, respiratory management, activity management and pain management measures. Result: After careful care, the patient recovered and discharged smoothly. Conclusion: It is particularly important to observe the overall observation and take timely corresponding nursing measures for patients with intrathoracic hemorrhage after thoracoscopic mediastinal surgery.