Mediastinal Mature Cystic Teratoma Research Articles

Surgical management of mediastinal mature cystic teratoma of the elderly remaining asymptomatic

BackgroundMediastinal teratoma is an uncommon disease, nevertheless they represent the most common mediastinal germ cell tumors. It may grow silently for several years and remain undiagnosed until the occurrence of a complication.AimThe main aim of this article is to illustrate the silent evolution of an anterior mediastinal teratoma for over 70 years without presenting any notable complications.Case presentationWe present the case of a 70-year-old female, treated for hypertension referred to our department for managing a voluminous mediastinal mass, discovered fortuitously by a general practitioner in a chest X-ray. The anamnesis didn’t relate any chest pain, cough, dyspnea nor hemoptysis. The clinical examination, in particular pleuropulmonary, was unremarkable. The workup (Chest X-Ray and CT scan) demonstrated a voluminous pleural mass at the expense of the right mediastinal pleura, rounded in shape, with calcified wall and fluid content. Blood tests did not demonstrate eosinophilia, and hydatid IgG serology was negative. serum human chorionic gonadotropin (hCG) and alpha fetoprotein (AFP) levels were found to be normal. The patient subsequently underwent a right posterolateral thoracotomy with resection of the lesion. The mass was dissected very carefully and then resected in toto. The macroscopic and microscopic histological examination demonstrated a mature cystic teratoma. Surgical resection was an adequate treatment and the prognosis was excellent for the patient.ConclusionCystic mature teratomas are rare thoracic tumors, often recognized by radiological examination. This article relates the silent evolution that a teratoma could have, and the late appearance of symptoms that it could have.

Mediastinal teratoma with double malignant transformation

We report a case of a 65-year-old woman with retrosternal discomfort, dyspnea, and weight loss in whom the computed tomography showed a multicystic mass with fat content and calcified wall in the anterior mediastinum. After surgical resection, pathological examination revealed synchronous primary colorectal adenocarcinoma and primary carcinoid tumor arising in a mediastinal mature cystic teratoma. Treatment with oxaliplatin and capecitabine was instituted, and subsequent checkups showed no evidence of recurrence. Malignant transformation of mature cystic teratoma is a rare complication that occurs in 1–3% of these tumors and consists of a nongerm cell malignant tumor arising from a preexisting mature teratoma. Any of the constituent tissues of a teratoma has the potential to undergo malignant transformation. In case of limited disease, treatment should be surgical. There is no consensus regarding adjuvant treatment, and the existence of a double neoplastic lineage may complicate the choice of chemotherapy treatment.

Traumatic Rupture of A Posterior Mediastinal Teratoma following Motor-Vehicle Accident.

We report a case of a posterior mediastinal mature cystic teratoma with rupture secondary to blunt chest trauma in a 20-year-old male involved in a motor-vehicle accident. Initial treatment was guided by Advanced Trauma Life Support and a tube thoracostomy was performed for presumed hemothorax. The heterogeneous collection within the thoracic cavity was discovered to be the result of a ruptured cystic mass. Pathologic findings confirmed the mass consistent with a mature cystic teratoma. As mediastinal teratomas are most commonly described arising from the anterior mediastinum, the posterior location of the teratoma described in this report is exceedingly rare.

Mediastinal mature teratoma with complex rupture into the lung, bronchus and skin: a case report

Mature teratoma is the most common primary germ cell tumor in the mediastinum. On rare occasions, cystic teratomas rupture in adjacent structures, such as pleural space, pericardium, lung or tracheobronchial tree. We present a case of a mediastinal mature cystic teratoma in 16-year-old female with complex rupture into the lung, bronchus and skin. Mature mediastinal teratoma fistulized to the skin has not been previously described.

Anterior mediastinal teratoma in a child presenting as trauma

SummaryAn eight‐year‐old girl presented to the Emergency Department with chest pain and dyspnoea following a low impact chest injury. A large haemothorax secondary to trauma was initially suspected on the basis of a chest radiograph and ultrasound scan; insertion of a chest drain was considered but not performed. The child remained stable and was transferred to the local trauma unit, where a CT scan revealed an anterior mediastinal mature cystic teratoma. She went on to have a successful resection of the tumour and an uneventful recovery. This case highlights the requirement for a high index of suspicion in circumstances where mechanism of injury and pathology are not congruous. Effective communication within trauma networks is vital for the management of paediatric trauma presenting to district general hospitals.

A case of granulocyte colony‐stimulating factor and interleukin 6 receptor‐producing mediastinal mature cystic teratoma with somatic‐type malignancy

Mediastinal germ cell tumor with somatic-type malignancy is a rare neoplasm. We describe one such case in a 49-year-old Japanese man who had shown an elevated serum concentration of granulocyte colony-stimulating factor (GCSF) and leukocytosis without a shift to the left. Histologically, the tumor formed a teratomatous cyst whose wall contained benign epithelial components, well-differentiated tubular and mucinous adenocarcinoma, and poorly-differentiated pleomorphic carcinoma. Immunohistochemically, both the well differentiated adenocarcinoma and poorly differentiated pleomorphic carcinoma expressed GCSF. Immunohistochemistry and molecular analysis revealed that both components also produced interleukin 6 receptor (IL6R). We diagnosed this tumor as a GCSF- and IL6R-producing mediastinal mature cystic teratoma with somatic-type malignancy. The tumor showed immunohistochemical expression of activated signal transducer and activator of transcription 3. The patient died 6 months after developing systemic symptoms. For a GCSF-producing tumor, complete resection appears to offer the best outcome at present. For any patient presenting with leukocytosis without a shift to the left, a thorough analysis should be conducted, and the tumor diagnosed as early as possible.

Colonic-type adenocarcinoma (somatic-type malignancy) arising in a mediastinal mature cystic teratoma: A case report of a rare entity

Colonic-type adenocarcinoma (somatic-type malignancy) arising in a mediastinal mature cystic teratoma: A case report of a rare entity

Mediastinal mature cystic teratoma perforating into the lung

Perforated cystic mediastinal teratoma is rare. The diagnosis of this condition and a clear demonstration of its associated complications are important for defining the surgical approach. We report the clinical manifestation, computed tomography (CT) and ultrasound findings of a case of mediastinal mature cystic teratoma perforating into the lung. Ultrasound features of teratoma-lung fistula have not been previously described. The pathological examination confirmed perforation of mediastinal teratoma into the lung without evidence of pulmonary invasion.

Successful resection of large mediastinal mature cystic teratoma immediately after evacuation of fluid content

Successful resection of large mediastinal mature cystic teratoma immediately after evacuation of fluid content Ryo Miyahara, Shinjiro Nagai, Toshihiko Sato, Chen Fengshi, Toru Bando, Kenichi Okubo, Hiroshi DateDepartment of Thoracic Surgery, Kyoto University, Kyoto, JapanAbstract: In this report, we presented a case of urgent resection of mature giant mediastinal teratoma. Its characteristic radiologic findings allowed us to plan evacuation of intratumoral fluid in order to make the surgical procedure safe and less invasive. In addition, a hybrid thoracoscopic-open approach also provided safety and allowed a somewhat less invasive tumor resection than otherwise would have been required. The patient recovered well without recurrence at nine months’ follow-up, with full expansion of the right middle and lower lobes. Here we discuss the diagnosis and surgical procedure with reference to the literature.Keywords: mediastinal mature teratoma, rupture, acute pleuritis

Lung Cancer Along with a Mediastinal Mature Cystic Teratoma: A Case Report

A mediastinal mass and 2 lung masses on the lower lobes were detected by chest CT in a 44-year old woman. The mass on the left lower lobe was diagnosed as an adeno type of cancer by preoperative lung biopsy. But the preoperative lung biopsy exam for the mass on the right lower lobe couldn’t perform because of patient’s noncooperation. Removal of the mediastinal mass, left lower pulmonary lobectomy and wedge resection of the right lower pulmonary lobe were done. The histopathologic diagnosis of the resected mediastinal mass was mature cystic teratoma and both lung masses were the adeno type of cancer with the same histopathologic patterns. We experienced a rare case of lung adeno cancer together with mediastinal mature cystic teratoma. (J Lung Cancer 2009;8(1):31�� 33)

Cystic Malignant Teratoma With Early Recurrence After Intraoperative Spillage

Teratoma with malignant transformation, defined as germ cell tumors with a malignant component of nongerm cell tumors, such as sarcomas and carcinomas, is rarely seen in the mediastinum. A rare case of the mediastinal mature cystic teratoma with focal gastrointestinal adenocarcinoma is described in this report. The patient underwent a video-assisted thoracoscopic surgery for tumor resection. Intraoperatively, the cystic tumor was ruptured due to dense adhesion. The rapid tumor dissemination was postoperatively noted. Careful and complete resection with the cyst wall of the mediastinal mature cystic teratoma intact is necessary to avoid a risk of relapse from a potentially malignant component.

Multilocular Thymic Cyst Associated with Mediastinal Teratoma: A Case Report

Multilocular thymic cyst (MTC) has been reported to develop in concert with various mediastinal neoplasms that have intrinsic inflammatory components, such as thymoma, thymic carcinoma, Hodgkin’s disease, and seminoma. However, development of mediastinal teratoma without intrinsic inflammation in association with MTC has rarely been reported. Here, we report the findings of a case of MTC associated with mediastinal mature cystic teratoma on computed tomography (CT) with CThistopathologic correlation.

A case of mediastinal mature cystic teratoma (dermoid cyst) presenting with respiratory failure requiring intubation and mechanical ventilation

INTRODUCTION: Mediastinal benign teratomas are rare germ cell tumors most commonly found in the anterior mediastinum, and constitute about 3-12% of all mediastinal tumors. They grow slowly and are usually diagnosed incidently, when the patient is still asymptomatic. This is a rare presentation of a mediastinal mature cytstic teratoma(dermoid cyst) presenting with respiratory failure requiring intubation and mechanical ventilation.