In recent years, China has begun introducing readily installable median separation facilities into its urban road network. Although some studies have recognized the benefits of using median separation, few have investigated the effects of different types of facilities on driver behavior. This driving simulator study aims to determine whether different types of medians on urban arterial roads in China affect driving behavior, and to provide new insights for designing more effective and safer forms of median separation. A driving simulator study was conducted, with 50 participants. The scenario exactly reproduced an existing six-lane urban arterial road in China, and four different median separation types were tested: (1) double yellow line; (2) raised pavement markers; (3) reboundable traffic cylinders; (4) traffic separator railing. Their effects were statistically analyzed using data on driver eye movements, trajectories, and speeds collected from simulation tests. The results showed that the median separation facilities significantly improved drivers’ access to road information, corrected drivers’ attention, and suppressed driving speeds. Although median separation facilities can be an effective solution to the current problem of chaotic vehicular traffic on China’s urban roads, their setup still needs to be optimized. This study demonstrates the calculation method for optimal median facility setup. The resulting 1.21-m-high median facility, paired with a 1.17-m-wide median strip and a certain lane-width compression, more effectively addresses driver factors, the driving task, and the spatial right-of-way. The study’s calculations can also be used to improve other types of roads that can take a median separation facility.