Median Mass Research Articles

ДОСЛІДЖЕННЯ ЕФЕКТИВНОСТІ ЗАСТОСУВАННЯ БПЛА ДЛЯ ПРОВЕДЕННЯ УЛЬТРАМАЛООБ’ЄМНОГО ОПРИСКУВАННЯ ПОСІВІВ

The purpose of the work is to study the effectiveness of using UAVs for ultra-small-volume spraying of crops by assessing the degree of coverage of the target plant surface with drops. Methods and materials: The study of the effectiveness of the use of UAVs in agriculture for high-quality spraying of crops was carried out on the lands of UkrNDIPVT named after L. Pohorily, using mobile sprayers «JT 6L-606» and «JT 15L-608P». Research of the «JT 6L-606» mobile sprayer model was carried out with a colored aqueous solution. The evaluation indicators were the median mass diameter of the settled droplets and the density of the coating of the treated surface with drops of the working solution, which were evaluated in accordance with the standard methodology of SOU 74.3-37-266:2005 “Testing of agricultural machinery. Tractor and self-propelled sprayers. Program and test methods”. Results. The size of the drops is a determining qualitative indicator of spraying. It characterizes the degree of grinding of the liquid and significantly affects the effectiveness of action and the rate of consumption of plant protection products. The value of the median mass droplet diameter, obtained as a result of tests of the «JT 6L-606» mobile sprayer, showed that the relative number of droplets whose diameter is less than or equal to 100 μm is 50% of the total number of droplets. However, asymmetry of droplet deposition on the right and left sides of the UAV and high unevenness of the distribution of drops of the working fluid along the width of the grip were found.Therefore, this sprayer model required additional settings in the future. Under the established conditions and modes of testing of the «JT 15L-608P» mobile sprayer, the obtained value of the median mass droplet diameter proved that the relative number of drops whose diameter is less than or equal to 100 μm is 60% of the total number of drops. The degree of coverage with drops of the target surface on the right and left sides of the UAV (grip width) of the «JT 15L-608P» sprayer was relatively symmetrical. Conclusions. According to the results of experimental studies of the effectiveness of the use of unmanned aerial sprayers «JT 6L-606» and «JT 15L-608P», it was established that in both unmanned mobile sprayers, the obtained values of the median mass diameter of drops, which are characteristic of the process of mechanical spraying, meet the requirements of ultra-small-volume spraying. However, the uneven distribution of drops of the working fluid along the width of the UAV was noted, which requires additional settings. When setting up agricultural drones, it is recommended to pay attention to the degree and impact of drift, which can be significantly reduced by following the following recommendations: reduce the distance between the rod and the target (the height of the rod should be approximately the same as the distance between the nozzles); use the coarsest effective droplet size typically achieved with drift-reducing nozzles such as air induction. Keywords: unmanned aerial vehicles, distribution uniformity, aerial spraying, quality of surface coverage, droplet size.

Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient-Free Dry Powder for Inhalation.

Curcumin has shown beneficial effects on pulmonary diseases with chronic inflammation or abnormal inflammatory responses, including chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. Clinical applications of curcumin are limited due to its chemical instability in solution, low water solubility, poor oral bioavailability, and intestinal and liver first-pass metabolism. Pulmonary delivery of curcumin can address these challenges and provide a high concentration in lung tissues. The purpose of the current work was to prepare a novel inhalable dry powder of curcumin nanocrystals without added excipients using electrospray drying (ED) with improved dissolution and aerosolization properties. ED of curcumin was performed at 2 and 4% w/v concentrations in acetone. Physicochemical properties of the formulated powders were evaluated by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), density and powder flow measurements, and in vitro dissolution. The in vitro deposition studies were conducted using next-generation impactor (NGI) and aerosol performance and aerodynamic particle size parameters were calculated for prepared formulations. ED could produce agglomerates of nanocrystals with a size of about 500 nm at an acceptable yield of about 50%. PXRD and FTIR data revealed that prepared nanocrystals were in a stable crystalline state. The bulk and tapped density of prepared agglomerates were in the range appropriate for pulmonary delivery. Formed nanocrystals could significantly improve the dissolution rate of water-insoluble curcumin. The optimized formulation exhibited acceptable recovered dose percentage, high emitted dose percentage, optimum mean mass median aerodynamic diameter, small geometric standard deviation, and high fine-particle fraction that favors delivery of curcumin to the deep lung regions. The ED proved to be an efficient technique to prepare curcumin nanocrystals for pulmonary delivery in a single step, at a mild condition, and with no surfactant.

Intraoperative magnet in removal of intracerebral metallic foreign bodies

Advisability of magnets in neurotrauma is due to pattern of patients admitted to neurosurgical departments of military hospitals with wounds accompanied by intracranial fixation of foreign metallic ferromagnetic bodies. To study dimensions, mass and magnetic properties of fragments extracted from gunshot wounds inflicted by modern weapons; to assess the feasibility of devices and instruments for removing foreign bodies. We analyzed foreign bodies extracted after gunshot wounds. Shape, dimension, weight and magnetic properties were studied. We estimated 532 foreign bodies (497 surgeries) extracted at the Kirov Military Medical Academy and 83 foreign bodies (79 surgeries) extracted at the Burdenko Military Clinical Hospital. Distribution by anatomical regions was established for both groups. We intraoperatively used cylindrical neodymium magnets 3×20 and 5×20 mm to extract magnetic foreign bodies. These magnets were brought to the target using standard surgical tweezers or original devices. The median mass of removed fragments was 0.385 (Q1-Q3=0.12-1.435; min-max≤0.01-30.5) g at the Kirov Military Medical Academy and 0.4 (Q1-Q3≤0.001-1.6; min-max≤0.01-11.4) g at the Burdenko Military Clinical Hospital. Magnetic foreign bodies were found in 501 (94.2%) and 74 (94.8%) cases, respectively. In 8.8% of cases, foreign bodies were not removed due to difficult-to-reach location accompanied by higher risk of adverse outcomes after extraction. Extracted foreign bodies after combat injuries have magnetic properties in 94% of cases. Intraoperative magnet allows for safe extraction of fragments in 91% of cases. Devices with adjustable magnetic field strength seem perspective. Further analysis of indications for removal of wounding projectiles in primary and, especially, repeated surgical treatment of craniocerebral wounds is needed.

ALMA-IMF. IX. Catalog and Physical Properties of 315 SiO Outflow Candidates in 15 Massive Protoclusters

We present a catalog of 315 protostellar outflow candidates detected in SiO J = 5 − 4 in the ALMA-IMF Large Program, observed with ∼2000 au spatial resolution, 0.339 km s−1 velocity resolution, and 2–12 mJy beam−1 (0.18–0.8 K) sensitivity. We find median outflow masses, momenta, and kinetic energies of ∼0.3 M ⊙, 4 M ⊙ km s−1, and 1045 erg, respectively. Median outflow lifetimes are 6000 yr, yielding median mass, momentum, and energy rates of Ṁ = 10−4.4 M ⊙ yr−1, Ṗ = 10−3.2 M ⊙ km s−1 yr−1, and Ė = 1 L ⊙. We analyze these outflow properties in the aggregate in each field. We find correlations between field-aggregated SiO outflow properties and total mass in cores (∼3σ–5σ), and no correlations above 3σ with clump mass, clump luminosity, or clump luminosity-to-mass ratio. We perform a linear regression analysis and find that the correlation between field-aggregated outflow mass and total clump mass—which has been previously described in the literature—may actually be mediated by the relationship between outflow mass and total mass in cores. We also find that the most massive SiO outflow in each field is typically responsible for only 15%–30% of the total outflow mass (60% upper limit). Our data agree well with the established mechanical force−bolometric luminosity relationship in the literature, and our data extend this relationship up to L ≥ 106 L ⊙ and Ṗ ≥ 1 M ⊙ km s−1 yr−1. Our lack of correlation with clump L/M is inconsistent with models of protocluster formation in which all protostars start forming at the same time.

Robotic parathyroidectomy is a feasible technique for primary hyperparathyroidism

PurposeFocused parathyroidectomy is the gold standard treatment modality for primary hyperparathyroidism, which allows accurate preoperative localization. Robotic parathyroidectomy has emerged as a feasible procedure for focused parathyroidectomy. This study aimed to report the experiences of gasless robotic transaxillary parathyroidectomy for primary hyperparathyroidism in a single center.MethodsWe assessed the data obtained from patients who underwent gasless robotic parathyroidectomy with the transaxillary approach between December 2013 and August 2022 and were diagnosed with primary hyperparathyroidism at our institute. The data included clinical, biochemical, and pathological features and operation time.ResultsOf the 12 patients, 11 were women and one was a man. The median age of the patients was 44.5 years (range: 15–65 years). The median preoperative maximum mass diameters on ultrasonography and neck computed tomography were 1.2 ± 0.5 and 1.1 ± 0.6 cm, respectively. The median size of the postoperative maximum mass diameter in gross pathology was 1.3 ± 0.4 cm. The location of the enlarged parathyroid was left superior in five patients, right inferior in four, left inferior in three, and no right superior in one. In the final pathological examination, all cases were parathyroid adenomas. Only one case experienced a postoperative bleeding complication. At six months from surgery, average of an axillary scar length was 5.85 cm, and an average width was 0.21 cm. The mean operative time was 113 ± 48 min. The mean robot docking and console times were 9 ± 5 and 47 ± 52 min, respectively.ConclusionsRobotic transaxillary parathyroidectomy is a feasible technique in select patients with primary hyperparathyroidism and preoperatively localized disease. The gasless robotic transaxillary approach provides procedural safety as well as superior cosmetic results without a neck scar.

The California Legacy Survey. IV. Lonely, Poor, and Eccentric: A Comparison between Solitary and Neighborly Gas Giants

We compare systems with single giant planets to systems with multiple giant planets using a catalog of planets from a high-precision radial velocity survey of FGKM stars. Our comparison focuses on orbital properties, planet masses, and host-star properties. We use hierarchical methods to model the orbital eccentricity distributions of giant singles and giant multiples, and find that the distributions are distinct. The multiple giant planets typically have moderate eccentricities and their eccentricity distribution extends to e = 0.47 (90th percentile), while the single giant planets have a pileup of nearly circular orbits and a long tail that extends to e = 0.77. We determine that the stellar hosts of multiple giants are distinctly more metal rich than the hosts of solitary giants, with respective mean metallicities of 0.228 ± 0.027 versus 0.129 ± 0.019 dex. We measure the distinct occurrence distributions of single and multiple giants with respect to orbital separation, and find that single gas giants have a ∼2.3σ significant hot Jupiter (a < 0.06) pileup not seen among multigiant systems. We find that the median mass () of giants in multiples is nearly double that of single giants (1.71 M J versus 0.92 M J). We find that giant planets in the same system have correlated masses, analogous to the “peas in a pod” effect seen among less-massive planets.

Increases in trade secret designations in hydraulic fracturing fluids and their potential implications for environmental health and water quality

Hydraulic fracturing is an increasingly common method of oil and gas extraction across the United States. Many of the chemicals used in hydraulic fracturing processes have been proven detrimental to human and environmental health. While disclosure frameworks have advanced significantly in the last 20 years, the practice of withholding chemical identities as “trade secrets” or “proprietary claims” continues to represent a major absence in the data available on hydraulic fracturing. Here, we analyze rates of trade secret claims using FracFocus, a nationwide database of hydraulic fracturing data, from January 1, 2014 to December 31, 2022. We use the open-source tool Open-FF, which collates FracFocus data, makes it accessible for systematic analysis, and performs several quality-control measures. We found that the use by mass of chemicals designated as trade secrets has increased over the study time period, from 728 million pounds in 2014 to 2.96 billion pounds in 2022 (or a 43.7% average yearly increase). A total of 10.4 billion pounds of chemicals were withheld as trade secrets in this time period. The water volume used (and therefore total mass of fracturing fluid) per fracturing job has shown a large increase from 2014 to 2022, which partly explains the increase in mass of chemicals withheld as trade secrets over this time period, even as total fracturing jobs and individual counts of proprietary records have decreased. Our analysis also shows increasing rates of claiming proppants (which can include small grains of sand, ceramic, or other mineral substances used to prop open fractures) as proprietary. However, the mean and median masses of non-proppant constituents designated as trade secrets have also increased over the study period. We also find that the total proportion of all disclosures including proprietary designations has increased by 1.1% per year, from 79.3% in 2014 to 87.5% in 2022. In addition, most disclosures designate more than one chemical record as proprietary: trade secret withholding is most likely to apply to 10–25% of all records in an individual disclosure. We also show the top ten reported purposes that most commonly include proprietary designations, after removing vague or multiple entries, the first three of which are corrosion inhibitors, friction reducers, and surfactants. Finally, we report the top ten operators and suppliers using and supplying proprietary chemicals, ranked by mass used or supplied, over our study period. These results suggest the importance of revisiting the role of proprietary designations within state and federal disclosure mechanisms.

Clump-scale Gas Infall in High-mass Star Formation: A Multitransition View with James Clerk Maxwell Telescope HCN (4–3) Mapping

Gas infall motions play a crucial role in high-mass star formation and are characterized by observable signatures of blueshifted asymmetric spectral line profiles (“blue profiles”). However, the connection between blue profiles and infall motions is unclear due to complex gas motions at parsec scales. In this study, we present the results of an HCN (4–3) mapping survey conducted with the James Clerk Maxwell Telescope, toward 38 massive clumps exhibiting blue profiles in HCO+ (3–2). We extract 34 HCN cores from the 38 observed fields. The core-averaged spectra show various line profiles, indicating that blue-profile HCO+ (3–2) does not guarantee the same in HCN (4–3). Through non-LTE radiative-transfer calculations, we attribute the low detection rate of high-J blue profiles to a combination of insufficient HCN (4–3) opacity and the intricate gas motion across different density layers. A comparison between the MALT90 and Bolocam Galactic Plane Survey line surveys highlights the importance of appropriate tracers, high spectral resolution, and column density thresholds when searching for blue profiles. We select 11 reliable infall candidates and adopt the Hill5 model to fit the infall velocity of 0.2–1.6 km s−1, corresponding to 5%–74% of freefall velocity. Assuming a spherically collapsing model, we estimate the median and mean mass infall rates to be 4.5 × 10−3 and 7.6 × 10−3 M ⊙ yr−1, respectively. The consistency of the mass infall rates among different transitions suggests a steady accretion process from the clump gas envelope to the inner region.

Higher subclinical cardiac fibrosis in South African youth with HIV: results from the CTAAC-heart study

Abstract Background Few data exist on cardiac fibrosis and inflammation in youth with HIV, particularly in sub-Saharan Africa. Purpose Our objective was to assess the association between HIV status and cardiovascular magnetic resonance (CMR) measures of subclinical cardiac fibrosis, inflammation, and function. Methods We performed CMR on a cross-section of youth in South Africa: youth with perinatally acquired HIV (YPHIV), youth with non-perinatally acquired HIV (YNPHIV), and HIV-seronegative youth (YHIV-). Subclinical fibrosis [late gadolinium enhancement (LGE) mass and fraction, extracellular volume (ECV)], inflammation [native T1 and T2 mapping], and cardiac function (cine, strain, and strain rate) were assessed. CD4, viral load (VL), and fasting glucose, insulin [for Homeostatic Model Assessment-Insulin Resistance (HOMA)] and lipids were obtained. Unadjusted and adjusted quantile regression models were used to assess the association between HIV status and CMR outcomes. In sub-group analyses of youth with HIV, we additionally adjusted for HIV factors. Results Of 464 youth, 287 were YPHIV, 87 YNPHIV, and 90 YHIV-. YNPHIV were older with a higher proportion self-identifying as female than YPHIV and YHIV- (median age 20 vs 18 and 17 years; 85% vs 50% and 49%, respectively). YPHIV had lower body surface area (1.6 vs 1.7 and 1.7m2) and a higher proportion with prior TB disease (70% vs. 20% vs 8%) compared to YNPHIV and YHIV-. Tobacco use, HOMA, total cholesterol, and low-density lipoproteins were similar between groups. Among youth with HIV, YPHIV had a higher proportion with CD4&amp;lt;200 cells/mm3 (10% vs 4%) or VL&amp;gt;50 copies/mL (39% vs 13%) but lower proportion on integrase inhibitors (33% vs 84%). LGE mass (0.13 vs 0.12 vs 0.07g respectively) and fraction (0.3% vs 0.3% vs. 0.2% respectively) were higher in YPHIV and YNPHIV than YHIV-; native T1 was highest in YNPHIV compared to YPHIV and YHIV- (Table). In adjusted analyses, compared to YHIV-, median LGE mass was higher in YPHIV and YNPHIV (β:0.06, p=0.01 for YPHIV, β:0.05, p=0.03 for YNPHIV) and LGE% was higher in YPHIV (β:0.14, p=0.02); native T1 and ECV did not differ between groups in adjusted analyses. Among youth with HIV, CMR outcomes did not differ significantly for persons with perinatal vs non-perinatal HIV. Findings did not vary in analyses restricted to females. Conclusion In one of the largest studies of CMR among youth with HIV in sub-Saharan Africa, we found that despite their young age, YPHIV and YNPHIV appear to have higher subclinical cardiac fibrosis than YHIV- and healthy adults in South Africa. Youth with HIV may benefit from early screening and long-term monitoring for cardiovascular disease.TableFigure

Aortic valve sclerosis, stenosis, and prognosis in the general population

Abstract Background The presence of aortic valve (AV) sclerosis and non-severe aortic stenosis has been a suggested marker of cardiovascular risk, but whether AV sclerosis and non-severe AV stenosis is independently associated with increased cardiovascular risk or a marker of coexistent risk factors remains to be clarified. Objective We examined clinical characteristics and prognosis associated with the presence of AV sclerosis and stenosis in the general population. Methods A total of 4,466 participants from a prospective cohort study of the general population were included. Patients with insufficient image quality (n=119) and known heart failure (n=130) were excluded, resulting in a population of 4,217 participants. Evaluation of AV sclerosis/stenosis was based on AV Doppler measurements, i.e., peak and mean AV velocity, and peak and mean AV gradient. The primary composite outcome was defined as major adverse cardiovascular events (MACE), including incident heart failure, myocardial infarction, or cardiovascular death. Multivariable Cox regression models were used to assess the association between AV sclerosis/stenosis by AV Doppler measurements and risk of the outcome. Results Mean age was 56.8 ± 17.5 years, and 56% were women. In total, 18.7% were smokers, 51% had hypertension (HTN), 5% had diabetes (DM), and 7% had ischemic heart disease (IHD). Mean left ventricular ejection fraction (LVEF) was 56.4 ± 6.4% with a median left ventricular mass index (LVMi) of 82.6 g/m2 (IQR 71.1; 96.8) and a mean AVA of 2.72 ± 0.72 cm2. Median AV peak velocity was 1.3 m/s (IQR 1.1; 1.4) and median AV peak gradient was 6.0 mmHg (IQR 5.0; 8.0). Median AV mean velocity was 0.9 m/s (IQR 0.8; 1.0) and median AV mean gradient was 3.0 mmHg (IQR 3.0; 4.0). During a median follow-up of 3.5 years (IQR 2.6; 4.3), 190 patients (4.5%) reached the composite outcome. The incidence rate per 1,000 person years in the fourth quartile of AV peak velocity (AV peak velocity &amp;gt;1.4 m/s) was more than double that of the first quartile (AV peak velocity ≤1.1 m/s) (26.6 [95% CI 21.1 – 33.6] versus 12.9 [95% CI 9.9 – 16.9], p&amp;lt;0.001). In univariable analysis, all AV measurements of sclerosis/stenosis were associated with the composite outcome (p&amp;lt;0.001 for all) (Figure 1). All AV measurements remained independent predictors of the outcome after adjustment for demographic, clinical and echocardiographic risk factors (age, gender, smoking, HTN, DM, IHD, eGFR, LVMi, LAVi, LVEF and E/e’); AV peak PG (HR 1.19 per 5 mmHg increase, 95% CI 1.06 – 1.33, p=0.002), AV peak velocity (HR 1.05 per 0.1 m/s increase [95% CI 1.01 – 1.20], p = 0.013), AV mean PG (HR 1.30 per 5 mmHg increase [95% CI 1.09 – 1.56], p=0.002), AV mean velocity (HR 1.08 per 0.1 m/s increase [95% CI 1.02 – 1.23], p=0.005). Conclusion A greater degree of AV sclerosis/stenosis was independently associated with a higher risk of MACE.Figure 1:Restricted cubic spline model

Characterizing cool, neutral gas, and ionized metals in the outskirts of low-z galaxy clusters

ABSTRACT We present the first detection of cool, neutral gas in the outskirts of low-z galaxy clusters using a statistically significant sample of 3191 z ≈ 0.2 background quasar-foreground cluster pairs by cross-matching the Hubble Spectroscopic Legacy Archive quasar catalogue with optically- and SZ-selected cluster catalogues. The median cluster mass of our sample is ≈1014.2 $\rm {\rm M}_{\odot }$ with a median impact parameter (ρcl) of ≈5 Mpc. We detect significant Lyα, marginal C iv, but no O vi absorption in the signal-to-noise ratio weighted mean stacked spectra with rest-frame equivalent widths of 0.096 ± 0.011, 0.032 ± 0.015, and &amp;lt;0.009 Å (3σ) for our sample. The Lyα REW shows a declining trend with increasing ρcl (ρcl/R500), which is well explained by a power-law with a slope of −0.79 (−0.70). The covering fractions (CFs) measured for Lyα (21 per cent), C iv (10 per cent), and O vi (10 per cent) in cluster outskirts are significantly lower than in the circumgalatic medium (CGM). We also find that the CGM of galaxies that are closer to cluster centres or that are in massive clusters is considerably deficient in neutral gas. The low CF of the Lyα along with the non-detection of Lyα signal when the strong absorbers ($N(\rm{H\,{\small I}}) &amp;gt; 10^{13}$ cm−2) are excluded, indicate the patchy distribution of cool gas in the outskirts. We argue that the cool gas in cluster outskirts in combination arises from the circumgalactic gas stripped from cluster galaxies and to large-scale filaments feeding the clusters with cool gas.

Choice of observation type affects Bayesian calibration of Greenland Ice Sheet model simulations

Abstract. Determining reliable probability distributions for ice sheet mass change over the coming century is critical to refining uncertainties in sea-level rise projections. Bayesian calibration, a method for constraining projection uncertainty using observations, has been previously applied to ice sheet projections but the impact of the chosen observation type on the calibrated posterior probability distributions has not been quantified. Here, we perform three separate Bayesian calibrations to constrain uncertainty in Greenland Ice Sheet (GrIS) simulations of the committed mass loss in 2100 under the current climate, using observations of velocity change, dynamic ice thickness change, and mass change. Comparing the posterior probability distributions shows that the median ice sheet mass change can differ by 119 % for the particular model ensemble that we used, depending on the observation type used in the calibration. More importantly for risk-averse sea-level planning, posterior probabilities of high-end mass change scenarios are highly sensitive to the observation selected for calibration. Furthermore, we show that using mass change observations alone may result in model simulations that overestimate flow acceleration and underestimate dynamic thinning around the margin of the ice sheet. Finally, we look ahead and present ideas for ways to improve Bayesian calibration of ice sheet projections.

Spectroscopy from Photometry: A Population of Extreme Emission Line Galaxies at 1.7 ≲ z ≲ 6.7 Selected with JWST Medium Band Filters

We use JWST/NIRCam medium band photometry in a single pointing of the Canadian NIRISS Unbiased Cluster Survey to identify 118 extreme emission-line galaxies (EELGs) over 1.7 ≲ z ≲ 6.7, selected using a set of color cuts that target galaxies with extreme [O iii] + Hβ and Hα emission. We show that our medium band color selections are able to select galaxies based on emission-line EW, which is advantageous to more commonly used selections since it does not require strong continuum emission, and can select galaxies with faint or red continuum fluxes. The median EWs of our sample is EW(Hα) = 893 Å and EW ([O III] + Hβ) = 1255 Å and includes some objects with EW ([O III] + Hβ) ∼ 3000 Å. These systems are mostly compact with low stellar mass (median ), low metallicity (median Z = 0.14 Z ⊙), little dust (median A V = 0.18 mag), and high SSFR (median SSFR = 1.18 × 10−8 yr−1). Additionally, galaxies in our sample show increasing EW(Hα) and EW([O iii] + Hβ) with redshift, an anticorrelation of EW(Hα) with stellar mass, and no correlation between EW([O iii] + Hβ) and stellar mass. Finally, we present NIRSpec spectroscopy of 15 of the EELGs in our sample. These spectra confirm the redshifts and EWs of the EELGs calculated from the medium bands, which demonstrates the accuracy and efficiency of our color selections. Overall, we show that there are significant advantages to using medium band photometry to identify and study EELGs at a wide range of redshifts.

Identification of Superclusters and Their Properties in the Sloan Digital Sky Survey Using the WHL Cluster Catalog

Superclusters are the largest massive structures in the cosmic web, on tens to hundreds of megaparsec scales. They are the largest assembly of galaxy clusters in the Universe. Apart from a few detailed studies of such structures, their evolutionary mechanism is still an open question. In order to address and answer the relevant questions, a statistically significant, large catalog of superclusters covering a wide range of redshifts and sky areas is essential. Here, we present a large catalog of 662 superclusters identified using a modified friends-of-friends algorithm applied on the WHL (Wen–Han–Liu) cluster catalog within a redshift range of 0.05 ≤ z ≤ 0.42. We name the most massive supercluster at z ∼ 0.25 as the Einasto Supercluster. We find that the median mass of superclusters is ∼5.8 × 1015 M ⊙ and the median size ∼65 Mpc. We find that the supercluster environment slightly affects the growth of clusters. We compare the properties of the observed superclusters with the mock superclusters extracted from the Horizon Run 4 cosmological simulation. The properties of the superclusters in the mocks and observations are in broad agreement. We find that the density contrast of a supercluster is correlated with its maximum extent with a power-law index, α ∼ −2. The phase-space distribution of mock superclusters shows that, on average, ∼90% of part of a supercluster has a gravitational influence on its constituents. We also show the mock halos’ average number density and peculiar velocity profiles in and around the superclusters.

MOSEL Survey: JWST Reveals Major Mergers/strong Interactions Drive the Extreme Emission Lines in the Early Universe

Abstract Extreme emission line galaxies (EELGs), where nebular emissions contribute 30%–40% of the flux in certain photometric bands, are ubiquitous in the early Universe (z &gt; 6). We utilize deep NIRCam imaging from the JWST Advanced Deep Extragalactic Survey (JADES) to investigate the properties of companion galaxies (projected distance &lt;40 kpc, ∣dv∣ &lt; 10,000 km s−1) around EELGs at z ∼ 3. Tests with TNG100 simulation reveal that nearly all galaxies at z = 3 will merge with at least one companion galaxy selected using similar parameters by z = 0. The median mass ratio of the most massive companion and the total mass ratio of all companions around EELGs is more than 10 times higher the control sample. Even after comparing with a stellar mass and stellar mass plus specific star formation rate (SFR)-matched control sample, EELGs have 3 to 5 times higher mass ratios than the brightest companion and total mass ratio of all companions. Our measurements suggest that EELGs are more likely to be experiencing strong interactions or undergoing major mergers irrespective of their stellar mass or specific SFRs. We suspect that gas cooling induced by strong interactions and/or major mergers could be triggering the extreme emission lines, and the increased merger rate might be responsible for the overabundance of EELGs at z &gt; 6.

QbD assisted development of inhalable spray-dried erlotinib procubosomal system for the effective management of non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is the most common and leading cause of cancer deaths worldwide. Erlotinib (ERL), an epidermal growth factor receptor (EGFR) kinase inhibitor, has been used as a primary prescription for the effective treatment of metastatic NSCLC. However, it has poor aqueous solubility, extensive first-pass metabolism, oral administration-related toxicities, and inconveniences for cancer patients with gastrointestinal tract (GIT) disorders that limit its therapeutic potential. To resolve the above challenges, inhalable ERL-loaded spray-dried procubosomal powder (ERL-SDPP) was developed employing a Box-Behnken design that exhibit impressive characteristics including a device removal efficiency (DRE) of 84.7 ± 2.37 %, aerosolization efficiency (AE) of 18.1 ± 0.75, fine particle fraction (FPFTSI) of 33.7 ± 1.28 %, drug content (DC) of 93.6 ± 3.9 %, and a reconstituted cubosome size (PS) of 453.87 ± 14.65 nm. During in-vitro characterization, the optimized inhalable ERL-SDPP formulation was found to have 96.2 ± 3.98 % entrapment efficiency, −28.6 ± 1.38 mV zeta potential, and 3.29 ± 0.53 μm mass median aerodynamic diameter (MMAD). In-vitro drug release studies revealed sustained release behavior of ERL from ERL-SDPP lasting up to 36 h, demonstrating the increased dissolution profile and stability of ERL-SDPP in simulated lung fluids compared to pure ERL. In-vitro cytotoxicity studies utilizing A549 cell lines uncovered the greater potential of ERL-SDPP formulation, with a ∼1.5-fold reduction in IC50 compared to pure ERL, after 24 h treatment. In-vivo pharmacokinetic parameters revealed that inhalable ERL-SDPP exhibited a 1.76-fold and 6.25-fold higher AUC than oral and intravenous administered ERL, respectively. Organ distribution studies confirmed enhanced retention and accumulation of ERL in lungs after administration of inhalable ERL-SDPP compared to oral ERL, thereby reducing the dose and related systemic toxicities. Thus, the developed inhalable ERL-SDPP has shown promise to improve therapeutic potential against NSCLC through a site-specific sustained drug delivery system as it requires lower doses and limits systemic side effects.

Hypertension: An Important But Reversible Cause of Systolic Dysfunction in a Cohort of Pediatric Patients.

Cardiac dysfunction due to hypertension (CDHTN) in pediatrics is not well described. We aimed to describe the presentation and outcomes of pediatric CDHTN and identify clinical features associated with resolution of dysfunction. A single-center retrospective cohort study of patients ≤ 21years with CDHTN from January 2005-September 2020 was performed. Patients with systolic dysfunction without another cause, blood pressure > 95th percentile, and physician judgment that dysfunction was secondary to hypertension were included. Demographics, clinical characteristics, echocardiographic findings, and outcomes were examined using Fisher's exact and Mann-Whitney U tests. Multiple correspondence analysis was used to explore the relationship of resolution of dysfunction to clinical features. Thirty-four patients were analyzed at a median age of 10.9 (IQR 0.3-16.9) years. Patients were divided into groups < 1year (n = 12) and ≥ 1year (n = 22). Causes of hypertension were varied by age, with renovascular disease most common in infants (42%) and medical renal disease most common in older patients (77%). Echocardiography demonstrated mild LV dilation (median LV end-diastolic z-score 2.6) and mild LV hypertrophy (median LV mass z-score 2.4). Most patients (81%) had resolution of dysfunction, particularly infants (92%). One patient died and one patient was listed for heart transplant. None required mechanical circulatory support (MCS). No clinical features were statistically associated with resolution of dysfunction. Hypertension is an important but reversible cause of systolic dysfunction in children. Patients are likely to recover with low mortality and low utilization of MCS or transplantation. Further studies are needed to confirm features associated with resolution of dysfunction.

Evidence for Large-scale, Rapid Gas Inflows in z ∼ 2 Star-forming Disks

We report high-quality Hα/CO imaging spectroscopy of nine massive (log median stellar mass = 10.65 M ⊙) disk galaxies on the star-forming main sequence (henceforth SFGs), near the peak of cosmic galaxy evolution (z ∼ 1.1–2.5), taken with the ESO Very Large Telescope, IRAM-NOEMA, and Atacama Large Millimeter/submillimeter Array. We fit the major axis position–velocity cuts with beam-convolved, forward models with a bulge, a turbulent rotating disk, and a dark matter (DM) halo. We include priors for stellar and molecular gas masses, optical light effective radii and inclinations, and DM masses from our previous rotation curve analysis of these galaxies. We then subtract the inferred 2D model-galaxy velocity and velocity dispersion maps from those of the observed galaxies. We investigate whether the residual velocity and velocity dispersion maps show indications for radial flows. We also carry out kinemetry, a model-independent tool for detecting radial flows. We find that all nine galaxies exhibit significant nontangential flows. In six SFGs, the inflow velocities (v r ∼ 30–90 km s−1, 10%–30% of the rotational component) are along the minor axis of these galaxies. In two cases the inflow appears to be off the minor axis. The magnitudes of the radial motions are in broad agreement with the expectations from analytic models of gravitationally unstable, gas-rich disks. Gravitational torques due to clump and bar formation, or spiral arms, drive gas rapidly inward and result in the formation of central disks and large bulges. If this interpretation is correct, our observations imply that gas is transported into the central regions on ∼10 dynamical timescales.

Preparation and evaluation of βcyclodextrin-based nanosponges loaded with Budesonide for pulmonary delivery

Budesonide (BUD) is a glucocorticosteroid used to treat chronic obstructive pulmonary disease. Despite this, it is a hydrophobic compound with low bioavailability. To address these hurdles, non-toxic and biocompatible βcyclodextrin-based nanosponges (βCD-NS) were attempted. BUD was loaded on five different βCD-NS at four different ratios. NS with 1,1′-carbonyldiimidazole (CDI) as a crosslinking agent, presented a higher encapsulation efficiency ( ̴ 80%) of BUD at 1:3 BUD: βCD-NS ratio (BUD-βCD-NS). The optimized formulations were characterized by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), water absorption capacity (WAC), scanning electron microscopy (SEM), X-ray powder diffraction studies (XRD), particle size, zeta potential, encapsulation efficiency, in vitro and in vivo release studies, acute toxicity study, solid-state characterization, and aerosol performance. In vitro-in vivo correlation and cytotoxicity of the formulations on alveolar cells in vitro were further determined. In vitro and in vivo studies showed almost complete drug release and drug absorption from the lungs in the initial 2 h for pure BUD, which were sustained up to 12 h from BUD loaded into nanosponges (BUD-βCD-NS). Acute toxicity studies and in vitro cytotoxicity studies on alveolar cells proved the safety of BUD-βCD-NS. Several parameters, including particle size, median mass aerodynamic diameter, % fine particle fraction, and % emitted dose, were evaluated for aerosol performance, suggesting the capability of BUD-βCD-NS to formulate as a dry powder inhaler (DPI) with a suitable diluent. To sum up, this research will offer new insights into the future advancement of βCD-NS as drug delivery systems for providing controlled release of therapeutic agents against pulmonary disease.

THU604 Characterization Of Adrenal Masses In Young Adults At A Tertiary Academic Medical Center

Abstract Disclosure: S.A. Jacob: None. M. Itani: None. M.J. Hoegger: None. D. Ludwig: None. T. Pandian: None. T.C. Brown: None. L.M. Brunt: None. I. Bancos: None. N. Genere: None. Introduction: Adrenal mass incidence has increased tenfold over the last two decades, with most masses detected in individuals over 40 years of age. The majority of these adrenal masses are benign (&amp;gt;80%), and few are malignant (8%) or hormonally active (4%); most are incidentally detected. Studies suggest higher rates of hormonally active and malignant adrenal masses in younger patients, however, evidence for this age group is scarce. In two recent large cohort studies of adrenal masses, young adults (18-40 years) represented only 0.2-7.1% of individuals studied. This study aimed to characterize clinical, imaging, and biochemical presentation of young adults diagnosed with adrenal masses. Methods: This is a retrospective cohort study of young adults (18-40 years) with adrenal masses detected based on a radiology report text database search between January 2015 and December 2021 at a tertiary medical center. Exclusion criteria included pre-existing adrenal masses before 2015, hyperplasia, or masses &amp;lt;1cm. Images were reviewed by abdominal radiologists, and clinical data were obtained through review of electronic medical records. Results: A total of 255 young adults (56% women, 61% white) were diagnosed with adrenal masses with median age 35 (IQR 30-39) years. Genetic predisposition syndrome was present in 6%. Comorbidities included: BMI &amp;gt;30 kg/m2 in 48%, hypertension in 35%, and diabetes in 10%. Adrenal masses were detected incidentally in 72% and during cancer staging in 16%. Median mass size was 1.9cm (IQR 1.4-2.7cm) and 49% (39/79) were lipid poor (Hounsfield units &amp;gt;10). Only 22% of patients underwent hormonal evaluation. Final diagnoses included 16% malignancy, 9% benign adenoma with overt hormone excess, 40% benign adenoma with incomplete hormonal evaluation and 24% radiographically indeterminate masses. Subgroup analysis showed that adrenal masses in those &amp;lt;30 years old compared to 31-40 year-olds were more frequently associated with tumor predisposition syndrome (15% vs 3%, p&amp;lt;0.01) and more often lipid poor (76% vs 40%, p&amp;lt;0.01); but, no differences in frequency of malignancy or overt hormone excess were identified. Discussion: We found a higher frequency of malignancy and overt hormonal excess in our cohort of young adults compared to previously published studies, though direct comparisons are limited by differences in methodology. These findings, in addition to high frequencies of metabolic disease in our cohort, would suggest the need for hormonal assessment in young adults; yet, this was completed in only a minority of patients. Additional areas of research may include studying hormonal status of adrenal masses in young adults in a multi-center cohort to overcome issues of selection bias and increase the rates of those with complete hormonal evaluation. Presentation: Thursday, June 15, 2023