Introduction Cardiovascular disease, including myocardial infarction, is a common cause of morbidity and mortality among patients with chronic kidney disease (CKD), independent of other common cardiovascular disease risk factors. CKD has been linked to a systemic proinflammatory state contributing to myocardial and vascular remodeling resulting in atherosclerotic lesions, vascular calcification, and senescence. The clinical characteristics and outcomes of MI among patients with CKD has not been extensively studied nationally. Objectives To evaluate the clinical characteristics, including gender, race, and age; and outcomes, including in-hospital mortality (IHM), length of hospital stay (LOS), and complications post-MI among those with CKD. Methods Adults diagnosed with myocardial infarction and had background CKD were identified from the National In-Patient Sample (NIS) dataset for the year 2019 using the International Classification of Disease (ICD-10) codes. Weighted multivariable logistic regression models were used as appropriate. Various sociodemographic and clinical factors were adjusted for in the analysis. Results Of the 23,590 patients identified with MI and CKD; 65.1% were male, 69.6% were White, while the median age was 62 years (Inter-Quartile Range (IQR): 54-71) and 72 years (IQR: 63-81) in the non-CKD and CKD population respectively. The median LOS was 2 days (IQR: 2-4) and 3 days (IQR: 2-7) in the non-CKD and CKD group, respectively. The incidence of new intracardiac thrombus was lower at 0.2% among CKD patients vs. 0.4% among those without CKD (p: 0.108). Conversely, IHM was higher among those with CKD at 13.9% compared to those without CKD, who had an IHM of 6.7% (p: 0.0001). The incidence of heart failure was 49.3% among those with CKD, almost twice that of those without CKD at 23.6% (p: 0.0001). Conclusion This study highlights critical clinical characteristics and outcomes of MI in the CKD population. The results, especially regarding the age of onset of MI and the incidence of intracardiac thrombi, warrant further studies to unravel the reason(s) behind these findings.