TOPIC: Cardiothoracic Surgery TYPE: Original Investigations PURPOSE: Tracheobronchoplasty (TBP) is the treatment of choice for severe symptomatic Excessive Central Airway Collapse (ECAC). Currently, there have not been any studies that investigate the impact of baseline supplemental oxygen requirements on patients undergoing TBP. This study compares short-term postoperative complications in patients with baseline supplemental oxygen versus patients with no supplemental oxygen requirements that underwent TBP. METHODS: A retrospective, single-center analysis was conducted on consecutive patients that underwent TBP for severe symptomatic ECAC from 2004 to 2018. Baseline characteristics, comorbidities, and functional status variables were collected. Short-term postoperative complications (90 days) were recorded and stratified using the Comprehensive Complication Index (CCI). Complications were compared between patients with supplemental oxygen requirements and patients with no supplemental oxygen requirements using a t-test, Wilcoxon rank-sum test, or Chi2 as appropriate. Propensity score matching was used to control for age, sex, race, Charlson Comorbidity Index, and operative time. RESULTS: One hundred three patients that underwent TBP during the study period were included. Fourteen patients had supplemental oxygen requirements at baseline. When the two groups were compared, the patients with supplemental oxygen requirements had a lower prevalence of COPD (p=0.03), a higher prevalence of OSA (p<0.01), and lower mean values of DLCO (p=0.03) and FEV1 (p=0.05) at baseline. When the propensity score matching was used, nine patients remained in each group. Baseline differences in demographics and pulmonary function testing were not observed any longer. In both the matched and unmatched cohort, there were no differences in ICU length of stay, reintubation rates, prolonged ventilation rates, the incidence of any kind of complication, the incidence of major complications (Clavien Dindo Score > IIIb), or median CCI scores. CONCLUSIONS: Short-term 90-day postoperative complications after TBP for severe symptomatic ECAC were no different in patients with or without supplemental oxygen requirements at baseline. Our findings suggest that oxygen requirements should not be considered a cause of increased complication rates, increased length of stay in ICU, prolonged ventilation, or reintubation in ECAC patients that underwent TBP. CLINICAL IMPLICATIONS: Supplemental oxygen requirement should not be a decisive factor when considering the surgical candidacy of patients with ECAC. DISCLOSURES: No relevant relationships by Erick Flores, source=Web Response no disclosure on file for Sidhu Gangadharan; No relevant relationships by Fayez Kheir, source=Web Response Consultant relationship with Boston Scientific Please note: $1001 - $5000 by Adnan Majid, source=Web Response, value=Consulting fee Consultant relationship with olympus Please note: $5001 - $20000 by Adnan Majid, source=Web Response, value=Consulting fee Consultant relationship with pinacle biologics Please note: $1001 - $5000 by Adnan Majid, source=Web Response, value=Consulting fee Consultant relationship with cook medical Please note: $1001 - $5000 by Adnan Majid, source=Web Response, value=Consulting fee Removed 06/23/2021 by Adnan Majid, source=Web Response No relevant relationships by Daniel Ospina-Delgado, source=Web Response No relevant relationships by Mihir Parikh, source=Web Response no disclosure on file for Jennifer Wilson