This study looked at the state of food security and the factors that affect it among individuals with disabilities in Durame, a town in southern Ethiopia. The study used cross-sectional survey data from 205 disabled individuals who were chosen using a combination of stratified, proportionate to population size, and random sampling techniques. The required primary and secondary data were collected using a variety of instruments, including survey questionnaires, key informant interviews, focus group discussions, and case narrative telling techniques. The disability aspects and severity level among people with disabilities were identified using descriptive statistics in conjunction with multidimensional techniques utilizing principal component analysis. To determine how factors affected the level of food security, ordered logit regression was utilized. The results showed that 10 variables, including education level, sex, food expenditure, empowerment, employment situation, social cohesion, water access, institutional supports, extension contact, and media access, were identified as the significant determinants of food security status poeple with disabilities in the study area out of the 19 variables included in the model. The results led to the presentation of policy recommendations. In order to achieve food security for people with disabilities, coordinated efforts of stakeholders should be increased to improve access to education, employment, empowerment, infrastructure like water and mass media, creating social cohesion, more expansion and recognition of female roles, and institutional supports.