Mechanism Of Process Research Articles

Research on the Mechanism of Femtosecond Laser Ablation Concave-Convex Microstructure Transformation.

The phenomenon of femtosecond laser ablation of convex structures from the bottom to the top is interesting. In this study, AZ31B magnesium alloy was used as the substrate to analyze the impact of the laser pulse energy and scanning speed on the morphology of concave-convex microstructures. Subsequently, a unified two-dimensional numerical model incorporating solid, liquid, and gas phases was established, and combined with experimental data, the mechanism and formation process of concave-convex transformation in magnesium alloy under laser ablation were revealed. The results indicate that the transition from concave to convex structures is significantly influenced by the laser scanning speed, whereas the laser pulse energy primarily affects the shape and size of the convex structures. During the ablation process, molten material is expelled and gradually accumulates on both sides of the ablation groove under the action of the recoil pressure. During cooling, the molten material at both ends of the groove merges to form protrusions under the combined effects of internal negative pressure, gravity, and Marangoni forces. Moreover, this method of femtosecond laser ablation for generating convex structures deviates from the traditional single-texture approach to concave structures, potentially broadening the application of laser composite processing surfaces.

Ionic Hydrogen-Bonded Organic Frameworks with a Two-Photon Synergistic Color Change and Their Information Encryption Applications.

Photochromic hydrogen-bonded organic frameworks (HOFs) can introduce different luminescent functional groups to achieve synergistic controlled multiple color change properties, which are in great demand for diverse information encryption applications. We report in this paper switchable photochromic and photoluminescent dual luminescent functional group HOFs constructed with synergistic effects by N,N'-bis(2-phenylalanine)-1,4,5,8-naphthalenediimine (H2PheNDI) and benzenecarboximidamide 4,4'-azobis(hydrochloride) (AZBH). The crystal powder of iHOF-41 is orange-red in color, which can be changed to black under the irradiation of a 365 nm ultraviolet (UV) light source for 15 min. The photoisomerization rate of the crystal solution under continuous UV irradiation for 5 h was close to 99%. The composite membranes can achieve the properties of photochromism and photoluminescence when they are discolored under 365 nm UV irradiation and, at the same time, excite red bright fluorescence. This work achieves the construction of HOFs based on switching biluminescent functional groups and explores the synergistic mechanism of the photoisomerization process and photochromism as well as its practical application in information encryption.

Double-Shell Co3O4 with Rich Surface Octahedron Oxygen Vacancies for High-Selectivity Electrocatalytic Chlorine Evolution.

The development of non-noble-metal-based chlorine evolution reaction (CER) catalysts with excellent activity, kinetics, and selectivity is urgently needed but still remains a major challenge. In this study, a morphology self-evolving and surface octahedron oxygen-vacancy-generating strategy is applied at double-shell nanospheres to obtain the target hierarchical double-shell Co3O4 nanospheres with abundant surface oxygen vacancies (DS-Co3O4-OVs). The DS-Co3O4-OVs display an overpotential of only 52 mV to reach a current density of 10 mA cm-2 in which an excellent chlorine selectivity of 98.9-99.9% is attained, which is better than that of the commercial RuO2/IrO2. Furthermore, density functional theory calculations demonstrate that the involved oxygen vacancies can not only limit the lattice oxygen mechanism of the oxygen evolution reaction process but also significantly improve the kinetics of the Volmer step to enhance the CER performance. Meanwhile, the unique hierarchical double-shell nanospheres can enhance the mass feeding and promote the rate-determining step of the Krishtalik step chlorine gas desorption reaction for enhanced kinetics. The self-evolution of non-noble catalysts with surface octahedron vacancies and the related exploration of the CER mechanism may provide a novel design idea for CER catalysts.

Hydration process and fluoride solidification mechanism of multi-source solid waste-based phosphogypsum cemented paste backfill under CaO modification

The large-scale, environmentally friendly utilization of phosphogypsum (PG) remains a global challenge. PG cemented paste backfill (PCPB) is a promising method to manage PG, but using ordinary Portland cement as the binder has drawbacks such as high cost, low mechanical strength, and high fluoride leaching risk. This paper presents a multi-source solid waste-based PCPB (MPCPB) material that enhances mechanical properties and reduces fluoride leaching risks. In MPCPB, industrial waste residues like steel slag (SS) and ground granulated blast furnace slag (GBFS) are used as precursors (SS: GBFS = 1:2). Additionally, 4–8 wt% CaO (relative to the dry weight of PG) is used as a neutralizing modifier and alkaline activator. The results indicate that an optimal amount of CaO can neutralize the residual acidity of PG, provide sufficient Ca(OH)2 for MPCPB hydration, and react with PG to produce significant amounts of AFt. Furthermore, CaO promotes the geopolymerization reaction between SS and GBFS, generating more calcium silicate hydrate (C-S-H) and calcium aluminate silicate hydrate (C-A-S-H) gels. Fluoride stabilization in MPCPB results from synergistic effects involving hydration reactions, complexation, ionic mobility, rearrangement, and physical adsorption. Notably, CaO enhances the conversion of free fluoride ions into stable compounds like fluorapatite, fluorite (CaF2), [AlF6]3-, and [FeF6]3- complexes. This approach offers a cost-effective, environmentally friendly, and efficient solution to the PG stockpiling challenge.

Coercivity mechanism and magnetization reversal of anisotropic La-Nd-Dy-Fe-B micron-sized films

The coercivity mechanism and magnetization reversal process of anisotropic La-Nd-Dy-Fe-B micron-sized films have been investigated. By varying the thickness of the single-layer film from 500 nm to 6 μm, the highest coercivity of 1.88 T in the film with 3 μm thickness is achieved at 300 K, due to the large dipole interaction and domain pinning effect. When the thickness is further increased to 6 μm, the coercivity decreases sharply to 1.11 T due to the microstructure and phase formation in the film. In the 6 μm multilayer film, the addition of a Ta spacer layer further enhances perpendicular magnetic anisotropy, the dipole interaction, and adjusts the phase distribution, collectively boosting the coercivity of the micron-sized film (1.63 T). As thickness of the film increases, the dominant mechanism of coercivity shifts from a pinning mechanism to a nucleation mechanism. This study contributes to the understanding of the coercivity mechanism and magnetization reversal process in La-Nd-Dy-Fe-B permanent magnet micron-sized films.

Structural insights into the membrane-bound proteolytic machinery of bacterial protein quality control.

In bacteria and eukaryotic organelles of prokaryotic origin, ATP-dependent proteases are crucial for regulating protein quality control through substrate unfolding and degradation. Understanding the mechanism and regulation of this key cellular process could prove instrumental in developing therapeutic strategies. Very recently, cryo-electron microscopy structural studies have shed light on the functioning of AAA+ proteases, including membrane-bound proteolytic complexes. This review summarizes the structure and function relationship of bacterial AAA+ proteases, with a special focus on the sole membrane-bound AAA+ protease in Escherichia coli, FtsH. FtsH substrates include both soluble cytoplasmic and membrane-incorporated proteins, highlighting its intricate substrate recognition and processing mechanisms. Notably, 12 copies of regulatory HflK and HflC proteins, arranged in a cage-like structure embedded in the bacterial inner membrane, can encase up to 4 FtsH hexamers, thereby regulating their role in membrane protein quality control. FtsH represents an intriguing example, highlighting both its similarity to cytosolic AAA+ proteases with respect to overall architecture and oligomerization as well as its unique features, foremost its incorporation into a membrane-bound complex formed by HflK and HflC to mediate its function in protein quality control.

Atomic-level design of biomimetic iron-sulfur clusters for biocatalysis.

Designing biomimetic materials with high activity and customized biological functions by mimicking the central structure of biomolecules has become an important avenue for the development of medical materials. As an essential electron carrier, the iron-sulfur (Fe-S) clusters have the advantages of simple structure and high electron transport capacity. To rationally design and accurately construct functional materials, it is crucial to clarify the electronic structure and conformational relationships of Fe-S clusters. However, due to the complex catalytic mechanism and synthetic process in vitro, it is hard to reveal the structure-activity relationship of Fe-S clusters accurately. This review introduces the main structural types of Fe-S clusters and their catalytic mechanisms first. Then, several typical structural design strategies of biomimetic Fe-S clusters are systematically introduced. Furthermore, the development of Fe-S clusters in the biocatalytic field is enumerated, including tumor treatment, antibacterial, virus inhibition and plant photoprotection. Finally, the problems and development directions of Fe-S clusters are summarized. This review aims to guide people to accurately understand and regulate the electronic structure of Fe-S at the atomic level, which is of great significance for designing biomimetic materials with specific functions and expanding their applications in biocatalysis.

Microwave-powered integrated carbon capture and utilisation (ICCU) for methane production with rapid temperature response from minimal thermal inertia

Integrated CO2 capture and utilisation (ICCU), emerging as an effective approach for achieving global carbon neutrality goals, demonstrates its potential through the transformation of captured CO2 into valuable methane and the concurrent hydrogen storage via methanation reaction. However, traditional ICCU strategies are heavily reliant on conventional thermal conduction heating, and the in-situ methanation process is constrained by reaction thermodynamics, posing significant challenges. In this study, we introduce for the first time a novel microwave-powered system, employing a clean and efficient energy source that offers rapid heating and on-demand operation and acts as an external field enhancement method in the ICCU-methanation procedure. The designed blend of Ni-loaded CaO and carbon nanotubes (CNTs) integrates the functions of CO2 adsorption, hydrogenation catalysis, and microwave absorbing ability. This novel approach achieved a CO2 capture capacity of 3.31 mmol gDFM-1 with CO2 conversion and CH4 selectivity reaching 71.01 % and 98.17 %, respectively, at a nickel loading of 20 wt%. We also propose a possible rate enhancement mechanism for the microwave-powered ICCU-methanation cyclic process compared to conventional methods. The microwave-powered system can substantially enhance overall efficiency by swiftly responding to temperature swings, thus reducing processing time in ICCU-methanation cycles.

Selective removal of organic dyes via polymer inclusion membrane containing a perbenzylated β-cyclodextrin derivative

Organic dyes threaten aquatic ecosystems due to carcino/mutagenic properties, and their removal from wastewater is a crucial issue. The novel PIM (Polymer Inclusion Membrane) containing perbenzylated β-cyclodextrin (CD) derivative was designed as an effective material for the selective removal of organic dyes because the CD characterizes strong affinity to these compounds via inclusion complex formation. The PIM was obtained through standard solvent casting from CTA as a matrix, o-NPOE as a plasticizer, and perbenzylated β-CD as the carrier. The membrane transport was evaluated towards two different types of dyes, cationic (Methylene Blue) and anionic (Acid Orange 7), where the optimal concentration for dye removal was 50 and 75 mg/L, respectively. The efficiency of this process was around 83–90 % after 8 h, when the pH of the source/receiving phase induced the formation of non−/ionic forms of dyes, respectively. The optimal membrane composition based on mass ratio was 11.1:72.2:16.7 for CD:o-NPOE:CTA with a membrane thickness of 0.053 mm. The PIM was characterized by high selectivity dependent on both the pH of each phase used in the transport and the chemical character of the dyes. The molecular mechanism of the removal process was mostly based on the complex inclusion of dyes inside the CD cavity. The activation energies were 8.73 and 13.93 kJ/mol for MB and AO7, respectively. The dyes transport was limited by diffusion. This study provides information about novel PIM with an effective and selective carrier, the perbenzylated β-CD derivative, towards organic dyes.

Control Patterning of Cyanobiphenyl Liquid Crystals for Electricity Applications.

Controlling molecular self-assembly from organic solution evaporation is an important strategy for developing many functional materials and systems. In this work, it is demonstrated that 4-octyloxy-4'-cyanobiphenyl (8OCB) liquid crystals can be patterned into well-oriented stripes with very high micrometer-scale precision using a sandwich system through a dewetting method. The preparation temperature, concentration, and surface energy are combined to control the morphology and orientation of 8OCB microstripe arrays assisted by silicon micropillars. Microstripes prepared below the isotropic temperature were uniform, well-ordered, and showed high electricity. In addition, 8OCB molecules have a strong tendency toward antiparallel alignment, nearly standing up on the substrate with long axes parallel to the microstripe. Also, we point out the mechanism for the self-assembly process of 8OCB on the air-liquid and liquid-solid surface.

The bimetallic 3,5-dinitrobenzoate composites: A flexible-synergistic catalysts for high-performance decomposition of ammonium perchlorate

Composites of metal complexes have catalytic effects on the thermal decomposition of ammonium perchlorate (AP), while the kinetics and mechanism studies of the processes are seldom mentioned. Here, composite microspheres of cupric 3,5-dinitrobenzoate and cobalt 3,5-dinitrobenzoate [(3,5-DNB)Cox•Cuy] were synthesized and employed to research the kinetics and mechanism of AP catalytic decomposition. The decomposition peak temperature of AP in the presence of the (3,5-DNB)Cox•Cuy microspheres decreased from 403 °C (pure AP) to 288 °C, and the released heat increased by 384.5–745.6 J/g. Notably, the (3,5-DNB)Cox•Cuy microspheres significantly improved the kinetic rate constant by 1.83–37.75 times. The (3,5-DNB)Cox•Cuy microspheres exhibited higher activity than their corresponding single components for the thermal decomposition of AP, indicating excellent synergistic effects and proposing a possible mechanism. Understanding the kinetics and mechanism of the catalytic process developed in this study could further improve the decomposition performance of AP.

Non-destructive Analytical Study of Raman Spectra Variations and Mechanisms of Calcite and Aragonite in Modern and Fossilized Oysters.

Oyster fossils are some of the most common bivalve mollusk fossils found all over the world, they are different from other fossils because the oyster is still alive in the present day, and the body structure of modern oyster is almost the same as that of ancient one. Therefore, we designed a control experiment comparing the Raman spectra of minerals from both modern oysters and fossil oysters to explore the mechanism of oyster's fossilization process, which is considered to be helpful for investigating biological evolution or paleoenvironment. The oyster fossil sample was found in Nagi-Cho, Okayama Prefecture, Japan. We focused on the variations of band position and full width half-maximum of ν1 Raman band (symmetric stretching mode) of calcite (CaCO3) from modern and fossil oysters and the mineral conversion between calcite and aragonite (CaCO3) around the adductor muscle inside the oyster. Compared to modern oysters, the ν1 band at around 1086 cm-1 of calcite from oyster fossils shifted to a high wavenumber region, and the possible reason for this phenomenon is considered an elemental substitution between Ca2+ and Mg2+. As for aragonite around adductor muscle in fossil oysters, it has been found by Raman spectra that most of the aragonite has been converted into calcite because calcite has a relatively more stable structure.

Preparation of Consolidated Dust Suppression Materials Based on Pectin: Graft Modification Experiment and Reaction Mechanism.

The natural material pectin was used as the matrix to prepare a dust suppressant. The regression model in response to the grafting ratio was established, and the optimum modification scheme was determined. The amount of monomer, initiator, cross-linking agent, and reaction temperature was 3.20 g, 0.20 g, and 0.15 g and 92 °C, respectively. Through Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy tests, not only the formation of the product in graft copolymerization reaction was validated but also the wettability of pectin was significantly improved. The surface morphology of pectin before and after modification was observed by a scanning electron microscope. After graft copolymerization treatment, the surface of pectin presented a dense grid structure, which proved that the pectin-modified dust suppressant can play a crucial role in wetting and condensing coal dust. Contact angle tests were used to characterize the effect of pectin modification on the wettability of bituminous coal before and after modification. The results of contact angle tests showed that when the droplets just contacted the bituminous coal flakes, the contact angle of modified pectin droplets on the flakes was the smallest, and the value was 55.21°. Compared with pure water droplets and unmodified pectin droplets, it decreased by 21.66° and 18.50°. The modification reaction process and dust suppression mechanism were explained at the molecular level.

The effects of environmental evolution on runoff and hydrological health variations in the upper Shule River, Northwest China

Promptly grasping the process of runoff change and the mechanism of hydrological health (H) variation in inland river basins is essential for the optimal use of water resources in the arid area of Northwest China. In this study, the upper Shule River (USR) was selected as the research area. The Budyko equation and the slope changing ratio of cumulative quantity method (SCRCQ) were used to analyze the response of environmental changes to the evolution of runoff and hydrological health during 1956–2022. The findings showed that the streamflow at various time scales in the USR showed a significantly increased trend from 1956 to 2022. The change rate of annual maximum runoff (Rmax) was 3.3 times that of annual runoff (R), the change rate of R in the flood period was 2.4 times that in the non-flood period, and the change rate in summer was 5 times that in winter. The H of the USR indicated a downtrend during 1956–2022, and the H in the Ta period was better than that in the Tb period. June and August were the main periods of runoff increase and hydrological health evolution, and precipitation (P) was the main driving factor. The response of Rmax increased to climate variability and anthropogenic stressors was 50.42 % and 49.58 %, respectively. The response degrees of H to climate variability and anthropogenic stressors were 62.89 % and 37.11 %, respectively. In general, climate variation was the major factor in the increase of R and the decrease of H in the USR. The findings are useful for getting the streamflow evolution process and hydrologic cycle mechanism and playing a supporting role in the sustainable management of water resources in the future.

From Humble Leadership to Follower Performance: A Meta-analysis of Relational and Cognitive Mechanisms

Unclarity remains in current literature pertaining to the effects and specific processes of humble leadership, calling for more in-depth reviews for boosting the understanding. Our research focuses on follower performance as an important outcome of humble leadership and aims to conduct a meta-analysis to uncover the mechanisms beneath the effecting process. Integrating social exchange theory and social cognitive theory, we proposed that follower's relationship with the leader and their belief in themselves, respectively acting as relational and cognitive mechanisms, would sequentially mediate the relationship between humble leadership and follower performance, including task performance and organizational citizenship behavior. We adopted meta-analytic structural equation modeling (MASEM) to examine our hypotheses and gained empirical support from the results. With the synthesis of literature, this article exerts to unfold the effecting process and potential mechanisms of humble leadership on follower performance, anticipating to make several theoretical contributions and practical implications as well as providing insights for future research.

State-of-the-art Review of Springback Behavior of Polymers

The spring-in and spring-back behavior of polymers is intricate and influenced by various process parameters and mechanisms, including interply slip, anisotropic thermal expansion, and crystallization, all of which can lead to residual stresses. Composite materials made of metal and polymer are being investigated by researchers as a promising alternative to monometallic materials due to their superior properties. However, the number of studies related to metal/polymer/metal laminates on the same topics is relatively limited. A comprehensive review study was carried out with a focus on research works that were conducted with the consideration of different process parameters, such as radius of die and punch, friction, and force applied by blank holder, in order to observe their impact on the springback behavior of polymers. Springback on polymer components depends on the accuracy of appropriate materials and the consideration of appropriate experimental strategies. However, due to their viscoelastic properties, polymers demonstrate distinctive springback behavior. Furthermore, when subjected to deformation, polymers experience a combination of elastic and viscous responses, resulting in immediate elastic recovery and time-dependent viscoelastic relaxation. This intricate behavior presents difficulties in precisely forecasting and managing springback. To enhance the control and optimization of springback in polymer-based manufacturing processes, it is essential to improve the understanding of polymer behavior under diverse loading conditions and to refine simulation techniques accordingly. This review focuses on springback prediction models specific to polymers.

Comparative Analysis of Simultaneous Electrochemical and Electrodischarge Machining Process

Abstract Recent advances have established electrochemical discharge machining (ECDM) as an effective alternative to electrical discharge machining (EDM) for producing microholes in conductive materials. However, ECDM leaves nonuniform layers, including recast layers and heat-affected zones, rendering it unsuitable for materials vital to aerospace, defence, and biomedical applications. To address this issue, the present work investigates a novel electrochemical machining (ECM)-based frugal engineering process known as simultaneous electrochemical and electrodischarge machining (SECEDM) for microhole fabrication. To evaluate the process effectiveness, the machining results of the SECEDM process were compared with ECDM, EDM, and ECM. The obtained results present the fundamental distinction between the process mechanism of SECEDM and ECDM. SECEDM has been reported to produce microholes with improved machined surfaces characterized by their freedom from recast layer and ECDM-induced defects. Moreover, SECEDM facilitated meticulously controlled high-speed anodic dissolution of work material, surpassing the material removal rate (MRR) achieved through ultrasonic-assisted ECDM (U-ECDM), ECM, and EDM processes by 2.67, 4.2, and 6.2 times, respectively. Furthermore, the substantial 67.72% and 68.82% reduction in the average machined hole diameter than ECM and U-ECDM, respectively, with a noteworthy 13.69% enhancement in average roundness error achieved while maintaining the repeatability accuracy with an accuracy range within ±0.009 mm through SECEDM process underscore SECEDM's accuracy and repeatability. In addition, lower surface roughness by 31.6% and 68% compared to ECM and EDM, along with reduced carbon and oxygen content as examined through energy dispersive X-ray (EDX) analysis, signifies the SECEDM process efficiency in microfabrication.

Study of the proton transfer during acidification of sodium salicylate based on ReaxFF molecular dynamics simulation

Salicylic acid (SA) is known for its pain-relieving and fever-reducing abilities and has a very broad range of applications, being an important ingredient in a wide variety of products such as pharmaceuticals, skin care products, agrochemicals, dyes, colorants, preservatives, and more. SA is mainly synthesized by the Kolbe-Schmitt method in industrial production, but there is still no standardized description of the mechanism of this reaction. The Kolbe-Schmitt reaction mechanism is divided into three steps, and the reaction mechanism of the first two steps has been fully investigated, while the reaction mechanism of Sodium salicylate (SS) acidification, as the last step in the synthesis of SA by the Kolbe-Schmitt process, has not been investigated, so we used the Reactive force-field molecular dynamics simulation (ReaxFF MD) method to simulate and reveal the reaction mechanism of the mixed solution of SS and sulfuric acid, followed by an orthogonal design to explore the effects of different factors on the yield of SA. Through the investigation, it was found that the reaction of SS with sulfuric acid mixed solution was divided into the following four stages in total: hydration reaction, proton transfer reaction, association reaction and dissociation reaction, respectively. It is concluded that the SA yield in SS acidification reaction is affected by the factors in the following order: concentration > pressure > time > temperature, where concentration and pressure significantly affect the SA yield. It is hoped that the present study can supplement the relevant understanding of the reaction mechanism of the Kolbe-Schmitt process, and at the same time have some practical significance and application value for the improvement and optimization of the synthetic SA process.

Physiological and gene expression response mechanisms of dehydration process in Cinnamomum cassia (L.) J. Presl seeds.

A critical factor in the storability of recalcitrant seeds is their moisture content (MC), but its effect on the viability of Cinnamomum cassia (L.) J. Presl (C. cassia) seeds is not fully understood. Measured the germination rate, starch and soluble sugar content, and transcriptome of 8 seed samples with different MC obtained by low-temperature drying method. It was found that the germination rate was significantly negatively correlated with MC. The lethal MC was around 15.6%. During the dehydration process, there was a significant increase in the content of soluble sugars and starch. Transcriptome analysis was performed on CK, W3, W6 showed a total of 62.78 Gb of clean data. Among the 30,228 Unigenes, 28,195 were successfully annotated. In the three comparative groups (CK and W3, CK and W6, W3 and W6), 6,842, 7,640, and 11,628 differentially expressed genes (DEGs) were obtained, respectively. These DEGs were found to be involved in a variety of metabolic pathways, including carbon metabolism, amino acid biosynthesis, starch and sucrose metabolism, glycolysis/gluconeogenesis, and nucleotide and amino sugar metabolism. A total of 1,416 common genes were identified among all three comparison groups. Furthermore, among all the DEGs, a total of 71 transcription factor families were identified, with the C2H2 transcription factor family having the highest number of genes. This ground-breaking study sheds light on the physiological response and gene expression profiles of C. cassia seeds after undergoing dehydration treatment, which will provide valuable insights for further research and understanding of this process.

Investigation of Hemorheological Parameters in Ischemic Stroke Patients.

The aim of this study is to determine whether there are any changes in hemorheological parameters, including whole blood viscosity (WBV), plasma viscosity, erythrocyte aggregation, and erythrocyte deformability, in acute ischemic stroke patients, and to establish their relationship with stroke etiology. The study also aims to observe the changes in these parameters, if any, over time and after treatment, and to assess the correlation between risk factors for ischemic stroke and neuroimaging findings. This was a prospective observational study including 70 patients diagnosed with acute ischemic stroke within the first 3 days of the onset of symptoms and 96 healthy controls. Stroke patients were categorized based on TOAST criteria, and hemorheological parameters were measured at admission and on the fifth day post-treatment. Erythrocyte aggregation and deformability were measured using a laser ektacytometer, and viscosity assessment was conducted with a rotational viscometer. Stroke patients exhibited significant differences from the control group in aggregation amplitude, aggregation index, and aggregation half-time (p = 0.001, p = 0.013, p = 0.009, respectively) and showed elevated maximum value of elongation index (p = 0.000). No significant differences in WBV and plasma viscosity were observed between the groups. Post-treatment, the small vessel occlusion subgroup demonstrated a notable reduction in WBV. Additionally, homocysteine levels showed a positive correlation with scattered white matter lesions in basal ganglia and infratentorial regions (p = 0.002, p = 0.039, respectively). Increased predisposition to erythrocyte aggregation may contribute to the occurrence of acute ischemic stroke. Moreover, gaining the ability of erythrocytes to deform and increase blood flow may serve as a compensatory mechanism in the chronic vascular disease process. The risk factors for ischemic stroke may exhibit connections to specific areas within the brain.